Integrin
Los inhibidores de integrinas se dirigen a las integrinas, una familia de receptores en la superficie celular que desempeñan un papel crucial en la adhesión celular, la migración y la transducción de señales. Las integrinas están involucradas en la regulación del ciclo celular, particularmente en procesos como la división y la diferenciación celular. Inhibir las integrinas puede interrumpir estos procesos, lo que lleva al arresto del ciclo celular y la apoptosis, lo que hace que estos inhibidores sean valiosos en la investigación del cáncer y el estudio de la metástasis. En CymitQuimica, ofrecemos una amplia gama de inhibidores de integrinas de alta calidad para apoyar su investigación en la regulación del ciclo celular, la biología del cáncer y el desarrollo terapéutico.
Se han encontrado 278 productos de "Integrin"
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REDV TFA
REDV TFA, the minimal active sequence of the CS5 site in the alternatively spliced type III connecting segment (IIICS) of fibronectin, mediates adhesion to theFórmula:C20H35N7O9·xC2HF3O2Pureza:98%Forma y color:SolidPeso molecular:517.53 (free acid)HB-3-20
HB-3-20 induces the degradation of integrin αVβ5 on the cell surface. Transglutaminase 2 (TG2) specifically interacts with HB-3-20, exhibiting a catalytic efficiency (kcat/KM) of 0.16 μM^-1min^-1.Fórmula:C69H102N20O20Forma y color:SolidPeso molecular:1531.67Cyclo(Gly-Arg-Gly-Asp-Ser-Pro)
CAS:Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) (c(GRGDSP)) is an RGD-containing inhibitory peptide and a synthetic α5β1 integrin ligand.Fórmula:C22H35N9O9Pureza:98%Forma y color:SolidPeso molecular:569.57FITC-Ahx-Gly-Arg-Gly-Asp-Ser-Pro
CAS:FITC-Ahx-Gly-Arg-Gly-Asp-Ser-Pro, also known as FITC-linked GRGDSP, is a fluorescent peptide with integrin inhibitory properties.Fórmula:C49H59N11O16SPureza:98%Forma y color:SolidPeso molecular:1090.12LXW7 TFA (1313004-77-1 free base)
LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor with an anti-inflammatory effect.Fórmula:C31H49F3N12O14S2Pureza:98%Forma y color:SolidPeso molecular:934.92JNJ-69086420
JNJ-69086420 (JNJ69086420) is a humanized antibody targeting human kininogenase-2 conjugated with Actinium-225, which can be used to study prostate cancer.Forma y color:LiquidPeso molecular:145.30 kDacRGDfK-thioacetyl ester
CAS:cRGDfK-thioacetyl ester, a bioactive polypeptide, exhibits selective affinity for integrins and can modify near-infrared (NIR) fluorescent probes for targetedFórmula:C31H45N9O9SPureza:98%Forma y color:SolidPeso molecular:719.81Surovatamig
Surovatamig is a bispecific antibody of the (H-γ4_L-κ)_VH-G4(h-CH2-CH3) type, targeting CD3D/CD3E/CD19.Forma y color:Odour LiquidCatumaxomab
CAS:Catumaxomab is a rat-mouse hybrid lgG2 monoclonal and bispecific antibody that binds to the antigens CD3 and EpCAM for malignant ascites in cancer patients.Pureza:95%Forma y color:LiquidPeso molecular:146.73 kDaOdulimomab
CAS:Odulimomab: anti-LFA-1 antibody, inhibits T cell growth, protects against ischemic injury, used in transplant rejection research.Forma y color:LiquidEtrolizumab
CAS:MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.Pureza:98.9% (SDS-PAGE); 96.6% (SEC-HPLC) - 98.9% (SDS-PAGE); 96.6% (SEC-HPLC)Forma y color:LiquidPeso molecular:144.1 kDaAnti-Mouse CD3E Antibody (1E11.D)
Anti-Mouse CD3E Antibody (1E11.D) is an IgG1 antibody inhibitor targeting the mouse CD3E molecule.Forma y color:Odour LiquidCyclo(RGDfC) TFA
Zelminemab (AMG-301) is a humanized monoclonal antibody targeting ADCYAP1R1 for use in neurological disorders.Fórmula:C26H35F3N8O9SPureza:98.59%Forma y color:SolidPeso molecular:692.67Besufetamig
CAS:Besufetamig is a bispecific antibody targeting programmed cell death protein 1 (PD-1) and the CD3ε chain. It modulates immune cell activity, exerting both immunosuppressive and antitumor effects. Besufetamig holds promise for cancer research.Forma y color:LiquidMSH-TP15e
MSH-TP15e is a human-derived monoclonal antibody inhibitor that targets intercellular adhesion molecule-1 (ICAM-1). By recruiting natural killer cells, MSH-TP15e significantly induces antibody-dependent cell-mediated cytotoxicity (ADCC) activity, thereby inhibiting tumor cell growth. MSH-TP15e shows potential for research in multiple myeloma (MM).Forma y color:Odour LiquidGS-1427
CAS:GS-1427, Integrin α4β7 antagonist, for studying α4β7-mediated diseases like inflammatory bowel disease (IBD).Fórmula:C35H32F4N6O6Pureza:99.05% - 99.65%Forma y color:SoildPeso molecular:708.66Ertumaxomab
CAS:Ertumaxomab (Anti-Human CD22 Recombinant Antibody) is a bispecific antibody that targets both HER2/neu and CD3. It functions by activating Fcγ type I/III receptors, which facilitates the formation of a tri-cell complex involving tumor cells, T cells, and accessory cells. This compound has been utilized in the research of breast cancer [1].Forma y color:LiquidTrosunilimab
Trosunilimab is a chimeric humanized antibody of the IgG1κ type targeting ITGA4_ITGB7, with HumanIgG1kappa, Isotype Control as its corresponding isotype control.Forma y color:Odour LiquidCyclo(Ala-Arg-Gly-Asp-Mamb)
CAS:Cyclo(Ala-Arg-Gly-Asp-Mamb) is a selective antagonist of the RGD peptide with potential applications in pulmonary arterial hypertension research [1].Fórmula:C23H32N8O7Pureza:98%Forma y color:SolidPeso molecular:532.55SMS 121
CAS:SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.Fórmula:C20H21NO5Pureza:98.29%Forma y color:SoildPeso molecular:355.38Obrixtamig
Obrixtamig is a chimeric human antibody of the L-κ-G1-h-CH2-CH3_L-λ-G1-h-CH2-CH3 type, targeting CD3E/HEK.Forma y color:Odour LiquidVolociximab
CAS:Volociximab (M200) is an IgG4 monoclonal antibody targeting the α5β1 integrin , with antiangiogenic, antitumor and anticancer activity, inhibits the growth of rabbit VX2 tumors and is used to study solid tumors.Pureza:95%Forma y color:LiquidPeso molecular:145.4 kDaIndatuximab
Indatuximab is a chimeric antibody targeting CD13, used in the synthesis of ADC compound Indatuximab ravtansine.Pureza:>95%Forma y color:LiquidPeso molecular:146.1 kDaGRGDSPK
CAS:GRGDSPK (EMD 56574) is an inhibitory peptide for RGD-mediated adhesion between integrin and extracellular matrix molecules.Fórmula:C28H49N11O11Pureza:98%Forma y color:SolidPeso molecular:715.76C16Y
CAS:C16Y, a short peptide, serves as an inhibitor for the integrins αvβ3 and α5β1. It targets the cell membrane and exerts its antitumor activity by inhibiting angiogenesis.Fórmula:C78H115N17O17Forma y color:SolidPeso molecular:1562.85GSK 3008348 hydrochloride
CAS:GSK 3008348 hydrochloride is an αvβ6 integrin inhibitor used to confirm idiopathic pulmonary fibrosis.Fórmula:C29H37N5O2xHClPureza:99.54%Forma y color:SolidPeso molecular:0Azelaoyl PAF
CAS:Azelaoyl PAF is a potent PPARγ agonist that competitively binds thiazolidinediones.promotes the uptake of oxLDL by macrophages by upregulating CD36 expression.Fórmula:C33H66NO9PForma y color:SolidPeso molecular:651.85Obtustatin triacetate
Obtustatin triacetate, a 41-residue non-RGD disintegrin isolated from the venom of Vipera lebetina obtusa, serves as a potent and selective inhibitor of theFórmula:C184H284N52O57S8·3C2H4O2Pureza:99.51%Forma y color:SolidPeso molecular:4573.21BT100
BT100, an aptamer, impedes the interaction of von Willebrand factor (VWF) with platelet glycoprotein GPIb, thus obstructing arterial thrombosis [1].Pureza:98%Forma y color:Odour SolidRGD Trifluoroacetate
CAS:RGD Trifluoroacetate is a tripeptide for cell adhesion, effective on 24 integrins, and widely used for synthetic surface binding.Fórmula:C14H23F3N6O8Pureza:98%Forma y color:SoildPeso molecular:460.367Cilengitide TFA
CAS:Cilengitide, αvβ3/αvβ5 inhibitor, IC50: 4.1/79 nM in vitro. 10x selectivity vs. gpIIbIIIa. Phase 2.Fórmula:C29H41F3N8O9Forma y color:SolidPeso molecular:702.68DOTA-cyclo(RGDfK)
CAS:DOTA-cyclo(RGDfK) is a and DOTA-like chelator peptide,the αvβ3 integrin receptor ,radionuclide coupled compounds RDCs cancer diagnostics and therapy.Fórmula:C43H67N13O14Forma y color:SoildPeso molecular:990.07MK-0429
CAS:MK-0429 is an orally active, selective, and nonpeptide antagonist of αvβ3 integrin (IC50: 80 nM).Fórmula:C23H29N5O4Forma y color:SolidPeso molecular:439.51Anti-Mouse CD3 Antibody (17A2)
Anti-Mouse CD3 Antibody (17A2) is an IgG2b class antibody of murine origin targeting CD3 and can be used to study TCR signaling and antigen recognition.Pureza:99%Forma y color:Odour LiquidGPRP
CAS:GPRP (Gly-Pro-Arg-Pro) is a fibrin polymerization inhibitor.Fórmula:C18H31N7O5Forma y color:White To Off-White PowderPeso molecular:425.48Lifitegrast sodium
CAS:Lifitegrast sodium (SAR-1118-023 sodium) is an integrin antagonist that reduces ocular surface inflammation and can be used to study dry eye.Fórmula:C29H23Cl2N2NaO7SPureza:99.33%Forma y color:SolidPeso molecular:637.46BIO-1211
CAS:BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).Fórmula:C36H48N6O9Pureza:99.33%Forma y color:SolidPeso molecular:708.8E7820
CAS:E7820 (ER68203-00) is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells).Fórmula:C17H12N4O2SPureza:98.31% - 99.11%Forma y color:SolidPeso molecular:336.37Ref: TM-T4435
1mg34,00€2mg49,00€5mg65,00€1mL*10mM (DMSO)80,00€10mg84,00€25mg137,00€50mg200,00€100mg321,00€200mg477,00€GPRP acetate (67869-62-9 free base)
CAS:GPRP acetate (Pefabloc FG) is fibrinogen-related peptides, which inhibit the interaction of fibrinogen with the platelet membrane glycoprotein IIbIIIa complex.
Fórmula:C20H35N7O7Pureza:>99.99%Forma y color:SolidPeso molecular:485.53Natalizumab
CAS:Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.Pureza:97.15% (SDS-PAGE); 97.2% (SEC-HPLC) - 98.00%Forma y color:LiquidPeso molecular:146.19 kDaGRGDSP acetate(91037-75-1 free base)
GRGDSP acetate(91037-75-1 free base) is a synthetic linear RGD peptide and is an integrin inhibitor.Fórmula:C24H41N9O12Pureza:99.77%Forma y color:SolidPeso molecular:647.64Gly-Arg-Gly-Asp-Ser acetate(96426-21-0 free base)
Gly-Arg-Gly-Asp-Ser (GRGDS) acetate is a cell binding protein domain derived from the cell-binding region of fibronectin.Fórmula:C19H34N8O11Pureza:99.81%Forma y color:SolidPeso molecular:550.52LXW7
CAS:LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (Fórmula:C29H48N12O12S2Pureza:>99.99%Forma y color:SolidPeso molecular:820.89MNS
CAS:MNS is a tyrosine kinases inhibitor, inhibits Syk, Src, p97 with IC50 of 2.5 μM, 29.3 μM and 1.7 μM, respectively.Fórmula:C9H7NO4Pureza:98.53%Forma y color:Yellow PowderPeso molecular:193.16GLPG0187
CAS:GLPG0187, a broad spectrum integrin receptor antagonist, inhibits αvβ1-integrin (IC50: 1.3 nM).Fórmula:C29H37N7O5SPureza:99.4% - 99.70%Forma y color:SolidPeso molecular:595.71Ref: TM-T4259
1mg44,00€5mg98,00€1mL*10mM (DMSO)129,00€10mg144,00€25mg236,00€50mg350,00€100mg522,00€500mg1.134,00€Cyclo(-RGDfK) TFA
CAS:Cyclo(-RGDfK) is a selective αvβ3 integrin inhibitor(IC50 : 0.94 nM).Fórmula:C29H42F3N9O9Pureza:98.99% - 99.54%Forma y color:SolidPeso molecular:717.69OSU-T315
CAS:OSU-T315 (OSU-T315 (1,5-regioisomer)) (1,5-regioisomer) is a ILK inhibitor.Fórmula:C30H30F3N5OPureza:98.69%Forma y color:SolidPeso molecular:533.59Ref: TM-T5485
1mg88,00€5mg187,00€1mL*10mM (DMSO)220,00€10mg298,00€25mg533,00€50mg755,00€100mg1.008,00€200mg1.359,00€A-205804
CAS:A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.Fórmula:C15H12N2OS2Pureza:98.07% - 98.52%Forma y color:SolidPeso molecular:300.4Ref: TM-T2254
2mg42,00€5mg50,00€1mL*10mM (DMSO)67,00€10mg77,00€25mg152,00€50mg258,00€100mg505,00€500mg1.108,00€Arginine-glycine-aspartic acid
CAS:RGD (RGD (Arg-Gly-Asp) Peptides) (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.Fórmula:C12H22N6O6Pureza:99.11%Forma y color:SolidPeso molecular:346.34TR-14035
CAS:TR-14035 (MDK-1191) is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).Fórmula:C24H21Cl2NO5Pureza:98.98%Forma y color:SolidPeso molecular:474.33Ref: TM-T5310
1mg50,00€5mg99,00€1mL*10mM (DMSO)102,00€10mg152,00€25mg245,00€50mg353,00€100mg492,00€200mg700,00€
