CDK
Los inhibidores de las quinasas dependientes de ciclina (CDK) son compuestos que bloquean la actividad de las CDK, un grupo de quinasas de proteínas que regulan el ciclo celular, la transcripción y otros procesos celulares. Las CDK se activan al unirse a las ciclinas, y su actividad es crucial para la progresión de las células a través de las diferentes fases del ciclo celular. Inhibir las CDK puede detener la división celular, provocando la detención del ciclo celular y la apoptosis, especialmente en células cancerosas donde las CDK a menudo están desreguladas. Los inhibidores de CDK se utilizan ampliamente en la investigación del cáncer y tienen un potencial terapéutico en el tratamiento de varios tipos de cáncer. En CymitQuimica, ofrecemos una selección completa de inhibidores de CDK de alta calidad para apoyar su investigación en el control del ciclo celular, el cáncer y el desarrollo terapéutico.
Se han encontrado 500 productos de "CDK"
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Senexin C
CAS:<p>Senexin C is a CDK8/19 inhibitor with anticancer activity.Senexin C inhibits the growth of MV4-11 leukemia cells.</p>Fórmula:C28H27N5OPureza:98.06%Forma y color:SolidPeso molecular:449.55Bisindolylmaleimide X hydrochloride
CAS:<p>Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM).</p>Fórmula:C26H25ClN4O2Pureza:99.23%Forma y color:SolidPeso molecular:460.96Cdc7-IN-7
CAS:<p>Cdc7-IN-7 is a potent inhibitor of Cdc7 kinase.</p>Fórmula:C21H22N4O5Pureza:98.78%Forma y color:SolidPeso molecular:410.42CDK9-IN-23
CAS:<p>CDK9-IN-23 (Example 4) is a potent inhibitor of CDK9, exhibiting an IC50 value of less than 20 nM [1].</p>Fórmula:C22H25ClN4O3Pureza:98%Forma y color:SolidPeso molecular:428.91Senexin A hydrochloride
CAS:<p>Senexin A hydrochloride functions as a selective inhibitor of CDK8/19, with an IC 50 of 280 nM for CDK8, and specifically inhibits p21-induced transcription without affecting other biological effects of p21. Additionally, it suppresses CMV-GFP induction and the stimulatory activity of the consensus NF-κB-dependent promoters [1] [2].</p>Fórmula:C17H15ClN4Forma y color:SolidPeso molecular:310.78CDK9-IN-19
CAS:<p>CDK9-IN-19: Potent CDK9 inhibitor, anti-cancer, moderate pharmacokinetics, low hERG impact, effective in AML research.</p>Fórmula:C26H22F2N4O5Forma y color:SolidPeso molecular:508.47Riviciclib
CAS:<p>Riviciclib, a CDK inhibitor (CDK9/T1, CDK4/D1, CDK1/B), has IC50s: 20, 63, 79 nM respectively, and fights cisplatin-resistant tumors.</p>Fórmula:C21H20ClNO5Pureza:98%Forma y color:SolidPeso molecular:401.84ML 315 hydrochloride
CAS:<p>ML 315, a selective dual inhibitor targeting CDK (Cyclin-Dependent Kinase) and DYRK (Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase) with IC50 values of 68 nM and 282 nM, respectively, is utilized in research pertaining to cancer and neurological diseases [1].</p>Fórmula:C18H14Cl3N3O2Forma y color:SolidPeso molecular:410.682(S)-Cdc7-IN-18
CAS:<p>'(S)-Cdc7-IN-18 from patent WO2020239107A1 inhibits CDC7, curbing MCM2 and tumor growth.'</p>Fórmula:C19H21N5OSForma y color:SolidPeso molecular:367.47CDK7-IN-25
CAS:<p>CDK7-IN-25 (CY-16-1) is a potent CDK7 inhibitor with an IC50 value of less than 1nM, utilized in cancer research [1].</p>Fórmula:C33H32N6O3Pureza:98%Forma y color:SolidPeso molecular:560.65Inixaciclib
CAS:<p>Inixaciclib is a potent CDK inhibitor, can be used to research anticancer.</p>Fórmula:C26H30F2N6OForma y color:SolidPeso molecular:480.55SZ-015268
CAS:<p>SZ-015268: CDK7 inhibitor, IC50=23.56 nM; hinders HCC70, OVCAR-3, HCT116, HCC1806 cell growth; strong anti-tumor effect.</p>Fórmula:C25H38N8O3Forma y color:SolidPeso molecular:498.62CDK4/6-IN-15
CAS:<p>CDK4/6-IN-15: Oral, selective CDK4/6 inhibitor, halts cancer cell growth, G1 arrest, suppresses Rb phosphorylation.</p>Fórmula:C21H27FN8SForma y color:SolidPeso molecular:442.56CDK4/6-IN-17
CAS:<p>CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells.</p>Fórmula:C27H28F4N8Pureza:98%Forma y color:SolidPeso molecular:540.56Cdc7-IN-12
CAS:<p>Cdc7-IN-12, a sub-1 nM CDC7 inhibitor, may aid cancer research; hinders COLO205 cell growth (IC50: 100-1000 nM).</p>Fórmula:C16H14N2O2SForma y color:SolidPeso molecular:298.36Xylocydine
CAS:<p>Xylocydine is a novel Cdk inhibitor that induces apoptosis in HCC, suppresses tumor growth, and is non-toxic to other tissues.</p>Fórmula:C12H14BrN5O5Forma y color:SolidPeso molecular:388.17CF53
CAS:<p>CF53: potent, selective oral BET inhibitor; Ki <1 nM, Kd 2.2 nM, IC50 2 nM for BRD4 BD1; high affinity for BRD2/3/4/BRDT; effective anti-tumor agent.</p>Fórmula:C24H25N7O2Pureza:99.72%Forma y color:SolidPeso molecular:443.5Cdk1/2 Inhibitor III
CAS:<p>Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B.</p>Fórmula:C15H13F2N7O2S2Pureza:99.07%Forma y color:SolidPeso molecular:425.44(R)-Simurosertib
CAS:<p>(R)-Simurosertib ((R)-TAK-931) is an inhibitor of the ATP-competitive cell division cycle 7 (CDC7) kinase.</p>Fórmula:C17H19N5OSPureza:99.89%Forma y color:SolidPeso molecular:341.43XY028-140
CAS:<p>XY028-140 is a selective CDK4/6 inhibitor and degrader, acting via PROTAC with ligands for Cereblon and CDK in cancer cells.</p>Fórmula:C39H40N10O7Pureza:98.59%Forma y color:SolidPeso molecular:760.8
