CDK
Los inhibidores de las quinasas dependientes de ciclina (CDK) son compuestos que bloquean la actividad de las CDK, un grupo de quinasas de proteínas que regulan el ciclo celular, la transcripción y otros procesos celulares. Las CDK se activan al unirse a las ciclinas, y su actividad es crucial para la progresión de las células a través de las diferentes fases del ciclo celular. Inhibir las CDK puede detener la división celular, provocando la detención del ciclo celular y la apoptosis, especialmente en células cancerosas donde las CDK a menudo están desreguladas. Los inhibidores de CDK se utilizan ampliamente en la investigación del cáncer y tienen un potencial terapéutico en el tratamiento de varios tipos de cáncer. En CymitQuimica, ofrecemos una selección completa de inhibidores de CDK de alta calidad para apoyar su investigación en el control del ciclo celular, el cáncer y el desarrollo terapéutico.
Se han encontrado 500 productos de "CDK"
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Longdaysin
CAS:<p>Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM).</p>Fórmula:C16H16F3N5Pureza:99.97%Forma y color:SolidPeso molecular:335.33TC11
CAS:<p>TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis</p>Fórmula:C20H22N2O2Pureza:97.86%Forma y color:SolidPeso molecular:322.4LY2857785
CAS:<p>LY2857785 is a type I competitive and reversible ATP kinase inhibitor against CDK7/CDK8/CDK9 (IC50s: 246 nM/16 nM/11 nM).</p>Fórmula:C26H36N6OPureza:99.68%Forma y color:Solid PowderPeso molecular:448.6BS194
CAS:<p>BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.</p>Fórmula:C20H27N5O3Pureza:99.85%Forma y color:SolidPeso molecular:385.46Palbociclib
CAS:<p>Palbociclib is an oral CDK4/6 inhibitor, halts Rb phosphorylation, arrests cell cycle, and curbs tumor growth.</p>Fórmula:C24H29N7O2Pureza:98% - 99.9%Forma y color:SolidPeso molecular:447.53OTS964 hydrochloride
CAS:<p>OTS964 hydrochloride (OTS964) is a potent and selective TOPK inhibitor with potential anticancer activity.</p>Fórmula:C23H24N2O2S·HClPureza:96.5% - 98.03%Forma y color:SolidPeso molecular:428.97NU2058
CAS:<p>NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.</p>Fórmula:C12H17N5OPureza:99.34% - 99.92%Forma y color:SolidPeso molecular:247.3Aminopurvalanol A
CAS:<p>Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1</p>Fórmula:C19H26ClN7OPureza:99.73%Forma y color:SolidPeso molecular:403.91Indirubin-3′-oxime
CAS:<p>Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.</p>Fórmula:C16H11N3O2Pureza:98.34%Forma y color:SolidPeso molecular:277.28SNS-032
CAS:<p>SNS-032 (BMS-387032) is a selective inhibitor of CDK2 and is 10- and 20-fold selective over CDK1/CDK4. SNS-032 is sensitive to CDK7/9, and no effect on CDK6.</p>Fórmula:C17H24N4O2S2Pureza:98.27% - 99.91%Forma y color:SolidPeso molecular:380.53NVP-LCQ195
CAS:<p>NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).</p>Fórmula:C17H19Cl2N5O4SPureza:99.56% - 99.85%Forma y color:SolidPeso molecular:460.33LY3177833
CAS:<p>LY3177833 is an Cdc7 kinase inhibitor (IC50 : 3.3 nM)</p>Fórmula:C16H12FN5OPureza:99.87%Forma y color:SolidPeso molecular:309.3Abemaciclib methanesulfonate
CAS:<p>Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM).</p>Fórmula:C27H32F2N8·CH4O3SPureza:98.69% - 99.44%Forma y color:SolidPeso molecular:602.7Cucurbitacin E
CAS:<p>Cucurbitacin E, from Cucumic melo, inhibits cyclin B1/CDC2, and has neuroprotective, anti-proliferative, anti-cancer, and pain relief properties.</p>Fórmula:C32H44O8Pureza:98.88% - 99.87%Forma y color:SolidPeso molecular:556.69KB-0742 dihydrochloride
CAS:<p>KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.</p>Fórmula:C16H27Cl2N5Pureza:99.79%Forma y color:SolidPeso molecular:360.33BMS-265246
CAS:<p>BMS-265246 is a potent and selective CDK1/2 inhibitor.</p>Fórmula:C18H17F2N3O2Pureza:99.25% - 99.57%Forma y color:SolidPeso molecular:345.34HQ461
CAS:HQ461, a molecular glue, boosts CDK12-DDB1 binding, lowers cyclin K, impedes CDK12 phosphorylation, hinders DNA repair genes, and induces cell death.Fórmula:C15H15N5OS2Pureza:98.11%Forma y color:SolidPeso molecular:345.44AT7519 Hydrochloride
CAS:<p>AT7519 Hydrochloride (AT7519 HCl) is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9.</p>Fórmula:C16H18Cl3N5O2Pureza:99.66% - 99.9%Forma y color:SolidPeso molecular:418.71NG 52
CAS:<p>NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.</p>Fórmula:C16H19ClN6OPureza:98% - 99.34%Forma y color:SolidPeso molecular:346.81THZ1
CAS:<p>THZ1 (CDK7 inhibitor) is a selective inhibitor of CDK7, binding to the Cys residue located at the outer end of the classical kinase domain. Cost-effective and quality-assured.</p>Fórmula:C31H28ClN7O2Pureza:95.09% - 99.27%Forma y color:SolidPeso molecular:566.05Bromosporine
CAS:<p>Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.</p>Fórmula:C17H20N6O4SPureza:99.65% - 99.79%Forma y color:SolidPeso molecular:404.44Briciclib
CAS:<p>Briciclib (ON 014185) is a small molecule that suppresses cyclin D1 accumulation in Y cells.</p>Fórmula:C19H23O10PSPureza:98% - 99.84%Forma y color:SolidPeso molecular:474.42AG-494
CAS:<p>AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.</p>Fórmula:C16H12N2O3Pureza:98.69%Forma y color:SolidPeso molecular:280.28PHA-767491
CAS:<p>PHA-767491 (CAY10572) is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively.</p>Fórmula:C12H11N3OPureza:99.49% - >99.99%Forma y color:SolidPeso molecular:213.24ON-013100
CAS:<p>ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.</p>Fórmula:C19H22O7SPureza:98.27%Forma y color:SolidPeso molecular:394.44MLS-573151
CAS:<p>MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM).</p>Fórmula:C21H19N3O2SPureza:98.80%Forma y color:SolidPeso molecular:377.46Senexin A
CAS:<p>Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively.</p>Fórmula:C17H14N4Pureza:99.74%Forma y color:SolidPeso molecular:274.32LDC-4297 HCl (1453834-21-3(free base))
<p>LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM.</p>Fórmula:C23H29ClN8OPureza:100%Forma y color:SolidPeso molecular:469.02FIT-039
CAS:<p>FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1).</p>Fórmula:C17H18FN3SPureza:98.61%Forma y color:SolidPeso molecular:315.41ON123300
CAS:ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).Fórmula:C24H27N7OPureza:99.53% - 99.7%Forma y color:SolidPeso molecular:429.52Ribociclib
CAS:<p>Ribociclib (LEE011) is an orally available, and highly specific CDK4/6 inhibitor (IC50：10/39 nM).</p>Fórmula:C23H30N8OPureza:97.91% - >99.99%Forma y color:SolidPeso molecular:434.54Milciclib
CAS:<p>Milciclib (PHA-848125) is a potent CDK2 inhibitor with a 45 nM IC50, selective over CDK1/2/4/5/7. In Phase 2 trials.</p>Fórmula:C25H32N8OPureza:99.28%Forma y color:SolidPeso molecular:460.57YKL-5-124
CAS:<p>YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displays</p>Fórmula:C28H33N7O3Pureza:99.36%Forma y color:SolidPeso molecular:515.61BGG463
CAS:<p>BGG463 (K 0859) can inhibit c-ABL-T334I, BCR-ABL and BCR-ABL-T315I variants with an IC50 of 0.25 μM, 0.09 μM and 0.590 μM, respectively.</p>Fórmula:C30H29F3N6O3Pureza:95.05% - >99.99%Forma y color:SolidPeso molecular:578.58Ro-3306
CAS:<p>RO-3306: ATP-competitive CDK1 inhibitor, Ki 20 nM, >15x more selective than other human kinases.</p>Fórmula:C18H13N3OS2Pureza:97.67% - 99.79%Forma y color:SolidPeso molecular:351.45KenPaullone
CAS:<p>KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.</p>Fórmula:C16H11BrN2OPureza:97.14% - 98.99%Forma y color:Tan SolidPeso molecular:327.18NU6027
CAS:<p>NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-</p>Fórmula:C11H17N5O2Pureza:98.36%Forma y color:SolidPeso molecular:251.29Abemaciclib
CAS:<p>Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity.</p>Fórmula:C27H32F2N8Pureza:99.43% - 99.87%Forma y color:SolidPeso molecular:506.59NSC23005 Sodium
CAS:<p>NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.</p>Fórmula:C13H16NNaO4SPureza:99.64%Forma y color:SolidPeso molecular:305.32BSJ-4-116
CAS:<p>BSJ-4-116: potent, selective CDK12 PROTAC, IC50 = 6 nM; downregulates DDR genes, induces premature transcription termination.</p>Fórmula:C40H49ClN8O8SPureza:99.09%Forma y color:SolidPeso molecular:837.38ALSTERPAULLONE
CAS:<p>Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec</p>Fórmula:C16H11N3O3Pureza:99.8%Forma y color:SolidPeso molecular:293.28BS-181 hydrochloride
CAS:<p>BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM.</p>Fórmula:C22H32N6·HClPureza:99.21%Forma y color:SolidPeso molecular:416.99JNJ-7706621
CAS:<p>JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.</p>Fórmula:C15H12F2N6O3SPureza:99.1% - 99.85%Forma y color:SolidPeso molecular:394.36MC180295
CAS:<p>MC180295 ((rel)-MC180295) is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs.</p>Fórmula:C17H18N4O3SPureza:99.84%Forma y color:SolidPeso molecular:358.41ML167
CAS:<p>ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.</p>Fórmula:C19H17N3O3Pureza:99.82% - >99.99%Forma y color:SolidPeso molecular:335.36R547
CAS:<p>R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM.</p>Fórmula:C18H21F2N5O4SPureza:90% - 99.64%Forma y color:SolidPeso molecular:441.45Bohemine
CAS:<p>Bohemine is a cyclin-dependent kinase inhibitor.</p>Fórmula:C18H24N6OPureza:99.09% - 99.53%Forma y color:SolidPeso molecular:340.42THZ531
CAS:<p>THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM).</p>Fórmula:C30H32ClN7O2Pureza:97.17% - 99.86%Forma y color:SolidPeso molecular:558.07PHA-793887
CAS:<p>PHA-793887 has been used in trials studying the treatment of Advanced/Metastatic Solid Tumors.</p>Fórmula:C19H31N5O2Pureza:98.02% - >99.99%Forma y color:SolidPeso molecular:361.48AUZ 454
CAS:<p>AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd of 50/18.6/15.4/9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.</p>Fórmula:C24H26F3N7O2Pureza:99.59%Forma y color:SolidPeso molecular:501.5
