Integrin
Los inhibidores de integrinas se dirigen a las integrinas, una familia de receptores en la superficie celular que desempeñan un papel crucial en la adhesión celular, la migración y la transducción de señales. Las integrinas están involucradas en la regulación del ciclo celular, particularmente en procesos como la división y la diferenciación celular. Inhibir las integrinas puede interrumpir estos procesos, lo que lleva al arresto del ciclo celular y la apoptosis, lo que hace que estos inhibidores sean valiosos en la investigación del cáncer y el estudio de la metástasis. En CymitQuimica, ofrecemos una amplia gama de inhibidores de integrinas de alta calidad para apoyar su investigación en la regulación del ciclo celular, la biología del cáncer y el desarrollo terapéutico.
Se han encontrado 278 productos de "Integrin"
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Pasotuxizumab
CAS:Pasotuxizumab (BAY 2010112) is a BiTE that targets PSMA & CD3 with K D s 47.0 & 9.4 nM, for mCRPC research.Forma y color:LiquidCaplacizumab
CAS:Caplacizumab (ALX-0681), a humanized anti-von Willebrand factor (vWF) nanobody, serves to impede vWF-mediated platelet adhesion, thereby averting additionalForma y color:LiquidLinvoseltamab
CAS:Linvoseltamab, a bispecific antibody, targets both BCMA (TNFRSF17) and CD3 epsilon, demonstrating a favorable safety profile and promising efficacy in relapsed/Forma y color:LiquidOS-2966
OS-2966 is a humanised de-immunised monoclonal antibody that target Integrin b1/ITGB1/CD29, malignant gliomas, glioblastomas, and astrocytomas.Pureza:95%Forma y color:LiquidPeso molecular:~150 kDaSB273005
CAS:SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.Fórmula:C22H24F3N3O4Pureza:99.58%Forma y color:SolidPeso molecular:451.44Tirofiban
CAS:Tirofiban (L700462) (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.Fórmula:C22H36N2O5SPureza:99.83%Forma y color:SolidPeso molecular:440.6TCS 2314
CAS:TCS 2314, Selective VLA-4 antagonist (IC50=4.4 nM), high clearance/low oral bioavailability, for asthma research.Fórmula:C28H34N4O6Pureza:99.86%Forma y color:SolidPeso molecular:522.59MK-0668 Mesylate
CAS:MK-0668 Mesylate is the mesylate form of MK-0668 that is a very potent and orally active very late antigen-4 antagonist.Fórmula:C32H34Cl2N6O9S2Forma y color:SolidPeso molecular:781.68αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)
αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).Fórmula:C28H35F3N6O8SPureza:98%Forma y color:SolidPeso molecular:672.67BMS-688521
CAS:BMS-688521 is an LFA-1/ICAM interaction inhibitor, a small molecule antagonist of LFA-1 with potential anti-inflammatory activity.Fórmula:C26H19Cl2N5O4Pureza:98.87%Forma y color:SolidPeso molecular:536.37Ref: TM-T14676
1mg108,00€5mg264,00€1mL*10mM (DMSO)311,00€10mg371,00€25mg665,00€50mg874,00€100mg1.063,00€200mg1.423,00€BMS-587101
CAS:BMS-587101 is a small molecule antagonist of LFA-1, which can reduce inflammation and joint destruction in the mouse model of arthritis.Fórmula:C26H20Cl2N4O4SForma y color:SolidPeso molecular:555.43BOP sodium
CAS:BOP sodium salt is an inhibitor of alpha9beta1 and alpha4beta1 integrin.Fórmula:C25H29N3NaO7SForma y color:SolidPeso molecular:538.57Zaurategrast ethyl ester
CAS:Zaurategrast ethyl ester, an α4β1/α4β7 integrin antagonist prodrug of CT7758, treats inflammatory/autoimmune conditions.Fórmula:C28H29BrN4O3Pureza:98%Forma y color:SolidPeso molecular:549.46RUC-1
CAS:RUC-1 is an αIIbβ3-selective ADP-induced platelet aggregation inhibitor.Fórmula:C11H15N5OSPureza:98%Forma y color:SolidPeso molecular:265.33Zalunfiban
CAS:RUC-4 is an aIIb 3 antagonist. It is also used for prehospital therapy of myocardial infarction.Fórmula:C16H18N8O2SForma y color:SolidPeso molecular:386.43L 703014
CAS:L 703014 is an antagonist of the fibrinogen receptor.Fórmula:C24H34N4O4Pureza:98%Forma y color:SolidPeso molecular:442.55MK-0668
CAS:MK-0668 is a very potent and orally active very late antigen-4 antagonist.Fórmula:C31H30Cl2N6O6SForma y color:SolidPeso molecular:685.58GSK-3008348
CAS:GSK-3008348 is an antagonist of integrin alpha(v)beta6.Fórmula:C29H37N5O2Pureza:99.547%Forma y color:SolidPeso molecular:487.64Ro 43-5054
CAS:Ro 43-5054 is a small molecular, noncyclic peptidomimetic inhibitor.Fórmula:C24H27N5O7Pureza:98%Forma y color:SolidPeso molecular:497.5XVA143
CAS:XVA143 is an integrin α/β I-like allosteric antagonist, inhibits LFA-1 (αLβ2 integrin)-dependent firm adhesion, induces extended conformations of integrins.Fórmula:C25H21Cl2N3O8Pureza:99.94%Forma y color:SolidPeso molecular:562.36GR 144053 trihydrochloride
CAS:platelet fibrinogen receptor glycoprotein IIb/IIIa (GpIIb/IIIa) antagonistFórmula:C18H30Cl3N5O2Pureza:98%Forma y color:SolidPeso molecular:454.82UR-3216
CAS:UR-3216 is a prodrug, selectively antagonizing GPIIb/IIIa receptors orally, with its active form, UR-2992, binding tightly to platelets.Fórmula:C27H29N7O7Pureza:98%Forma y color:SolidPeso molecular:563.56IMB-10
CAS:IMB-10 is an alphaMbeta2 integrin modulator, inhibiting leukocyte migration and recruitment in vitro and in vivo.Fórmula:C19H15NOS2Forma y color:SolidPeso molecular:337.46Balamapimod
CAS:Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.Fórmula:C30H32ClN7OSPureza:98%Forma y color:SolidPeso molecular:574.14CLT-28643
CAS:CLT-28643 is a specific α5β1-Integrin inhibitor that prevents fibrosis in GFS, inhibits tumor growth and angiogenesis, suppresses fibrosis and inflammation.Fórmula:C19H17N3O4Pureza:99.89%Forma y color:SolidPeso molecular:351.36IS-741 potassium
CAS:IS-741 potassium is a phospholipase A2 inhibitor.Fórmula:C15H19F3KN3O3SForma y color:SolidPeso molecular:417.49IS-741 calcium
CAS:IS-741 calcium is a phospholipase A2 inhibitor.Fórmula:C30H38CaF6N6O6S2Forma y color:SolidPeso molecular:796.86Integrin-IN-2
CAS:Integrin-IN-2, an oral αv integrin blocker, enhances αvβ6/3/5/8 affinities with pIC50s: 7.8/8.4/8.4/7.4.Fórmula:C27H30N4O3Pureza:98%Forma y color:SolidPeso molecular:458.55Valategrast hydrochloride
CAS:Valategrast hydrochloride (R411), a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.Fórmula:C30H33Cl4N3O4Pureza:98%Forma y color:SolidPeso molecular:641.41UR-2922
CAS:UR-2922: Oral GPIIb/IIIa blocker with <1 nM affinity, slow 90 min k(off), no LIBS or prothrombotic effects.Fórmula:C25H25N7O6Pureza:98%Forma y color:SolidPeso molecular:519.51NSC47924
CAS:NSC47924 is a laminin receptor (LR) inhibitor.Fórmula:C18H17NO2Pureza:98%Forma y color:SolidPeso molecular:279.33Valategrast
CAS:Valategrast: potent, oral dual α4β1/α4β7 integrin antagonist, may treat COPD and asthma.Fórmula:C30H32Cl3N3O4Pureza:98%Forma y color:SolidPeso molecular:604.95Sibrafiban
CAS:Sibrafiban (RO 48-3657), an oral, nonpeptide prodrug, inhibits platelet aggregation as a selective IIb/IIIa antagonist.Fórmula:C20H28N4O6Forma y color:SolidPeso molecular:420.46Integrin modulator 1
CAS:Integrin modulator 1 is a selective α4β1 integrin agonist (IC50 9.8 nM) that enhances adhesion with EC50 12.9 nM, aiding integrin-dependent studies.Fórmula:C13H14N2O4Pureza:99.61%Forma y color:SolidPeso molecular:262.26Chrysotobibenzyl
CAS:Chrysotobibenzyl from Dendrobium pulchellum stems may trigger cell death in detached cells and hinder lung cancer growth.Fórmula:C19H24O5Forma y color:SolidPeso molecular:332.39Zaurategrast ethyl ester sulfate
CAS:Zaurategrast ethyl ester sulfate is a α4β1/α4β7 integrin antagonist, and used for the treatment of inflammatory and autoimmune disorders.Fórmula:C56H60Br2N8O10SPureza:98%Forma y color:SolidPeso molecular:1197.01Nexinhib20
CAS:Nexinhib20 is an inhibitor of exosome synthesis and transport with anti-inflammatory activity, inhibits RAB27A and neutral sphingomyelinase 2 (nSMase2) nsMase2.Fórmula:C15H16N4O3Pureza:99.89%Forma y color:SolidPeso molecular:300.31Firategrast
CAS:Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervousFórmula:C27H27F2NO6Pureza:99.67%Forma y color:SolidPeso molecular:499.5Ref: TM-TQ0291
1mg44,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg133,00€25mg268,00€50mg439,00€100mg708,00€200mg964,00€Elarofiban
CAS:Elarofiban(RWJ-53308) is a novel and orally active GPIIb/IIIa antagonist.Fórmula:C22H32N4O4Pureza:98.76%Forma y color:SolidPeso molecular:416.51Integrin Antagonists 27
CAS:Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist. It has a binding affinity of 18 nM and as a novel anticancer agent.Fórmula:C24H20N4O5Forma y color:SolidPeso molecular:444.44JNJ-26076713
CAS:JNJ-26076713, an oral alpha V integrin blocker, may treat macular edema, AMD, and diabetic retinopathy.Fórmula:C29H38N4O3Pureza:98%Forma y color:SolidPeso molecular:490.64α7β1 integrin modulator-1
CAS:α7β1 Integrin Modulator-1 is a potent modulator with research potential for muscular dystrophy [1].Fórmula:C23H29N3O6SPureza:98%Forma y color:SolidPeso molecular:475.56L-739758
CAS:L-739758 is a glycoprotein IIb/IIIa inhibitor.Fórmula:C22H26N4O5S3Forma y color:SolidPeso molecular:522.663-Hydroxyxanthone
CAS:3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical veinFórmula:C13H8O3Pureza:98%Forma y color:SolidPeso molecular:212.2TC-I 15
CAS:α2β1 integrin inhibitorFórmula:C23H28N4O6S2Pureza:98%Forma y color:SolidPeso molecular:520.62Synstatin (92-119)
CAS:Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 andFórmula:C133H207N35O46Pureza:98%Forma y color:SolidPeso molecular:3032.27BIO-7662
CAS:BIO-7662 is an effective and highly selective antagonist of α4β1 integrin.Fórmula:C38H48N6O8SPureza:98%Forma y color:SolidPeso molecular:748.89TAK 029
CAS:TAK 029 is a local glycoprotein IIb/IIIa receptor inhibitor.Fórmula:C19H23N5O7Forma y color:SolidPeso molecular:433.42ATN-161
CAS:ATN-161 is an integrin α5β1 binding peptide and antagonist that inhibits VEGF-induced hCECs migration and angiogenesis.Fórmula:C23H35N9O8SPureza:98%Forma y color:SolidPeso molecular:597.64Teclistamab
CAS:Teclistamab(JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor on t-cells and the BCMA for relapsed and refractory multiple myeloma.Pureza:95%Forma y color:LiquidPeso molecular:143.64 kDa
