CDK
Los inhibidores de las quinasas dependientes de ciclina (CDK) son compuestos que bloquean la actividad de las CDK, un grupo de quinasas de proteínas que regulan el ciclo celular, la transcripción y otros procesos celulares. Las CDK se activan al unirse a las ciclinas, y su actividad es crucial para la progresión de las células a través de las diferentes fases del ciclo celular. Inhibir las CDK puede detener la división celular, provocando la detención del ciclo celular y la apoptosis, especialmente en células cancerosas donde las CDK a menudo están desreguladas. Los inhibidores de CDK se utilizan ampliamente en la investigación del cáncer y tienen un potencial terapéutico en el tratamiento de varios tipos de cáncer. En CymitQuimica, ofrecemos una selección completa de inhibidores de CDK de alta calidad para apoyar su investigación en el control del ciclo celular, el cáncer y el desarrollo terapéutico.
Se han encontrado 502 productos de "CDK"
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Senexin A
CAS:<p>Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively.</p>Fórmula:C17H14N4Pureza:99.74%Forma y color:SolidPeso molecular:274.32Voruciclib
CAS:Voruciclib: oral, selective CDK inhibitor (Ki: 0.626-9.1 nM), reduces MCL-1, targets CDK9 in diffuse large B-cell lymphoma.Fórmula:C22H19ClF3NO5Pureza:99.89% - 99.99%Forma y color:SolidPeso molecular:469.84Palbociclib monohydrochloride
CAS:<p>Palbociclib monohydrochloride (PD 0332991 hydrochloride) is a selective inhibitor of CDK4/6, with no inhibition against a panel of 36 additional protein kinases</p>Fórmula:C24H29N7O2·HClPureza:99.73% - >99.99%Forma y color:SolidPeso molecular:483.99MLS-573151
CAS:<p>MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM).</p>Fórmula:C21H19N3O2SPureza:98.80%Forma y color:SolidPeso molecular:377.46ON-013100
CAS:<p>ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.</p>Fórmula:C19H22O7SPureza:98.27%Forma y color:SolidPeso molecular:394.44Purvalanol B
CAS:<p>Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively)</p>Fórmula:C20H25ClN6O3Pureza:98.95%Forma y color:SolidPeso molecular:432.9PHA-767491
CAS:<p>PHA-767491 (CAY10572) is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively.</p>Fórmula:C12H11N3OPureza:99.49% - >99.99%Forma y color:SolidPeso molecular:213.24GSK 3 Inhibitor IX
CAS:<p>GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex.</p>Fórmula:C16H10BrN3O2Pureza:98% - 99.72%Forma y color:SolidPeso molecular:356.17Amantadine
CAS:<p>Amantadine (1-Aminoadamantane), an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release and blocks dopamine reuptake.</p>Fórmula:C10H17NPureza:99.73% - 99.94%Forma y color:Hexakistetrahedral Crystals By Sublimation SolidPeso molecular:151.25CDK12-IN-5
CAS:CDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer.Fórmula:C18H15F5N8OPureza:99.37%Forma y color:SolidPeso molecular:454.36AZ5576
CAS:<p>AZ5576 is a potent and highly selective CDK9 inhibitor. AZ5576 can be used for the research of Hematological Malignancy [1].</p>Fórmula:C21H24FN3O3Pureza:99.88%Forma y color:SoildPeso molecular:385.43LSN2839567
CAS:<p>LSN2839567 (Abemaciclib metabolite M2) is a CDK4 and CDK6 inhibitor with anticancer activity, inhibits CDK9, and can be used in breast cancer research.</p>Fórmula:C25H28F2N8Pureza:99.14%Forma y color:SolidPeso molecular:478.54(R)-(+)-O-Demethylbuchenavianine
CAS:<p>(R)-(+)-O-Demethylbuchenavianine is a cyclin-dependent kinase (CDK) inhibitor. It inhibits CDK1, CDK5, glycogen synthase kinase 3 (GSK3), cdc2-like kinase (CLK1), and dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) with IC50 values of 1.1 μM, 0.95 μM, >10 μM, >10 μM, and >10 μM, respectively.</p>Fórmula:C21H21NO4Forma y color:SolidPeso molecular:351.40XL413
CAS:<p>XL-413 is an oral CDC7 kinase inhibitor, potentially blocking DNA replication, mitosis, and cancer cell growth.</p>Fórmula:C14H12ClN3O2Pureza:98.40% - >99.99%Forma y color:SolidPeso molecular:289.72Riviciclib hydrochloride
CAS:<p>Riviciclib hydrochloride (P276-00) is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. Phase 2/3.</p>Fórmula:C21H20ClNO5·HClPureza:99.51%Forma y color:SolidPeso molecular:438.3BSJ-01-175
CAS:<p>BSJ-01-175: Selective, potent covalent inhibitor of CDK12/13, targets cancer cells, inhibits phosphorylated RNA polymerase II, downregulates CDK12 genes.</p>Fórmula:C30H33ClN6O2Forma y color:SolidPeso molecular:545.08(E/Z)-BIO-acetoxime
CAS:<p>(E/Z)-BIO-acetoxime: potent GSK-3 α/β inhibitor; IC50: GSK-3α/β 10nM, CDK5/p25 2.4μM, CDK2/A 4.3μM, CDK1/B 63μM.</p>Fórmula:C18H12BrN3O3Forma y color:SolidPeso molecular:398.21MFH290
CAS:<p>MFH290 is a selective CDK12/13 inhibitor, covalently bonding with CDK12 Cys-1039, blocks Pol II CTD phosphorylation, and enhances olaparib's efficacy.</p>Fórmula:C26H31N5O3S2Forma y color:SolidPeso molecular:525.69Aloisine A
CAS:Aloisine A, a CDK/GSK-3 inhibitor with IC50: Cdk1/B-150nM, Cdk2/A-120nM, Cdk2/E-400nM, Cdk5/25-200nM, Cdk5/35-160nM, GSK-3α-500nM, GSK-3β-650nM, JNK-3-10μM.Fórmula:C16H17N3OPureza:98%Forma y color:SolidPeso molecular:267.33RP-106
CAS:<p>RP-106 is an ATP-competitive inhibitor of CDK5/p25, CDK1/cyclin B, and GSK-3.</p>Fórmula:C17H19N3OPureza:98%Forma y color:SolidPeso molecular:281.35
