LIM quinasa
Los inhibidores de la quinasa LIM se dirigen a las quinasas LIM, una familia de enzimas involucradas en la regulación del citoesqueleto de actina y la progresión del ciclo celular. Las quinasas LIM fosforilan e inactivan la cofilina, una proteína que desensambla los filamentos de actina, controlando así la forma, motilidad y división celular. La inhibición de las quinasas LIM puede afectar estos procesos, lo que lleva a alteraciones en la dinámica del ciclo celular y posible apoptosis. Los inhibidores de la quinasa LIM son herramientas importantes en la investigación del cáncer y en el estudio de la motilidad e invasión celular. En CymitQuimica, ofrecemos una selección de inhibidores de la quinasa LIM de alta calidad para apoyar su investigación en señalización celular, dinámica del citoesqueleto y oncología.
Se han encontrado 23 productos para "LIM quinasa".
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R-10015
CAS:R-10015, potent LIMK inhibitor with 38 nM IC50 for LIMK1, targets ATP pocket, and serves as a broad-spectrum HIV antiviral.Fórmula:C20H19ClN6O2Pureza:98.68%Forma y color:SolidPeso molecular:410.857MDI-117740
MDI-117740 is a dual LIMK1/2 inhibitor. It demonstrates strong cellular target binding in HEK293 cells, inhibiting LIMK1 (pIC50=6.73) and LIMK2 (pIC50=7.18). In MDA-MB-231 cells, MDI-117740 shows significant anti-migratory activity. This compound is useful for studying diseases associated with LIMK dysregulation, such as cancer and neurodegenerative disorders.SM311
SM311 (Compound 10) is a potent, selective, and irreversible inhibitor of LIMK1, with an EC50 of 0.045 μM and over 30-fold selectivity for LIMK1 over LIMK2. It can inhibit cofilin phosphorylation and actin cytoskeleton regulation. SM311 shows potential for research in neurodegenerative disorders such as Fragile X Syndrome (FXS) and Alzheimer's disease, as well as in tumor invasion.Forma y color:Odour SolidS3 Fragment
S3 Fragment is a biologically active peptide featuring the amino-terminal phosphorylation site unique to Xenopus ADF/cofilin, which is the target of LIM kinaseFórmula:C73H120N18O24S2Forma y color:SolidPeso molecular:1697.97LX-7101 hydrochloride
CAS:LX-7101 hydrochloride is a potent LIMK and ROCK2 inhibitor with antihypertensive activity, inhibits LIMK1/2, ROCK, PKA, and can be used to study glaucoma.Fórmula:C23H29N7O3xHClPureza:97.61%Forma y color:SolidPeso molecular:487.99THNAN69
THNAN69 is a potent chemical probe degrader specifically targeting LIMK2, with a DC50 value of 1 nM. This compound is useful for researching diseases driven by LIMK2 overexpression or dysregulation, such as cancer and ophthalmic conditions.BMS-3
CAS:BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.Fórmula:C17H12Cl2F2N4OSPureza:99.31% - 99.81%Forma y color:White SolidPeso molecular:429.271TH-257
CAS:TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).Fórmula:C24H26N2O3SPureza:98.23%Forma y color:SolidPeso molecular:422.54TH-263
CAS:TH-263 is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257, and is a diaryl sulfonamide derivative.Fórmula:C21H20N2O3SPureza:99.54%Forma y color:SolidPeso molecular:380.46BMS-5
CAS:BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.Fórmula:C17H14Cl2F2N4OSPureza:98.01% - 99.88%Forma y color:SolidPeso molecular:431.29LIMK-IN-22j
CAS:LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.Fórmula:C20H21BrN8Pureza:99.16%Forma y color:SolidPeso molecular:453.338T56-LIMKi
CAS:T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.Fórmula:C19H14F3N3O3Pureza:98.39% - 99.57%Forma y color:SolidPeso molecular:389.328SR7826
CAS:SR7826 is a selective LIMK inhibitor.Fórmula:C22H21N5O2Pureza:98%Forma y color:SolidPeso molecular:387.43CRT-0105446
CAS:CRT-0105446 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.Fórmula:C20H18F3N3O2SPureza:98%Forma y color:SolidPeso molecular:421.44TH470
CAS:TH470, a potent and highly selective inhibitor of LIM kinase 1/2 (LIMK1/2), demonstrates specificity with IC50 values of 9.8 nM for LIMK1 and 13 nM for LIMK2,Fórmula:C30H31N5O5S2Forma y color:SolidPeso molecular:605.73LIMK-IN-14
CAS:LIMK-IN-14 is an effective and selective inhibitor of LIMK.Fórmula:C22H27N7O3Pureza:98%Forma y color:SolidPeso molecular:437.49LIMK1 inhibitor BMS-4
CAS:BMS-4 is a LIMK inhibitor targeting LIMK1/2, reduces cofilin phosphorylation, noncytotoxic to A549 cells.Fórmula:C23H23N7O2SForma y color:SolidPeso molecular:461.54CRT-0105950
CAS:CRT-0105950 is an effective LIMK inhibitor that acts by suppressing cofilin phosphorylation and increasing αTubulin acetylation in cells.Fórmula:C21H16ClN3OSPureza:99.78% - 99.91%Forma y color:SolidPeso molecular:393.889LX7101
CAS:LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).Fórmula:C23H29N7O3Pureza:99.08%Forma y color:SolidPeso molecular:451.5215LX7101 hydrochloride
CAS:LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 μM. The topical administration of LX7101 (3 μl of a 1 mg/ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.Fórmula:C23H29N7O3HClForma y color:SolidPeso molecular:488
