Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Se han encontrado 2235 productos de "Cromatina / Epigenética"
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HDAC/NAMPT-IN-1
CAS:<p>HDAC/NAMPT-IN-1 (compound 39h) simultaneously inhibits HDAC and NAMPT, exhibiting IC 50 values ranging from 0.72 to 37081 nM for HDAC and 1618 nM for NAMPT [1].</p>Fórmula:C19H21N5O2Forma y color:SolidPeso molecular:351.4IACS-9571 hydrochloride
CAS:<p>IACS-9571 hydrochloride: potent TRIM24/BRPF1 inhibitor; IC50 = 8 nM (TRIM24); Kd = 31 nM (TRIM24), 14 nM (BRPF1).</p>Fórmula:C32H43ClN4O8SForma y color:SolidPeso molecular:679.22KDM2B-IN-4
CAS:<p>KDM2B-IN-4, from patent WO2016112284A1 as 182b, is a potent KDM2B inhibitor used in cancer research.</p>Fórmula:C24H28N2O2Forma y color:SolidPeso molecular:376.49CEP-8983
CAS:<p>CEP-8983 is a PARP inhibitor potentially for the treatment of solid tumours.</p>Fórmula:C18H14N2O3Pureza:98%Forma y color:SolidPeso molecular:306.32BRM/BRG1 ATP Inhibitor-4
CAS:<p>BRM/BRG1 ATP Inhibitor-4, a potent inhibitor of BRG1/BRM, is utilized in the research of cancers and BAF complex-related disorders.</p>Fórmula:C25H32N6O3SForma y color:SolidPeso molecular:496.62MAT2A-IN-7
CAS:<p>MAT2A-IN-7 inhibits MAT2A in various cancers, especially MTAP-deficient cancer cells, with potential for research use.</p>Fórmula:C17H13ClF3N3O2Forma y color:SolidPeso molecular:383.75Dihydro-5-azacytidine acetate
CAS:<p>Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1</p>Fórmula:C10H18N4O7Pureza:98%Forma y color:SolidPeso molecular:306.27LT052
CAS:<p>LT052 is a BET BD1 inhibitor with anti-inflammatory activity. It mediates the BRD4/NF-κB/NLRP3 signaling inflammatory pathway.</p>Fórmula:C22H19N5O4SPureza:98.82%Forma y color:SolidPeso molecular:449.48Sirt2-IN-6
CAS:<p>Sirt2-IN-6 is a potent and selective inhibitor of SIRT2 (IC50: 0.815 μM) and can be used to study cancer.</p>Fórmula:C26H26N6O3SForma y color:SolidPeso molecular:502.59BRD4884
CAS:<p>BRD4884 is a highly selective and efficient HDAC1 and HDAC2 inhibitor that also inhibits HDAC3, used in research on neurological disorders.</p>Fórmula:C18H19FN2O2Pureza:99.19% - 99.21%Forma y color:SolidPeso molecular:314.35Lorpucitinib
CAS:<p>Lorpucitinib (JNJ-64251330) is a JAK kinase inhibitor used in the study of inflammatory and gastrointestinal diseases.</p>Fórmula:C22H28N6O2Pureza:99.72%Forma y color:SolidPeso molecular:408.5KDM2/7-IN-1
CAS:<p>KDM2/7-IN-1 is a selective histone demethylase inhibitor (IC50s: 0.2–>120 μM) that inhibits HeLa and KYSE-150 cell proliferation, epigenetic and cancer.</p>Fórmula:C15H27NO4Pureza:99.87%Forma y color:SolidPeso molecular:285.38BETi-211
CAS:<p>BETi-211 is a selective inhibitor BET bromodomain.</p>Fórmula:C26H29N7O3Forma y color:SolidPeso molecular:487.55ZYJ-25e
CAS:<p>ZYJ-25e is an oral histone deacetylase inhibitor (HDACi) with potent antitumor activities.</p>Fórmula:C30H40N4O8Pureza:98%Forma y color:SolidPeso molecular:584.66IND 1316
CAS:<p>IND 1316 is an activator of AMP-activated protein kinase (AMPK).</p>Fórmula:C22H17NO3Forma y color:SolidPeso molecular:343.38CCT077791
CAS:<p>CCT077791 is a potent inhibitor of p300 and PCAF histone acetyltransferase activity for cancer research.</p>Fórmula:C9H5ClN2O3SPureza:98.60%Forma y color:SolidPeso molecular:256.67ZIKV-IN-2
CAS:<p>ZIKV-IN-2 blocks ZIKV replication, is a strong NS5 MTase inhibitor (IC50: 38.86 μM), and aids Zika virus research.</p>Fórmula:C39H42O4Forma y color:SolidPeso molecular:574.75KU-0058684
CAS:<p>KU-0058684 is a potent PARP and DNA-PK inhibitors.</p>Fórmula:C19H14FN3O3Forma y color:SolidPeso molecular:351.33ML753286
CAS:<p>ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions.</p>Fórmula:C20H25N3O3Pureza:98%Forma y color:SolidPeso molecular:355.43Trotabresib
CAS:<p>Trotabresib (CC-90010) is an orally active inhibitor of BET and can be used in studies about advanced solid tumors.</p>Fórmula:C21H21NO4SPureza:99.86%Forma y color:SolidPeso molecular:383.46JAK1-IN-4
CAS:<p>JAK1-IN-4 selectively blocks JAK1 (IC50 = 85 nM) over JAK2/JAK3 and halts STAT3 phosphorylation in NCI-H 1975 cells (IC50 = 227 nM).</p>Fórmula:C26H32FN9O2Pureza:98%Forma y color:SolidPeso molecular:521.59Y02224
CAS:<p>Y02224 is a BET inhibitor. It shows the reasonable antiproliferative effect on leukemia cells.</p>Fórmula:C20H17BrN2O4SPureza:98%Forma y color:SolidPeso molecular:461.33Dot1L-IN-5
CAS:<p>Dot1L-IN-5 is a potent inhibitor of the disruptor of telomeric silencing 1-like protein ( DOT1L ) with an IC 50 SPA DOT1L of 0.17 nM [1].</p>Fórmula:C23H19ClF2N8O5SForma y color:SolidPeso molecular:592.96HAT-IN-1
CAS:<p>HAT-IN-1 is an inhibitor of HAT used in the research of cancer.</p>Fórmula:C23H18BrF4N3O4Pureza:98%Forma y color:SolidPeso molecular:556.3Helenalin Acetate
CAS:<p>Helenalin Acetate: anti-inflammatory, anti-cancer, hinders C/EBPß and p300 cooperation.</p>Fórmula:C17H20O5Pureza:98%Forma y color:SolidPeso molecular:304.34HDAC-IN-45
CAS:<p>HDAC-IN-45, a small HDAC blocker, forms H-bonds with Y303 and shows anticancer properties; IC50 for HDAC1/2/3: 0.108/0.585/0.563 μM.</p>Fórmula:C25H20ClFN8OForma y color:SolidPeso molecular:502.93DM-01
CAS:<p>DM-01 is a potent and selective inhibitor of EZH2.</p>Fórmula:C23H24F3N3O2Forma y color:SolidPeso molecular:431.45dBRD9-A
CAS:<p>Potent BRD9 degrader that binds selectively, fully degrades BRD9 at low doses, and hinders synovial sarcoma growth in vitro and in mice.</p>Fórmula:C42H49N7O8Forma y color:SolidPeso molecular:779.88PB118
<p>PB118 clears Aβ, boosts phagocytosis, enhances tubulin networks, reduces p-tau & inflammation in AD; HDAC6 IC50: 5.6 nM.</p>Fórmula:C18H19FN2O2Forma y color:SoildPeso molecular:314.35Dot1L-IN-7
CAS:<p>Dot1L-IN-7 (compound 25), a potent DOT1L inhibitor with an IC50 of 1.0 μM, selectively kills MLL-AF9, sparing E2A-HLF cells.</p>Fórmula:C23H27N9O2Forma y color:SolidPeso molecular:461.52CeMMEC2
CAS:<p>CeMMEC2, a novel inhibitor of BRD4, binds both the first and the second bromodomain of BRD4.</p>Fórmula:C14H19N5Forma y color:SolidPeso molecular:257.33(1S,2R)-Tranylcypromine hydrochloride
CAS:<p>(1S,2R)-Tranylcypromine hydrochloride ((1S,2R)-SKF 385), a potent antidepressant, functions by inhibiting both MAO and LSD1.</p>Fórmula:C9H12ClNForma y color:SolidPeso molecular:169.651Guadecitabine sodium
CAS:<p>Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .</p>Fórmula:C18H24N9NaO10PPureza:98%Forma y color:SolidPeso molecular:580.407HDAC6-IN-46
CAS:<p>HDAC6-IN-46 (compound 12) is a selective inhibitor of histone deacetylase 6 (HDAC6), exhibiting an IC50 of 6.2 nM. It is utilized in research related to Alzheimer's disease.</p>Fórmula:C26H21N3O4Forma y color:SolidPeso molecular:439.46HDAC3-IN-T326
CAS:<p>HDAC3-IN-T326: potent, selective HDAC3 inhibitor, boosts NF-κB acetylation, activates latent HIV gene expression.</p>Fórmula:C21H18N6O3SPureza:98%Forma y color:SolidPeso molecular:434.47Gue1654
CAS:<p>Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.</p>Fórmula:C23H17N3OS3Pureza:98.02% - 98.04%Forma y color:SolidPeso molecular:447.6LSD1-IN-6
CAS:<p>LSD1-IN-6, a potent LSD1 inhibitor (IC50: 123 nM), enhances H3K4me2 without altering LSD1 expression. Reversible.</p>Fórmula:C15H13BrN2O3Pureza:98%Forma y color:SolidPeso molecular:349.18SC-9
CAS:<p>SC-9 is a protein kinase C activator.</p>Fórmula:C22H24ClNO2SPureza:98%Forma y color:SolidPeso molecular:401.95PS432
CAS:<p>PS432 inhibits atypical PKCs, targets PIF-pocket, reduces tumors in mice sans side effects.</p>Fórmula:C25H19ClN2O5SPureza:98%Forma y color:SolidPeso molecular:494.95SMYD2-IN-1
CAS:<p>SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).</p>Fórmula:C25H25Cl2F2N7O2Pureza:98%Forma y color:SolidPeso molecular:564.41Piribedil dihydrochloride
CAS:<p>dopamine agonist</p>Fórmula:C16H20Cl2N4O2Pureza:98%Forma y color:SolidPeso molecular:371.26Akt Inhibitor X
CAS:<p>Akt Inhibitor X is a cell-permeable and reversible inhibitor of Akt phosphorylation.</p>Fórmula:C20H25ClN2OPureza:98%Forma y color:SolidPeso molecular:344.88KDM5B-IN-3
CAS:<p>KDM5B-IN-3 inhibits KDM5B/JARID1B with IC50 of 9.32 μM, useful in gastric cancer studies.</p>Fórmula:C19H25ClN4O2Forma y color:SolidPeso molecular:376.88DDP-38003 dihydrochloride
CAS:<p>DDP-38003 dihydrochloride is an orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor (IC50: 84 nM).</p>Fórmula:C21H28Cl2N4OPureza:99.76%Forma y color:SolidPeso molecular:423.38CID-4785700
CAS:<p>CID-4785700 is a potent pan-GTPase inhibitor that inhibits Rab7 and inhibits the fungal histone acetyltransferase Rtt109 that binds to Asf1 and Vps75</p>Fórmula:C22H23ClFN3O3Pureza:98.16%Forma y color:SolidPeso molecular:431.89Kgp-IN-1
CAS:<p>Kgp-IN-1 is an arginine-specific gingipain (Rgp) inhibitor.</p>Fórmula:C19H24F4N4O3Pureza:98%Forma y color:SolidPeso molecular:432.41PARP-1/2-IN-1
CAS:<p>PARP-1-/2-IN-1 is a potent inhibitor of PARP-1 (IC50: 0.51 nM) and PARP-2 (IC50: 23.11 nM).</p>Fórmula:C24H27FN4O3Forma y color:SolidPeso molecular:438.49NSC-636819
CAS:<p>NSC-636819 is a novel inhibitor of KDM4A/KDM4B.</p>Fórmula:C22H12Cl4N2O4Pureza:98%Forma y color:SolidPeso molecular:510.15M-110
CAS:<p>M-110 selectively targets PIM kinases, best at PIM-3 (IC50=47nM), and inhibits prostate cancer cell growth (IC50=0.6-0.9μM).</p>Fórmula:C22H28ClN5O3Pureza:99.55%Forma y color:SolidPeso molecular:445.94MI-1
CAS:<p>MI-1 inhibits Menin-MLL interaction with an IC 50 of 1.9 μM [1].</p>Fórmula:C19H25N5S2Forma y color:SolidPeso molecular:387.57
