HSP
Los inhibidores de proteínas de choque térmico (HSP) se dirigen a las HSP, una familia de chaperonas moleculares que asisten en el plegamiento de proteínas, la estabilidad y la protección contra daños inducidos por el estrés. Las HSP suelen estar sobreexpresadas en células cancerosas, ayudándolas a sobrevivir en condiciones estresantes como la hipoxia y la quimioterapia. Inhibir las HSP puede interrumpir estos mecanismos de protección, lo que conduce a la muerte celular. Por lo tanto, los inhibidores de HSP son valiosos en la terapia contra el cáncer y en la investigación de respuestas al estrés. En CymitQuimica, ofrecemos una amplia gama de inhibidores de HSP de alta calidad para apoyar su investigación en homeostasis de proteínas, respuestas al estrés y oncología.
Se han encontrado 176 productos para "HSP".
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Alvespimycin hydrochloride
CAS:Alvespimycin hydrochloride (BMS 826476) is a potent HSP90 inhibitor with IC50 of 62 nM. Phase 2.Fórmula:C32H48N4O8·HClPureza:99.85% - 99.94%Forma y color:Purple SolidPeso molecular:653.21Feretoside
CAS:Feretoside is a natural product extracted from the barks of E. ulmoides. Feretoside shows inducible activity on the heat shock factor 1 (HSF1).Fórmula:C17H24O11Pureza:99.85%Forma y color:SolidPeso molecular:404.37Ref: TM-TQ0280
1mg73,00€5mg167,00€1mL*10mM (DMSO)190,00€10mg260,00€25mg440,00€50mg628,00€100mg872,00€200mg1.153,00€Apoptozole
CAS:Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, and can induce apoptosis.Fórmula:C33H25F6N3O3Pureza:99.75%Forma y color:SolidPeso molecular:625.56Ref: TM-T3293
2mg34,00€5mg48,00€1mL*10mM (DMSO)63,00€10mg79,00€25mg130,00€50mg222,00€100mg331,00€200mg489,00€VER-50589
CAS:VER-50589 is a potent HSP90 inhibitor.Fórmula:C19H17ClN2O5Pureza:99.96% - >99.99%Forma y color:SolidPeso molecular:388.8Ref: TM-T2258
1mg39,00€5mg92,00€1mL*10mM (DMSO)92,00€10mg150,00€25mg250,00€50mg384,00€100mg557,00€200mg787,00€Teprenone
CAS:Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).Fórmula:C23H38OPureza:99.1% - 99.96%Forma y color:SolidPeso molecular:330.55Alvespimycin
CAS:Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.Fórmula:C32H48N4O8Pureza:99.88%Forma y color:SolidPeso molecular:616.75Calenduloside E
CAS:Calenduloside E (Silphioside F) exhibits hypoglycemic activities by suppressing the transfer of glucose from the stomach to the small intestine and byFórmula:C36H56O9Pureza:96.16% - 98.99%Forma y color:SolidPeso molecular:632.82EV206
CAS:EV206 is an effective inhibitor of Hsp70, exhibiting antiproliferative properties. This compound induces cell apoptosis (apoptosis) and enhances the protein expression of cleaved PARP and caspase-3. Additionally, EV206 demonstrates antitumor activity.Fórmula:C21H19N3OForma y color:SolidPeso molecular:329.40Ref: TM-T200885
1mgA consultar5mgA consultar1mL*10mM (DMSO)A consultar10mg245,00€25mg487,00€50mg782,00€100mg1.251,00€HSP90-IN-20
CAS:HSP90-IN-20, a potent inhibitor of HSP90, exhibits an IC50 of ≤10 μM, indicating its potential application in cancer research.Fórmula:C26H32N4O4Forma y color:SolidPeso molecular:464.56HSP90-IN-12
CAS:VAC, a potent anti-cancer vibsanin A analog, inhibits cell proliferation and affects HSP90 protein levels.Fórmula:C25H36O4Forma y color:SolidPeso molecular:400.55YM-01 Tosylate
CAS:YM-01 Tosylate, a potent antitumor agent, selectively targets cancer cells and overcoming tamoxifen resistance.Fórmula:C27H27N3O4S3Forma y color:SolidPeso molecular:553.72Displurigen
CAS:Displurigen is an inhibitor of ATPase activity of HSP70.Fórmula:C15H10O4SPureza:98%Forma y color:SolidPeso molecular:286.36BrCaQ
CAS:6BrCaQ inhibits TRAP1, has antiproliferative effects, and is used in 6BrCaQ-TPP synthesis.Fórmula:C18H15BrN2O3Forma y color:SolidPeso molecular:387.23PU3
CAS:PU3 is an inhibitor of Hsp90.Fórmula:C19H25N5O3Pureza:98%Forma y color:SolidPeso molecular:371.43SEW84
CAS:SEW84, an Aha1-stimulated Hsp90 inhibitor, has an IC50 of 0.3 μM, aiding protein deposition disease research.Fórmula:C19H14F4N4OSForma y color:SolidPeso molecular:422.4HSP90-IN-14
CAS:HSP90-IN-14 inhibits Hsp90 (Kd=0.26 μM) and fights influenza A/H3N2, A/H1N1, B with EC50 of 2.6, 3.9, 17 μM in MDCK cells.Fórmula:C14H8Cl2N4O4SForma y color:SolidPeso molecular:399.21CH5164840
CAS:CH5164840 is an HSP90 inhibitor; IC50=4.1 nM; oral active; degrades client proteins; cancer research tool.Fórmula:C19H23N5O2SPureza:99.80%Forma y color:White SolidPeso molecular:385.48Hsp90-Cdc37-IN-1
CAS:Hsp90-Cdc37-IN-1 is an Hsp90-Cdc37 interaction disruptor (IC50: 140 nM) that inhibit cell migration and reverse drug resistance.Fórmula:C43H57FN2O6SPureza:98%Forma y color:SolidPeso molecular:748.99Vibsanin A
CAS:Vibsanin A, an activator of protein kinase C (PKC) and an inhibitor of HSP90, demonstrates anti-proliferative effects on human cancer cell lines.Fórmula:C25H38O4Forma y color:SolidPeso molecular:402.57YM-1
CAS:YM-1 is an HSP70 inhibitor; promotes client protein degradation; disrupts protein folding; cancer research tool.Fórmula:C20H20ClN3OS2Pureza:99.58%Forma y color:Red SolidPeso molecular:417.98BIIB028
CAS:BIIB028: Hsp90 inhibitor, may degrade oncogenic proteins, potentially hindering tumor growth.Fórmula:C19H21ClN5O5PForma y color:SolidPeso molecular:465.83Retaspimycin
CAS:Retaspimycin is a potent and water-soluble Hsp90 inhibitor(EC50s of 119 nM for both Hsp90 and Grp9).Fórmula:C31H45N3O8Pureza:98%Forma y color:SolidPeso molecular:587.7KUNB31
CAS:KUNB31 is a potent and selective inhibitor of Hsp90β.Fórmula:C19H18N2O3Forma y color:SolidPeso molecular:322.36Hsp90-IN-17
CAS:Hsp90-IN-17 (Example 5) is an inhibitor of HSP90, applicable in researching proliferative diseases, including cancer and neurodegenerative conditions.Fórmula:C21H20N4O7Forma y color:SolidPeso molecular:440.41Heat Shock Protein Inhibitor II
CAS:Hsp inhibitor II, an active benzylidene lactam, blocks inducible Hsp synthesis, reduces tumor thermotolerance, and enhances AmB effects on A. fumigatus.Fórmula:C12H11NO3Forma y color:SolidPeso molecular:217.22SW02
CAS:SW02 is a potent ATPase activator of Hsp70 (EC50: 150 μM). SW02 is able to accumulate total tau and phosphorylated tau (pTau).Fórmula:C19H23BrN2O5Forma y color:SolidPeso molecular:439.3PU24FCl
CAS:PU24FCl is a specific inhibitor of tumor Hsp90.Fórmula:C20H21ClFN5O3Forma y color:SolidPeso molecular:433.86BMS-358233
CAS:BMS-358233 is an effective LCK inhibitor with excellent cell activity against T cell proliferation.Fórmula:C25H25ClN6O2SForma y color:SolidPeso molecular:509.02CH5138303
CAS:CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.Fórmula:C19H18ClN5O2SPureza:98%Forma y color:SolidPeso molecular:415.9JG-48
CAS:JG-48 is an inhibitor of Hsp70. JG-48 suppresses phosphorylated and total Tau in cells, endogenous Tau in neuroblastoma cells.Fórmula:C20H16F3N3OS2Forma y color:SolidPeso molecular:435.49CCT251236
CAS:CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen.Fórmula:C32H32N4O5Pureza:98.82% - 99.89%Forma y color:White SolidPeso molecular:552.62Ref: TM-T14905
1mg34,00€5mg105,00€1mL*10mM (DMSO)130,00€10mg200,00€25mg414,00€50mg662,00€100mg1.054,00€Icapamespib HCl
CAS:Icapamespib (PU-HZ151) is an HSP90 inhibitor; EC50 of 5 nM, logD of 2.37; targets epichaperomes, effective in cells, mice, and humans.Fórmula:C19H25Cl2IN6O2SForma y color:SolidPeso molecular:599.31CH5015765
CAS:CH5015765: potent, selective HSP90 inhibitor with high affinity and antitumor effects in human cancer mouse models.Fórmula:C16H13ClN4OSForma y color:SolidPeso molecular:344.82Grp94-IN-2
CAS:Grp94-IN-2 is a inhibitor of Grp94.Fórmula:C22H23ClN2O5Forma y color:SolidPeso molecular:430.88BF844
CAS:BF844 chemical counters USH3-induced hearing loss by transporting mutated CLRN1 to cell membranes, effectively preserving hearing in vivo.Fórmula:C21H19ClN4OForma y color:SolidPeso molecular:378.85STA-2842
CAS:STA-2842 is an inhibitor of heat shock protein 90 (HSP90).Fórmula:C29H38N6O5Forma y color:SolidPeso molecular:550.65EC 144
CAS:EC 144, a second-generation selective inhibitor of Hsp90 , inhibits tumor growth for Hsp90α and degradation of Her-2 in MCF-7 cells.Fórmula:C21H24ClN5O2Forma y color:SolidPeso molecular:413.9Retaspimycin Hydrochloride
CAS:Retaspimycin Hydrochloride is a potent and water-soluble Hsp90 inhibitor(Hsp90 and Grp9 with EC50s of 119 nM).Fórmula:C31H46ClN3O8Pureza:98%Forma y color:SolidPeso molecular:624.17MPC-3100
CAS:MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with significant antitumor activity [1].Fórmula:C22H25BrN6O4SForma y color:SolidPeso molecular:549.44HSP90-IN-22
CAS:HSP90-IN-22 is a potent HSP90 inhibitor; client protein degrader; blocks oncogenic signaling; cancer research tool.Fórmula:C25H30N4O3Pureza:99.90%Forma y color:White SolidPeso molecular:434.53Bimoclomol
CAS:Bimoclomol is a heat shock protein co-inducer used for the research of cardiovascular diseases.Fórmula:C14H20ClN3O2Forma y color:SolidPeso molecular:297.78Hsp90-IN-15
CAS:Hsp90-IN-15: Hsp90 blocker with anticancer properties; halts S phase, triggers apoptosis, cuts Hsp90 in Hela cells.Fórmula:C23H27F3N4Forma y color:SolidPeso molecular:416.48SNX0723
CAS:SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity.Fórmula:C22H26FN3O3Pureza:99.85%Forma y color:White SolidPeso molecular:399.46Ref: TM-T28824
500mgA consultar1mg85,00€5mg178,00€1mL*10mM (DMSO)195,00€10mg299,00€25mg485,00€50mg665,00€100mg892,00€Arimoclomol
CAS:Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (Fórmula:C14H20ClN3O3Pureza:99.15%Forma y color:SolidPeso molecular:313.78Iroxanadine
CAS:Iroxanadine (BRX-005) is a Novel small molecule MAPK p38 inhibitor that induces phosphorylation of p38 SAPK and induces concentration-dependent relaxation inFórmula:C14H20N4OPureza:98.04% - 99.04%Forma y color:SolidPeso molecular:260.33Colletofragarone A2
CAS:Colletofragarone A2 from Colletotrichum sp. blocks mutant p53 and HSP90, aiding cancer treatment.Fórmula:C22H26O6Forma y color:SolidPeso molecular:386.44MAO A/HSP90-IN-2
CAS:MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 μM for MAO A and 4.58 μM for HSP90.Fórmula:C25H31ClN2O4Pureza:98%Forma y color:SolidPeso molecular:458.98KU-177
CAS:KU-177 is an Aha1 inhibitor that disrupts the interaction between Hsp90 and Aha1, eliminating cell proliferation and PI resistance induced by elevated AHSA1.Fórmula:C27H23NO8Pureza:96.92% - 98.54%Forma y color:SolidPeso molecular:489.47YM-08
CAS:YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].Fórmula:C19H17N3OS2Pureza:98%Forma y color:SolidPeso molecular:367.49HSP90-IN-19
CAS:HSP90-IN-19: potent Hsp90 inhibitor, IC50 = 0.27 μM, used in research on viral diseases, neurodegeneration, inflammation.Fórmula:C29H38O7Pureza:98%Forma y color:SolidPeso molecular:498.61
