BCL

Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor with anticancer activity.

AZD4320 is an inhibitor of BH3-mimicking dual BCL2/BCLxL. For KPUM-MS3, KPUM-UH1, and STR-428 cells, the …

Mcl1-IN-2 is a myeloid cell factor 1 (Mcl-1) inhibitor.

BI-3812 is an inhibitor of BCL6. Which inhibiting the BTB domain of BCL6 (IC50: 3 …

Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.

Metaldehyde is used for snails and other gastropods pesticide against.

Dehydrocorydaline chloride is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of …

S55746 is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of …

Navitoclax-piperazine is an inhibitor of B-cell lymphoma extra large (BCL-XL).

BH3I-1 is a Bcl-2 antagonist.

BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM. BT2 (compound …

Maritoclax (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor, shows >8 fold selectivity than …

Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).

Rasagiline is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa …

MIM1 is an myeloid cell factor 1 (Mcl-1) inhibitor.

Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 …

BCL6-IN-6 is an inhibitor of Bcl-6 and can be used in studies about diffuse large …

WEHI-9625 is a tricyclic sulfone small molecule apoptosis inhibitor (EC50: 69 nM).

Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor …

Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in …

Isochamaejasmine is a biflavonoid isolated from S. chamaejasme L. with inhibition of NF-κB activation. Isochamaejasmine …

BM 957 is an effective Bcl-2 and Bcl-xL inhibitor (Kis: 1.2 and <1 nM; IC50s: …

Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is …

Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of …

Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of …

Physalin B shows antimalarial, anti-Trypanosoma cruzi, anti-bacterial, anti- leukemia activities, it has the potential to …

Isoverticine exhibits significant antitussive, expectorant and anti-inflammatory activities, it also displays significant cytotoxicity.

Lucidenic acid B shows antioxidative, and anti-invasive effects, it inhibits PMA-induced invasion of human hepatoma …

Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO …

Protodeltonin may have anti-thrombotic activity by both improving the anticoagulation activity and inhibiting platelet aggregation …

AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with …

Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of …

Ginsenoside F4 has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis, the …

AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is an Mcl-1 inhibitor …

Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via …

Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, inhibitive effect in …

Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also …

Clerosterol as a precursor of cyasterone, isocyasterone and 29-norcyasterone in biosynthesis of phytoecdysteroids of Ajuga …

Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, …

Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in …

VU0661013 is an effective and selective inhibitor of MCL-1.

Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis …

Obovatol has antioxidant, neuroprotective, antiinflammatory, antithrombotic and antitumour effects, it is a potent NF-κB inhibitors …

6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 …

VHD-valtrate has anticancer effects against human ovarian cancer cells in vitro and in vivo, it …

Thevetiaflavone is a natural flavonoid from Wikstroemia indica that inhibits the leakage of lactate dehydrogenase …

Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration …

Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing …

Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth.

Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the …

Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT …

Ergosta-4,6,8(14),22-tetraen-3-one has cytotoxic activity against human gastric cancer cell, it can induce G2/M cell cycle …

Dehydrocavidine has antitumor activity, it inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating …

Wilfortrine can induce liver cancer cell HepG2 apoptosis, but with no effect on the cell …

Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in …

Mcl1-IN-12 has anti-tumor activity.It is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis …

PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 …

MIK665 (S-64315) has an inhibitory effect on myeloid leukemia.

Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat …

Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also …

Myricanol can elicit growth inhibitory and cytotoxic effects on lung cancer cells, it can significantly …

Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity …

Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and …

PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 …

Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, …

Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce apoptosis …

3',4',5',5,7-Pentamethoxyflavone has anti-inflammatory and cancer chemopreventive activities. 3',4',5',5,7-Pentamethoxyflavone could be used as an effective adjuvant …

Lisaftoclax is a dual Bcl-2 and Bcl-xl inhibitor (IC50: 2 nM and 5.9 nM) with …

2',3'-Dehydrosalannol possesses antifeedant activity against Spodptera litura. It shows anticancer effects on triple-negative breast cancer(TNBC), …

A-385358 is a selective Bcl-xL inhibitor with Kis of 0.80 nM for Bcl-xL and 67 …

Cimidahurinine can attenuate Doxorubicin (DOX)-induced cardiotoxicity in a dose-dependent manner with EC50 values of 45.79 …

Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 …

2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing …