Integrin
Los inhibidores de integrinas se dirigen a las integrinas, una familia de receptores en la superficie celular que desempeñan un papel crucial en la adhesión celular, la migración y la transducción de señales. Las integrinas están involucradas en la regulación del ciclo celular, particularmente en procesos como la división y la diferenciación celular. Inhibir las integrinas puede interrumpir estos procesos, lo que lleva al arresto del ciclo celular y la apoptosis, lo que hace que estos inhibidores sean valiosos en la investigación del cáncer y el estudio de la metástasis. En CymitQuimica, ofrecemos una amplia gama de inhibidores de integrinas de alta calidad para apoyar su investigación en la regulación del ciclo celular, la biología del cáncer y el desarrollo terapéutico.
Se han encontrado 286 productos para "Integrin".
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Fibronectin CS1 Peptide
CAS:Fibronectin CS1 peptide inhibits tumor metastasis, lacking RGD domain; may aid cancer therapy.Fórmula:C38H64N8O15Pureza:98%Forma y color:SolidPeso molecular:872.96αvβ6-BP
αvβ6-BP is a selective αvβ6-binding peptide, useful for research in molecular imaging.Fórmula:C93H164N34O27Peso molecular:2189.25052KGDS
CAS:KGDS is a synthetic peptide that targets the integrin GPIIb-IIIa on the membrane of activated human platelets, with the amino acid sequence Lys-Gly-Asp-Ser [1].Fórmula:C15H27N5O8Forma y color:SolidPeso molecular:405.4HSDVHK-NH2
CAS:Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.Fórmula:C30H48N12O9Pureza:98%Forma y color:SolidPeso molecular:720.78EMD527040
CAS:EMD527040 is a potent αvβ6 antagonist with antifibrotic effects, used in carcinoma and liver fibrosis research.Fórmula:C29H32Cl2N4O5Forma y color:SolidPeso molecular:587.5Orbofiban acetate
CAS:Orbofiban Acetate is a compound that serves as an antagonist to the platelet GPIIb/IIIa receptor, effectively inhibiting platelet aggregation when administeredFórmula:C19H27N5O6Forma y color:SolidPeso molecular:421.45huATN-658
huATN-658 (MNPR-101) is a humanized monoclonal antibody inhibitor targeting the urokinase-type plasminogen activator receptor (uPAR). It effectively disrupts the interaction between uPAR and integrins, thereby inhibiting tumor cell proliferation, invasion, and migration. huATN-658 shows potential for research in breast cancer, particularly in cases of triple-negative breast cancer.Forma y color:Odour Liquidc(phg-isoDGR-(NMe)k) TFA
C(phg-isoDGR-(NMe)k) TFA is a selective and potent ligand for α5β1-integrin, exhibiting an IC50 of 2.9 nM [1].Fórmula:C29H42F3N9O9Forma y color:SolidPeso molecular:717.69LT25
CAS:LT25 (compound 17) acts as an agonist for the α5β1 integrin, exhibiting an EC50 value of 9.9 nM.Fórmula:C15H17N3O5Forma y color:SolidPeso molecular:319.31GRGDSPK TFA
GRGDSPK TFA is an RGD peptide, competitive inhibitor of integrin-fibronectin, used to research integrins in bone dynamics.Fórmula:C30H50F3N11O13Forma y color:SolidPeso molecular:829.78JNJ-69086420
JNJ-69086420 (JNJ69086420) is a humanized antibody targeting human kininogenase-2 conjugated with Actinium-225, which can be used to study prostate cancer.Forma y color:LiquidPeso molecular:145.30 kDaBGC0222
BGC0222 is a novel Irinotecan prodrug. As a PEG-cRGD conjugated derivative of Irinotecan, BGC0222 enables the slow and steady release of Irinotecan. It binds to the αVβ3 target with an IC50 of 4.25 μM and has an IC50 of 58.7 μM for αVβ5. BGC0222 can induce angiogenesis and demonstrates significant antitumor activity in various tumors.Fórmula:C1241H2276N64O552Forma y color:SolidPeso molecular:26927.36cRGDfK-thioacetyl ester
CAS:cRGDfK-thioacetyl ester, a bioactive polypeptide, exhibits selective affinity for integrins and can modify near-infrared (NIR) fluorescent probes for targetedFórmula:C31H45N9O9SPureza:98%Forma y color:SolidPeso molecular:719.81G-Pen-GRGDSPCA TFA
G-Pen-GRGDSPCA TFA is an αvβ3 inhibitory RGD peptide. It inhibits neointimal hyperplasia and luminal narrowing following vascular injury and regulates the migration and proliferation of smooth muscle cells. This compound can be utilized in studies related to mechanisms of vascular injury repair.Forma y color:Odour SolidSAN-300
SAN-300 is a human-derived IgG1 monoclonal antibody (mAb) that targets ITGA1/VLA-1. It is utilized in the research of rheumatoid arthritis.Forma y color:Odour LiquidEmaretamig
CAS:Emaretamig is a humanized IgG1κ monoclonal antibody inhibitor that targets CLDN18 and CD3E. Abdakibart is applicable for cancer research related to gastric and pancreatic cancers.Forma y color:LiquidASP5094
ASP5094 is a humanized anti-integrin α9 monoclonal antibody. It exhibits excellent safety and tolerability. ASP5094 can be utilized in the research of diseases such as rheumatoid arthritis.Forma y color:Odour LiquidICAM-1988
CAS:ICAM-1988 is a LFA-1 antagonist.Fórmula:C22H22Cl2N4O6SForma y color:SolidPeso molecular:541.4P8RI acetate
P8RI acetate mimics CD31, activates CDP8RI, and suppresses the immune response by restoring CD31 pathway.Fórmula:C53H81N13O11Pureza:98.39%Forma y color:SolidPeso molecular:1076.29TRAP-14 amide
CAS:TRAP-14 amide is a protease-activated receptor (PAR) activating peptide and acts as a PAR agonist, with an EC50 of 24 μM. It induces significant platelet aggregation via ADP and MMP-2 dependent pathways and is insensitive to Aspirin. Additionally, TRAP-14 amide effectively increases the surface expression of glycoprotein (GP) Ib and GPIIb/IIIa, as well as the release of ADP.Fórmula:C81H119N21O22Forma y color:SolidPeso molecular:1738.94BRM/BRG1 ligand 3
CAS:BRM/BRG1 ligand 3 is a target protein ligand utilized in the synthesis of PROTAC BRM/BRG1 degrader-3.Fórmula:C19H24N6OForma y color:SolidPeso molecular:352.43αvβ6-IN-1
αvβ6-IN-1 (compound 28) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 8.1. This compound shows potential for research in idiopathic pulmonary fibrosis.Fórmula:C25H32F2N4O3Forma y color:SolidPeso molecular:474.54PLN-1474
CAS:PLN-1474 is a potent αVβ1 inhibitor with IC50 < 50 nM.Fórmula:C24H37N3O4Pureza:99.92%Forma y color:SolidPeso molecular:431.57Ref: TM-T60101
1mg50,00€5mg105,00€1mL*10mM (DMSO)117,00€10mg170,00€25mg289,00€50mg416,00€100mg580,00€PDI-IN-4
PDI-IN-4 (Compound 14d) is a protein disulfide isomerase inhibitor with an IC50 value of 0.48 μM. It prevents platelet aggregation and thrombosis by reducing the activation of GPIIb/IIIa, without causing significant cytotoxicity. PDI-IN-4 is applicable in thrombosis research.Fórmula:C17H12F3NO2Forma y color:SolidPeso molecular:319.278Bimosiamose disodium
CAS:Bimosiamose disodium (TBC-1269Z), a pan-selectin inhibitor, has IC50s: E-selectin 88 μM, P-selectin 20 μM, L-selectin 86 μM; anti-inflammatory.Fórmula:C46H52Na2O16Pureza:98%Forma y color:SolidPeso molecular:906.88α2β1 Integrin Ligand Peptide TFA
α2β1 Integrin Ligand Peptide TFA interacts with the integrin receptor on the cell membrane and enters the cell to mediate extracellular signaling.It is aFórmula:C16H23F3N4O11Pureza:98%Forma y color:SolidPeso molecular:504.37Echistatin TFA
Echistatin TFA: a minimal RGD protein from snake venom; inhibits platelet aggregation and bone resorption; targets αIIbβ3, αvβ3, α5β1.Forma y color:Odour SolidGamgertamig
CAS:Gamgertamig is a humanized bispecific antibody of the IgG4 type that targets TNFRSF17 and CD3E.Forma y color:LiquidEchistatin
CAS:Potent αVβ3 integrin blocker, stops osteoclast binding & bone loss, hinders platelet aggregation. Ki=0.27 nM, IC50s: 0.1 nM (bone), 30 nM (platelets).Fórmula:C217H341N71O74S9Pureza:98%Forma y color:SolidPeso molecular:5417.1TC113
TC113, a c(RGDyK)-linked Gemcitabine, targets αvβ3 integrin, entering A549 cells, and inhibits WM266.4 and A549 cell growth.Fórmula:C37H50F2N12O13Forma y color:SolidPeso molecular:908.86Bimosiamose
CAS:Bimosiamose has anti-inflammatory effects[1].Fórmula:C46H54O16Pureza:98%Forma y color:SolidPeso molecular:862.91Lumivatamig
CAS:Lumivatamig is a bispecific antibody targeting CLDN18.2 and CD3E, and is classified as an H-γ1_L-κ-scFvhl dimer.Forma y color:LiquidGly-Arg-Gly-Asp-Ser
CAS:Gly-Arg-Gly-Asp-Ser (GRGDS) GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin.Fórmula:C17H30N8O9Pureza:98%Forma y color:SolidPeso molecular:490.47HSDVHK-NH2 TFA
HSDVHK-NH2 TFA acts as an antagonist to the αvβ3-vitronectin integrin interaction, displaying an inhibitory concentration (IC 50) of 1.74 pg/mL (2.414 pM) [1] [Fórmula:C32H49F3N12O11Forma y color:SolidPeso molecular:834.8BIO5192 hydrate
BIO5192 hydrate: potent α4β1 inhibitor, binds selectively (Kd<10 pM, IC50=1.8 nM), boosts murine HSPC mobilization 30x.Forma y color:Solidα2β1 Integrin Ligand Peptide
CAS:The Asp-Gly-Glu-Ala (DGEA) amino acid domain of type I collagen interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellularFórmula:C14H22N4O9Pureza:98%Forma y color:SolidPeso molecular:390.35AB-3PRGD2
CAS:AB-3PRGD2 is a radiolabeled agent that targets integrin αvβ3. It enhances tumor uptake and prolongs retention time in tumors, significantly improving the inhibition of tumor growth. AB-3PRGD2 also remodels the tumor immune microenvironment by upregulating PD-L1 expression and increasing tumor-infiltrating CD8+ T cells.Fórmula:C137H215IN30O45SForma y color:SolidPeso molecular:3161.32Lamifiban trifluoroacetate
CAS:Lamifiban trifluoroacetate is an antagonist of the nonpeptide platelet fibrinogen receptor (GPIIb/IIIa).Fórmula:C26H29F3N4O8Forma y color:SolidPeso molecular:582.533Integrin Binding Peptide acetate
Integrin Binding Peptide acetate is a fibronectin-derived peptide that binds integrins, enabling PEG-hydrogel functionalization for cell adhesion.Fórmula:C42H63N15O16S·xC2H4O2Pureza:95.03%Forma y color:White SolidPeso molecular:1066.12 (free base)Ac-MRGDH-NH2
Ac-MRGDH-NH2 is a pentapeptide containing the RGD sequence. It is utilized in the synthesis of the diastereomeric prodrugs Λ- and Δ-[Ru(Ph2phen)2(κS,κN-(Ac-MRGDH-NH2))]Cl2. In these prodrugs, Ac-MRGDH-NH2 serves as a photolabile protecting group for the cytotoxic diruthenium aqua complexes [Ru(Ph2phen)2(OH2)2]2+, offering integrin targeting and photoactivation properties. Consequently, Ac-MRGDH-NH2 can be applied in studies exploring tumor-targeted photoactivatable chemotherapy.Fórmula:C25H41N11O8SForma y color:SolidPeso molecular:655.727Fradafiban hydrochloride
Fradafiban (BIBU-52) is a nonpeptide GPIIb/IIIa antagonist with Kd 148 nM for human platelets.Fórmula:C20H22ClN3O4Forma y color:SolidPeso molecular:403.86Anti-EMMPRIN/CD147 Antibody
Anti-EMMPRIN/CD147 Antibody is a mAb targeting CD147 used to study the inhibition mechanisms of viral infection by blocking receptor binding to viralForma y color:Odour LiquidMumefural
CAS:Mumefural, from Prunus mume fruit, hinders platelets, has anti-thrombotic properties, and boosts cognition.Fórmula:C12H12O9Forma y color:SolidPeso molecular:300.22R-BC154 acetate
R-BC154 acetate: selective α9β1 antagonist, high-affinity integrin probe for α9β1/α4β1 activity study.Fórmula:C56H65N9O14S3Forma y color:SolidPeso molecular:1184.36A20FMDV2
CAS:A20FMDV2 is a highly selective αvβ6 integrin inhibitor with an IC 50 of 3 nM, demonstrating 1,000-fold greater selectivity for αvβ6 compared to other RGD-directed integrins like αvβ3, αvβ5, and α5β1. This compound can be derived from the foot-and-mouth disease virus and is suitable for radiolabeling, enabling PET imaging of αvβ6 integrin-positive tumors.Fórmula:C93H163N31O28Forma y color:SolidPeso molecular:2163.48αvβ5 integrin-IN-1
CAS:αvβ5 integrin-IN-1, a potent and selective αvβ5 integrin inhibitor, exhibits a high inhibitory potency with a pIC50 value of 8.2.Fórmula:C25H28F3N3O3Forma y color:SolidPeso molecular:475.512LDV
CAS:α4β1 integrin (VLA-4) ligand (Kd ~ 12 nM). Non-fluorescent derivative of LDV FITC.Fórmula:C48H70N10O12Pureza:98%Forma y color:SolidPeso molecular:979.13EMD527040 hydrochloride
EMD527040 (hydrochloride) is a potent and selective αvβ6 antagonist with antifibrotic properties. It is applicable in research related to liver cancer and hepatic fibrosis.Forma y color:Odour SolidαVβ8-IN-1
CAS:αVβ8-IN-1 is an αVβ8 integrin inhibitor that suppresses the growth of multiple tumour cell lines (EMT6, CT26, KPC, TKCC-10).Fórmula:C25H32ClN5O4Forma y color:White SolidPeso molecular:502.01Obtustatin
Potent α1β1 integrin inhibitor, 0.8 nM IC50 for IV collagen binding. Selective over other integrins. Inhibits FGF2 angiogenesis; antitumor in mouse models.Fórmula:C184H284N52O57S8Pureza:98%Forma y color:SolidPeso molecular:4393.07
