Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa(94 productos)
- CDK(500 productos)
- Detención del ciclo celular(4 productos)
- Chk(42 productos)
- DYRK(48 productos)
- Dynamin(23 productos)
- Ferroptosis(215 productos)
- HSP(169 productos)
- Integrin(224 productos)
- Kinesina(66 productos)
- LIM quinasa(19 productos)
- Asociado a microtúbulos(261 productos)
- PKC(102 productos)
- PLK(28 productos)
- ROCK(70 productos)
- Rho(2 productos)
- Wee1(15 productos)
- c-Myc(69 productos)
Mostrar 10 subcategorías más
Se han encontrado 3477 productos de "Ciclo celular / Checkpoint"
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TREX1-IN-3
CAS:<p>TREX1-IN-3 (Compound 95) is an inhibitor of TREX1 and TREX2, with an IC50 of less than 0.1 μM for TREX1 and less than 1 μM for TREX2, as well as an EC50 of less than 1 μM for HCT116 cells. It is applicable for research in the field of cancer.</p>Fórmula:C24H19ClN6O4Forma y color:SolidPeso molecular:490.898SCH-1473759
CAS:<p>SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).</p>Fórmula:C20H26N8OSPureza:98%Forma y color:SolidPeso molecular:426.54SR121566A
CAS:<p>SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).</p>Fórmula:C20H25N5O4SPureza:98%Forma y color:SolidPeso molecular:431.51Epolactaene
CAS:<p>Epolactaene: neuritogenic, inhibits mammalian DNA polymerases & human DNA topoisomerase II.</p>Fórmula:C21H27NO6Forma y color:SolidPeso molecular:389.44Dyrk1A-IN-1
<p>Dyrk1A-IN-1 is a triple inhibitor of Dyrk1A kinase activity, aggregation of tau and α-syn oligomers, with an IC50 value of 119 nM for Dyrk1A kinase.</p>Fórmula:C23H20N4O3SForma y color:SolidPeso molecular:432.49CDK2-IN-8
<p>CDK2-IN-8 is a potent CDK2 inhibitor (IC50= 1.74 μM). CDK2-IN-8 exhibits antiproliferative activity. CDK2-IN-8 can be used for the research of melanoma.</p>Fórmula:C22H25N5O3Forma y color:SolidPeso molecular:407.47Cdc7-IN-11
CAS:<p>Cdc7-IN-11 is a potent inhibitor of Cdc7 (IC50 ≤ 1 nM) and can be used in the study of proliferative diseases.</p>Fórmula:C20H22F2N4O2SForma y color:SolidPeso molecular:420.48MU147
CAS:<p>MU147 is an MRE11 nuclease inhibitor and chemical probe with anticancer properties, exhibiting lethal effects on Ehrlich ascites tumor cells both in vivo and in vitro. It disrupts the MRE11 nuclease-dependent double-strand break repair mechanism without impairing ATM activation. Additionally, MU147 damages the degradation of nascent strands at stalled replication forks and selectively affects BRCA2-deficient cells.</p>Fórmula:C19H13N3O3SForma y color:SolidPeso molecular:363.39CDK2-IN-40
CAS:<p>CDK9-IN-40 is an inhibitor of CDK2 (Cyclin-dependent kinase 2). It effectively inhibits CDK2/Cyclin E1, with an IC50 of ≤ 10 nM.</p>Fórmula:C16H21N7O2Forma y color:SolidPeso molecular:343.384FT3967385
<p>FT3967385: New USP30 inhibitor boosts mitochondrial ubiquitylation via PINK1-PARKIN.</p>Fórmula:C21H19N5O2Forma y color:SolidPeso molecular:373.41CLK1/2-IN-1
CAS:<p>CLK1/2-IN-1 is a CLK1 and CLK2 inhibitor and it also inhibits SRPK1 and SRPK2.</p>Fórmula:C21H20F3N7OPureza:98%Forma y color:SolidPeso molecular:443.42CDK8-IN-11 hydrochloride
<p>CDK8-IN-11 HCl: potent, selective CDK8 inhibitor (IC50: 46 nM), blocks WNT/β-catenin pathway, used in colon cancer research.</p>Fórmula:C19H16ClF3N4O2Forma y color:SolidPeso molecular:424.8p38α inhibitor 9
CAS:<p>p38α inhibitor9 (Compound 2015) is a p38α inhibitor that effectively blocks the enzyme activity of p38α, with an IC50 of less than 20 nM. It inhibits MK2T334 phosphorylation and activates Cdc25b and Cdc25c while inactivating Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy, and DNA damage. Additionally, p38α inhibitor9 can suppress colorectal cancer (CRC) metastasis.</p>Fórmula:C27H24FN3O3Forma y color:SolidPeso molecular:457.496USP7-IN-10
CAS:<p>USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.</p>Fórmula:C26H29ClN4O3SForma y color:SolidPeso molecular:513.05L-I-OddU
CAS:<p>L-I-OddU: Selective anti-EBV, halts virus DNA/protein synthesis. EC50: 0.03 µM, low toxicity (CC50: 1000 nM).</p>Fórmula:C8H9IN2O5Forma y color:SolidPeso molecular:340.07FT709
CAS:<p>FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.</p>Fórmula:C23H22N4O7SForma y color:SolidPeso molecular:498.51SF0166
CAS:<p>SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.</p>Fórmula:C23H27F2N5O4Forma y color:SolidPeso molecular:475.49LN-439A
CAS:<p>LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.</p>Fórmula:C24H26FN3O4Forma y color:SolidPeso molecular:439.48DNA polymerase-IN-6
CAS:<p>DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, with EC50 values of 0.33 µM for HCMV, 1.9 µM for HSV-1, 0.76 µM for HSV-2, and 0.066 µM for EBV.</p>Fórmula:C26H28ClFN8O4Forma y color:SolidPeso molecular:571.003CDK1-IN-3
<p>CDK1-IN-3 is a selective inhibitor targeting CDK1 (36.8 nM), CDK2 (305.17 nM), CDK5 (369.37 nM); used in cancer research.</p>Fórmula:C28H25ClF3N5O2Forma y color:SolidPeso molecular:555.98And1 degrader 1
CAS:<p>And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.</p>Fórmula:C26H27Cl2N3OForma y color:SolidPeso molecular:468.42WRN inhibitor 13
CAS:<p>WRN inhibitor 13 is an inhibitor of the WRN helicase with a pIC50 value ranging from 6 to 7.</p>Fórmula:C16H20N2O5SForma y color:SolidPeso molecular:352.405PD-1-IN-17
CAS:<p>PD-1-IN-17 is an inhibitor of programmed cell death-1 (PD-1). PD-1-IN-17 inhibits 92% splenocyte proliferation at 100 nM.</p>Fórmula:C13H22N6O7Pureza:99.6%Forma y color:SolidPeso molecular:374.35LIMK1 inhibitor 1
CAS:<p>LIMK1 inhibitor1 (compound 24) is a LIMK1 inhibitor, potentially useful for cancer research.</p>Fórmula:C12H15N3S2Forma y color:SolidPeso molecular:265.398DNA Gyrase-IN-1
<p>DNA Gyrase-IN-1: potent, selective promoter inhibitor. IC50: 2.6 μM, inhibits Mtb, MIC: 0.49 μM. Useful for tuberculosis research.</p>Fórmula:C24H24FN7O6Forma y color:SolidPeso molecular:525.49GR 83895
CAS:<p>GR 83895 is an antagonist of prototype fibrinogen receptor.</p>Fórmula:C29H39N9O8SPureza:98%Forma y color:SolidPeso molecular:673.745'-DMT-5-F-2'-dU Phosphoramidite
CAS:<p>5'-DMT-5-F-2'-dU Phosphoramidite is a nucleoside phosphoramidite analog employed in oligonucleotide synthesis. It plays a crucial role in developing therapeutic oligonucleotides, which are used in crafting drugs for cancer treatment.</p>Fórmula:C39H46FN4O8PForma y color:SolidPeso molecular:748.777CDK9 autophagic degrader 1
CAS:<p>CDK9 autophagic degrader 1 (Compound 28) is an ATTEC degrader used to target and degrade CDK9, also impacting the levels of its associated Cyclin T1. At a concentration of 100 nM, it exhibits over 80% inhibition of CDK9.</p>Fórmula:C34H39N7O4S2Forma y color:SolidPeso molecular:673.848KL-50
CAS:<p>KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.</p>Fórmula:C7H7FN6O2Forma y color:SolidPeso molecular:226.17LNA-GDP
CAS:<p>LNA-GDP is a nucleotide analog utilized in the synthesis of oligonucleotides.</p>Fórmula:C11H15N5O11P2Forma y color:SolidPeso molecular:455.217-Methylguanosine 5′-monophosphate
CAS:<p>7-Methylguanosine 5′-monophosphate (7-Methylguanylic acid) is a component of nucleic acids.</p>Fórmula:C11H16N5O8PForma y color:SolidPeso molecular:377.25CDK2-IN-39
CAS:<p>CDK2-IN-39 (compound 4) is a CDK2 inhibitor.</p>Fórmula:C14H15N3O4SForma y color:SolidPeso molecular:321.352CDK4/6-IN-3
CAS:<p>CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.</p>Fórmula:C25H31FN8Pureza:98%Forma y color:SolidPeso molecular:462.57MtTMPK-IN-8
<p>MtTMPK-IN-8 inhibits MtbTMPK, has low cytotoxicity, shows 0.78-9.4 μM activity against Mycobacterium, useful for tuberculosis research.</p>Fórmula:C24H24N6O7Forma y color:SolidPeso molecular:508.48Metesind Glucuronate
CAS:<p>Metesind Glucuronate is an antineoplastic. It also is a specific thymidylate synthase inhibitor.</p>Fórmula:C29H34N4O10SForma y color:SolidPeso molecular:630.67AB25583
CAS:<p>AB25583 is a small molecule inhibitor of Polθ helicase (Polθ-hel) with an IC50 of 6 nM. It selectively kills cells deficient in BRCA1/2 and synergizes with Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. AB25583 can be utilized in tumor research.</p>Fórmula:C22H17ClN4O3SForma y color:SolidPeso molecular:452.91LIMK1 inhibitor 2
CAS:<p>LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with an IC50 value of 9 μM.</p>Fórmula:C10H11N3OSForma y color:SolidPeso molecular:221.279MKLP2-IN-1
CAS:<p>MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.</p>Fórmula:C23H19BrFN3O2Forma y color:SolidPeso molecular:468.318Antibacterial agent 110
<p>Compound 4e, an antibacterial against P. aeruginosa, disrupts cell membranes (MIC: 1 μg/ml).</p>Fórmula:C22H21N5O4SForma y color:SolidPeso molecular:451.5CDK4/9-IN-1
CAS:<p>CDK4/9-IN-1 (Compound 29) is a selective dual inhibitor of CDK4 and CDK9, exhibiting IC50 values of 23 nM and 12 nM, respectively. It holds potential for use in cancer research.</p>Fórmula:C22H34N6O2Forma y color:SolidPeso molecular:414.544Antiangiogenic agent 2
<p>Antiangiogenic agent 2 (compound 3b) is a potent inhibitor of thymidine phosphorylase (IC50: 39.71 μM) and exhibits anti-angiogenic effects.</p>Fórmula:C26H26FN3O4Forma y color:SolidPeso molecular:463.5Valopicitabine dihydrochloride
CAS:<p>Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>Fórmula:C15H25ClN4O6Forma y color:SolidPeso molecular:392.84CDK7-IN-17
CAS:<p>CDK7-IN-17, a pyrimidine-based CDK7 inhibitor, shows promise for various cancers, especially with abnormal transcription.</p>Fórmula:C24H26F3N6OPForma y color:SolidPeso molecular:502.47JY-3-094
CAS:<p>JY-3-094 is a selective Myc inhibitor that targets the hydrophobic domain of Myc and inhibits the formation of the Myc-Max heterodimer, with an IC50 of 33 μM, and can be used for cancer research.</p>Fórmula:C13H8N4O5Pureza:98.72%Forma y color:SolidPeso molecular:300.23CDK7/12-IN-1
CAS:<p>CDK7/12-IN-1 is a selective CDK7 (IC50: 3 nM) and CDK12 (IC50: 277 nM) inhibitor, effective against tumor growth.</p>Fórmula:C25H34N8OForma y color:SolidPeso molecular:462.598-Oxo-dATP
CAS:<p>8-Oxo-dATP can be hydrolyzed to its monophosphate form by the oxidation of purine nucleoside triphosphate MTH1, preventing erroneous incorporation during DNA replication or transcription.</p>Fórmula:C10H12Li4N5O13P3Forma y color:SolidPeso molecular:530.9135-Methylcytosine hydrochloride
CAS:<p>5-Methylcytosine hydrochloride plays a critical role in regulating gene expression, promoting genomic imprinting, and inhibiting transposon factors. It is also closely associated with translation fidelity and tRNA recognition.</p>Fórmula:C5H8ClN3OForma y color:SolidPeso molecular:161.59IIP0943
CAS:<p>IIP0943 is a selective PLK1 (polo-like kinase 1) inhibitor with an IC50 of 5.1 nM for PLK1. It also exhibits inhibitory activity on the proliferation of HCT116 cells, with an IC50 of 0.22 µM. IIP0943 shows potential for research in the field of oncology.</p>Fórmula:C26H28N6O3SForma y color:SolidPeso molecular:504.60412(S)-HETE
CAS:<p>Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.</p>Fórmula:C20H32O3Forma y color:SolidPeso molecular:320.47NSC 641396
CAS:<p>NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. Additionally, it acts as an inhibitor of protein arginine N-methyltransferase 9 (PRMT9) and exhibits antitumor properties.</p>Fórmula:C18H13NO3Forma y color:SolidPeso molecular:291.301
