PKC
Los inhibidores de la proteína quinasa C (PKC) se dirigen a la familia de quinasas serina/treonina PKC, que están involucradas en una amplia gama de procesos celulares, incluidos la regulación del ciclo celular, la apoptosis y la diferenciación. La PKC desempeña un papel clave en las vías de transducción de señales que influyen en la proliferación y supervivencia celular. Inhibir la PKC puede provocar cambios en la progresión del ciclo celular, lo que hace que estos inhibidores sean valiosos en la investigación relacionada con el cáncer, la neurobiología y las enfermedades cardiovasculares. En CymitQuimica, ofrecemos una selección diversa de inhibidores de PKC de alta calidad para apoyar su investigación en transducción de señales, regulación del ciclo celular y desarrollo terapéutico.
Se han encontrado 124 productos de "PKC"
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Ingenol
CAS:Ingenol mebutate treats actinic keratosis, has anticancer properties, and may reactivate latent HIV.
Fórmula:C20H28O5Pureza:99.78% - 99.87%Forma y color:SolidPeso molecular:348.43PKCβ inhibitor 1
CAS:PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2,Fórmula:C24H21N5O2Pureza:99.33%Forma y color:SolidPeso molecular:411.46Ref: TM-T8376
1mg93,00€5mg255,00€10mg363,00€25mg552,00€50mg730,00€100mg998,00€500µg58,00€1mL*10mM (DMSO)225,00€Protein Kinase C 19-31 acetate
PKC 19-31 acetate, a serine-altered PKCa-derived PKC inhibitor, tests PKC activity.Fórmula:C69H122N26O18Pureza:>99.99%Forma y color:SolidPeso molecular:1603.9Hypericin
CAS:Hypericin (Cyclosan) is a natural anthraquinone compound. Hypericin exhibits antimicrobial, antiviral, antitumor, and antidepressant effects. Cost-effective and quality-assured.Fórmula:C30H16O8Pureza:98.90% - ≥98%Forma y color:Red-Coloured Anthraquinone-DerivativePeso molecular:504.44Ref: TM-T6S0923
1mg54,00€5mg120,00€10mg172,00€25mg341,00€50mg504,00€100mg705,00€500mg1.431,00€1mL*10mM (DMSO)133,00€Enzastaurin
CAS:Enzastaurin (LY317615) (LY317615) is an effective PKCβ selective inhibitor (IC50: 6 nM), 6- to 20-fold selectivity against PKCα/γ/ε.Fórmula:C32H29N5O2Pureza:98% - >99.99%Forma y color:SolidPeso molecular:515.6Ruboxistaurin hydrochloride
CAS:Ruboxistaurin HCl (LY 333531) selectively inhibits PKCβI/II with IC50 of 4.7/5.9 nM; much less effective on other PKC types and ATP-kinases.Fórmula:C28H28N4O3·HClPureza:99.14% - 99.28%Forma y color:SolidPeso molecular:505.01Ref: TM-T3689
1mg67,00€2mg87,00€5mg148,00€10mg244,00€25mg487,00€50mg702,00€100mg982,00€500mg1.963,00€1mL*10mM (DMSO)190,00€Ionomycin calcium
CAS:Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, exhibiting high specificity for calcium ions. Cost-effective and quality-assured.
Fórmula:C41H70CaO9Pureza:98% - 98.11%Forma y color:SolidPeso molecular:747.07PKCTheta-IN-2
CAS:PKCTheta-IN-2 (compound 14) is a potent and selective PKCθ inhibitor (IC50 = 0.25 nM) that suppresses IL-2 production in mice (IC50 = 682 nM).Fórmula:C24H23N5O2Pureza:99.38%Forma y color:SolidPeso molecular:413.47Phorbol 12,13-dibutyrate
CAS:Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator that induces contraction of isolated rabbit vascular smooth muscle.Fórmula:C28H40O8Pureza:99.32% - 99.37%Forma y color:SolidPeso molecular:504.61Ref: TM-T16526
1mg58,00€5mg160,00€10mg268,00€25mg530,00€50mg827,00€100mg1.314,00€200mg1.773,00€1mL*10mM (DMSO)170,00€CGP60474
CAS:CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC.Fórmula:C18H18ClN5OPureza:98.81%Forma y color:SolidPeso molecular:355.82Ref: TM-T14943
1mg34,00€2mg46,00€5mg71,00€10mg92,00€25mg177,00€50mg314,00€100mg518,00€1mL*10mM (DMSO)78,00€PS315
CAS:PS315, a PS48 derivative, allosterically inhibits PKCζ/η (IC50: 10/30 μM), targeting aPKC's PIF-pocket, with anti-cancer properties.Fórmula:C23H19ClO2Pureza:98%Forma y color:SolidPeso molecular:362.85SC-10
CAS:SC-10 is a direct activator of PKC with potential antiproliferative activity, useful in leukemia research.Fórmula:C17H22ClNO2SPureza:99.24% - 99.58%Forma y color:SolidPeso molecular:339.88AJH-836
CAS:AJH-836 is a compound that activates Munc13-1 and PKC ε/α, demonstrating a dissociation constant (Kd) of 4.5 nM for PKCα, and facilitates the translocation ofFórmula:C22H38O5Pureza:98%Forma y color:SolidPeso molecular:382.53DCPLA-ME
CAS:DCPLA-ME (2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester) is the methyl ester form of DCPLA and can be used to treat neurodegenerativeFórmula:C21H38O2Pureza:99.80%Forma y color:SolidPeso molecular:322.53Ref: TM-T10980
1mg62,00€5mg126,00€10mg172,00€25mg350,00€50mg572,00€100mg772,00€200mg1.054,00€1mL*10mM (DMSO)138,00€NSC668394
CAS:NSC668394 is an ezrin phosphorylation inhibitor.NSC668394 has antitumor activity and increases ezrin cleavage.NSC668394 can be used to study tumor metastasis.Fórmula:C17H12Br2N2O3Pureza:99.29% - 99.29%Forma y color:SolidPeso molecular:452.1CRT0066854 hydrochloride
CAS:CRT0066854 HCl inhibits atypical PKCs; IC50: PKCι 132 nM, PKCζ 639 nM, ROCK-II 620 nM.Fórmula:C24H27Cl2N5SPureza:99.63%Forma y color:SolidPeso molecular:488.48Ref: TM-T10888
1mg57,00€5mg122,00€10mg192,00€25mg324,00€50mg459,00€100mg642,00€200mg888,00€1mL*10mM (DMSO)146,00€(-)-Indolactam V
CAS:(-)-Indolactam V: PKC activator, antitumor, Ki 3.36 nM/1.03 μM for η/γ-CRD2, Kd 5.5-213 nM for C1 domains.Fórmula:C17H23N3O2Pureza:98%Forma y color:SolidPeso molecular:301.38TCS 21311
CAS:TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.Fórmula:C27H25F3N4O4Pureza:99.39% - ≥98%Forma y color:SolidPeso molecular:526.51VTX-27
CAS:VTX-27 is a selective inhibitor of protein kinase C θ (PKC θ) (Kis: 0.08 nM and 16 nM for PKC θ and PKC δ).Fórmula:C20H24ClFN6OPureza:99.84%Forma y color:SolidPeso molecular:418.9Ref: TM-T13314
1mg93,00€2mg125,00€5mg244,00€10mg364,00€25mg562,00€50mg780,00€100mg1.035,00€1mL*10mM (DMSO)225,00€PKC-θ inhibitor 1
CAS:PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)Fórmula:C17H15F3N4OPureza:98%Forma y color:SolidPeso molecular:348.32PKC-IN-1
CAS:PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6,Fórmula:C25H37FN8O2Pureza:98% - 98.79%Forma y color:SolidPeso molecular:500.61AS2521780
CAS:AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).Fórmula:C30H41N7OSPureza:98%Forma y color:SolidPeso molecular:547.76YAP/TAZ-TEAD-IN-2
YAP/TAZ-TEAD-IN-2 (Compound 51) is a YAP/TAZ-TEAD inhibitor that disrupts the interaction between YAP/TAZ and TEAD. It inhibits the transcriptional activity of TEAD with an IC50 of 1.2 nM. Additionally, YAP/TAZ-TEAD-IN-2 suppresses the expression of target genes (Cyr61, CTGF, AXL, and Survivin) and the proliferation of breast cancer cells.Fórmula:C19H20N2O3SForma y color:SolidPeso molecular:356.44Cercosporin
CAS:Cercosporin, produced by the plant pathogen Cercospora kikuchii and the elsinochromes, is a potent photosensitizer with a short activation wavelength. Cercosporin contains perylene quinone structural features essential for PKC activity (IC50: 0.6-1.3 μM).Fórmula:C29H26O10Pureza:98%Forma y color:SolidPeso molecular:534.51
