PKC
Los inhibidores de la proteína quinasa C (PKC) se dirigen a la familia de quinasas serina/treonina PKC, que están involucradas en una amplia gama de procesos celulares, incluidos la regulación del ciclo celular, la apoptosis y la diferenciación. La PKC desempeña un papel clave en las vías de transducción de señales que influyen en la proliferación y supervivencia celular. Inhibir la PKC puede provocar cambios en la progresión del ciclo celular, lo que hace que estos inhibidores sean valiosos en la investigación relacionada con el cáncer, la neurobiología y las enfermedades cardiovasculares. En CymitQuimica, ofrecemos una selección diversa de inhibidores de PKC de alta calidad para apoyar su investigación en transducción de señales, regulación del ciclo celular y desarrollo terapéutico.
Se han encontrado 130 productos para "PKC".
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N-Desmethyltamoxifen hydrochloride
CAS:N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans.Fórmula:C25H28ClNOPureza:99.15%Forma y color:SolidPeso molecular:393.95Delcasertib
CAS:Delcasertib (KAI-9803) is a potent and selective inhibitor of δ-protein kinase C (δPKC).Fórmula:C120H199N45O34S2Pureza:99.96%Forma y color:SolidPeso molecular:2880.28Ref: TM-T11740
1mg192,00€5mg485,00€10mg700,00€25mg1.063,00€50mg1.459,00€1mL*10mM (DMSO)1.603,00€100mg1.963,00€PKC β pseudosubstrate acetate
PKC β pseudosubstrate acetate (PKC β pseudosubstrate acetate (172308-76-8 Free base)) is a selective cell-permeable inhibitor of PKC.Pureza:95.42%Forma y color:SoildA-3 hydrochloride
CAS:A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.Fórmula:C12H14Cl2N2O2SPureza:99.32%Forma y color:SolidPeso molecular:321.22Ref: TM-T14069
1mg34,00€5mg63,00€10mg90,00€1mL*10mM (DMSO)95,00€25mg161,00€50mg260,00€100mg416,00€500mg888,00€Bisindolylmaleimide VIII acetate
CAS:Bisindolylmaleimide VIII acetate is a selective PKC inhibitor with an IC50 of 158 nM in rat brain and varying IC50s for different PKC isoforms.Fórmula:C26H26N4O4Pureza:99.27%Forma y color:Red SolidPeso molecular:458.51CMPD101
CAS:CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).Fórmula:C24H21F3N6OPureza:99.01% - 99.04%Forma y color:SolidPeso molecular:466.46Mitoxantrone dihydrochloride
CAS:Mitoxantrone dihydrochloride (NSC-301739) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone is a type II topoisomerase inhibitor.Fórmula:C22H30Cl2N4O6Pureza:97.05% - >99.99%Forma y color:SolidPeso molecular:517.4ZIP
CAS:Novel inhibitor for PKMζ, halts synaptic potentiation and reverses LTP with IC50 of 1-2.5 μM, erasing spatial memory.Fórmula:C90H154N30O17Pureza:98%Forma y color:SolidPeso molecular:1928.4Delcasertib acetate
Delcasertib acetate is a selective δ protein kinase C (δPKC) inhibitor for the study of acute myocardial infarction and pain.Fórmula:C122H203N45O36S2Pureza:98.92%Forma y color:SolidPeso molecular:2940.33Ref: TM-T11740L
1mg166,00€2mg213,00€5mg313,00€10mg442,00€25mg642,00€50mg880,00€100mg1.179,00€200mg1.594,00€[Ala113]MBP(104-118)
CAS:Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 28 - 62 mM).Fórmula:C67H104N20O19Pureza:98%Forma y color:SolidPeso molecular:1493.68Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg
CAS:Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg is a protein kinase C substrate.Fórmula:C56H110N22O14Pureza:98%Forma y color:SolidPeso molecular:1315.61LY 379196
LY 379196, a potent PKC-β inhibitor (IC 50: 50 nM for PKC βI and 30 nM for PKC βII), effectively suppresses the proliferation of bovine retinal microvascular endothelial cells (BREC) induced by VEGF, IGF-1, and bFGF. This compound serves as an antiproliferative agent for proliferative retinopathy.Fórmula:C30H34N4O5SForma y color:SolidPeso molecular:562.68Pep2m, myristoylated
CAS:Myristoylated pep2m peptide; inhibits GluA2-NSF interaction, reducing AMPA receptor function and surface expression.Fórmula:C63H118N18O14SPureza:98%Forma y color:SolidPeso molecular:1383.8Fasudil
CAS:Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Fórmula:C14H17N3O2SPureza:99.79% - 99.97%Forma y color:SolidPeso molecular:291.37Protein Kinase C (19-36)
CAS:Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM.Fórmula:C93H159N35O24Pureza:98%Forma y color:SolidPeso molecular:2151.48pTH-Related Protein (1-40) (human, mouse, rat)
CAS:pTH-Related Protein (1-40) boosts rat calcium absorption via PTHR1 and PKCα/β. It up-regulates PTHR1, TRPV6, CaBP-D9k, NCX1, and PMCA1.Fórmula:C207H334N66O58Peso molecular:4675.27(8R)-8-Hydroxyepoxyboetirane A
(8R)-8-Hydroxyepoxyboetirane A is a neuroactivating compound that interacts with PKCδ-C1B. This compound binds into the PKC enzyme pocket through hydrogen bonds with glycine-253, leucine-251, and threonine-242. It induces the release of NRG1 and promotes the differentiation of neural stem cells into neurons. (8R)-8-Hydroxyepoxyboetirane A holds potential for research into nervous system disorders.Forma y color:Odour SolidPKCiota-IN-2
CAS:PKCiota-IN-2 selectively inhibits PKC-ι (IC50=2.8nM) and also blocks PKC-α, ε (IC50s=71nM, 350nM).Fórmula:C24H21N5OPureza:98.86%Forma y color:SolidPeso molecular:395.46Ref: TM-T9863
1mg109,00€2mg163,00€5mg243,00€1mL*10mM (DMSO)264,00€10mg355,00€25mg532,00€50mg750,00€100mg1.009,00€Bisindolylmaleimide III
CAS:Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC).Bisindolylmaleimide III selectively interacts with PKCα or ribosomal S6Fórmula:C23H20N4O2Pureza:97.2%Forma y color:SolidPeso molecular:384.43Myelin Basic Protein
CAS:Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system.Fórmula:C60H103N21O17Pureza:98%Forma y color:SolidPeso molecular:1390.59
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