BCL
Los inhibidores de BCL son compuestos que se dirigen a la familia de proteínas BCL-2, que juegan un papel clave en la regulación de la apoptosis. La familia BCL-2 incluye miembros proapoptóticos y antiapoptóticos que controlan la vía mitocondrial de la apoptosis. Inhibir las proteínas BCL-2 antiapoptóticas puede promover la muerte celular en células cancerosas, lo que convierte a los inhibidores de BCL en herramientas cruciales en la investigación de terapias contra el cáncer. En CymitQuimica, ofrecemos una selección completa de inhibidores de BCL de alta calidad para apoyar su investigación en cáncer, apoptosis y biología celular.
Se han encontrado 11 productos de "BCL"
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BM 957
CAS:<p>BM 957 is an effective Bcl-2 and Bcl-xL inhibitor (Kis: 1.2 and <1 nM; IC50s: 5.4 and 6.0 nM).</p>Fórmula:C52H56ClF3N6O7S3Pureza:98%Forma y color:SolidPeso molecular:1065.68Mcl-1 inhibitor 3
CAS:<p>Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activate</p>Fórmula:C40H52ClF2N5O7SPureza:98%Forma y color:SolidPeso molecular:820.39PROTAC Bcl2 degrader-1
CAS:<p>PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).</p>Fórmula:C45H45BrN6O10SPureza:98%Forma y color:SolidPeso molecular:941.84Mcl1-IN-12
CAS:<p>Mcl1-IN-12 has anti-tumor activity.It is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively.</p>Fórmula:C45H46N4O6S2Pureza:98%Forma y color:SolidPeso molecular:803Pyridoclax
CAS:<p>Pyridoclax is an inhibitor of potential Mcl-1.</p>Fórmula:C29H22N4Pureza:98%Forma y color:SolidPeso molecular:426.51S55746 hydrochloride
CAS:<p>S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity.</p>Fórmula:C43H43ClN4O6Pureza:98%Forma y color:SolidPeso molecular:747.28Tapotoclax
CAS:<p>Tapotoclax (AMG-176) is an orally active MCL1 inhibitor for the study of myeloid leukemia.</p>Fórmula:C33H41ClN2O5SPureza:98.8%Forma y color:SolidPeso molecular:613.21MCL-1/BCL-2-IN-1
CAS:<p>MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective dual inhibitor of Mcl-1 and Bcl-2 with IC 50 s of 4.45 and 3.18 μM, respectively [1].</p>Fórmula:C31H27BrN2O3SPureza:98%Forma y color:SolidPeso molecular:587.53Mcl1-IN-11
CAS:<p>Mcl1-IN-11 (Compound G) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.06 and 4.2 μM, respectively.</p>Fórmula:C38H41N3O5S2Pureza:98%Forma y color:SolidPeso molecular:683.88Mcl1-IN-9
CAS:<p>Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM.</p>Fórmula:C37H39ClN4O4Pureza:98%Forma y color:SolidPeso molecular:639.18WEHI-539 hydrochloride
CAS:<p>WEHI-539 hydrochloride is a selective Bcl-XL inhibitor with an IC50 of 1.1 nM.</p>Fórmula:C31H30ClN5O3S2Pureza:98%Forma y color:SolidPeso molecular:620.18
