HSP
Los inhibidores de proteínas de choque térmico (HSP) se dirigen a las HSP, una familia de chaperonas moleculares que asisten en el plegamiento de proteínas, la estabilidad y la protección contra daños inducidos por el estrés. Las HSP suelen estar sobreexpresadas en células cancerosas, ayudándolas a sobrevivir en condiciones estresantes como la hipoxia y la quimioterapia. Inhibir las HSP puede interrumpir estos mecanismos de protección, lo que conduce a la muerte celular. Por lo tanto, los inhibidores de HSP son valiosos en la terapia contra el cáncer y en la investigación de respuestas al estrés. En CymitQuimica, ofrecemos una amplia gama de inhibidores de HSP de alta calidad para apoyar su investigación en homeostasis de proteínas, respuestas al estrés y oncología.
Se han encontrado 176 productos para "HSP".
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Debio 0932
CAS:Debio 0932 (CUDC-305) is a Hsp9 inhibitor, apoptosis, and has the advantage of being orally available and cross the BBB for cancers NSCLC and neuroblastoma.Fórmula:C22H30N6O2SPureza:98.98%Forma y color:White SolidPeso molecular:442.58VER-155008
CAS:VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively.Fórmula:C25H23Cl2N7O4Pureza:97.03% - 99.55%Forma y color:SolidPeso molecular:556.4Ref: TM-T7010
2mg44,00€5mg65,00€1mL*10mM (DMSO)80,00€10mg88,00€25mg155,00€50mg268,00€100mg442,00€200mg620,00€DDO-5936
CAS:DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.Fórmula:C25H29N5O4SPureza:99.81%Forma y color:SolidPeso molecular:495.59Ref: TM-T9202
1mg34,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg119,00€25mg250,00€50mg369,00€100mg525,00€200mg710,00€NVP-HSP990
CAS:NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).Fórmula:C20H18FN5O2Pureza:98.03% - 99.32%Forma y color:White SolidPeso molecular:379.39ML346
CAS:ML346 is a novel activator of Hsp70.Fórmula:C14H12N2O4Pureza:97.32% - 99.36%Forma y color:Red SolidPeso molecular:272.26Ref: TM-T3594
1mg38,00€2mg50,00€5mg80,00€1mL*10mM (DMSO)80,00€10mg109,00€25mg168,00€50mg259,00€100mg405,00€500mg888,00€Dihydroberberine
CAS:Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities.Fórmula:C20H19NO4Pureza:99.86%Forma y color:Yellow SolidPeso molecular:337.37Ganetespib
CAS:Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.Fórmula:C20H20N4O3Pureza:98% - 99.95%Forma y color:SolidPeso molecular:364.4Ref: TM-T2309
5mg63,00€1mL*10mM (DMSO)71,00€10mg93,00€25mg126,00€50mg158,00€100mg236,00€200mg401,00€500mg665,00€JG-98
CAS:JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).Fórmula:C24H21Cl2N3OS3Pureza:99.13%Forma y color:Yellow SolidPeso molecular:534.53Eupalinolide A
CAS:Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.Fórmula:C24H30O9Pureza:98.82% - 99.22%Forma y color:SolidPeso molecular:462.49Grp94 Inhibitor-1
CAS:Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).Fórmula:C22H28N2O2Pureza:97.02% - 98.83%Forma y color:White SolidPeso molecular:352.47HM03 trihydrochloride
CAS:HM03 trihydrochloride is a potent and selective inhibitor of HSPA5, also known as Bip or Grp78. It exhibits anticancer activity.Fórmula:C26H30Cl4N4O2Forma y color:SolidPeso molecular:572.35KW-2478
CAS:KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.Fórmula:C30H42N2O9Pureza:98.68% - 99.52%Forma y color:SolidPeso molecular:574.66Ref: TM-T6558
1mg52,00€2mg77,00€5mg113,00€1mL*10mM (DMSO)145,00€10mg177,00€25mg299,00€50mg447,00€100mg627,00€MitoBloCK-10
CAS:MitoBloCK-10 inhibits Tim44-Hsp70 binding; first to reduce PAM complex activity.Fórmula:C12H8FN3O3SPureza:99.51%Forma y color:SolidPeso molecular:293.27Ref: TM-T8741
500µg46,00€1mg66,00€1mL*10mM (DMSO)136,00€5mg144,00€10mg205,00€25mg349,00€50mg500,00€100mg700,00€200mg954,00€Shepherdin 79-87 acetate
Shepherdin 79-87 acetate is a peptidomimetic antagonist of the complex between Hsp90 and survivin, another key regulator of tumor cell viability.Fórmula:C43H68N12O14SPureza:98.08%Forma y color:SolidPeso molecular:1009.14Pimitespib
CAS:Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).Fórmula:C25H26N8OPureza:99.22% - 99.49%Forma y color:White SolidPeso molecular:454.53Paeoniflorin
CAS:Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.Fórmula:C23H28O11Pureza:96.9% - 97.43%Forma y color:White Fine PowderPeso molecular:480.46Iroxanadine hydrochloride
CAS:Iroxanadine hydrochloride is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.Fórmula:C14H21ClN4OForma y color:SolidPeso molecular:296.8Tanespimycin
CAS:Tanespimycin (KOS 953) is an Hsp90 inhibitor (IC50=5 nM) and is selective. Tanespimycin depletes intracellular STK38/NDR1. High-Quality, Low-Cost!Fórmula:C31H43N3O8Pureza:98.24% - 99.83%Forma y color:Purple SolidPeso molecular:585.69Gedunin
CAS:Gedunin, a Meliaceae seed limonoid, inhibits Hsp90 and ovarian cancer growth.Fórmula:C28H34O7Pureza:99.64% - 99.68%Forma y color:SolidPeso molecular:482.57Ref: TM-T21883
1mg371,00€5mg1.108,00€1mL*10mM (DMSO)1.215,00€10mg1.513,00€25mg2.242,00€50mg3.025,00€100mg4.078,00€p5 Ligand for Dnak and DnaJ acetate
p5 Ligand for Dnak and DnaJ acetate is a nonapeptide. It is a high-affinity ligand for DnaK (E. coli Hsp70) and DnaJ (E. coli Hsp40).Fórmula:C46H85N15O13SPureza:96.33%Forma y color:White SolidPeso molecular:1088.32VER49009
CAS:VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).Fórmula:C19H18ClN3O4Pureza:99.24% - >99.99%Forma y color:White SolidPeso molecular:387.82Ref: TM-T2268
1mg57,00€2mg80,00€1mL*10mM (DMSO)90,00€5mg105,00€10mg164,00€25mg268,00€50mg447,00€100mg610,00€KBU2046
CAS:KBU2046: oral anti-metastasis compound, enhances survival, targets chaperone complexes, not a typical HSP90 inhibitor.Fórmula:C15H11FO2Pureza:99.89%Forma y color:White SolidPeso molecular:242.24Ref: TM-T15646
2mg33,00€5mg50,00€1mL*10mM (DMSO)50,00€10mg71,00€25mg133,00€50mg200,00€100mg304,00€200mg425,00€YUM70
CAS:YUM70 inhibits GRP78 (IC50: 1.5μM), inducing ER stress and apoptosis in pancreatic cancer.Fórmula:C21H19ClN2O4Pureza:97.25%Forma y color:White SolidPeso molecular:398.84Ref: TM-T8901
1mg46,00€1mL*10mM (DMSO)90,00€5mg92,00€10mg128,00€25mg250,00€50mg369,00€100mg525,00€200mg710,00€HSF1A
CAS:HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.Fórmula:C21H19N3O2S2Pureza:98.89%Forma y color:SolidPeso molecular:409.52Ref: TM-T4125
1mg52,00€2mg94,00€1mL*10mM (DMSO)123,00€5mg132,00€10mg195,00€25mg439,00€50mg642,00€100mg888,00€Azadiradione
CAS:Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indicaFórmula:C28H34O5Pureza:99.52%Forma y color:White SolidPeso molecular:450.57Ref: TM-TN6729
1mg124,00€5mg271,00€1mL*10mM (DMSO)334,00€10mg489,00€25mg735,00€50mg1.018,00€100mg1.378,00€Geldanamycin
CAS:Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.Fórmula:C29H40N2O9Pureza:97.59% - 99.27%Forma y color:Yellow To Orange PowderPeso molecular:560.64L-Alanyl-L-glutamine
CAS:L-Alanyl-L-glutamine (Ala-Gln), a dipeptide composed of alanine and Gln, is an alternative supplement to L-glutamine in the production of biopharmaceuticals.Fórmula:C8H15N3O4Pureza:99.71% - 99.97%Forma y color:White SolidPeso molecular:217.22MK2-IN-1
CAS:MK2-IN-1 is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode.Fórmula:C27H25ClN4O2Forma y color:SolidPeso molecular:472.97DTHIB
CAS:DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.Fórmula:C13H9ClFN3O3Pureza:98.86% - 99.29%Forma y color:SolidPeso molecular:309.68Ref: TM-T8858
1mg34,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg99,00€25mg200,00€50mg319,00€100mg512,00€500mg1.071,00€PU-H54
CAS:PU-H54 is a purine-derived Grp94 inhibitor targeting the S2 subpocket's unique binding region.Fórmula:C18H19N5SPureza:99.13%Forma y color:SolidPeso molecular:337.44TRC051384
CAS:TRC051384 is a HSP70 inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke.Fórmula:C25H31N5O4Pureza:98.79%Forma y color:SolidPeso molecular:465.54Ref: TM-T3527
1mg34,00€5mg75,00€1mL*10mM (DMSO)77,00€10mg105,00€25mg200,00€50mg281,00€100mg409,00€200mg590,00€TRC051384 HCl
CAS:TRC051384 is an inducer of heat shock protein Hsp70, activating heat shock factor-1 and enhancing Hsp72 expression in neurons and glial cells.Fórmula:C25H32ClN5O4Pureza:97.55%Forma y color:Yellow SolidPeso molecular:502.01BIIB021
CAS:BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).Fórmula:C14H15ClN6OPureza:98% - 99.82%Forma y color:SolidPeso molecular:318.76MKT-077
CAS:MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines.Fórmula:C21H22ClN3OS2Pureza:98.2%Forma y color:SolidPeso molecular:432Pifithrin-μ
CAS:Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.Fórmula:C8H7NO2SPureza:99.33% - 99.79%Forma y color:SolidPeso molecular:181.21XL888
CAS:XL888 is an orally bioavailable Hsp90 inhibitor, blocking cell proliferation and inducing tumor regression with an IC50 of 24 nM.Fórmula:C29H37N5O3Pureza:99.18%Forma y color:SolidPeso molecular:503.64HSP70-IN-1
CAS:HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).Fórmula:C24H28N6O2SPureza:99.91%Forma y color:White SolidPeso molecular:464.58Ref: TM-T3487
1mg90,00€5mg215,00€1mL*10mM (DMSO)219,00€10mg334,00€25mg587,00€50mg802,00€100mg1.108,00€MK2-IN-1 hydrochloride
CAS:MK2-IN-1 hydrochloride (MK 25) selectively inhibits MK2 with IC50 of 0.11 μM, non-ATP competitive.Fórmula:C27H26Cl2N4O2Pureza:97.32%Forma y color:SolidPeso molecular:509.43KNK437
CAS:KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).Fórmula:C13H11NO4Pureza:98.90%Forma y color:SolidPeso molecular:245.23Ref: TM-T2444
2mg38,00€5mg54,00€1mL*10mM (DMSO)59,00€10mg77,00€25mg149,00€50mg220,00€100mg331,00€200mg530,00€Palmitic acid
CAS:Palmitic acid (Cetylic acid) is a natural product, a common saturated fatty acid found in animals, plants and microorganisms.Fórmula:C16H32O2Pureza:99.17% - 99.67%Forma y color:White SolidPeso molecular:256.42HSP27 inhibitor J2
CAS:HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function ofFórmula:C13H12O4SPureza:99.51%Forma y color:SolidPeso molecular:264.3Ref: TM-T7265
1mg123,00€2mg175,00€5mg295,00€1mL*10mM (DMSO)326,00€10mg447,00€25mg713,00€50mg1.009,00€100mg1.341,00€VER-82576
CAS:VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.Fórmula:C21H23Cl2N5O2SPureza:97.31% - 99.85%Forma y color:SolidPeso molecular:480.41KRIBB11
CAS:KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.Fórmula:C13H12N6O2Pureza:97.25% - 99.91%Forma y color:SolidPeso molecular:284.27Ref: TM-T3652
5mg49,00€1mL*10mM (DMSO)50,00€10mg73,00€25mg150,00€50mg249,00€100mg484,00€200mg680,00€500mg1.035,00€VER-49009
CAS:VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).Fórmula:C19H18ClN3O4Pureza:99.36% - 99.99%Forma y color:SolidPeso molecular:387.82Ref: TM-T3454
2mg43,00€1mL*10mM (DMSO)50,00€5mg60,00€10mg96,00€25mg156,00€50mg245,00€100mg335,00€200mg475,00€HM03
CAS:HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.Fórmula:C26H27ClN4O2Pureza:97.15%Forma y color:SolidPeso molecular:462.972-hexyl-4-Pentynoic Acid
CAS:2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.Fórmula:C11H18O2Pureza:98%Forma y color:SolidPeso molecular:182.26Luminespib
CAS:Luminespib (VER-52296) is an HSP90 inhibitor that inhibits HSP90α and HSP90β. Luminespib has antitumor activity. Cost-effective and quality-assured.Fórmula:C26H31N3O5Pureza:98% - 99.25%Forma y color:SolidPeso molecular:465.54Ref: TM-T1989
5mg54,00€1mL*10mM (DMSO)59,00€10mg77,00€25mg138,00€50mg210,00€100mg344,00€200mg512,00€500mg825,00€Onalespib
CAS:Onalespib (AT13387) is an oral Hsp90 inhibitor with anticancer potential, disrupting tumor cell growth and survival.Fórmula:C24H31N3O3Pureza:99.01% - 99.66%Forma y color:SolidPeso molecular:409.52HA15
CAS:HA15 targets BiP/GRP78/HSPA5, showing anti-cancer effects on all tested melanoma cells, resistant or patient-derived.Fórmula:C23H22N4O3S2Pureza:99.77% - 99.86%Forma y color:SolidPeso molecular:466.58Rocaglamide
CAS:Rocaglamide (Roc-A) from Aglaia treats coughs, injuries, asthma, skin issues, and inhibits NF-κB in T-cells.Fórmula:C29H31NO7Pureza:95.32% - 99.67%Forma y color:SolidPeso molecular:505.56Ref: TM-TQ0131
500µg155,00€1mg187,00€5mg410,00€1mL*10mM (DMSO)449,00€10mg710,00€25mg1.381,00€50mg2.352,00€
