Caspasa
Los inhibidores de caspasas son compuestos que bloquean la actividad de las caspasas, una familia de proteasas que son ejecutores centrales de la apoptosis. Las caspasas escinden sustratos específicos dentro de la célula para desencadenar el proceso apoptótico, lo que conduce a la muerte celular programada. Los inhibidores de caspasas se utilizan para estudiar los mecanismos de la apoptosis, así como para prevenir la muerte celular no deseada en varios modelos de investigación. Estos inhibidores también se exploran en contextos terapéuticos para proteger las células de la apoptosis en enfermedades como la neurodegeneración. En CymitQuimica, ofrecemos una amplia gama de inhibidores de caspasas de alta calidad para apoyar su investigación en apoptosis, muerte celular y campos relacionados.
Se han encontrado 125 productos de "Caspasa"
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N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride
CAS:<p>N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride (TLCK hydrochloride) is an irreversible serine protease inhibitor that functions by alkylating the histidine residue at the active site, thus inhibiting trypsin and trypsin-like proteases. It effectively inhibits caspase-3, caspase-6, and caspase-7 with IC50 values of 12.0, 54.5, and 19.3 μM, respectively. Additionally, N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride induces apoptosis in HL-60 cells and prevents the reduction of mitochondrial transmembrane potential during the apoptosis process.</p>Fórmula:C14H22Cl2N2O3SPeso molecular:369.31M826
<p>M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in</p>Fórmula:C28H45N7O6Pureza:98%Forma y color:SolidPeso molecular:575.7Ac-DMLD-CMK
CAS:<p>Ac-DMLD-CMK is a peptide designed to target the caspase3-Gsdme signaling pathway in mice. It specifically inhibits the activation of caspase 3 and Gsdme, preventing the cleavage of Gsdme by caspase 3, which reduces pyroptosis. This process helps alleviate damage to renal tubular epithelial cells and decrease the secretion of inflammatory cytokines. Ac-DMLD-CMK can lower serum creatinine and blood urea nitrogen levels in mice induced by Cisplatin, thereby mitigating the progression of renal dysfunction. It holds potential for research into chemotherapy-induced nephrotoxicity.</p>Fórmula:C22H35ClN4O9SForma y color:SolidPeso molecular:567.053(2R,3S)-Emricasan
CAS:<p>(2R,3S)-Emricasan ((2R,3S)-PF 03491390) is an isomer of Emricasan. This compound acts as an orally effective irreversible pan-caspase inhibitor. (2R,3S)-Emricasan inhibits the increase in caspase-3 activity induced by Zika virus (ZIKV) and protects human cortical neural progenitor cells.</p>Fórmula:C26H27F4N3O7Forma y color:SolidPeso molecular:569.5Z-VA-DL-D-FMK
CAS:Z-VA-DL-D-FMK (Z-VA-DL-D(OH)-FMK) acts as an inhibitor of caspases. It irreversibly binds to caspases, enhancing the sensitivity to TNF-α and stimulating HIV replication in infected T cells ACH-2.Fórmula:C21H28FN3O7Forma y color:SolidPeso molecular:453.46
