DYRK
Los inhibidores de las quinasas DYRK (quinasas reguladas por fosforilación de tirosina de doble especificidad) son compuestos que se dirigen a la familia de quinasas DYRK, involucradas en la regulación del ciclo celular, el desarrollo neuronal y la apoptosis. Las quinasas DYRK tienen doble especificidad, lo que significa que pueden fosforilar residuos de tirosina y serina/treonina. Inhibir las quinasas DYRK puede afectar varios procesos celulares, incluida la progresión del ciclo celular y la diferenciación. Los inhibidores de DYRK son herramientas importantes en la investigación sobre cáncer, enfermedades neurodegenerativas y señalización celular. En CymitQuimica, ofrecemos una selección de inhibidores de DYRK de alta calidad para apoyar su investigación en el control del ciclo celular, neurobiología y desarrollo terapéutico.
Se han encontrado 47 productos para "DYRK".
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BT173
CAS:BT173 is a novel inhibitor of homeodomain interacting protein kinase 2 (HIPK2 ), attenuating renal fibrosis through suppression of the TGF-ß1/Smad3 pathway.Fórmula:C18H12BrN3O2Pureza:98.24%Forma y color:SolidPeso molecular:382.211GSK-626616
CAS:GSK-626616: strong, oral DYRK3 inhibitor (IC50: 0.7 nM), affects DYRK family, may treat anemia.Fórmula:C18H10Cl2N4OSPureza:98.27%Forma y color:SolidPeso molecular:401.269AZ-Dyrk1B-33
CAS:AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.Fórmula:C19H16N4Pureza:99.91%Forma y color:SolidPeso molecular:300.3571DYR684
CAS:DYR684 is a PROTAC designed to target the protein kinase DYRK1A, promoting its rapid, efficient, potent, and selective degradation in cellular assays.Fórmula:C58H58FN15O5Forma y color:SolidPeso molecular:1064.18GNF2133
CAS:GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.Fórmula:C24H30N6O2Pureza:98.51%Forma y color:SolidPeso molecular:434.534Dyrk1A-IN-7
Dyrk1A-IN-7 (Compound 29) is a selective DYRK1A kinase inhibitor with notable kinase selectivity, exhibiting an IC50 value of 28 nM for DYRK1A and a Kd of 17.5 nM for CLK2. This selective inhibitor is applicable in research related to cancer, type II diabetes, and neurological disorders.Fórmula:C19H13F3N4OForma y color:SolidPeso molecular:370.10415KTD-092
KTD-092, a DYRK1A inhibitor, exhibits an IC50 of 22 nM against human DYRK1A. It is applicable in research related to Down syndrome (DS), Alzheimer's disease (AD), autism spectrum disorder (ASD), diabetes, and other neurodegenerative diseases.Mirk-IN-1
CAS:Mirk-IN-1 is an effective inhibitor of Dyrk1B(Mirk kianse) and Dyrk1A (IC50: 68±48 nM and 22±8 nM respectively).Fórmula:C23H17Cl2N5O4Pureza:98%Forma y color:SolidPeso molecular:498.318Protein kinase inhibitors 1 hydrochloride
CAS:Protein Kinase Inhibitors 1 Hydrochloride effectively inhibits HIPK2, demonstrating high potency with IC50 values of 136 nM for HIPK1 and 74 nM for HIPK2,Fórmula:C18H18ClN5O3SForma y color:SolidPeso molecular:419.8852-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi
CAS:2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine serves as an intermediate.Fórmula:C6H6N4OPureza:99.21% - 99.39%Forma y color:SolidPeso molecular:150.138GNF4877
CAS:GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.Fórmula:C25H27FN6O4Pureza:98.68% - 99.51%Forma y color:SolidPeso molecular:494.5181Harmine
CAS:Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.Fórmula:C13H12N2OPureza:98.29% - 99.92%Forma y color:White SolidPeso molecular:212.2472AZ191
CAS:AZ191（IC50 of 17 nM） is an effective and specific DYRK1B inhibitor.Fórmula:C24H27N7OPureza:98.04% - 99.65%Forma y color:SolidPeso molecular:429.52LDN-192960 hydrochloride
CAS:LDN-192960 hydrochloride is an inhibitor of Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) and Haspin with IC50s of 48 nM and 10 nM, respectively.Fórmula:C18H22Cl2N2O2SPureza:98%Forma y color:SolidPeso molecular:401.35GNF2133 hydrochloride
CAS:GNF2133 hydrochloride: selective oral DYRK1A inhibitor (IC50: 0.0062 μM), boosts β-cell growth and insulin, potential for type 1 diabetes research.Fórmula:C24H31ClN6O2Forma y color:SolidPeso molecular:471.0Harmine hydrochloride
CAS:Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus.Fórmula:C13H13ClN2OPureza:99.61% - >99.99%Forma y color:Yellow SolidPeso molecular:248.708Protein kinase inhibitors 1
CAS:Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.Fórmula:C18H17N5O3SPureza:98%Forma y color:SolidPeso molecular:383.42ILK-IN-3
CAS:ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.Fórmula:C10H12N6OPureza:99.69%Forma y color:White SolidPeso molecular:232.2419LDN-192960
CAS:LDN-192960 is a potent inhibitor of Haspin and DYRK2 (IC50s: 10 nM and 48 nM).Fórmula:C18H22Cl2N2O2SPureza:99.01% - 99.51%Forma y color:Yellow SolidPeso molecular:401.35ID-8
CAS:ID-8, a DYRK inhibitor, sustains embryonic stem cell self-renewal in long-term culture.Fórmula:C16H14N2O4Pureza:99.32%Forma y color:White SolidPeso molecular:298.2934
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