Wee1
Los inhibidores de Wee1 se dirigen a la quinasa Wee1, un regulador clave del punto de control G2/M en el ciclo celular. Wee1 controla el momento de la mitosis al inhibir las quinasas dependientes de ciclinas (CDK) para evitar la entrada prematura en la mitosis. Inhibir Wee1 puede llevar a la abolición del punto de control G2/M, forzando a las células con ADN dañado a entrar prematuramente en mitosis, lo que a menudo resulta en la muerte celular. Esto hace que los inhibidores de Wee1 sean particularmente útiles en la terapia contra el cáncer, especialmente en combinación con agentes que dañan el ADN. En CymitQuimica, ofrecemos una selección de inhibidores de Wee1 de alta calidad para apoyar su investigación en control del ciclo celular, respuesta al daño del ADN y tratamiento del cáncer.
Se han encontrado 14 productos de "Wee1"
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WEE1-IN-6
CAS:WEE1-IN-6 (compound 110) is an orally active inhibitor of WEE1, displaying a DC50 value of ≤ 100 nM. This compound effectively inhibits cell proliferation [1].Fórmula:C45H52FN11O4Forma y color:SolidPeso molecular:829.96PKMYT1-IN-3
PKMYT1-IN-3 (compound 8ma) is a potent, selective inhibitor of PKMYT1, demonstrating an IC50 of 16.5 nM and exhibiting antitumor activity.Fórmula:C24H26FN5O2Forma y color:SolidPeso molecular:435.49PKMYT1-IN-4
PKMYT1-IN-4 (compound 27) functions as a PKMYT1 inhibitor with an IC50 value under 50 nM.Fórmula:C19H15F3N4O2Forma y color:SolidPeso molecular:388.34ZN-c3
CAS:<p>Azenosertib (ZN-c3) is a potent and selective Wee1 inhibitor with balanced potency, ADME, and pharmacokinetic properties. Cost-effective and quality-assured.</p>Fórmula:C29H34N8O2Pureza:99.98%Forma y color:SolidPeso molecular:526.63PD0166285
CAS:PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.Fórmula:C26H27Cl2N5O2Pureza:99.23%Forma y color:SolidPeso molecular:512.43WEE1-IN-3
CAS:WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.Fórmula:C28H31N7O2Pureza:98.33%Forma y color:SolidPeso molecular:497.59Adavosertib
CAS:Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.Fórmula:C27H32N8O2Pureza:98.65% - 99.86%Forma y color:SolidPeso molecular:500.6RP-6306
CAS:<p>Lunresertib (RP-6306) is a potent, selective, and orally active PKMYT1 inhibitor with an IC50 of 14 nM.Cost-effective and quality-assured.</p>Fórmula:C18H20N4O2Pureza:98.41% - 99.28%Forma y color:SolidPeso molecular:324.38WEE1-IN-10
CAS:WEE1-IN-10 is a Wee1 kinase inhibitor that inhibits the growth of LOVO cells, such as pancreatic cancer, malignant melanoma, and malignant glioma.Fórmula:C28H30Cl2N8OPureza:98.18%Forma y color:SolidPeso molecular:565.5WEE1/PKMYT1-IN-1
CAS:<p>WEE1/PKMYT1-IN-1 (compound 75) is an effective and orally bioavailable inhibitor of WEE1 and PKMYT1. It demonstrates antiproliferative activity.</p>Fórmula:C16H16N4O3Forma y color:SolidPeso molecular:312.323WEE1-IN-11
CAS:WEE1-IN-11 (Compound 13) serves as a potent CDK2 inhibitor with an IC50 of 2.0 nM. It exhibits inhibitory effects on several cell lines, including NCI-H446, A427, OVCAR3, C33A, and WiDr, with respective IC50 values of 93.9, 34.5, 86.7, 23.1, and 85 nM.Fórmula:C26H29FN8OS2Forma y color:SolidPeso molecular:552.69PKMYT1-IN-2
CAS:PKMYT1-IN-2 (compound 2) serves as a powerful inhibitor of PKMYT1, exhibiting an IC 50 of 5.7 nM. Additionally, it effectively suppresses the proliferation of HCC1569 cells with an IC 50 of 22 nM [1].Fórmula:C22H19N5O2Forma y color:SolidPeso molecular:385.42WEE1 degrader 1
WEE1degrader 1 (Compound 10) functions as a Wee1 degrader, exhibiting a DC50 value of 1.5 nM against Wee1. This compound also possesses anticancer properties that inhibit cell proliferation.Fórmula:C30H31N5O3Forma y color:SolidPeso molecular:509.6PKMYT1-IN-9
CAS:PKMYT1-IN-9 is a highly selective, orally active inhibitor of PKMYT1 with an IC50 of 4.4 nM. It exhibits greater selectivity for PKMYT1 compared to WEE1, for which the IC50 is 32.4 μM. Additionally, PKMYT1-IN-9 demonstrates antitumor activity.Fórmula:C17H14FN5OForma y color:SolidPeso molecular:323.324
