HSP
Los inhibidores de proteínas de choque térmico (HSP) se dirigen a las HSP, una familia de chaperonas moleculares que asisten en el plegamiento de proteínas, la estabilidad y la protección contra daños inducidos por el estrés. Las HSP suelen estar sobreexpresadas en células cancerosas, ayudándolas a sobrevivir en condiciones estresantes como la hipoxia y la quimioterapia. Inhibir las HSP puede interrumpir estos mecanismos de protección, lo que conduce a la muerte celular. Por lo tanto, los inhibidores de HSP son valiosos en la terapia contra el cáncer y en la investigación de respuestas al estrés. En CymitQuimica, ofrecemos una amplia gama de inhibidores de HSP de alta calidad para apoyar su investigación en homeostasis de proteínas, respuestas al estrés y oncología.
Se han encontrado 176 productos para "HSP".
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3-Phenyltoxoflavin
CAS:3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.Fórmula:C13H11N5O2Pureza:99.88%Forma y color:SolidPeso molecular:269.26Chetomin
CAS:Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolarFórmula:C31H30N6O6S4Pureza:98%Forma y color:Off-White To Fawn SolidPeso molecular:710.87MPC-0767
CAS:MPC-0767, a potent, selective, and orally active hsp90 inhibitor, is the L-alanine ester prodrug of MPC-3100, exhibiting enhanced chemical stability.Fórmula:C26H36BrN7O9S2Forma y color:SolidPeso molecular:734.64PROTAC HSP90 degrader BP3
CAS:PROTAC BP3 selectively degrades HSP90, inhibits breast cancer growth (DC50=0.99µM), CRBN-dependent.Fórmula:C32H29ClN8O5Forma y color:SolidPeso molecular:641.08MAL3-101
CAS:MAL3-101 is a molecular chaperone inhibitor of heat shock protein 70 (Hsp 70).Fórmula:C54H66N4O10Forma y color:SolidPeso molecular:931.12A17 peptide
CAS:A17 peptide is an Hsp70-targeting peptide. It binds to the ATP-binding domain of Hsp70, specifically inhibiting its chaperone activity. This enhances cellular sensitivity to chemotherapeutic drugs, such as those inducing apoptosis via Cisplatin. A17 peptide is applicable in cancer chemotherapy research, including studies on multiple myeloma.Fórmula:C76H105N19O20SForma y color:SolidPeso molecular:1636.83NMS-E973
CAS:NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.Fórmula:C22H22N4O7Pureza:99.84%Forma y color:Yellow SolidPeso molecular:454.43Ref: TM-T6609
2mg39,00€5mg60,00€1mL*10mM (DMSO)66,00€10mg92,00€25mg187,00€50mg294,00€100mg419,00€200mg590,00€Neoantimycin
CAS:Neoantimycin: S. orinoci antibiotic, mild antifungal, like antimycin, from different Streptomyces, biosynthesis known, active variants found.Fórmula:C36H46N2O12Forma y color:SolidPeso molecular:698.766Myrtucommulone
CAS:Myrtucommulone is an inhibitor of the chaperonin activity of HSP60, correlating to LRP130 and LONP aggregation.Fórmula:C38H52O10Pureza:98%Forma y color:SolidPeso molecular:668.81Alvespimycin TFA
Alvespimycin (17-DMAG) TFA is a potent inhibitor of Hsp90, binding with an EC50 of 62 ± 29 nM.Fórmula:C34H49F3N4O10Forma y color:SolidPeso molecular:730.34008Gamitrinib TPP
CAS:Gamitrinib TPP targets mitochondrial HSP90, inhibiting cancer, and blocks mitochondrial matrix.Fórmula:C52H65N3O8PPureza:98%Forma y color:SolidPeso molecular:891.078p5 Ligand for Dnak and DnaJ
CAS:P5 is a nonapeptide ligand for DnaK/DnaJ, mimicking the key sites of mitochondrial aspartate aminotransferase presequence.Fórmula:C44H81N15O11SPureza:98%Forma y color:SolidPeso molecular:1028.27Hsp70-derived octapeptide
CAS:TPR proteins including CHIP, TPR1, and hSGT affect luciferase refolding by DnaJ and hsc70.Fórmula:C36H58N8O16Pureza:98%Forma y color:SolidPeso molecular:858.896BrCaQ-C10-TPP
6BrCaQ-C10-TPP inhibits TRAP1, halts cancer cell growth (IC50=0.008-0.30µM), disrupts mitochondrial membrane.Fórmula:C45H47Br2N2O3PForma y color:SolidPeso molecular:854.65Shepherdin (79-87)
CAS:Shepherdin 79-87: Amino acid fragment 79-87 of Hsp90/Survivin antagonist with anticancer properties.Fórmula:C41H64N12O12SPureza:98%Forma y color:SolidPeso molecular:949.09JG-258
CAS:JG-258 is an inactive negative control for Hsp70 inhibitors [1] .Fórmula:C20H22ClN3OS3Forma y color:SolidPeso molecular:452.06trans-Dehydrocurvularin
CAS:trans-Dehydrocurvularin is a useful organic compound for research related to life sciences. The catalog number is T125357 and the CAS number is 21178-57-4.Fórmula:C16H18O5Forma y color:SolidPeso molecular:290.315HSP70/SIRT2-IN-1
HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.Pureza:98%Forma y color:Odour SolidArimoclomol citrate
CAS:Arimoclomol citrate boosts Hsp expression, aiding protein aggregation and neuron protection.Fórmula:C20H28ClN3O10Forma y color:SolidPeso molecular:505.91Grp94 Inhibitor-3
Grp94 Inhibitor-3 (Compound C6) is a selective inhibitor of glucose-regulated protein 94 (Grp94), with an affinity of 5.52 μM. It shows potential for research in primary open-angle glaucoma and metastatic cancer.Fórmula:C24H20ClNO4Forma y color:SolidPeso molecular:421.87
