CDK
Los inhibidores de las quinasas dependientes de ciclina (CDK) son compuestos que bloquean la actividad de las CDK, un grupo de quinasas de proteínas que regulan el ciclo celular, la transcripción y otros procesos celulares. Las CDK se activan al unirse a las ciclinas, y su actividad es crucial para la progresión de las células a través de las diferentes fases del ciclo celular. Inhibir las CDK puede detener la división celular, provocando la detención del ciclo celular y la apoptosis, especialmente en células cancerosas donde las CDK a menudo están desreguladas. Los inhibidores de CDK se utilizan ampliamente en la investigación del cáncer y tienen un potencial terapéutico en el tratamiento de varios tipos de cáncer. En CymitQuimica, ofrecemos una selección completa de inhibidores de CDK de alta calidad para apoyar su investigación en el control del ciclo celular, el cáncer y el desarrollo terapéutico.
Se han encontrado 526 productos de "CDK"
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AMG 925 HCl
CAS:AMG 925 HCl is a selective and potent dual inhibitor of FLT3 (IC50: 2±1 nM) and CDK4 (IC50: 3±1 nM).Fórmula:C26H30ClN7O2Forma y color:SolidPeso molecular:508.02Trilaciclib
CAS:Trilaciclib is a short-acting, orally effective CDK4/6 inhibitor with IC₅₀ values of 1 nM and 4 nM respectively. enhances antitumour immunity.Fórmula:C24H30N8OPureza:99.624%Forma y color:SolidPeso molecular:446.55TP-353
CAS:TP-353 (EOS-61973) is a CDK7 inhibitor.Fórmula:C35H30FNO3Pureza:99.12%Forma y color:SolidPeso molecular:531.62(E/Z)-TG003
CAS:(E/Z)-TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor.Fórmula:C13H15NO2SPureza:98% - 99.04%Forma y color:SolidPeso molecular:249.33AT7519
CAS:AT7519 is a CDK1/2/4/6/9 inhibitor (IC50: 10-210 nM). It is less effective to CDK3 and little active to CDK7.Fórmula:C16H17Cl2N5O2Pureza:98.88% - 99.65%Forma y color:SolidPeso molecular:382.24NSC23005
CAS:<p>NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM).</p>Fórmula:C13H17NO4SPureza:>99.99%Forma y color:SolidPeso molecular:283.34SRI-29329
CAS:SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).Fórmula:C20H26ClN7Pureza:99.18%Forma y color:SolidPeso molecular:399.92Palbociclib dihydrochloride
<p>Palbociclib, oral CDK4/6 inhibitor (IC50: 11/16 nM), targets HR+/HER2- breast cancer and hepatocellular carcinoma.</p>Fórmula:C24H31Cl2N7O2Forma y color:SolidPeso molecular:520.45BI-1347
CAS:BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.Fórmula:C22H20N4OPureza:96.7% - 99.63%Forma y color:SolidPeso molecular:356.42AT7519 TFA
CAS:AT7519 inhibits CDK1-6 kinases; IC50 ranges 0.018-0.66 μM.Fórmula:C18H18Cl2F3N5O4Forma y color:SolidPeso molecular:496.27AZD-5597
CAS:<p>AZD-5597 ((S)-(4-((5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone) is a potent</p>Fórmula:C23H28FN7OPureza:98.01%Forma y color:SolidPeso molecular:437.51SU9516
CAS:<p>SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively.</p>Fórmula:C13H11N3O2Pureza:99.34% - 99.87%Forma y color:SolidPeso molecular:241.25Palbociclib Isethionate
CAS:<p>Palbociclib Isethionate (PD 0332991 isethionate) 是一种高选择性的CDK4/6抑制剂，IC50为11 nM 和16 nM。它对一组 36 种额外的蛋白激酶没有抑制作用。</p>Fórmula:C24H29N7O2·C2H6O4SPureza:99.01% - 99.27%Forma y color:SolidPeso molecular:573.66SCH900776 (S-isomer)
CAS:SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).Fórmula:C15H18BrN7Pureza:99.88%Forma y color:SolidPeso molecular:376.25Wogonin
CAS:<p>Wogonin (Vogonin) is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties.</p>Fórmula:C16H12O5Pureza:98% - 99.8%Forma y color:Yellow CrystalPeso molecular:284.26Fadraciclib
CAS:Fadraciclib (CYC065) is an orally available, second-generation ATP-competitive inhibitor of CDK2/CDK9 kinases (IC50s: 5/26 nM).Fórmula:C21H31N7OPureza:99.75%Forma y color:SolidPeso molecular:397.52Cdk5 Substrate acetate
Cdk5, a serine/threonine kinase active in neurons, phosphorylates proteins like histone H1; its synthetic substrate has a Km of 5 µM.Fórmula:C55H103N15O14Pureza:96.21%Forma y color:SolidPeso molecular:1198.5Toyocamycin
CAS:<p>Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (</p>Fórmula:C12H13N5O4Pureza:98.1% - 98.17%Forma y color:SolidPeso molecular:291.262-Chloropyrazine
CAS:2-Chloropyrazine is used in chemical industry.Fórmula:C4H3ClN2Pureza:98.98% - 99.89%Forma y color:Clear Colorless To Yellowish LiquidPeso molecular:114.53Palbociclib monohydrochloride
CAS:<p>Palbociclib monohydrochloride (PD 0332991 hydrochloride) is a selective inhibitor of CDK4/6, with no inhibition against a panel of 36 additional protein kinases</p>Fórmula:C24H29N7O2·HClPureza:99.73% - >99.99%Forma y color:SolidPeso molecular:483.99Purvalanol B
CAS:Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively)Fórmula:C20H25ClN6O3Pureza:98.95%Forma y color:SolidPeso molecular:432.9GSK 3 Inhibitor IX
CAS:<p>GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex.</p>Fórmula:C16H10BrN3O2Pureza:98% - 99.72%Forma y color:SolidPeso molecular:356.17CVT-313
CAS:CVT-313 (NG-26) is a potent, selective, reversible, and ATP-competitive inhibitor.Fórmula:C20H28N6O3Pureza:97.46% - 97.97%Forma y color:SolidPeso molecular:400.47THZ2
CAS:THZ2 (CDK7-IN-1), an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC).Fórmula:C31H28ClN7O2Pureza:98.28%Forma y color:SolidPeso molecular:566.05CID44216842
CAS:CID44216842 is a potent Cdc42-selective inhibitor with EC50: 1.0μM (WT), 1.2μM (Q61L) in GTP assay; 0.3μM (WT), 0.5μM (Q61L) in GDP assay. Use as a probe.Fórmula:C22H20BrN3O3SPureza:99.66%Forma y color:SolidPeso molecular:486.38CKI-7
CAS:CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.Fórmula:C11H14Cl3N3O2SPureza:>99.99%Forma y color:SolidPeso molecular:358.67Indirubin-3'-monoxime
CAS:Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/Fórmula:C16H11N3O2Pureza:99.55%Forma y color:Dark Red SolidPeso molecular:277.28AMG 925
CAS:AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively.Fórmula:C26H29N7O2Pureza:99.75%Forma y color:SolidPeso molecular:471.55THZ1 Hydrochloride
THZ1 Hydrochloride: selective covalent CDK7 inhibitor, IC50 of 3.2 nM; affects CDK12/13 & lowers MYC expression.Fórmula:C31H29Cl2N7O2Forma y color:SolidPeso molecular:602.51AUZ 454
CAS:AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd of 50/18.6/15.4/9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.Fórmula:C24H26F3N7O2Pureza:99.59%Forma y color:SolidPeso molecular:501.5Dalpiciclib hydrochloride
Dalpiciclib (SHR-6390) HCl is an oral CDK4/6 inhibitor with IC50s of 12.4/9.9 nM, an antitumor for breast and esophageal cancers.Fórmula:C25H31ClN6O2Forma y color:SolidPeso molecular:483.01PHA-793887
CAS:PHA-793887 has been used in trials studying the treatment of Advanced/Metastatic Solid Tumors.Fórmula:C19H31N5O2Pureza:98.02% - >99.99%Forma y color:SolidPeso molecular:361.48PHA-767491 hydrochloride
CAS:PHA-767491 (CAY-10572) is a potent Cdc7/CDK9 inhibitor (IC50: 10/34 nM), selective against GSK3-β, CDK1/2, CDK5, MK2, CHK2, PLK1.Fórmula:C12H12ClN3OPureza:99.56% - 99.92%Forma y color:SolidPeso molecular:249.69PF 477736
CAS:PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Fórmula:C22H25N7O2Pureza:97.58% - 99.94%Forma y color:SolidPeso molecular:419.48THZ531
CAS:THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM).Fórmula:C30H32ClN7O2Pureza:97.17% - 99.86%Forma y color:SolidPeso molecular:558.07Bohemine
CAS:Bohemine is a cyclin-dependent kinase inhibitor.Fórmula:C18H24N6OPureza:99.09% - 99.53%Forma y color:SolidPeso molecular:340.42M2N12
CAS:M2N12 selectively inhibits Cdc25C (IC50=0.09μM) and has anti-tumor properties, affecting Cdc25A and B as well.Fórmula:C20H16ClN5O2Pureza:98.01%Forma y color:SolidPeso molecular:393.83AS2863619
CAS:AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.Fórmula:C16H14Cl2N8OPureza:>99.99%Forma y color:SolidPeso molecular:405.24Voruciclib
CAS:Voruciclib: oral, selective CDK inhibitor (Ki: 0.626-9.1 nM), reduces MCL-1, targets CDK9 in diffuse large B-cell lymphoma.Fórmula:C22H19ClF3NO5Pureza:99.89% - 99.99%Forma y color:SolidPeso molecular:469.84BUR1
CAS:BUR1 is a Saccharomyces cerevisiae cyclin-dependent kinase (CDK) and is homologous to mammalian Cdk9, which functions in transcriptional elongation.Fórmula:C16H17N5Pureza:90%Forma y color:SolidPeso molecular:279.34R547
CAS:R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM.Fórmula:C18H21F2N5O4SPureza:90% - 99.64%Forma y color:SolidPeso molecular:441.45LY3143921
CAS:LY3143921 ((S)-Example 2) is an orally active inhibitor of CDC7 kinase with broad in vitro anticancer activity [1].Fórmula:C16H12FN5OForma y color:SolidPeso molecular:309.3ML167
CAS:<p>ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.</p>Fórmula:C19H17N3O3Pureza:99.82% - >99.99%Forma y color:SolidPeso molecular:335.36RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Fórmula:C29H35N7O4Pureza:98% - 99.91%Forma y color:SolidPeso molecular:545.63(E/Z)-Zotiraciclib citrate
(E/Z)-Zotiraciclib ((E/Z)-TG02) citrate is a potent inhibitor of CDK2, JAK2 and FLT3 and can be used in cancer research.Fórmula:C29H32N4O8Forma y color:SolidPeso molecular:564.59MC180295
CAS:<p>MC180295 ((rel)-MC180295) is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs.</p>Fórmula:C17H18N4O3SPureza:99.84%Forma y color:SolidPeso molecular:358.41Longdaysin
CAS:Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).Fórmula:C16H16F3N5Pureza:99.97%Forma y color:SolidPeso molecular:335.33TC11
CAS:TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosisFórmula:C20H22N2O2Pureza:97.86%Forma y color:SolidPeso molecular:322.4LY2857785
CAS:LY2857785 is a type I competitive and reversible ATP kinase inhibitor against CDK7/CDK8/CDK9 (IC50s: 246 nM/16 nM/11 nM).Fórmula:C26H36N6OPureza:99.68%Forma y color:Solid PowderPeso molecular:448.6BS194
CAS:BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.Fórmula:C20H27N5O3Pureza:99.85%Forma y color:SolidPeso molecular:385.46Palbociclib
CAS:Palbociclib is an oral CDK4/6 inhibitor, halts Rb phosphorylation, arrests cell cycle, and curbs tumor growth.Fórmula:C24H29N7O2Pureza:98% - 99.9%Forma y color:SolidPeso molecular:447.53JNJ-7706621
CAS:<p>JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.</p>Fórmula:C15H12F2N6O3SPureza:99.1% - 99.85%Forma y color:SolidPeso molecular:394.36OTS964 hydrochloride
CAS:OTS964 hydrochloride (OTS964) is a potent and selective TOPK inhibitor with potential anticancer activity.Fórmula:C23H24N2O2S·HClPureza:96.5% - 98.03%Forma y color:SolidPeso molecular:428.97NU2058
CAS:NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.Fórmula:C12H17N5OPureza:99.34% - 99.92%Forma y color:SolidPeso molecular:247.3BS-181 hydrochloride
CAS:BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM.Fórmula:C22H32N6·HClPureza:99.21%Forma y color:SolidPeso molecular:416.99Aminopurvalanol A
CAS:Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1Fórmula:C19H26ClN7OPureza:99.73%Forma y color:SolidPeso molecular:403.91Indirubin-3′-oxime
CAS:<p>Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.</p>Fórmula:C16H11N3O2Pureza:98.34%Forma y color:SolidPeso molecular:277.28SNS-032
CAS:SNS-032 (BMS-387032) is a selective inhibitor of CDK2 and is 10- and 20-fold selective over CDK1/CDK4. SNS-032 is sensitive to CDK7/9, and no effect on CDK6.Fórmula:C17H24N4O2S2Pureza:98.27% - 99.91%Forma y color:SolidPeso molecular:380.53NVP-LCQ195
CAS:NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).Fórmula:C17H19Cl2N5O4SPureza:99.56% - 99.85%Forma y color:SolidPeso molecular:460.33LY3177833
CAS:LY3177833 is an Cdc7 kinase inhibitor (IC50 : 3.3 nM)Fórmula:C16H12FN5OPureza:99.87%Forma y color:SolidPeso molecular:309.3Abemaciclib methanesulfonate
CAS:<p>Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM).</p>Fórmula:C27H32F2N8·CH4O3SPureza:98.69% - 99.44%Forma y color:SolidPeso molecular:602.7Cucurbitacin E
CAS:Cucurbitacin E, from Cucumic melo, inhibits cyclin B1/CDC2, and has neuroprotective, anti-proliferative, anti-cancer, and pain relief properties.Fórmula:C32H44O8Pureza:98.88% - 99.87%Forma y color:SolidPeso molecular:556.69(E/Z)-Zotiraciclib
CAS:(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.Fórmula:C23H24N4OPureza:97.75% - 99.92%Forma y color:SolidPeso molecular:372.46KB-0742 dihydrochloride
CAS:KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.Fórmula:C16H27Cl2N5Pureza:99.79%Forma y color:SolidPeso molecular:360.33SR-4835
CAS:SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (Fórmula:C21H20Cl2N10OPureza:98.09% - >99.99%Forma y color:SolidPeso molecular:499.36BMS-265246
CAS:BMS-265246 is a potent and selective CDK1/2 inhibitor.Fórmula:C18H17F2N3O2Pureza:99.25% - 99.57%Forma y color:SolidPeso molecular:345.34HQ461
CAS:HQ461, a molecular glue, boosts CDK12-DDB1 binding, lowers cyclin K, impedes CDK12 phosphorylation, hinders DNA repair genes, and induces cell death.Fórmula:C15H15N5OS2Pureza:98.11%Forma y color:SolidPeso molecular:345.44AT7519 Hydrochloride
CAS:AT7519 Hydrochloride (AT7519 HCl) is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9.Fórmula:C16H18Cl3N5O2Pureza:99.66% - 99.9%Forma y color:SolidPeso molecular:418.71NG 52
CAS:NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.Fórmula:C16H19ClN6OPureza:98% - 99.34%Forma y color:SolidPeso molecular:346.81SB1317 hydrochloride (1204918-72-8(free base))
SB1317 hydrochloride (1204918-72-8(free base)) (TG-02 hydrochloride) is an effective inhibitor of CDK2/JAK2/FLT3 (IC50: 13/73/56 nM).Fórmula:C23H25ClN4OPureza:99.84%Forma y color:SolidPeso molecular:408.92PF-562271
CAS:PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).Fórmula:C21H20F3N7O3SPureza:97.17% - >99.99%Forma y color:SolidPeso molecular:507.49THZ1
CAS:THZ1 (CDK7 inhibitor) is a selective inhibitor of CDK7, binding to the Cys residue located at the outer end of the classical kinase domain. Cost-effective and quality-assured.Fórmula:C31H28ClN7O2Pureza:97.42% - 99.27%Forma y color:SolidPeso molecular:566.05Bromosporine
CAS:Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.Fórmula:C17H20N6O4SPureza:99.65% - 99.79%Forma y color:SolidPeso molecular:404.44PF-562271 besylate
CAS:PF-562271 besylate: potent, ATP-competitive FAK inhibitor, IC50 1.5 nM, 10x less effective on Pyk2, highly selective vs other kinases.Fórmula:C21H20F3N7O3S·C6H6O3SPureza:97.65% - 99.01%Forma y color:SolidPeso molecular:665.661-NM-PP1
CAS:1-NM-PP1 (PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.Fórmula:C20H21N5Pureza:98% - 98.93%Forma y color:White Cyrstalline SolidPeso molecular:331.41Atuveciclib
CAS:Atuveciclib Racemate is an oral CDK9 inhibitor with a 13 nM IC50, targeting P-TEFb/CDK9 selectively.Fórmula:C18H18FN5O2SPureza:98.8%Forma y color:SolidPeso molecular:387.43ALSTERPAULLONE
CAS:Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing EffecFórmula:C16H11N3O3Pureza:99.8%Forma y color:SolidPeso molecular:293.28AG-494
CAS:AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.Fórmula:C16H12N2O3Pureza:98.69%Forma y color:SolidPeso molecular:280.28SCH900776
CAS:SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities.Fórmula:C15H18BrN7Pureza:96.69% - 99.6%Forma y color:SolidPeso molecular:376.25CDK12-IN-5
CAS:CDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer.Fórmula:C18H15F5N8OPureza:99.37%Forma y color:SolidPeso molecular:454.36LSN2839567
CAS:<p>LSN2839567 (Abemaciclib metabolite M2) is a CDK4 and CDK6 inhibitor with anticancer activity, inhibits CDK9, and can be used in breast cancer research.</p>Fórmula:C25H28F2N8Pureza:99.14%Forma y color:SolidPeso molecular:478.54(R)-(+)-O-Demethylbuchenavianine
CAS:(R)-(+)-O-Demethylbuchenavianine is a cyclin-dependent kinase (CDK) inhibitor. It inhibits CDK1, CDK5, glycogen synthase kinase 3 (GSK3), cdc2-like kinase (CLK1), and dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) with IC50 values of 1.1 μM, 0.95 μM, >10 μM, >10 μM, and >10 μM, respectively.Fórmula:C21H21NO4Forma y color:SolidPeso molecular:351.40Riviciclib hydrochloride
CAS:Riviciclib hydrochloride (P276-00) is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. Phase 2/3.Fórmula:C21H20ClNO5·HClPureza:99.51%Forma y color:SolidPeso molecular:438.3XL413
CAS:XL-413 is an oral CDC7 kinase inhibitor, potentially blocking DNA replication, mitosis, and cancer cell growth.Fórmula:C14H12ClN3O2Pureza:98.40% - 99.94%Forma y color:SolidPeso molecular:289.72(S)-LY3177833 hydrate
CAS:(S)-LY3177833 ((S)-Example 2) hydrate, an orally active CDC7 kinase inhibitor, exhibits extensive in vitro anticancer efficacy.Fórmula:C16H14FN5O2Forma y color:SolidPeso molecular:327.31Cdc7-IN-5
CAS:Cdc7-IN-5: potent Cdc7 serine-threonine kinase inhibitor, critical for starting DNA replication.Fórmula:C25H23N3O5Pureza:98.4%Forma y color:SolidPeso molecular:445.47CDK9-IN-14
CAS:CDK9-IN-14: Potent CDK9 inhibitor, IC50=6.92 nM, effective on MV-4-11 cells and in vivo tumors, low toxicity, minimal side effects.Fórmula:C21H23F2N3O4Forma y color:SolidPeso molecular:419.42(S)-CR8
CAS:(S)-CR8 is an effective second-generation cyclin-dependent kinase inhibitor.Fórmula:C24H29N7OForma y color:SolidPeso molecular:431.53Cdc7-IN-17
CAS:Cdc7-IN-17 is a potent inhibitor of CDC7 with an IC 50 of <10 μM that can be used in cancer research [1].Fórmula:C13H15N5OSForma y color:SolidPeso molecular:289.36K 00546
CAS:K00546 inhibits CDK1/cyclin B (IC50: 0.6 nM), CDK2/cyclin A (IC50: 0.5 nM), CLK1 (IC50: 8.9 nM), and CLK3 (IC50: 29.2 nM).Fórmula:C15H13F2N7O2S2Pureza:99.12%Forma y color:SolidPeso molecular:425.44CDK8-IN-7
CAS:CDK8-IN-7 is a potent CDK8 inhibitor with a Kd of 3.5 nM, showing promise for AML research.Fórmula:C30H40N2Forma y color:SolidPeso molecular:428.65Cdc7-IN-15
CAS:Cdc7-IN-15 (Example 108) is an inhibitor of cdc7 kinase that has potential to be used for cancer research [1].Fórmula:C12H14N4OSForma y color:SolidPeso molecular:262.33CP681301
CAS:CP681301 is a potent CDK5 inhibitor with anti-tumor effects in Drosophila and reduces Glioma stem cells' growth and renewal.Fórmula:C17H22N4OForma y color:SolidPeso molecular:298.38CCT068127
CAS:CCT068127 is a potent CDK2 and CDK9 inhibitor.Fórmula:C19H27N7OForma y color:SolidPeso molecular:369.46CDK4/6-IN-12
CAS:CDK4/6-IN-12 inhibits CDK4/6 with IC50s of 592.3 nM & 3090 nM, useful in cancer research.Fórmula:C12H10N6Forma y color:SolidPeso molecular:238.25Cdc7-IN-9
CAS:Cdc7-IN-9 can be used for the research of cancer which is a potent inhibitor of Cdc7 [1].Fórmula:C15H17N5OSForma y color:SolidPeso molecular:315.39CDK7-IN-15
CAS:CDK7-IN-15, a pyrimidine-based potent CDK7 inhibitor, shows promise for various cancers with defective transcription.Fórmula:C21H24F4N6OSPureza:99.27%Forma y color:SolidPeso molecular:484.51CDK7-IN-10
CAS:CDK7-IN-10: CDK7 inhibitor, IC50<100 nM, may hinder cell growth, induce apoptosis. (Patent WO2021016388A1, I-1)Fórmula:C29H35N7O3Forma y color:SolidPeso molecular:529.63CDK7-IN-16
CAS:CDK7-IN-16, a potent CDK7 inhibitor (IC50: 1-10 nM), is used in cancer research with transcription defects.Fórmula:C19H21F3N6O2SForma y color:SolidPeso molecular:454.47ARN22089
CAS:<p>ARN22089 is an oral active CDC42 GTPase interaction inhibitor that blocks tumour growth in BRAF mutant mouse melanoma models and PDXs in vivo.</p>Fórmula:C23H27N5Pureza:98.37%Forma y color:SolidPeso molecular:373.49
