Asociado a microtúbulos
Los inhibidores de proteínas asociadas a microtúbulos se dirigen a proteínas que interactúan con los microtúbulos, los componentes estructurales del citoesqueleto de la célula, esenciales para la división celular. Estas proteínas regulan la estabilidad y la dinámica de los microtúbulos durante la mitosis. Inhibir las proteínas asociadas a microtúbulos puede interrumpir la función de los microtúbulos, lo que lleva al arresto del ciclo celular y la apoptosis, particularmente en células cancerosas de rápida división. Estos inhibidores se utilizan ampliamente en la investigación del cáncer y el desarrollo de fármacos. En CymitQuimica, ofrecemos una amplia gama de inhibidores de proteínas asociadas a microtúbulos de alta calidad para apoyar su investigación en división celular, dinámica del citoesqueleto y terapia contra el cáncer.
Se han encontrado 283 productos de "Asociado a microtúbulos"
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Tubulin inhibitor 36
Tubulin Inhibitor 36 (Compound 10) serves as a potent novel inhibitor of tubulin polymerization, which consequently induces apoptosis in glioblastoma cells,Fórmula:C16H13ClN6SForma y color:SolidPeso molecular:356.83Tubulin polymerization-IN-44
Tubulinpolymer-in-44 (compound 7w) effectively inhibits Tubulin with an IC50 value of 0.21 μM and induces apoptosis by arresting the G2/M phase, making itFórmula:C19H15Cl2N3O3SForma y color:SolidPeso molecular:436.31Tubulin Polymerization-IN-1 prodrug
CAS:Tubulin Polymerization-IN-1 prodrug (Compound 2b) is a microtubule polymerization inhibitor prodrug mediated by Pd. Developed from colchicine-binding site inhibitors (CBSIs), it aims to reduce toxicity and enhance targeted release. Compared to the parent compound, its cytotoxicity is decreased by 68.3 times, but can be in situ restored in the presence of Pd resin. Mechanistic studies show it retains the same antitumor activity as CBSIs. In vivo tests demonstrate that, once activated by Pd resin, it significantly suppresses tumor growth (63.2% inhibition rate). Tubulin Polymerization-IN-1 prodrug is a promising candidate for cancer research.Fórmula:C22H23FN2O4Forma y color:SolidPeso molecular:398.43Vinblastine
CAS:Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer.Fórmula:C46H58N4O9Pureza:97.42%Forma y color:PowderPeso molecular:810.97Epothilone F
CAS:Epothilone F, an active metabolite of Epothilone D with a hydroxymethyl on thiazole, disrupts cell division, shows promise over taxanes, and is water-soluble.Fórmula:C27H41NO7SForma y color:SolidPeso molecular:523.687-Epi-docetaxel
CAS:7-Epi-10-oxo-docetaxel (7-Epitaxotere) is a impurity of docetaxel.Fórmula:C43H53NO14Pureza:98%Forma y color:SolidPeso molecular:807.88Microtubule-associated protein tau (26-44)
Microtubule-associated protein tau (26-44) is a synthetic peptide with an amino group conjugated to glutamine and a carboxyl group conjugated to lysine.
Fórmula:C83H127N25O34SPureza:98%Forma y color:SolidPeso molecular:2051.11Bifidenone
CAS:Bifidenone is an effective tubulin polymerization inhibitor.Fórmula:C21H26O5Forma y color:SolidPeso molecular:358.43Indicine N-oxide
CAS:Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, serves as an antitumor agent in pediatric cancer and solid tumors research.Fórmula:C15H25NO6Forma y color:SolidPeso molecular:315.37Cy5-Paclitaxel
Cy5-Paclitaxel is a Cy5-labeled paclitaxel conjugate. Cy5 is a cyanine dye (with an approximate wavelength of 662 nm) utilized in molecular labeling and microscopy imaging. Paclitaxel stabilizes tubulin polymerization, causing mitotic arrest and apoptotic death. It also induces autophagy.Fórmula:C93H104N4O16Forma y color:SolidPeso molecular:1533.8410-Oxo Docetaxel
CAS:10-Oxo Docetaxel is a Docetaxel intermediate having remarkable antitumor properties.Fórmula:C43H51NO14Pureza:98%Forma y color:SolidPeso molecular:805.874OncoFAP-GlyPro-MMAE
CAS:OncoFAP-GlyPro-MMAE is a FAP small molecule-drug conjugate (SMDC) with an IC50 of 0.49 nM. It is composed of the FAP ligand OncoFAP, a microtubule inhibitor (MMAE), and a linker. OncoFAP-GlyPro-MMAE can be utilized in cancer research, including studies on renal cancer.Fórmula:C102H141F2N19O27SForma y color:SolidPeso molecular:2135.38ALB-109564 dihydrochloride
CAS:ALB-109564 dihydrochloride: Semi-synthetic, vinblastine-derived, microtubule inhibitor, arrests tumor cells in G2/M phase.Fórmula:C47H62Cl2N4O9SPureza:98%Forma y color:SolidPeso molecular:929.99Tubulin polymerization-IN-50
Tubulin Polymerization-IN-50 (compound 7n) serves as an inhibitor of tubulin polymerization, exhibiting an IC50 of 5.05 μM in SK-Mel-28 cells and inducing cellFórmula:C24H20FN3O3Forma y color:SolidPeso molecular:417.43Phomopsinamine
CAS:Phomopsinamine, a phomopsin A derivative, hampers microtubule assembly in sheep brain tubulin (IC50: 0.53-0.59 μM).Fórmula:C32H43ClN6O8Forma y color:SolidPeso molecular:675.17Tubulin inhibitor 21
Compound 6f, a chalcone-melatonin hybrid, is a potent tubulin inhibitor with IC50=0.26μM in SW480 cells, less toxic to non-cancer cells.Fórmula:C28H25N3O4SForma y color:SolidPeso molecular:499.58PM050489
CAS:PM050489, a polyketone inhibitor from Lithoplocamia lithistoides, halts mitosis at 26.4 nM IC50 and aids cancer research.Fórmula:C31H44ClN3O7Forma y color:SolidPeso molecular:606.15T-808
CAS:T-808 is a tau tracer which may be used in radiographic labeling of Tau aggregates during Alzheimer's disease.Fórmula:C17H19FN4Forma y color:SolidPeso molecular:298.36KGP591
KGP591, a tubulin polymerization inhibitor with an IC50 of 0.57 µM, effectively induces G2/M arrest, inhibits cell migration, and disrupts microtubule structureFórmula:C24H21NO5Forma y color:SolidPeso molecular:403.43Combretastatin A-1 phosphate tetrasodium
CAS:OXi-4503, a prodrug of Combretastatin A-1, disrupts tubulin, inhibits Wnt/β-catenin and AKT, and has anti-tumor/vascular effects.Fórmula:C18H18Na4O12P2Forma y color:SolidPeso molecular:580.24Vinflunine Tartrate
CAS:Vinflunine Tartrate, a uniquely fluorinated vinca alkaloid, exhibits mitotic-arresting and tubulin-interacting properties.Fórmula:C45H54F2N4O8·xC4H6O6Pureza:98%Forma y color:SolidPeso molecular:967.02Ref: TM-T6722
2mgA consultar5mgA consultar10mgA consultar25mgA consultar50mgA consultar1mL*10mM (DMSO)A consultarTubulin polymerization-IN-49
Tubulin polymerization-IN-49 (compound 12d), a potent inhibitor of tubulin polymerization, binds to the colchicine site on tubulin, subsequently inducing cellFórmula:C20H24O5Forma y color:SolidPeso molecular:344.4Modified MMAF
CAS:Modified MMAF, an ADC cytotoxin, aids in ADC synthesis for targeted cancer research.Fórmula:C45H73N7O8Forma y color:SolidPeso molecular:840.1Tubulin inhibitor 37
Tubulin Inhibitor 37 (Compound 12) effectively impedes tubulin aggregation (IC50 = 1.3 µM) and demonstrates antiproliferative activity against human tumor cellFórmula:C16H10Cl2N6OForma y color:SolidPeso molecular:373.2Tubulin polymerization-IN-46
Tubulin polymerization-IN-46 (compound 9q) is a microtubule/tubulin inhibitor that impedes tubulin polymerization, induces apoptosis, and arrests MCF-7 breastFórmula:C22H25NO6Forma y color:SolidPeso molecular:399.44Tubulin polymerization-IN-48
Tubulin polymerization-IN-48 (Compound 4k) is an inhibitor of tubulin polymerization, moderately disrupting the microtubule network.Fórmula:C20H15Cl2N3OForma y color:SolidPeso molecular:384.2620-O-Demethyl-AP3
CAS:20-O-Demethyl-AP3, a derivative of the microtubule-inhibiting antitumor agent Ansamitocin P-3, is a secondary metabolite.Fórmula:C31H41ClN2O9Forma y color:SolidPeso molecular:621.12Anticancer agent 139
Compound 6h (Anticancer Agent 139) exhibits potent anticancer activity, engaging in a π-cationic interaction with Lys352 of Tubulin and demonstrating highFórmula:C16H12F3N3OForma y color:SolidPeso molecular:319.28TNIR7-1A
CAS:TNIR7-1A is a fused cycloheptatriene-BODIPY derivative that is optimized for near-infrared (NIR) imaging characteristics (Ex/Em = 600/774 nm in PBS) and exhibits high affinity and specificity for neurofibrillary tangles (NFT) in vitro. Additionally, TNIR7-1A can effectively penetrate the blood-brain barrier.Fórmula:C23H20BF2N3Forma y color:SolidPeso molecular:387.23Microtubule destabilizing agent-1
CAS:Compound 12b is a hydroxamic acid-based MDA with stable metabolism, high bioavailability, and strong antitumor properties.Fórmula:C22H26N4O4Forma y color:SolidPeso molecular:410.47Phomopsin A
CAS:Phomopsin A is a cyclic hexapeptide mycotoxin isolated from the fungus Phomopsis leptostomiformis.Fórmula:C36H45ClN6O12Pureza:98%Forma y color:SolidPeso molecular:789.23Tubulin polymerization-IN-78
Tubulin polymerization-IN-78 (compound 10a) is an inhibitor of tubulin polymerization, with an IC50 value of 2.69 μM. It exhibits antiproliferative activity.Forma y color:Odour SolidTBL-100
TBL-100 is a human monoclonal antibody (mAb) that targets Tau. It is applicable for research in Alzheimer's disease (AD) and progressive supranuclear palsy.Forma y color:Odour LiquidAntiproliferative agent-66
Antiproliferative agent-66 (Compound B3) is an antiproliferative compound that induces apoptosis and causes cell cycle arrest. It demonstrates IC50 values ranging from 2.03 to 3.6 µM against SH-SY5Y neuroblastoma, HT-29 colorectal adenocarcinoma, and fibroblasts. Additionally, Antiproliferative agent-66 functions as a microtubule polymerization inhibitor with an IC50 of 0.79 µM.Fórmula:C18H15N3SForma y color:SolidPeso molecular:305.397Ceratamine A
CAS:Ceratamine A, from Pseudoceratina sponge, is a cytotoxic, microtubule-stabilizing antimitotic alkaloid.
Fórmula:C17H16Br2N4O2Pureza:98%Forma y color:SolidPeso molecular:468.14Aβ-IN-1 TFA
Aβ-IN-1 TFA inhibits and reverses different types of protein aggregation.
Fórmula:C37H50F3NO2Pureza:99.82%Forma y color:SoildPeso molecular:597.79Diminutol
CAS:Diminutol, a purine derivative, inhibits NQO1 (Ki=1.72μM), affects tubulin polymerization, and disrupts mitosis at 50μM without impacting Cdk1 or actin.Fórmula:C19H26N6OSForma y color:SolidPeso molecular:386.51PhosTAC7
CAS:PhosTAC7 successfully induced ternary protein complex formation of Halo-FOXO3a in a dose-dependent manner.Fórmula:C58H87ClN2O17Pureza:98.96%Forma y color:SolidPeso molecular:1119.77Tirbanibulin dihydrochloride
CAS:Tirbanibulin is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).Fórmula:C26H31Cl2N3O3Pureza:98%Forma y color:SolidPeso molecular:504.45Ombrabulin hydrochloride
CAS:Ombrabulin hydrochloride is a synthetic, selective CA-4 phosphate ester or derivative of Ombrabulin to disrupt the tubulin cytoskeleton of endothelial cells andFórmula:C21H27ClN2O6Pureza:98%Forma y color:SolidPeso molecular:438.9Trifluralin
CAS:Trifluralin (Treflan) is an agricultural herbicide with mild toxicity. Trifluralin is a novel pollutant that can interfere with mitochondrial respiration.Fórmula:C13H16F3N3O4Pureza:99.84%Forma y color:Yellow-Orange Crystalline SolidPeso molecular:335.28colchiceine
CAS:colchiceine has a wide range of applications in life science related research.Fórmula:C21H23NO6Pureza:99.38%Forma y color:SolidPeso molecular:385.41Amiprofos methyl
CAS:Amiprofos methyl (BAY-NTN 6867) is an organophosphorus herbicide that specifically and competitively inhibits microtubule polymerization in plant cells.Fórmula:C11H17N2O4PSPureza:99.66%Forma y color:SolidPeso molecular:304.30BSc3094
CAS:BSc3094 is a potent Tau aggregation inhibitor that demonstrates the potential for Alzheimer's disease (AD) research.Fórmula:C17H12N6O3SForma y color:SolidPeso molecular:380.38Avanbulin
CAS:Avanbulin hinders tubulin polymerization, has unique antitumor properties, and is effective against various human tumors at low concentrations.Fórmula:C20H17N7O2Forma y color:SolidPeso molecular:387.39Oryzalin
CAS:Oryzalin is a selective pre-emergence herbicide belonging to the dinitroaniline class, which exerts its effect by inhibiting cell division in weeds.Fórmula:C12H18N4O6SPureza:99.86%Forma y color:SolidPeso molecular:346.36TTBK1-IN-1
CAS:TTBK1-IN-1 (compound 31) is a potent and selective TTBK1 inhibitor with CNS penetration that inhibits tau phosphorylation , Alzheimer's disease.Fórmula:C18H19N5O2Forma y color:SolidPeso molecular:337.38Valecobulin
CAS:Valecobulin is a potent β-tubulin polymerization inhibitor. Valecobulin is a valine prodrug of (S516) and an avascular disrupting compound.Fórmula:C26H28N6O5SPureza:98%Forma y color:SolidPeso molecular:536.6Vindesine sulfate
CAS:Vindesine sulfate, a vinca alkaloid derived from vinblastine, binds to spindle microtubules, causing cell death.Fórmula:C43H57N5O11SPureza:97.51%Forma y color:Amorphous SolidPeso molecular:8524-Isopropoxybenzoic acid
CAS:4-Isopropoxybenzoic acid (AI3 12104) is a Centromere-Associated Protein E inhibitor.Fórmula:C10H12O3Pureza:99.88%Forma y color:White To Off-White PowderPeso molecular:180.2Ref: TM-T24977
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