HSP
Los inhibidores de proteínas de choque térmico (HSP) se dirigen a las HSP, una familia de chaperonas moleculares que asisten en el plegamiento de proteínas, la estabilidad y la protección contra daños inducidos por el estrés. Las HSP suelen estar sobreexpresadas en células cancerosas, ayudándolas a sobrevivir en condiciones estresantes como la hipoxia y la quimioterapia. Inhibir las HSP puede interrumpir estos mecanismos de protección, lo que conduce a la muerte celular. Por lo tanto, los inhibidores de HSP son valiosos en la terapia contra el cáncer y en la investigación de respuestas al estrés. En CymitQuimica, ofrecemos una amplia gama de inhibidores de HSP de alta calidad para apoyar su investigación en homeostasis de proteínas, respuestas al estrés y oncología.
Se han encontrado 169 productos de "HSP"
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MK2-IN-1 hydrochloride
CAS:<p>MK2-IN-1 hydrochloride (MK 25) selectively inhibits MK2 with IC50 of 0.11 μM, non-ATP competitive.</p>Fórmula:C27H26Cl2N4O2Pureza:97.32%Forma y color:SolidPeso molecular:509.43XL888
CAS:<p>XL888 is an orally bioavailable Hsp90 inhibitor, blocking cell proliferation and inducing tumor regression with an IC50 of 24 nM.</p>Fórmula:C29H37N5O3Pureza:99.18%Forma y color:SolidPeso molecular:503.64HM03 trihydrochloride
CAS:<p>HM03 trihydrochloride is a potent and selective inhibitor of HSPA5, also known as Bip or Grp78. It exhibits anticancer activity.</p>Fórmula:C26H30Cl4N4O2Forma y color:SolidPeso molecular:572.35Tanespimycin
CAS:<p>Tanespimycin (KOS 953) is an Hsp90 inhibitor (IC50=5 nM) and is selective. Tanespimycin depletes intracellular STK38/NDR1. High-Quality, Low-Cost!</p>Fórmula:C31H43N3O8Pureza:99.07% - 99.83%Forma y color:Dark Purple SolidPeso molecular:585.69VER49009
CAS:<p>VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).</p>Fórmula:C19H18ClN3O4Pureza:98.95% - >99.99%Forma y color:SolidPeso molecular:387.82MitoBloCK-10
CAS:<p>MitoBloCK-10 inhibits Tim44-Hsp70 binding; first to reduce PAM complex activity.</p>Fórmula:C12H8FN3O3SPureza:99.51%Forma y color:SolidPeso molecular:293.27HSP70-IN-1
CAS:<p>HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).</p>Fórmula:C24H28N6O2SPureza:99.91%Forma y color:SolidPeso molecular:464.58HM03
CAS:<p>HM03 is a potent and selective inhibitor of HSPA5, and has anticancer activity.</p>Fórmula:C26H27ClN4O2Pureza:97.15%Forma y color:SolidPeso molecular:462.97VER-50589
CAS:<p>VER-50589 is a potent HSP90 inhibitor.</p>Fórmula:C19H17ClN2O5Pureza:99.96% - >99.99%Forma y color:SolidPeso molecular:388.8MK2-IN-1
CAS:<p>MK2-IN-1 is a potent and selecitve MAPKAPK2(MK2) inhibitor(IC50=0.11 uM) with a non-ATP competitive binding mode.</p>Fórmula:C27H25ClN4O2Forma y color:SolidPeso molecular:472.97MKT-077
CAS:<p>MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines.</p>Fórmula:C21H22ClN3OS2Pureza:98.2%Forma y color:SolidPeso molecular:432HSP27 inhibitor J2
CAS:<p>HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of</p>Fórmula:C13H12O4SPureza:99.51%Forma y color:SolidPeso molecular:264.3ML346
CAS:<p>ML346 is a novel activator of Hsp70.</p>Fórmula:C14H12N2O4Pureza:97.32% - 99.36%Forma y color:SolidPeso molecular:272.262-hexyl-4-Pentynoic Acid
CAS:<p>2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.</p>Fórmula:C11H18O2Pureza:98%Forma y color:SolidPeso molecular:182.26Luminespib
CAS:<p>Luminespib (VER-52296) is an HSP90 inhibitor that inhibits HSP90α and HSP90β. Luminespib has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C26H31N3O5Pureza:98% - 99.25%Forma y color:SolidPeso molecular:465.54Onalespib
CAS:<p>Onalespib (AT13387) is an oral Hsp90 inhibitor with anticancer potential, disrupting tumor cell growth and survival.</p>Fórmula:C24H31N3O3Pureza:98.05% - 99.66%Forma y color:SolidPeso molecular:409.52Rocaglamide
CAS:<p>Rocaglamide (Roc-A) from Aglaia treats coughs, injuries, asthma, skin issues, and inhibits NF-κB in T-cells.</p>Fórmula:C29H31NO7Pureza:95.32% - 99.67%Forma y color:SolidPeso molecular:505.56Alvespimycin hydrochloride
CAS:<p>Alvespimycin hydrochloride (BMS 826476) is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.</p>Fórmula:C32H48N4O8·HClPureza:99.94%Forma y color:SolidPeso molecular:653.21PF-04929113 Mesylate
CAS:<p>PF-04929113 Mesylate (SNX-5422 Mesylate), a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37</p>Fórmula:C26H34F3N5O7SPureza:99% - 99.46%Forma y color:SolidPeso molecular:617.63JG-98
CAS:<p>JG-98 is an allosteric Hsp70 inhibitor, displays high active against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50s: 0.4/0.7 μM).</p>Fórmula:C24H21Cl2N3OS3Pureza:99.13%Forma y color:SolidPeso molecular:534.53Teprenone
CAS:<p>Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).</p>Fórmula:C23H38OPureza:99.1% - 99.96%Forma y color:SolidPeso molecular:330.55DDO-5936
CAS:<p>DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.</p>Fórmula:C25H29N5O4SPureza:99.81%Forma y color:SolidPeso molecular:495.59NVP-HSP990
CAS:<p>NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).</p>Fórmula:C20H18FN5O2Pureza:98.03% - 99.32%Forma y color:SolidPeso molecular:379.39L-Alanyl-L-glutamine
CAS:<p>L-Alanyl-L-glutamine (Ala-Gln), a dipeptide composed of alanine and Gln, is an alternative supplement to L-glutamine in the production of biopharmaceuticals.</p>Fórmula:C8H15N3O4Pureza:99.71% - 99.97%Forma y color:SolidPeso molecular:217.22PF04929113
CAS:<p>PF04929113 (SNX-5422), a synthetic small molecule Hsp90 inhibitor, offers potent efficacy orally for various cancers.</p>Fórmula:C25H30F3N5O4Pureza:99.04%Forma y color:SolidPeso molecular:521.53Eupalinolide A
CAS:<p>Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.</p>Fórmula:C24H30O9Pureza:98.82% - 99.22%Forma y color:SolidPeso molecular:462.49Grp94 Inhibitor-1
CAS:<p>Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).</p>Fórmula:C22H28N2O2Pureza:97.02%Forma y color:SolidPeso molecular:352.47Paeoniflorin
CAS:<p>Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.</p>Fórmula:C23H28O11Pureza:96.9% - 97.43%Forma y color:White Fine PowderPeso molecular:480.46Gedunin
CAS:<p>Gedunin, a Meliaceae seed limonoid, inhibits Hsp90 and ovarian cancer growth.</p>Fórmula:C28H34O7Pureza:99.64% - 99.68%Forma y color:SolidPeso molecular:482.57Ganetespib
CAS:<p>Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.</p>Fórmula:C20H20N4O3Pureza:98% - 99.95%Forma y color:SolidPeso molecular:364.4TRC051384
CAS:<p>TRC051384 is a HSP70 inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke.</p>Fórmula:C25H31N5O4Pureza:98.79%Forma y color:SolidPeso molecular:465.54KRIBB11
CAS:<p>KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.</p>Fórmula:C13H12N6O2Pureza:97.25% - 99.91%Forma y color:SolidPeso molecular:284.27Pimitespib
CAS:<p>Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).</p>Fórmula:C25H26N8OPureza:99.22% - 99.49%Forma y color:SolidPeso molecular:454.53VER-49009
CAS:<p>VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).</p>Fórmula:C19H18ClN3O4Pureza:99.36% - 99.99%Forma y color:SolidPeso molecular:387.82TRC051384 HCl
CAS:<p>TRC051384 is an inducer of heat shock protein Hsp70, activating heat shock factor-1 and enhancing Hsp72 expression in neurons and glial cells.</p>Fórmula:C25H32ClN5O4Pureza:97.55%Forma y color:SolidPeso molecular:502.01BIIB021
CAS:<p>BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).</p>Fórmula:C14H15ClN6OPureza:98% - 99.82%Forma y color:SolidPeso molecular:318.76Geldanamycin
CAS:<p>Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.</p>Fórmula:C29H40N2O9Pureza:97.59% - 99.27%Forma y color:Yellow To Orange PowderPeso molecular:560.64Feretoside
CAS:<p>Feretoside is a natural product extracted from the barks of E. ulmoides. Feretoside shows inducible activity on the heat shock factor 1 (HSF1).</p>Fórmula:C17H24O11Pureza:99.85%Forma y color:SolidPeso molecular:404.37HA15
CAS:<p>HA15 targets BiP/GRP78/HSPA5, showing anti-cancer effects on all tested melanoma cells, resistant or patient-derived.</p>Fórmula:C23H22N4O3S2Pureza:99.77% - 99.86%Forma y color:SolidPeso molecular:466.58Palmitic acid
CAS:<p>Palmitic acid (Cetylic acid) is a natural product, a common saturated fatty acid found in animals, plants and microorganisms.</p>Fórmula:C16H32O2Pureza:99.17% - 99.67%Forma y color:White Crystalline Scales SolidPeso molecular:256.42KNK437
CAS:<p>KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).</p>Fórmula:C13H11NO4Pureza:98.90%Forma y color:SolidPeso molecular:245.23DTHIB
CAS:<p>DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.</p>Fórmula:C13H9ClFN3O3Pureza:98.86% - 99.29%Forma y color:SolidPeso molecular:309.68Apoptozole
CAS:<p>Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, and can induce apoptosis.</p>Fórmula:C33H25F6N3O3Pureza:99.75%Forma y color:SolidPeso molecular:625.56Azadiradione
CAS:<p>Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indica</p>Fórmula:C28H34O5Pureza:99.52%Forma y color:SolidPeso molecular:450.57HSF1A
CAS:<p>HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.</p>Fórmula:C21H19N3O2S2Pureza:98.89%Forma y color:SolidPeso molecular:409.52YUM70
CAS:<p>YUM70 inhibits GRP78 (IC50: 1.5μM), inducing ER stress and apoptosis in pancreatic cancer.</p>Fórmula:C21H19ClN2O4Pureza:97.25%Forma y color:SolidPeso molecular:398.84KBU2046
CAS:<p>KBU2046: oral anti-metastasis compound, enhances survival, targets chaperone complexes, not a typical HSP90 inhibitor.</p>Fórmula:C15H11FO2Pureza:99.89%Forma y color:SolidPeso molecular:242.24VER-82576
CAS:<p>VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.</p>Fórmula:C21H23Cl2N5O2SPureza:97.31% - 99.85%Forma y color:SolidPeso molecular:480.41VER-155008
CAS:<p>VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively.</p>Fórmula:C25H23Cl2N7O4Pureza:97.03% - 99.55%Forma y color:SolidPeso molecular:556.4PU-H54
CAS:<p>PU-H54 is a purine-derived Grp94 inhibitor targeting the S2 subpocket's unique binding region.</p>Fórmula:C18H19N5SPureza:99.13%Forma y color:SolidPeso molecular:337.44
