PKC
Los inhibidores de la proteína quinasa C (PKC) se dirigen a la familia de quinasas serina/treonina PKC, que están involucradas en una amplia gama de procesos celulares, incluidos la regulación del ciclo celular, la apoptosis y la diferenciación. La PKC desempeña un papel clave en las vías de transducción de señales que influyen en la proliferación y supervivencia celular. Inhibir la PKC puede provocar cambios en la progresión del ciclo celular, lo que hace que estos inhibidores sean valiosos en la investigación relacionada con el cáncer, la neurobiología y las enfermedades cardiovasculares. En CymitQuimica, ofrecemos una selección diversa de inhibidores de PKC de alta calidad para apoyar su investigación en transducción de señales, regulación del ciclo celular y desarrollo terapéutico.
Se han encontrado 126 productos de "PKC"
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Bisindolylmaleimide VIII acetate
CAS:Bisindolylmaleimide VIII acetate is a selective PKC inhibitor with an IC50 of 158 nM in rat brain and varying IC50s for different PKC isoforms.Fórmula:C26H26N4O4Pureza:99.27%Forma y color:SolidPeso molecular:458.51A-3 hydrochloride
CAS:A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.Fórmula:C12H14Cl2N2O2SPureza:99.32%Forma y color:SolidPeso molecular:321.22Ref: TM-T14069
1mg34,00€5mg63,00€10mg90,00€25mg161,00€50mg260,00€100mg416,00€500mg888,00€1mL*10mM (DMSO)95,00€Delcasertib
CAS:Delcasertib (KAI-9803) is a potent and selective inhibitor of δ-protein kinase C (δPKC).Fórmula:C120H199N45O34S2Pureza:99.96%Forma y color:SolidPeso molecular:2880.28Ref: TM-T11740
1mg192,00€5mg485,00€10mg700,00€25mg1.063,00€50mg1.459,00€100mg1.963,00€1mL*10mM (DMSO)1.603,00€N-Desmethyltamoxifen hydrochloride
CAS:N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans.Fórmula:C25H28ClNOPureza:99.15%Forma y color:SolidPeso molecular:393.95Mitoxantrone dihydrochloride
CAS:Mitoxantrone dihydrochloride (NSC-301739) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone is a type II topoisomerase inhibitor.Fórmula:C22H30Cl2N4O6Pureza:97.05% - >99.99%Forma y color:Blue-Black Solid From Water Ethanol SolidPeso molecular:517.4PKC β pseudosubstrate acetate
PKC β pseudosubstrate acetate (PKC β pseudosubstrate acetate (172308-76-8 Free base)) is a selective cell-permeable inhibitor of PKC.Pureza:95.42%Forma y color:SoildCMPD101
CAS:CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM).Fórmula:C24H21F3N6OPureza:99.01% - 99.04%Forma y color:SolidPeso molecular:466.46Sangivamycin
CAS:Sangivamycin (NSC-65346) inhibits PKC (Ki=10μM) and hinders growth in various human cancers.
Fórmula:C12H15N5O5Pureza:99.85%Forma y color:SolidPeso molecular:309.28PKC 20-28,myristoylated
Myristoylated protein kinase C inhibitor 20-28 (PKC 20-28,myristoylated) is a cell-permeable inhibitor of protein kinase C, utilized in cancer research [1].Fórmula:C60H106N18O11Pureza:98%Forma y color:SolidPeso molecular:1255.6Protein kinase inhibitor H-7
CAS:H-7: potent PKC inhibitor with 6 μM Ki, also blocks cyclic nucleotide-dependent kinases.Fórmula:C14H17N3O2SPureza:99.91%Forma y color:SoildPeso molecular:291.37PKCε inhibitor peptide,myristoylated
Myristoylated PKCε inhibitor peptide (Myr-PKCε-) is a cell-permeable inhibitor consisting of a peptide linked to myristic acid that specifically inhibitsFórmula:C51H91N9O14Pureza:98%Forma y color:SolidPeso molecular:1054.32Delcasertib acetate
Delcasertib acetate is a selective δ protein kinase C (δPKC) inhibitor for the study of acute myocardial infarction and pain.Fórmula:C122H203N45O36S2Pureza:98.92%Forma y color:SolidPeso molecular:2940.33Ref: TM-T11740L
1mg166,00€2mg213,00€5mg313,00€10mg442,00€25mg642,00€50mg880,00€100mg1.179,00€200mg1.594,00€PKCβII Peptide Inhibitor I
CAS:PKCβII Peptide Inhibitor I, a specific PKCβII inhibitor, exhibits cardioprotective properties in a rat cardiac ischemia/reperfusion injury model and mitigatesFórmula:C61H94N12O19Pureza:98%Forma y color:SolidPeso molecular:1299.47Myelin Basic Protein
CAS:Myelin basic protein (MBP) is a protein believed to be important in the process of myelination of nerves in the nervous system.Fórmula:C60H103N21O17Pureza:98%Forma y color:SolidPeso molecular:1390.59PKCε Inhibitor Peptide acetate
PKCε Inhibitor Peptide acetate is a selective PKCε inhibitor containing the site for its specific receptor for activated C kinase (RACK).Fórmula:C39H69N9O15Pureza:98.93%Forma y color:SolidPeso molecular:904.02Ref: TM-T35827L
1mg62,00€2mg89,00€5mg110,00€10mg177,00€25mg298,00€50mg429,00€100mg587,00€200mg792,00€PKC β pseudosubstrate TFA
PKC β pseudosubstrate TFA is a selective cell-permeable inhibitor of PKC [1] .Fórmula:C179H295F3N62O40S3Forma y color:SolidPeso molecular:4108.84PKCα (C2-4) inhibitor peptide
PKCα (C2-4) inhibitor peptide is a specific antagonist to PKCα that impedes the α1A-adrenoreceptor agonist A-61603 [1] from inhibiting I_Kr.Fórmula:C47H74N14O17Pureza:98%Forma y color:SolidPeso molecular:1107.17[Ala9,10, Lys11,12] Glycogen Synthase (1-12)
CAS:[Ala9,10, Lys11,12] Glycogen Synthase (1-12): PKC's selective phosphorylation substrate, used to assess PKC activity. [1]Fórmula:C56H103N17O16Forma y color:SolidPeso molecular:1270.52K-252b
CAS:K-252b, an indolocarbazole derived from the actinomycete Nocardiopsis, functions as a protein kinase C (PKC) inhibitor.
Fórmula:C26H19N3O5Pureza:98%Forma y color:Ready-To-Use SolutionPeso molecular:453.45N-Myristoyl-Lys-Arg-Thr-Leu-Arg
CAS:N-Myristoyl-Lys-Arg-Thr-Leu-Arg: PKC inhibitor, IC50=75μM, blocks IL-2 in Jurkat cells.Fórmula:C42H82N12O8Forma y color:SolidPeso molecular:883.18pep2-EVKI
CAS:Peptide inhibits GluA2-PICK1 binding, sparing GluA2-GRIP/ABP interaction and LTD, without boosting AMPA current.Fórmula:C62H95N13O19Pureza:98%Forma y color:SolidPeso molecular:1326.51Protein Kinase C Peptide Substrate
CAS:PKC Peptide Substrate acts on cell spacers, driven by second messengers/adaptors due to external signals via g protein/tyrosine kinase receptors.Fórmula:C83H155N39O21SPureza:98%Forma y color:SolidPeso molecular:2067.43ɛPKC(85-92),Myristoylated
CAS:PKC(85-92)，Myristoylated is a myristic acid-conjugated, cell-permeable peptide activator of PKC that has been shown to increase nitric oxide (NO) release inFórmula:C53H80N10O15Pureza:98%Forma y color:SolidPeso molecular:1097.26PKCθ pseudosubstrate peptide inhibitor,myristoylated
Myristoylated PKCθ pseudosubstrate peptide inhibitor is a synthetic peptide utilized to investigate the mechanism of action of protein kinase C theta (PKCθ) [1Fórmula:C105H184N36O21SPureza:98%Forma y color:SolidPeso molecular:2318.88Bisindolylmaleimide III
CAS:Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC).Bisindolylmaleimide III selectively interacts with PKCα or ribosomal S6Fórmula:C23H20N4O2Pureza:97.2%Forma y color:SolidPeso molecular:384.43FKKSFKL-NH2
CAS:FKKSFKL-NH2 is a selective peptide for protein kinase C, employed in biochemical research [1].Fórmula:C45H73N11O8Forma y color:SolidPeso molecular:896.13LY 379196
LY 379196, a potent PKC-β inhibitor (IC 50: 50 nM for PKC βI and 30 nM for PKC βII), effectively suppresses the proliferation of bovine retinal microvascular endothelial cells (BREC) induced by VEGF, IGF-1, and bFGF. This compound serves as an antiproliferative agent for proliferative retinopathy.Fórmula:C30H34N4O5SForma y color:SolidPeso molecular:562.68(8R)-8-Hydroxyepoxyboetirane A
(8R)-8-Hydroxyepoxyboetirane A is a neuroactivating compound that interacts with PKCδ-C1B. This compound binds into the PKC enzyme pocket through hydrogen bonds with glycine-253, leucine-251, and threonine-242. It induces the release of NRG1 and promotes the differentiation of neural stem cells into neurons. (8R)-8-Hydroxyepoxyboetirane A holds potential for research into nervous system disorders.Forma y color:Odour SolidTAT-P4-(DATC5)2 TFA
TAT-P4-(DATC5)2 TFA, a high-affinity peptide inhibitor targeting the PDZ domain of protein interacting with C kinase-1 (PICK1), exhibits a K i of 1.7 nM andForma y color:Odour SolidProtein Kinase C (19-36)
CAS:Protein Kinase C (19-36) is a pseudosubstrate peptide inhibitor of protein kinase C (PKC), with an IC50 of 0.18 μM.Fórmula:C93H159N35O24Pureza:98%Forma y color:SolidPeso molecular:2151.48PKCiota-IN-2
CAS:PKCiota-IN-2 selectively inhibits PKC-ι (IC50=2.8nM) and also blocks PKC-α, ε (IC50s=71nM, 350nM).Fórmula:C24H21N5OPureza:98.86%Forma y color:SolidPeso molecular:395.46Ref: TM-T9863
1mg109,00€2mg163,00€5mg243,00€10mg355,00€25mg532,00€50mg750,00€100mg1.009,00€1mL*10mM (DMSO)264,00€PKCδ Peptide Substrate
CAS:PKCδ Peptide Substrate is a highly specific substrate for the δ-type of Protein kinase C, composed of a sequence that mirrors murine eEF-1α (422-443) andFórmula:C109H191N35O29SForma y color:SolidPeso molecular:2487.97Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg
CAS:Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg is a protein kinase C substrate.Fórmula:C56H110N22O14Pureza:98%Forma y color:SolidPeso molecular:1315.61PKC β pseudosubstrate
CAS:Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM).Fórmula:C177H294N62O38S3Pureza:98%Forma y color:SolidPeso molecular:3994.84Ac-MBP (1-11)
CAS:Ac-MBP 1-11, a primary encephalitogenic epitope in myelin basic protein (MBP), is a dominant short peptide sequence[1].Fórmula:C2H3K2OPS3Pureza:98%Forma y color:SolidPeso molecular:248.41Fasudil
CAS:Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Fórmula:C14H17N3O2SPureza:99.79% - 99.84%Forma y color:SolidPeso molecular:291.37ZIP
CAS:Novel inhibitor for PKMζ, halts synaptic potentiation and reverses LTP with IC50 of 1-2.5 μM, erasing spatial memory.Fórmula:C90H154N30O17Pureza:98%Forma y color:SolidPeso molecular:1928.41-Oleoyl-2-acetyl-sn-glycerol
CAS:1-Oleoyl-2-acetyl-sn-glycerol (1-oleoyl-2-acetyl-glycerol) is a PKC activator that induces superoxide production.Fórmula:C23H42O5Forma y color:SolidPeso molecular:398.58Pep2m, myristoylated
CAS:Myristoylated pep2m peptide; inhibits GluA2-NSF interaction, reducing AMPA receptor function and surface expression.Fórmula:C63H118N18O14SPureza:98%Forma y color:SolidPeso molecular:1383.8Protein kinase C α peptide TFA
CAS:Protein Kinase C (alpha) Peptide (TFA) is a PKC-α-associated peptide functioning as a lipid-dependent serine/threonine protein kinase.Fórmula:C68H115F3N24O26SForma y color:SolidPeso molecular:1773.85[Ala113]MBP(104-118)
CAS:Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 28 - 62 mM).Fórmula:C67H104N20O19Pureza:98%Forma y color:SolidPeso molecular:1493.68Protein Kinase C (19-35) Peptide
CAS:PKC (19-35) Peptide inhibits PKC by blocking its substrate-binding, rendering cytoplasmic PKC inactive.Fórmula:C89H153N33O22Forma y color:SolidPeso molecular:2037.4[Ala107]MBP(104-118)
CAS:Synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 46 - 145 mM).Fórmula:C67H104N20O19Pureza:98%Forma y color:SolidPeso molecular:1493.68Neuropeptide DF2
CAS:Neuropeptide DF2 is an FMRFamide-related neuropeptide from crayfish.Fórmula:C44H67N15O10Pureza:98%Forma y color:SolidPeso molecular:966.1ε-V1-2, Cys-conjugated
Epsilon-V1-2, a Cys-conjugated, is a biologically active peptide known as the εPKC-specific inhibitor.Fórmula:C40H70N10O14SPureza:98%Forma y color:SolidPeso molecular:947.11Bisindolylmaleimide XI hydrochloride
CAS:Bisindolylmaleimide XI hydrochloride (Ro 32-0432) is an orally active pan-PKC inhibitor that inhibits PKCα, PKCβI, PKCβII, and PKCγ.Fórmula:C28H29ClN4O2Pureza:99.45%Forma y color:SolidPeso molecular:489.01NPC-15437 dihydrochloride
CAS:NPC-15437 dihydrochloride is a PKC inhibitor blocking enzyme activity and phorbol ester binding, selective over other kinases, in cellular signaling research.Fórmula:C25H52Cl2N4O2Forma y color:SolidPeso molecular:511.62TAT-SAMβA
TAT-SAMβA, an RNAENFDRF (SAMβA) peptide conjugated to the TAT 47–57 protein-derived cell-penetrating peptide, acts as a selective antagonist of the Mfn1-βIIPKCFórmula:C118H195N51O31Pureza:98%Forma y color:SolidPeso molecular:2824.13PKC-ε translocation inhibitor peptide
PKC-ε Translocation Inhibitor Peptide is a selective modulator that controls the FcγR-mediated internalization rate of opsonized beads without affecting FcαRPureza:98%Forma y color:Odour SolidProtein Kinase C (19-31)
CAS:Protein Kinase C (19-31), a PKC inhibitor derived from PKCa, has a serine at position 25 and tests PKC activity.Fórmula:C67H118N26O16Pureza:98%Forma y color:Lyophilized PowderPeso molecular:1543.82
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