CDK
Los inhibidores de las quinasas dependientes de ciclina (CDK) son compuestos que bloquean la actividad de las CDK, un grupo de quinasas de proteínas que regulan el ciclo celular, la transcripción y otros procesos celulares. Las CDK se activan al unirse a las ciclinas, y su actividad es crucial para la progresión de las células a través de las diferentes fases del ciclo celular. Inhibir las CDK puede detener la división celular, provocando la detención del ciclo celular y la apoptosis, especialmente en células cancerosas donde las CDK a menudo están desreguladas. Los inhibidores de CDK se utilizan ampliamente en la investigación del cáncer y tienen un potencial terapéutico en el tratamiento de varios tipos de cáncer. En CymitQuimica, ofrecemos una selección completa de inhibidores de CDK de alta calidad para apoyar su investigación en el control del ciclo celular, el cáncer y el desarrollo terapéutico.
Se han encontrado 561 productos para "CDK".
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NVP-2
CAS:NVP-2 selectively inhibits CDK9 (IC50: 0.514 nM), prompts apoptosis, and affects other CDKs (IC50: 0.584-0.706 μM).Fórmula:C27H37ClN6O2Pureza:99.13%Forma y color:Yellow SolidPeso molecular:513.07Ref: TM-T16363
1mg52,00€2mg74,00€5mg113,00€1mL*10mM (DMSO)128,00€10mg192,00€25mg416,00€50mg615,00€100mg875,00€Ribociclib succinate
CAS:Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively).Fórmula:C27H36N8O5Pureza:99.90%Forma y color:White SolidPeso molecular:552.63CDK8-IN-12
CAS:CDK8-IN-12: selective CDK8 inhibitor (Ki 14 nM), oral anticancer, blocks GSK-3α/β, PCK-θ, halts MV4-11 cell growth.Fórmula:C21H20ClN3O2Pureza:98.55% - 99.22%Forma y color:SoildPeso molecular:381.86Ref: TM-T72048
1mg49,00€5mg96,00€1mL*10mM (DMSO)110,00€10mg142,00€25mg236,00€50mg344,00€100mg482,00€200mg658,00€Garcinone C
CAS:Garcinone C, a xanthone from Garcinia oblongifolia, is anti-inflammatory, promotes healing, and may fight some cancers.Fórmula:C23H26O7Pureza:99.13% - 99.92%Forma y color:Yellow SolidPeso molecular:414.45Samuraciclib hydrochloride
CAS:Samuraciclib HCl is an oral CDK7 inhibitor (IC50: 41 nM), 45-230x selective over CDK1/2/5/9, inhibiting breast cancer growth (GI50: 0.2-0.3 μM).Fórmula:C22H31ClN6OPureza:99.14% - 99.63%Forma y color:SolidPeso molecular:430.97Ref: TM-T10898
1mg108,00€2mg147,00€5mg222,00€1mL*10mM (DMSO)245,00€10mg335,00€25mg595,00€50mg847,00€100mg1.153,00€GSK-3 inhibitor 4
CAS:Orally active GSK-3 inhibitor 4 targets GSK-3α/β, CDK2/5 (IC50: 0.45-0.68 μM) and may aid in Alzheimer's research by lowering Tau protein.Fórmula:C22H15F2N5OPureza:99.82%Forma y color:SolidPeso molecular:403.38Ref: TM-T77341
1mg315,00€5mg873,00€10mg1.080,00€25mg1.431,00€50mg1.783,00€100mg2.250,00€500mg3.537,00€Ca2+ channel agonist 1
CAS:Ca2+ channel agonist 1 activates N-type Ca2+ channels and inhibits Cdk2 (EC50: 14.23 μM/3.34 μM) for motor nerve issues.Fórmula:C19H26N6OPureza:97.71%Forma y color:SolidPeso molecular:354.45Ref: TM-T10659
1mg62,00€5mg111,00€1mL*10mM (DMSO)128,00€10mg167,00€25mg258,00€50mg366,00€100mg492,00€hSMG-1 inhibitor 11j
CAS:hSMG-1 inhibitor 11j: pyrimidine, IC50=0.11 nM, >455x selective vs. mTOR/PI3Kα/γ/CDK1/CDK2; cancer research use.Fórmula:C27H28ClN7O3SPureza:99.22% - 99.65%Forma y color:Yellow SolidPeso molecular:566.07Cyclin K degrader 1
Cyclin K degrader 1 is a Cyclin K degrader.Cyclin K degrader 1 is a degrader converted from AT-7519.Cyclin K degrader 1 has weak degrading activity against Cyclin K but does not result in a sustained decrease in degradation affinity.Cyclin K degrader 1 is a degrader converted from AT-7519.Fórmula:C23H17Cl2N5O2Pureza:99.91%Forma y color:SolidPeso molecular:466.32(±)-Enitociclib
CAS:(±)-Enitociclib ((±)-BAY-1251152) is a racemic mixture of BAY-1251152. BAY-1251152 is highly selective inhibitor of PTEF/CDK9.Fórmula:C19H18F2N4O2SPureza:99.29%Forma y color:White SolidPeso molecular:404.43Ref: TM-T13467
1mg34,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg114,00€25mg205,00€50mg334,00€100mg537,00€200mg762,00€Lerociclib dihydrochloride
CAS:Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 2 nM and 1 nM for CDK6/CyclinD3 and CDK4/Fórmula:C26H36Cl2N8OPureza:97.4%Forma y color:SolidPeso molecular:547.52CDKI-73
CAS:CDKI-73: strong CDK9 blocker, Ki 4 nM, kills CLL cells selectively, aids cisplatin.Fórmula:C15H15FN6O2S2Pureza:98.11%Forma y color:SolidPeso molecular:394.45Ref: TM-T14919
1mg136,00€2mg178,00€5mg278,00€1mL*10mM (DMSO)290,00€10mg399,00€25mg658,00€50mg888,00€100mg1.251,00€CDK4/6-IN-2
CAS:CDK4/6-IN-2 是一种CDK4和CDK6抑制剂，IC50分别为 2.7 和 16 nM。Fórmula:C27H32F2N8Pureza:99.47%Forma y color:SolidPeso molecular:506.59XPW1
CAS:XPW1 is a CDK9 inhibitor with antitumor activity, inhibits DNA repair procedures, and can be used for the research of clear cell renal cell carcinoma.Fórmula:C36H39ClFN7O2Pureza:99.63%Forma y color:White SolidPeso molecular:656.19Ref: TM-T77810
10mgA consultar25mgA consultar50mgA consultar100mgA consultar200mgA consultar1mg77,00€5mg167,00€CDK2-IN-4
CAS:CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A.Fórmula:C23H18N6O2SPureza:97.24% - 99.10%Forma y color:SolidPeso molecular:442.49Ref: TM-T14916
1mg82,00€5mg192,00€1mL*10mM (DMSO)212,00€10mg304,00€25mg522,00€50mg713,00€100mg1.018,00€Amantadine hydrochloride
CAS:Amantadine hydrochloride (CI-719) is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A and Parkinson disease.Fórmula:C10H18ClNPureza:99.98%Forma y color:SolidPeso molecular:187.71Cirtuvivint
CAS:Cirtuvivint (SM08502) is a potent and orally active CDC-like kinase (CLK) inhibitor that can be used to study arthritis.Fórmula:C24H25N7OPureza:99.95% - 99.96%Forma y color:Yellow SolidPeso molecular:427.5Ref: TM-T39608
10mgA consultar25mgA consultar50mgA consultar100mgA consultar500mgA consultar1mg100,00€5mg236,00€BRD6989
CAS:BRD6989, a cortistatin A analog, inhibits CDK8/19, enhances IL-10, and binds CDK8 with a 200 nM IC50.Fórmula:C16H16N4Pureza:99.43%Forma y color:SolidPeso molecular:264.33Ref: TM-T14778
1mg34,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg92,00€25mg177,00€50mg268,00€100mg398,00€200mg575,00€(E/Z)-THZ1 2HCl
CAS:THZ1 2HCl: selective CDK7 allosteric inhibitor, IC50 3.2 nM, hinders cancer cell growth.Fórmula:C31H30Cl3N7O2Pureza:99.51%Forma y color:SolidPeso molecular:638.98AZ1495
CAS:AZ1495: oral IRAK4 inhibitor (IC50: 5 nM), IRAK1 (23 nM), treats MYD88L265P DLBCL.Fórmula:C21H31N5O2Pureza:98.81%Forma y color:SolidPeso molecular:385.5Ref: TM-T14367
1mg93,00€5mg156,00€1mL*10mM (DMSO)170,00€10mg245,00€25mg349,00€50mg494,00€100mg750,00€200mg1.009,00€
