CDK
Los inhibidores de las quinasas dependientes de ciclina (CDK) son compuestos que bloquean la actividad de las CDK, un grupo de quinasas de proteínas que regulan el ciclo celular, la transcripción y otros procesos celulares. Las CDK se activan al unirse a las ciclinas, y su actividad es crucial para la progresión de las células a través de las diferentes fases del ciclo celular. Inhibir las CDK puede detener la división celular, provocando la detención del ciclo celular y la apoptosis, especialmente en células cancerosas donde las CDK a menudo están desreguladas. Los inhibidores de CDK se utilizan ampliamente en la investigación del cáncer y tienen un potencial terapéutico en el tratamiento de varios tipos de cáncer. En CymitQuimica, ofrecemos una selección completa de inhibidores de CDK de alta calidad para apoyar su investigación en el control del ciclo celular, el cáncer y el desarrollo terapéutico.
Se han encontrado 502 productos de "CDK"
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BS194
CAS:<p>BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.</p>Fórmula:C20H27N5O3Pureza:99.85%Forma y color:SolidPeso molecular:385.46ON-013100
CAS:<p>ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.</p>Fórmula:C19H22O7SPureza:98.27%Forma y color:SolidPeso molecular:394.44YKL-5-124
CAS:<p>YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displays</p>Fórmula:C28H33N7O3Pureza:99.36%Forma y color:SolidPeso molecular:515.61AZD-5597
CAS:<p>AZD-5597 ((S)-(4-((5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone) is a potent</p>Fórmula:C23H28FN7OPureza:98.01%Forma y color:SolidPeso molecular:437.51SEL120-34A HCl
CAS:<p>SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectively</p>Fórmula:C15H19Br2ClN4Pureza:98.13% - 98.47%Forma y color:SolidPeso molecular:450.6AS2863619
CAS:<p>AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.</p>Fórmula:C16H14Cl2N8OPureza:>99.99%Forma y color:SolidPeso molecular:405.24Longdaysin
CAS:Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).Fórmula:C16H16F3N5Pureza:99.97%Forma y color:SolidPeso molecular:335.33THZ1
CAS:<p>THZ1 (CDK7 inhibitor) is a selective inhibitor of CDK7, binding to the Cys residue located at the outer end of the classical kinase domain. Cost-effective and quality-assured.</p>Fórmula:C31H28ClN7O2Pureza:95.09% - 99.27%Forma y color:SolidPeso molecular:566.056-(Dimethylamino)purine
CAS:<p>6-(Dimethylamino)purine (N,N-Dimethyladenine) is a serine threonine protein kinase and CDK inhibitor</p>Fórmula:C7H9N5Pureza:99.01% - 99.77%Forma y color:SolidPeso molecular:163.18Bromosporine
CAS:<p>Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.</p>Fórmula:C17H20N6O4SPureza:99.65% - 99.79%Forma y color:SolidPeso molecular:404.44AT7519 TFA
CAS:<p>AT7519 inhibits CDK1-6 kinases; IC50 ranges 0.018-0.66 μM.</p>Fórmula:C18H18Cl2F3N5O4Forma y color:SolidPeso molecular:496.27LDC000067
CAS:<p>LDC000067 (LDC067) is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM.</p>Fórmula:C18H18N4O3SPureza:98.08% - 99.07%Forma y color:SolidPeso molecular:370.43Senexin B
CAS:<p>Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).</p>Fórmula:C27H26N6OPureza:99.67%Forma y color:SolidPeso molecular:450.53Aminopurvalanol A
CAS:<p>Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1</p>Fórmula:C19H26ClN7OPureza:99.73%Forma y color:SolidPeso molecular:403.91Cdk5 Substrate acetate
<p>Cdk5, a serine/threonine kinase active in neurons, phosphorylates proteins like histone H1; its synthetic substrate has a Km of 5 µM.</p>Fórmula:C55H103N15O14Pureza:96.21%Forma y color:SolidPeso molecular:1198.5NG 52
CAS:<p>NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.</p>Fórmula:C16H19ClN6OPureza:98% - 99.34%Forma y color:SolidPeso molecular:346.81R547
CAS:<p>R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM.</p>Fórmula:C18H21F2N5O4SPureza:90% - 99.64%Forma y color:SolidPeso molecular:441.45OTS964 hydrochloride
CAS:<p>OTS964 hydrochloride (OTS964) is a potent and selective TOPK inhibitor with potential anticancer activity.</p>Fórmula:C23H24N2O2S·HClPureza:96.5% - 98.03%Forma y color:SolidPeso molecular:428.97M2N12
CAS:<p>M2N12 selectively inhibits Cdc25C (IC50=0.09μM) and has anti-tumor properties, affecting Cdc25A and B as well.</p>Fórmula:C20H16ClN5O2Pureza:98.01%Forma y color:SolidPeso molecular:393.83THAL-SNS-032
CAS:<p>THAL-SNS-032 is a selective CDK9 degrader PROTAC.</p>Fórmula:C40H52N8O10S2Pureza:99.68%Forma y color:SolidPeso molecular:869.02
