DYRK
Los inhibidores de las quinasas DYRK (quinasas reguladas por fosforilación de tirosina de doble especificidad) son compuestos que se dirigen a la familia de quinasas DYRK, involucradas en la regulación del ciclo celular, el desarrollo neuronal y la apoptosis. Las quinasas DYRK tienen doble especificidad, lo que significa que pueden fosforilar residuos de tirosina y serina/treonina. Inhibir las quinasas DYRK puede afectar varios procesos celulares, incluida la progresión del ciclo celular y la diferenciación. Los inhibidores de DYRK son herramientas importantes en la investigación sobre cáncer, enfermedades neurodegenerativas y señalización celular. En CymitQuimica, ofrecemos una selección de inhibidores de DYRK de alta calidad para apoyar su investigación en el control del ciclo celular, neurobiología y desarrollo terapéutico.
Se han encontrado 48 productos de "DYRK"
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AZ-Dyrk1B-33
CAS:<p>AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.</p>Fórmula:C19H16N4Pureza:99.91%Forma y color:SolidPeso molecular:300.36BT173
CAS:<p>BT173 is a novel inhibitor of homeodomain interacting protein kinase 2 (HIPK2 ), attenuating renal fibrosis through suppression of the TGF-ß1/Smad3 pathway.</p>Fórmula:C18H12BrN3O2Pureza:98.247%Forma y color:SolidPeso molecular:382.21GSK-626616
CAS:<p>GSK-626616: strong, oral DYRK3 inhibitor (IC50: 0.7 nM), affects DYRK family, may treat anemia.</p>Fórmula:C18H10Cl2N4OSPureza:98.27%Forma y color:SolidPeso molecular:401.27CLK1-IN-3
CAS:<p>Clk1-in-3 is a + selective and highly potent sexual Clk1 inhibitor with an IC50 of 5 nM and 300 pairs higher affinity than Dyrk1A.</p>Fórmula:C24H23FN6OPureza:98.46% - 99.76%Forma y color:SoildPeso molecular:430.48Leucettine L41
CAS:<p>Leucettine L41 (LeucettineL41) is an inhibitor of DYRKs/CLKs, preferentially targeting DYRK1A, and inhibits DYRK2.</p>Fórmula:C17H13N3O3Pureza:99.08%Forma y color:SolidPeso molecular:307.3GNF2133
CAS:<p>GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.</p>Fórmula:C24H30N6O2Pureza:98.51%Forma y color:SolidPeso molecular:434.53Protein kinase inhibitors 1 hydrochloride
CAS:<p>Protein Kinase Inhibitors 1 Hydrochloride effectively inhibits HIPK2, demonstrating high potency with IC50 values of 136 nM for HIPK1 and 74 nM for HIPK2,</p>Fórmula:C18H18ClN5O3SForma y color:SolidPeso molecular:419.88Mirk-IN-1
CAS:<p>Mirk-IN-1 is an effective inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A (IC50: 68±48 nM and 22±8 nM respectively).</p>Fórmula:C23H17Cl2N5O4Pureza:98%Forma y color:SolidPeso molecular:498.32ML167
CAS:<p>ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.</p>Fórmula:C19H17N3O3Pureza:99.82% - >99.99%Forma y color:SolidPeso molecular:335.36GNF4877
CAS:<p>GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.</p>Fórmula:C25H27FN6O4Pureza:98.68% - 99.40%Forma y color:SolidPeso molecular:494.52Harmine
CAS:<p>Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.</p>Fórmula:C13H12N2OPureza:98.29% - 99.92%Forma y color:Off-White SolidPeso molecular:212.25LDN-192960 hydrochloride
CAS:<p>LDN-192960 hydrochloride is an inhibitor of Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) and Haspin with IC50s of 48 nM and 10 nM, respectively.</p>Fórmula:C18H22Cl2N2O2SPureza:98%Forma y color:SolidPeso molecular:401.35Harmine hydrochloride
CAS:<p>Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus.</p>Fórmula:C13H13ClN2OPureza:99.61% - >99.99%Forma y color:Yellow To Slightly Green Crystalline PowderPeso molecular:248.71ID-8
CAS:<p>ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.</p>Fórmula:C16H14N2O4Pureza:99.32%Forma y color:SolidPeso molecular:298.29LDN-192960
CAS:<p>LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).</p>Fórmula:C18H20N2O2SPureza:98.01% - 99.51%Forma y color:SolidPeso molecular:328.43AZ191
CAS:<p>AZ191（IC50 of 17 nM） is an effective and specific DYRK1B inhibitor.</p>Fórmula:C24H27N7OPureza:98.04% - 99.65%Forma y color:SolidPeso molecular:429.52Protein kinase inhibitors 1
CAS:<p>Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.</p>Fórmula:C18H17N5O3SPureza:98%Forma y color:SolidPeso molecular:383.42ILK-IN-3
CAS:<p>ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.</p>Fórmula:C10H12N6OPureza:99.69%Forma y color:SolidPeso molecular:232.24GNF2133 hydrochloride
CAS:<p>GNF2133 hydrochloride: selective oral DYRK1A inhibitor (IC50: 0.0062 μM), boosts β-cell growth and insulin, potential for type 1 diabetes research.</p>Fórmula:C24H31ClN6O2Forma y color:SolidPeso molecular:471.02-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi
CAS:<p>2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine serves as an intermediate.</p>Fórmula:C6H6N4OPureza:99.21% - 99.42%Forma y color:SolidPeso molecular:150.14
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