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PLK

PLK

Los inhibidores de las quinasas Polo-like (PLK) se dirigen a las PLK, una familia de quinasas serina/treonina que son esenciales para varias etapas de la división celular, incluida la entrada en mitosis, el ensamblaje del huso y la citocinesis. Las PLK son cruciales para la correcta ejecución del ciclo celular, y su desregulación a menudo está asociada con el cáncer. Inhibir las PLK puede inducir el arresto del ciclo celular y la apoptosis en células cancerosas, lo que convierte a estos inhibidores en herramientas importantes en la investigación y terapia del cáncer. En CymitQuimica, ofrecemos una gama de inhibidores de PLK de alta calidad para apoyar su investigación en mitosis, control del ciclo celular y oncología.

Se han encontrado 29 productos para "PLK".

productos por página.
  • Cyclapolin 9
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    Cyclapolin 9

    CAS:
    Cyclapolin 9: Selective PLK1 inhibitor, IC50 500 nM, ATP-competitive, inactive against other kinases.
    Fórmula:C9H4F3N3O4S
    Pureza:99.64%
    Forma y color:Yellow Solid
    Peso molecular:307.21

    Ref: TM-T22700

  • Poloxin-2
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    Poloxin-2

    CAS:
    Poloxin-2 is a potent and selective Plk1 PBD inhibitor with anti-tumour activity that reduces the protein level of Plk1 in HeLa cells.
    Fórmula:C16H15NO3
    Pureza:99.76%
    Forma y color:Solid
    Peso molecular:269.3

    Ref: TM-T25969

  • TC-S 7005
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    TC-S 7005

    CAS:
    TC-S 7005 is an effective inhibitor of Polo-like kinases (IC50s: 214 nM, 4 nM and 24 nM for Plk1, Plk2, and Plk3).
    Fórmula:C21H17N3O3
    Pureza:99.51%
    Forma y color:Solid
    Peso molecular:359.38

    Ref: TM-T17008

  • Plogosertib
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    Plogosertib

    CAS:
    Plogosertib (CYC140) is a PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib is antiproliferative and can be used to study solid and hematologic tumors.
    Fórmula:C34H48N8O3
    Pureza:99.22% - 99.42%
    Forma y color:White Solid
    Peso molecular:616.797

    Ref: TM-T71399

  • IIP0943
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    IIP0943

    CAS:
    IIP0943 is a selective PLK1 (polo-like kinase 1) inhibitor with an IC50 of 5.1 nM for PLK1. It also exhibits inhibitory activity on the proliferation of HCT116 cells, with an IC50 of 0.22 µM. IIP0943 shows potential for research in the field of oncology.
    Fórmula:C26H28N6O3S
    Forma y color:Solid
    Peso molecular:504.604

    Ref: TM-T206115

  • Logo de CymitQuimica
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    Y207-5465

    CAS:
    Y207–5465 is a potent and highly selective inhibitor of PLK2 with an IC50 value of 584.3 nM. It exhibits limited anticancer activity in HT-29 and HCT-116 cell lines. Y207–5465 is applicable for cancer research.
    Fórmula:C20H16N4O3
    Peso molecular:360.37

    Ref: TM-T214775

  • CD 10899
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    CD 10899

    CAS:
    CD 10899, a hydroxylated metabolite of Volasertib, is pharmacologically active against Polo-like kinase 1 (PLK1) with an IC50 of 6 nM. Volasertib is an orally active, highly potent, and ATP-competitive PLK1 inhibitor. CD 10899 can be used for cancer research [1].
    Fórmula:C34H50N8O4
    Forma y color:Solid
    Peso molecular:634.81

    Ref: TM-T86023

  • PLK1-IN-11
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    PLK1-IN-11

    CAS:
    PLK1-IN-11 (Cluster 4, 16953209) is a PLK1 inhibitor with an IC50 of 1 μM. It is applicable in research on various cancers such as pancreatic, ovarian, breast, and non-small cell lung cancer.
    Fórmula:C12H11N5O
    Forma y color:Solid
    Peso molecular:241.2486

    Ref: TM-T205548

  • PLK1-IN-5
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    PLK1-IN-5

    CAS:
    PLK1-IN-5, a potent PLK1 inhibitor, has an IC50 of less than 500 nM and demonstrates anticancer effects (WO2008113711A1; compound I-4) [1].
    Fórmula:C28H39N7O3
    Forma y color:Solid
    Peso molecular:521.65

    Ref: TM-T87222