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Ciclo celular / Checkpoint

Ciclo celular / Checkpoint

Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.

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Se han encontrado 3480 productos de "Ciclo celular / Checkpoint"

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  • 2′-OMe-GDP
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    2′-OMe-GDP

    CAS:
    <p>2′-OMe-GDP is a nucleotide analog utilized for the synthesis of oligonucleotides.</p>
    Fórmula:C11H17N5O11P2
    Forma y color:Solid
    Peso molecular:457.23

    Ref: TM-TSW-00953

  • DNA ligase-IN-2
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    DNA ligase-IN-2

    CAS:
    <p>DNA ligase-IN-2 (compound 2) acts as a potent LigA inhibitor, effectively hindering the DNA-independent spontaneous adenylation activity of full-length LigA and the truncated enzyme LigA:AD with an IC50 of 29 nM. It also significantly suppresses the in vitro growth of Staphylococcus aureus, showing MIC values of 1 μg/mL for S. aureus ATCC 29213 and S. aureus ATCC 700699, while the MIC for Escherichia coli (E. coli) ATCC 25922 is &gt;64 μg/mL.</p>
    Fórmula:C13H8FN3O3
    Forma y color:Solid
    Peso molecular:273.219

    Ref: TM-T204415

  • RAD51-IN-7
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    RAD51-IN-7

    CAS:
    <p>RAD51-IN-7 inhibits RAD51 gene, with potential for mitochondrial disorders. (From WO2021164746A1, cmpd 71)</p>
    Fórmula:C25H31N5O4S2
    Forma y color:Solid
    Peso molecular:529.67

    Ref: TM-T63728

  • Aurora A inhibitor 1
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    Aurora A inhibitor 1

    CAS:
    <p>Aurora A inhibitor 1: potent, selective, targets cancer-linked Aurora A overexpression, potential for cancer research. (WO2021147974A1, 49)</p>
    Fórmula:C25H28ClF2N5O2
    Forma y color:Solid
    Peso molecular:503.97

    Ref: TM-T63436

  • Logo de CymitQuimica
    Targetmol
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    CDK1-IN-5

    <p>CDK1-IN-5 is a selective inhibitor for CDK1 (IC50: 42.19 nM), CDK2, CDK5, halting cancer cell growth.</p>
    Fórmula:C27H26ClN5OS
    Forma y color:Solid
    Peso molecular:504.05

    Ref: TM-T63437

  • (R)-Atuveciclib
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    (R)-Atuveciclib

    CAS:
    <p>Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].</p>
    Fórmula:C18H18FN5O2S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:387.43

    Ref: TM-T10464

  • LNA-GTP
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    LNA-GTP

    CAS:
    <p>LNA-GTP is a nucleotide analog used in the synthesis of oligonucleotides.</p>
    Fórmula:C11H16N5O14P3
    Forma y color:Solid
    Peso molecular:535.19

    Ref: TM-TSW-00969

  • RNAP-σ interaction inhibitor-2
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    RNAP-σ interaction inhibitor-2

    CAS:
    <p>RNAP-σ interaction inhibitor-2 (compound 7d) is an inhibitor targeting the interaction between RNA polymerase and the sigma factor. It demonstrates inhibitory activity against S. aureus with a minimum inhibitory concentration (MIC) of 2 µg/mL.</p>
    Fórmula:C27H19Cl3N2O6S2
    Forma y color:Solid
    Peso molecular:637.939

    Ref: TM-T206884

  • LZ9
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    LZ9

    CAS:
    <p>LZ9 is an ATP-competitive inhibitor of CDK1 and CDK2, with potential applications in colorectal cancer (CRC) research.</p>
    Fórmula:C17H11F3N4O2
    Forma y color:Solid
    Peso molecular:360.29

    Ref: TM-T204957

  • CDK2 degrader 4
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    CDK2 degrader 4

    CAS:
    <p>CDK2 degrader4 (compound 104) is a potent degrader of CDK2, showing promise for cancer research applications.</p>
    Fórmula:C23H26ClN3O5
    Forma y color:Solid
    Peso molecular:459.923

    Ref: TM-T204856

  • LNA-CTP
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    LNA-CTP

    CAS:
    <p>LNA-CTP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>
    Fórmula:C10H16N3O14P3
    Forma y color:Solid
    Peso molecular:495.17

    Ref: TM-TSW-00954

  • 5-Iminodaunorubicin hydrochloride
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    5-Iminodaunorubicin hydrochloride

    CAS:
    <p>5-Iminodaunorubicin HCl: quinone-modified anthracycline with antitumor properties, induces DNA breaks in cancer cells.</p>
    Fórmula:C27H31ClN2O9
    Forma y color:Solid
    Peso molecular:563.00

    Ref: TM-T72115

  • Dyrk1A-IN-12
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    Dyrk1A-IN-12

    CAS:
    <p>Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A). It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV).</p>
    Fórmula:C22H16FN3O2S
    Forma y color:Solid
    Peso molecular:405.445

    Ref: TM-T205530

  • CDK2 degrader 6
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    CDK2 degrader 6

    CAS:
    <p>CDK2 degrader6 (compound 6) is an orally active CDK2 degrader with a DC50 of 46.5 nM, and is applicable in breast cancer research.</p>
    Fórmula:C23H22F5N5O3
    Forma y color:Solid
    Peso molecular:511.44

    Ref: TM-T207287

  • PCNA-IN-1
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    PCNA-IN-1

    CAS:
    <p>PCNA-IN-1 (Compound 11) is an inhibitor of the PCNA/PIP-box interaction, with an IC50 greater than 50 μM. It is applicable in cancer research.</p>
    Fórmula:C19H18I3NO3
    Forma y color:Solid
    Peso molecular:689.065

    Ref: TM-T204170

  • RMS-07
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    RMS-07

    CAS:
    <p>RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.</p>
    Fórmula:C35H40N8O2
    Forma y color:Solid
    Peso molecular:604.74

    Ref: TM-T73483

  • NRTT-IN-1
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    NRTT-IN-1

    CAS:
    <p>NRTT-IN-1 (Compound 1) is an inhibitor of the nucleoside reverse transcriptase translocation (NRTT), effectively blocking HIV DNA synthesis and viral replication.</p>
    Fórmula:C28H24FN5O5
    Forma y color:Solid
    Peso molecular:529.519

    Ref: TM-T205482

  • RECTAS-2.0
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    RECTAS-2.0

    CAS:
    <p>RECTAS-2.0 is a small molecule designed to correct RNA mis-splicing caused by the GLA c.639+919G&gt;A mutation, intended for research in Fabry disease.</p>
    Fórmula:C18H17ClN4O4
    Forma y color:Solid
    Peso molecular:388.805

    Ref: TM-T206725

  • (Rac)-Plevitrexed
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    (Rac)-Plevitrexed

    CAS:
    <p>(Rac)-Plevitrexed is a racemate of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).</p>
    Fórmula:C26H25FN8O4
    Pureza:98%
    Forma y color:Solid
    Peso molecular:532.53

    Ref: TM-T12674

  • INX-315
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    INX-315

    CAS:
    <p>INX-315 is an orally active, selective CDK2 inhibitor that induces cell cycle arrest and senescence in solid tumours, suppresses E2F target gene expression.</p>
    Fórmula:C19H21N7O3S
    Pureza:99.88%
    Forma y color:Solid
    Peso molecular:427.48

    Ref: TM-T86723