Asociado a microtúbulos
Los inhibidores de proteínas asociadas a microtúbulos se dirigen a proteínas que interactúan con los microtúbulos, los componentes estructurales del citoesqueleto de la célula, esenciales para la división celular. Estas proteínas regulan la estabilidad y la dinámica de los microtúbulos durante la mitosis. Inhibir las proteínas asociadas a microtúbulos puede interrumpir la función de los microtúbulos, lo que lleva al arresto del ciclo celular y la apoptosis, particularmente en células cancerosas de rápida división. Estos inhibidores se utilizan ampliamente en la investigación del cáncer y el desarrollo de fármacos. En CymitQuimica, ofrecemos una amplia gama de inhibidores de proteínas asociadas a microtúbulos de alta calidad para apoyar su investigación en división celular, dinámica del citoesqueleto y terapia contra el cáncer.
Se han encontrado 283 productos de "Asociado a microtúbulos"
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MAP4343
CAS:Map4343, a 3-methyl ether pregnenolone derivative, binds MAP2, boosts tubulin polymerization, spurs neurite growth, and guards neurons.Fórmula:C22H34O2Pureza:97.024%Forma y color:SolidPeso molecular:330.5N-Phenylbenzylamine
CAS:A series of N-Phenylbenzylamine (Benzenemethanamine) as potential cytotoxic and antimitotic agents acting by inhibition of tubulin polymerizationFórmula:C13H13NPureza:98.75%Forma y color:Colorless To Pale Yellow Crystalline PowderPeso molecular:183.25Valecobulin
CAS:Valecobulin is a potent β-tubulin polymerization inhibitor. Valecobulin is a valine prodrug of (S516) and an avascular disrupting compound.Fórmula:C26H28N6O5SPureza:98%Forma y color:SolidPeso molecular:536.6Vindesine sulfate
CAS:Vindesine sulfate, a vinca alkaloid derived from vinblastine, binds to spindle microtubules, causing cell death.Fórmula:C43H57N5O11SPureza:97.51%Forma y color:Amorphous SolidPeso molecular:852Tau protein (592-597), Human TFA
Tau protein (592-597), Human (TFA) is a peptide fragment of human Tau protein.Fórmula:C36H63F3N10O11Pureza:>99.99%Forma y color:SolidPeso molecular:868.94Albendazole sulfoxide
CAS:Albendazole sulfoxide (Ricobendazole) is a metabolite of Albendazole, an anthelmintic.Fórmula:C12H15N3O3SPureza:97.29%Forma y color:White To Off-White PowderPeso molecular:281.33Clanfenur
CAS:Clanfenur belongs to a new group of substituted benzoylphenylureas. The drug shows both in vitro and in vivo antitumour activity.Fórmula:C16H15ClFN3O2Pureza:99.93%Forma y color:SolidPeso molecular:335.76Ref: TM-T5448
1mg37,00€5mg81,00€10mg116,00€25mg188,00€50mg284,00€100mg395,00€200mg560,00€1mL*10mM (DMSO)92,00€Suprafenacine
CAS:<p>Suprafenacine (N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide) is a cell-permeable microtubule destabilizer that induces</p>Fórmula:C16H18N4OPureza:99.91%Forma y color:SolidPeso molecular:282.34D-64131
CAS:D-64131 is a tubulin polymerization inhibitor with an IC50 value of 0.53 μM.Fórmula:C16H13NO2Pureza:99.48% - 99.67%Forma y color:SolidPeso molecular:251.28LP-261
CAS:LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest.Fórmula:C22H19N3O4SPureza:99.91%Forma y color:SolidPeso molecular:421.47Ref: TM-T9595
1mg38,00€2mg49,00€5mg79,00€10mg119,00€25mg187,00€50mg354,00€100mg528,00€1mL*10mM (DMSO)87,00€MMAF
CAS:MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.Fórmula:C39H65N5O8Pureza:97.00% - 99.88%Forma y color:SolidPeso molecular:731.96Plinabulin
CAS:Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM).Fórmula:C19H20N4O2Pureza:98.69% - >99.99%Forma y color:SolidPeso molecular:336.39Spastazoline
CAS:Spastazoline is a potent and selective inhibitor of spastin(Human spastin with IC50 of 99 nM ).Fórmula:C20H30N8Pureza:99.23%Forma y color:SolidPeso molecular:382.51Ref: TM-T8513
1mg35,00€5mg74,00€10mg111,00€25mg215,00€50mg324,00€100mg465,00€200mg645,00€1mL*10mM (DMSO)82,00€Parbendazole
CAS:Parbendazole (SKF 29044) is a potent inhibitor of microtubule assembly(EC50 : 8.79 nM).Parbendazole is a carbamate ester-amine.Fórmula:C13H17N3O2Pureza:99.60%Forma y color:Physical Description Crystals Or Fine White Powder (Ntp 1992)Peso molecular:247.29T807
CAS:T807 (AV-1451) is a novel tracer of tau positron emission tomography (PET).Fórmula:C16H10FN3Pureza:99.72%Forma y color:SolidPeso molecular:263.27Ref: TM-T19573
2mg47,00€5mg70,00€10mg107,00€25mg187,00€50mg323,00€100mg550,00€200mg758,00€500mg1.159,00€MMAD
CAS:MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs).Fórmula:C41H66N6O6SPureza:99.25% - 99.91%Forma y color:SolidPeso molecular:771.06Soblidotin
CAS:Soblidotin (TZT-1027) (Auristatin PE) is an inhibitor of tubulin polymerization. It is also a novel synthetic Dolastatin 10 derivative.Fórmula:C39H67N5O6Pureza:99.89%Forma y color:SolidPeso molecular:701.98Curvulin
CAS:Curvulin is the active metabolite isolated from Paraphoma sp. VIZR 1.46. Curvularin inhibits iNOS expression and microtubule assembly.Fórmula:C12H14O5Pureza:98.65%Forma y color:SolidPeso molecular:238.24Ref: TM-T36850
1mg145,00€5mg319,00€10mg472,00€25mg753,00€50mg1.074,00€100mg1.444,00€1mL*10mM (DMSO)284,00€Estramustine
CAS:Estramustine (LEO-275), a nitrogen mustard-estradiol compound, treats prostate cancer and protects against radiation.Fórmula:C23H31Cl2NO3Pureza:98.09%Forma y color:SolidPeso molecular:440.4Ref: TM-T20681
5mg47,00€10mg70,00€25mg126,00€50mg202,00€100mg329,00€200mg487,00€1mL*10mM (DMSO)50,00€NQTrp
CAS:NQTrp is an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects.Fórmula:C21H16N2O4Pureza:98.35%Forma y color:SolidPeso molecular:360.36ST-401
CAS:ST-401, a microtubule-targeting agent (MTA), functions as a brain-penetrant microtubule (MT) assembly inhibitor. It disrupts microtubule (MT) function by gently and reversibly reducing MT assembly, which leads to mitotic delay and interphase cell death. ST-401 demonstrates potent antitumor activity.Fórmula:C24H20N2OForma y color:SolidPeso molecular:352.43Semorinemab
CAS:Semorinemab (RG6100) is a humanised monoclonal antibody targeting the N-terminal domain of tau protein with a Kd of 3.8 nM, suitable for Alzheimer's disease.Pureza:95% - 96.7% (SDS-PAGE); 97.2% (SEC-HPLC)Forma y color:LiquidPeso molecular:145.24 kDa4-Desacetylvinblastine hydrazide
CAS:Deacetylvinblastine hydrazide, a cytotoxic vinca alkaloid often conjugated with folic acid to produce EC145, a novel folate-receptor targeted agent.Fórmula:C43H56N6O7Forma y color:SolidPeso molecular:768.94Gosuranemab
CAS:Gosuranemab (BIIB092) is a humanised monoclonal antibody targeting N-terminal tau, inhibiting the propagation and aggregation of pathological tau protein.Pureza:95% - 97.5% (SDS-PAGE); 95.2% (SEC-HPLC)Forma y color:LiquidPeso molecular:144.93 kDaPosdinemab
CAS:<p>Posdinemab, a humanized IgG1κ antibody, targets the microtubule-associated protein tau (MAPT) [1].</p>Forma y color:LiquidTubulin polymerization-IN-2
CAS:Tubulin-IN-2, anticancer β-tubulin binder, IC50 0.92 μM, effective against various cancers.Fórmula:C17H12F2N2O2Forma y color:SolidPeso molecular:314.29Auristatin F
CAS:Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates.Fórmula:C40H67N5O8Pureza:98.41% - 99.25%Forma y color:SolidPeso molecular:745.99Hydromethylthionine HBr
CAS:Hydromethylthionine (LMTM/Leucomethylene Blue) inhibits tau in Alzheimer's/frontotemporal dementia and improves brain function.Fórmula:C16H21Br2N3SForma y color:SolidPeso molecular:447.233(S)-Dolaphenine hydrochloride
CAS:(S)-Dolaphenine hydrochloride is a useful componet of compound synthesis.Fórmula:C11H13ClN2SPureza:98%Forma y color:SolidPeso molecular:240.75Microtubule inhibitor 7
CAS:Compounds 17o and 17p have IC50s of 14.0 nM and 2.9 nM respectively, in NCI-H460 cancer cells, showing potent activity.Fórmula:C25H19FN2O5Forma y color:SolidPeso molecular:446.43(R)-TTBK1-IN-1
CAS:(R)-TTBK1-IN-1: potent, selective brain-penetrant TTBK1 inhibitor, studies Alzheimer’s & tauopathies.Fórmula:C18H19N5O2Forma y color:SolidPeso molecular:337.38Tubulin polymerization-IN-25
CAS:Tubulin polymerization-IN-25 inhibits tubulin (IC50: 1.11 μM) & FTase (IC50: 0.39 μM), and is cytotoxic to cancer cells, halting growth.Fórmula:C24H18N2O3SForma y color:SolidPeso molecular:414.48Tubulin polymerization-IN-15
CAS:Tubulin polymerization-IN-15 (compound 4) is a highly effective inhibitor of tubulin polymerization, with significant potential in cancer research [1].Fórmula:C18H17N3O4Forma y color:SolidPeso molecular:339.35Tubulin polymerization-IN-20
CAS:Tubulin aggregation-IN-20, a potent inhibitor, may be studied for breast and drug-resistant colon cancers.Fórmula:C25H24FNO5Forma y color:SolidPeso molecular:437.46Tubulin inhibitor 18
CAS:"Tubulin inhibitor 18 (5j), a potent chalcone, uniquely structured for cancer research."Fórmula:C22H26O5Forma y color:SolidPeso molecular:370.44Tubulin/MMP-IN-1
Tubulin/MMP-IN-1 inhibits tubulin, MMP, and cancer cell growth; disrupts cell cycles and induces apoptosis.Fórmula:C38H44NO9PForma y color:SolidPeso molecular:689.73Synstab A
CAS:Synstab A is a microtubule stabilizer.Fórmula:C15H13BrCl3N3O3SForma y color:SolidPeso molecular:501.61Tubulin inhibitor 12
CAS:New tubulin inhibitor 12 (Hit 9); potent anti-cancer agent; IC50=25.3 μM; strong anti-tumor effect.Fórmula:C24H20N2OForma y color:SolidPeso molecular:352.43Tau tracer 1
CAS:Tau tracer 1 is a radiopharmaceutical for imaging Tau aggregates linked to neurodegenerative disease diagnosis.Fórmula:C34H23N5O2Forma y color:SolidPeso molecular:533.591SB26019
CAS:SB26019: Potent anti-neuroinflammation; inhibits NF-κB via α-tubulin monomers preventing p65 translocation.Fórmula:C24H20O4Forma y color:SolidPeso molecular:372.41Deox B 7,4
CAS:Deox B 7,4 is a reversible microtubule inhibitor that acts by increasing lysosomal V-ATPase activity and lysosome acidity.Fórmula:C18H18O5Forma y color:SolidPeso molecular:314.33Tubulin inhibitor 20
CAS:Tubulin inhibitor 20 (compound 1) shows the potential for the cancer research that is a potent tubulin inhibitor [1].Fórmula:C19H18O4Forma y color:SolidPeso molecular:310.34Tubulin inhibitor 26
CAS:Compound 3c, a potent indazole-based tubulin inhibitor, halts G2/M phase and induces apoptosis in various cancers without weight loss in mice.Fórmula:C17H19N3O3Forma y color:SolidPeso molecular:313.35Microtubule inhibitor 5
CAS:Compound 17f, a potent microtubule inhibitor, shows strong cytotoxicity in NCI-H460 cells with an IC50 of 154.5 nM and high cell permeability.Fórmula:C22H15FN2O4Forma y color:SolidPeso molecular:390.36Tubulin polymerization-IN-37
CAS:Tubulin polymerization-IN-37 inhibits tubulin polymerization at the colchicine site (IC50: 2.3 μΜ), potentially aiding lymphoma research.Fórmula:C19H20N2O4Forma y color:SolidPeso molecular:340.37THK-5117
CAS:THK-5117, a tau PET probe, has a high tau fibril affinity (Ki 10.5 nM) and binds well to AD brain aggregates.Fórmula:C19H19FN2O2Forma y color:SolidPeso molecular:326.36OXi8007
CAS:OXi8007, a water-soluble prodrug for OXi8006, disrupts vasculature and exhibits strong cytotoxicity against DU-145 cancer cells.Fórmula:C26H24NNa2O10PForma y color:SolidPeso molecular:587.428Iso-Fludelone
CAS:Iso-Fludelone: a stable, soluble, potent, 3rd-gen epothilone B inhibiting cell division and inducing apoptosis, with low toxicity.Fórmula:C27H36F3NO6Forma y color:SolidPeso molecular:527.57Tubulin polymerization-IN-18
CAS:Tubulin aggregation-IN-18 (compound 3) is a potent tubulin aggregation inhibitor with potential for breast cancer and drug-resistant colon cancer studies.Fórmula:C25H25NO6Forma y color:SolidPeso molecular:435.47O-GlcNAcase-IN-4
CAS:O-GlcNAcase-IN-4, an inhibitor from patent WO2018140299A1, may aid in neurodegenerative disease research.Fórmula:C16H22FN5O3SForma y color:SolidPeso molecular:383.44
