LIM quinasa
Los inhibidores de la quinasa LIM se dirigen a las quinasas LIM, una familia de enzimas involucradas en la regulación del citoesqueleto de actina y la progresión del ciclo celular. Las quinasas LIM fosforilan e inactivan la cofilina, una proteína que desensambla los filamentos de actina, controlando así la forma, motilidad y división celular. La inhibición de las quinasas LIM puede afectar estos procesos, lo que lleva a alteraciones en la dinámica del ciclo celular y posible apoptosis. Los inhibidores de la quinasa LIM son herramientas importantes en la investigación del cáncer y en el estudio de la motilidad e invasión celular. En CymitQuimica, ofrecemos una selección de inhibidores de la quinasa LIM de alta calidad para apoyar su investigación en señalización celular, dinámica del citoesqueleto y oncología.
Se han encontrado 19 productos de "LIM quinasa"
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R-10015
CAS:<p>R-10015, potent LIMK inhibitor with 38 nM IC50 for LIMK1, targets ATP pocket, and serves as a broad-spectrum HIV antiviral.</p>Fórmula:C20H19ClN6O2Pureza:98.68%Forma y color:SolidPeso molecular:410.86S3 Fragment
<p>S3 Fragment is a biologically active peptide featuring the amino-terminal phosphorylation site unique to Xenopus ADF/cofilin, which is the target of LIM kinase</p>Fórmula:C73H120N18O24S2Forma y color:SolidPeso molecular:1697.978β,9α-Dihydroxylindan-4(5),7(11)-dien-8α,12-olide
CAS:<p>8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, exhibits anti-LIMK1 activity and inhibits cell motility [1].</p>Fórmula:C15H18O4Forma y color:SolidPeso molecular:262.3BMS-3
CAS:<p>BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.</p>Fórmula:C17H12Cl2F2N4OSPureza:99.31% - 99.81%Forma y color:SolidPeso molecular:429.27T56-LIMKi
CAS:<p>T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.</p>Fórmula:C19H14F3N3O3Pureza:98.39% - 99.57%Forma y color:SolidPeso molecular:389.33BMS-5
CAS:<p>BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.</p>Fórmula:C17H14Cl2F2N4OSPureza:98.01% - 99.88%Forma y color:SolidPeso molecular:431.29LIMK-IN-22j
CAS:<p>LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.</p>Fórmula:C20H21BrN8Pureza:99.165%Forma y color:SolidPeso molecular:453.34TH-263
CAS:<p>TH-263 is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257, and is a diaryl sulfonamide derivative.</p>Fórmula:C21H20N2O3SPureza:99.54%Forma y color:SolidPeso molecular:380.46TH-257
CAS:<p>TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).</p>Fórmula:C24H26N2O3SPureza:98.23%Forma y color:SolidPeso molecular:422.54TH470
CAS:<p>TH470, a potent and highly selective inhibitor of LIM kinase 1/2 (LIMK1/2), demonstrates specificity with IC50 values of 9.8 nM for LIMK1 and 13 nM for LIMK2,</p>Fórmula:C30H31N5O5S2Forma y color:SolidPeso molecular:605.73LIMK1 inhibitor BMS-4
CAS:<p>BMS-4 is a LIMK inhibitor targeting LIMK1/2, reduces cofilin phosphorylation, noncytotoxic to A549 cells.</p>Fórmula:C23H23N7O2SForma y color:SolidPeso molecular:461.54CRT-0105446
CAS:<p>CRT-0105446 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.</p>Fórmula:C20H18F3N3O2SPureza:98%Forma y color:SolidPeso molecular:421.44SR7826
CAS:<p>SR7826 is a selective LIMK inhibitor.</p>Fórmula:C22H21N5O2Pureza:98%Forma y color:SolidPeso molecular:387.43LIMK-IN-14
CAS:<p>LIMK-IN-14 is an effective and selective inhibitor of LIMK.</p>Fórmula:C22H27N7O3Pureza:98%Forma y color:SolidPeso molecular:437.49CRT-0105950
CAS:<p>CRT-0105950 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.</p>Fórmula:C21H16ClN3OSPureza:99.78% - 99.86%Forma y color:SolidPeso molecular:393.89LX7101 hydrochloride
CAS:<p>LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 μM. The topical administration of LX7101 (3 μl of a 1 mg/ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.</p>Fórmula:C23H29N7O3HClForma y color:SolidPeso molecular:488LIMK-IN-2
CAS:<p>LIMK-IN-2 (Compound 52), an LIMK inhibitor, has demonstrated potential anti-angiogenic activity by suppressing the cell migration of osteosarcoma and cervical cancer cells [1].</p>Fórmula:C28H27N5O2Forma y color:SolidPeso molecular:465.55LIMK1 inhibitor 1
CAS:<p>LIMK1 inhibitor1 (compound 24) is a LIMK1 inhibitor, potentially useful for cancer research.</p>Fórmula:C12H15N3S2Forma y color:SolidPeso molecular:265.398LIMK1 inhibitor 2
CAS:<p>LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with an IC50 value of 9 μM.</p>Fórmula:C10H11N3OSForma y color:SolidPeso molecular:221.279
