Daño al ADN / Reparación del ADN
Los inhibidores de daño/ reparación del ADN son compuestos que interfieren con los procesos involucrados en la detección y reparación de daños en el ADN. Estos inhibidores son fundamentales para estudiar los mecanismos de estabilidad genómica, mutagénesis y respuesta al daño del ADN. También son importantes en la investigación del cáncer, ya que muchos tumores dependen de vías específicas de reparación del ADN para sobrevivir. Al inhibir estas vías, los inhibidores de daño/reparación del ADN pueden aumentar la eficacia de la quimioterapia y la radioterapia. En CymitQuimica, ofrecemos una amplia gama de inhibidores de daño/reparación del ADN de alta calidad para apoyar su investigación en biología molecular, oncología y farmacología.
Subcategorías de "Daño al ADN / Reparación del ADN"
- ATM / ATR(71 productos)
- Alquilación de ADN(11 productos)
- ADN metiltransferasa(422 productos)
- ADN girasa(11 productos)
- ADN-PK(50 productos)
- MTH1(1 productos)
- Antimetabolito / análogo nucleósido(1.388 productos)
- Transcriptasa inversa(43 productos)
- Sirtuin(88 productos)
- Telomerasa(33 productos)
- Topoisomerasa(136 productos)
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Se han encontrado 963 productos de "Daño al ADN / Reparación del ADN"
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Antibacterial agent 236
CAS:<p>Anti bacterial agent 236 (Compound 4l), an orally effective inhibitor of DNA gyrase and topoisomerase IV (with IC50 values of 3.2 and 300 nM in Staphylococcus aureus, respectively), exhibits broad-spectrum antibacterial activity. It also demonstrates favorable pharmacokinetic properties in mice.</p>Fórmula:C26H27N5O2SForma y color:SolidPeso molecular:473.59ATR-IN-11
<p>ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.</p>Fórmula:C25H30N6O2Forma y color:SolidPeso molecular:446.54SARS-CoV-2 nsp14-IN-1
<p>SARS-CoV-2 nsp14-IN-1 inhibits Nsp14 Mtase with an IC50 of 0.061 μM, affecting multiple substrates.</p>Fórmula:C20H20N6O5SForma y color:SolidPeso molecular:456.48ATR kinase-IN-3
CAS:<p>ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.</p>Fórmula:C24H27F2N9O2Forma y color:SolidPeso molecular:511.53TMU 35435
CAS:<p>TMU 35435 is an inhibitor of histone deacetylases (HDAC). It enhances radiosensitivity by inducing the accumulation of misfolded proteins and autophagy (autophagy) in TNBC, and inhibits the NHEJ pathway through ubiquitination of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs).</p>Fórmula:C22H25N3O3Forma y color:SolidPeso molecular:379.45Camptothecin-20(S)-O-propionate
CAS:<p>CZ-48 is a DNA topoisomerase inhibitor.</p>Fórmula:C23H20N2O5Forma y color:SolidPeso molecular:404.42G-631
CAS:<p>G-631 acts as a selective tankyrase inhibitor, effectively hindering tankyrase auto-PARsylation (poly ADP ribosylation) at an IC 50 of 7 nM and suppressing the Wnt signaling pathway. This compound also demonstrates favorable pharmacokinetic properties in mice.</p>Fórmula:C19H22F2N6O3Forma y color:SolidPeso molecular:420.41DNA crosslinker 1 dihydrochloride
CAS:<p>DNA Crosslinker 1 binds DNA minor groove with 1.1°C affinity increase; used in cancer research.</p>Fórmula:C15H22Cl2N8OForma y color:SolidPeso molecular:401.29Atiratecan
CAS:<p>Atiratecan (TP300), a CH0793076-based camptothecin prodrug, combats BCRP+/- tumors; doesn't affect AChE.</p>Fórmula:C31H34N6O6Pureza:98%Forma y color:SolidPeso molecular:586.64PPARγ agonist 1
<p>PPARγ agonist 1 is a potent agonist of PPARγ that efficiently activates hPPARγ without causing full agonism, thereby avoiding adverse effects.</p>Fórmula:C34H39NO3Forma y color:SolidPeso molecular:509.68Pparδ agonist 5
<p>Pparδ agonist 5 is a selective, orally active PPARδ agonist with an EC50 of 0.335 μM and better selectivity than GW0742.</p>Fórmula:C23H21F3N2O2SForma y color:SolidPeso molecular:446.49Sirtuin-IN-2
<p>Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.</p>Fórmula:C28H46N8O6SForma y color:SolidPeso molecular:622.78MC3138
CAS:<p>MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.</p>Fórmula:C25H25NO6Pureza:99.57%Forma y color:SolidPeso molecular:435.47DNA-PK-IN-6
CAS:<p>DNA-PK-IN-6 inhibits DNA-PKcs, disrupting tumor DNA repair and triggering apoptosis; enhances radiotherapy and targets various tumors (WO2021197159A1).</p>Fórmula:C19H21N7OForma y color:SolidPeso molecular:363.42DNA crosslinker 2 dihydrochloride
CAS:<p>Potent DNA crosslinker 2 binds minor groove, increases Tm by 1.2°C, and inhibits NCI-H460, A2780, MCF-7 cancer cells.</p>Fórmula:C15H22Cl2N8OForma y color:SolidPeso molecular:401.29ATM Inhibitor-3
<p>ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.</p>Fórmula:C25H29FN6O3Forma y color:SolidPeso molecular:480.53LP-284
CAS:<p>LP-284 is a DNA alkylating agent effective against solid tumors and hematologic cancers like MCL.</p>Fórmula:C16H20N2O4Forma y color:SolidPeso molecular:304.34(Rac)-RG108
CAS:<p>(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.</p>Fórmula:C19H14N2O4Forma y color:SolidPeso molecular:334.326ATR kinase-IN-2
CAS:<p>ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.</p>Fórmula:C24H29F2N9O2Forma y color:SolidPeso molecular:513.54PPARα/γ agonist 1
<p>PPARα/γ agonist 1 is a potent and dual PPARα/γ partial agonist which is a promising prototype for the research of dyslipidemia and diabetes.</p>Fórmula:C18H19NO2Forma y color:SolidPeso molecular:281.35DNA-PK-IN-15
CAS:DNA-PK-IN-15 (compound 6) acts as an inhibitor of DNA-PK, exhibiting an IC50 value of 0.08 nM.Fórmula:C23H23N9OForma y color:SolidPeso molecular:441.49Topoisomerase inhibitor 5
CAS:<p>Topoisomerase inhibitor 5 (compound 158) is an inhibitor of bacterial topoisomerase, with a minimum inhibitory concentration of 0.125 μg/mL, and exhibits anti-tuberculosis activity.</p>Fórmula:C24H25FN4O6Forma y color:SolidPeso molecular:484.477KU 59403
CAS:KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).Fórmula:C29H32N4O4S2Pureza:99.10%Forma y color:SolidPeso molecular:564.72HDAC6-IN-51
CAS:HDAC6-IN-51 (Compound 7e) is a selective inhibitor of HDAC6, exhibiting an IC50 value of 42.9 nM. This compound demonstrates effective anti-pulmonary fibrosis activity.Fórmula:C24H24ClN5O3Forma y color:SolidPeso molecular:465.93Cas9-IN-1
<p>Cas9-IN-1 is a potent inhibitor of Cas9 with an IC50 value of 7.02 μM. Cas9-IN-1 acts by binding apo-Cas9 and blocking the formation of the Cas9:gRNA complex.</p>Fórmula:C17H11Cl2F3N2O3SForma y color:SolidPeso molecular:451.25SP-C01
CAS:<p>SP-C01 is an orally active soluble epoxide hydrolase (sEH) inhibitor and a partial agonist of PPARγ. It can inhibit the phosphorylation of Ser273.</p>Fórmula:C22H22F4N2O5Forma y color:SolidPeso molecular:470.41TDI-015051
CAS:<p>TDI-015051 is an orally active inhibitor of SARS-CoV-2 non-structural protein 14 (SARS-CoV-2 NSP14) with an IC50 of ≤0.15 nM. It effectively inhibits SARS-CoV-2 NSP14 in Huh-7.5 cells (EC50=11.4 nM) and A549 cells expressing ACE2-TMPRSS2 (EC50=64.7 nM). Additionally, TDI-015051 suppresses other coronaviruses such as α-hCoV-NL63, α-hCoV-229E, and β-hCoV-MERS with IC50 values of 1.7, 2.6, and 3.6 nM, respectively. This compound inhibits viral RNA methylation and replication by binding to a stable SAH-cap pocket and demonstrates anti-infection activity in mouse models.</p>Fórmula:C22H22FN5O4SForma y color:SolidPeso molecular:471.505Carbacyclin
CAS:<p>Carbacyclin, a PGI2 analog, is a prostacyclin (PGI2) receptor agonist and vasodilator with potent inhibitory platelet aggregation.</p>Fórmula:C21H34O4Pureza:98%Forma y color:SolidPeso molecular:350.49DLK-IN-1
CAS:DLK-IN-1: Oral DLK (MAP3K12) inhibitor, Ki=3nM, effective in Alzheimer's model, CNS permeable, well-tolerated with sustained brain levels.Fórmula:C20H24F3N5O2Forma y color:SolidPeso molecular:423.43WSD0628
CAS:WSD0628 is a brain-penetrant and potent ATM inhibitor with a significant radiosensitizing effect [1].Fórmula:C23H23F2N5O2Forma y color:SolidPeso molecular:439.462-Ethylhexyl diphenyl phosphate
CAS:<p>2-Ethylhexyl diphenyl phosphate is an organophosphorus flame retardant (OPFRs) and acts as a PPARG agonist (EC20: 2.04 µM). Additionally, it inhibits the transcriptional activity of ERRγ (IC50: 1.3 µM) and enhances the expression of 3β-HSD1, human chorionic gonadotropin (hCG), and progesterone secretion. This compound is applicable in studies related to female reproduction and fetal development.</p>Fórmula:C20H27O4PForma y color:SolidPeso molecular:362.40Topoisomerase II inhibitor 18
CAS:<p>Topoisomerase II inhibitor 18 (Compound IV), a Quinoxaline derivative, exhibits an IC 50 of 7.5 μM in inhibiting topoisomerase II. It impedes PC-3 cell proliferation, arrests the cell cycle at the S phase, and induces apoptosis. Moreover, this compound demonstrates substantial antitumor activity against cancer [1].</p>Fórmula:C20H21N3OSForma y color:SolidPeso molecular:351.47PPARγ agonist 17
CAS:<p>PPARγ agonist17 (Compound C1) is an orally active PPARγ agonist. It enhances PPARγ activity, arrests the cell cycle of HT-29 cells at the G2/M phase, inhibits cell migration, and induces apoptosis. PPARγ agonist17 exhibits broad-spectrum antiproliferative activity against cancer cells with relatively low toxicity to normal cells and does not cross the blood-brain barrier.</p>Fórmula:C48H63NO7Forma y color:SolidPeso molecular:766.016Anti-NASH agent 2
CAS:<p>Anti-NASH agent 2 (compound 21) is an inhibitor of neolipogenesis activity and α-SMA gene expression. It improves hepatic steatosis, edema, inflammatory infiltration, and liver fibrosis in NASH mouse models.</p>Fórmula:C32H51N3O2Forma y color:SolidPeso molecular:509.766Intoplicine
CAS:Intoplicine is an inhibitor of DNA topoisomerase I and II.Fórmula:C21H24N4OPureza:98%Forma y color:SolidPeso molecular:348.44Gimatecan
CAS:Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Fórmula:C25H25N3O5Pureza:98.47%Forma y color:SolidPeso molecular:447.48E-3030 free acid
CAS:<p>E-3030 free acid, a PPAR agonist, lowers blood glucose, triglycerides, and insulin; boosts adiponectin; reduces apo C-III; and raises lipoprotein lipase.</p>Fórmula:C22H23ClFNO5Pureza:98%Forma y color:SolidPeso molecular:435.87Levofloxacin mesylate
CAS:<p>Levofloxacin mesylate is an orally active antibiotic effective against both Gram-positive and Gram-negative bacteria. It inhibits DNA gyrase and topoisomerase IV enzymes. Levofloxacin mesylate is employed in research related to chronic periodontitis, airway inflammation, and BK viremia. Additionally, it possesses anti-Orthopoxvirus activity.</p>Fórmula:C19H24FN3O7SForma y color:SolidPeso molecular:457.473Namitecan
CAS:Namitecan is an effective inhibitor of topoisomerase I. It has antitumor property.Fórmula:C23H22N4O5Pureza:98%Forma y color:SolidPeso molecular:434.44PARP1/2-IN-4
CAS:<p>PARP1/2-IN-4 (compound 3) is an inhibitor of PARP1/2.</p>Fórmula:C23H30FN5O6Forma y color:SolidPeso molecular:491.51PPARα agonist 1
<p>PPARα agonist 1 is a complete and potent PPARα agonist.</p>Fórmula:C27H34O4Forma y color:SolidPeso molecular:422.56TP3011
CAS:<p>TP3011 is a potent topoisomerase I inhibitor equipotent as SN38 and is an active metabolite of CH-0793076.</p>Fórmula:C26H26N4O5Pureza:98%Forma y color:SolidPeso molecular:474.51Bizelesin
CAS:<p>Bizelesin, a synthetic antineoplastic agent, binds DNA, disrupts replication, triggers cell-cycle arrest, and induces senescence.</p>Fórmula:C43H36Cl2N8O5Forma y color:SolidPeso molecular:815.7Edotecarin
CAS:<p>Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).</p>Fórmula:C29H28N4O11Pureza:98%Forma y color:SolidPeso molecular:608.55ATR-IN-14
CAS:<p>ATR-IN-14: potent ATR kinase inhibitor; 98.03% inhibition at 25 nM; IC50 of 64 nM in LoVo cells.</p>Fórmula:C20H20FN7OForma y color:SolidPeso molecular:393.42ATM Inhibitor-2
<p>ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM).</p>Fórmula:C26H31N7O3Forma y color:SolidPeso molecular:489.57Simmitecan hydrochloride
CAS:<p>Simmitecan hydrochloride is a camptothecin derivative, a topoisomerase I inhibitor with anticancer activity, which can be used to study is solid tumors.</p>Fórmula:C34H39ClN4O6Pureza:98.20% - 98.93%Forma y color:SolidPeso molecular:635.15KU-60019
CAS:<p>KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).</p>Fórmula:C30H33N3O5SPureza:98.05% - 98.50%Forma y color:SolidPeso molecular:547.67BAY-8400
<p>BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase ( DNA-PK ) inhibitor ( IC 50 =81 nM) which shows synergistic efficacy in</p>Fórmula:C21H17F2N5OPureza:99.53%Forma y color:SolidPeso molecular:393.39OBI-3424
CAS:OBI-3424, a highly selective prodrug, is converted by aldo-keto reductase family 1 member C3 (AKR1C3) to a potent DNA-alkylating agent.Fórmula:C21H25N4O6PPureza:98%Forma y color:SolidPeso molecular:460.427Merbarone
CAS:<p>Merbarone is a Type II DNA topoisomerase inhibitor. Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage. Merbarone induces activation of caspase-activated DNase and excision of chromosomal DNA loops from the n</p>Fórmula:C11H9N3O3SForma y color:SolidPeso molecular:263.27Phenanthriplatin
CAS:<p>Phenanthriplatin, also known as cis-[Pt(NH3)2-(phenanthridine)Cl]NO3, is a new drug candidate. It belongs to a family of platinum(II)-based agents which includes cisplatin, oxaliplatin and carboplatin. Phenanthriplatin Acts As a Covalent Poison of Topoiso</p>Fórmula:C13H11ClN4O3PtForma y color:SolidPeso molecular:501.79YF438
CAS:<p>YF438 is an HDAC inhibitor that demonstrates potent anti-cancer activity both in vitro and in vivo. It inhibits the growth and metastasis of triple-negative breast cancer (TNBC) cells by blocking the interaction between HDAC and MDM2, inducing the dissociation of MDM2 from MDMX, and promoting the degradation of MDM2.</p>Fórmula:C23H26N4O5Forma y color:SolidPeso molecular:438.48NSC61610
CAS:<p>NSC61610 is anti-inflammatory that activates PPARγ in vitro via LANCL2 and adenylate cyclase/cAMP-dependent pathways, thereby improving experimental colitis.</p>Fórmula:C34H24N6O2Pureza:98%Forma y color:SolidPeso molecular:548.59Zabofloxacin hydrochloride
CAS:<p>Zabofloxacin hydrochloride is a potent and seletive bacterial type II and IV topoisomerases inhibitor, has excellent activity against gram-positive pathogens including Steptococcus aureus, Streptococcus pyogenes and S.pneumonia.</p>Fórmula:C19H21ClFN5O4Pureza:98%Forma y color:SolidPeso molecular:437.86SR-4370
CAS:<p>SR-4370 is an HDAC inhibitor. SR- 4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp.</p>Fórmula:C17H18F2N2OPureza:99.50%Forma y color:SolidPeso molecular:304.33Fotemustine
CAS:<p>Fotemustine: antineoplastic, chloroethylates DNA, blocks synthesis, causes cell arrest/apoptosis, lipophilic, crosses blood-brain barrier.</p>Fórmula:C9H19ClN3O5PForma y color:SolidPeso molecular:315.69Mavodelpar free base
CAS:<p>Mavodelpar free acid (REN001 free acid) is an selective agonist of PPARδ.</p>Fórmula:C31H30FNO5Pureza:98%Forma y color:SolidPeso molecular:515.57ATR-IN-24
CAS:<p>ATR-IN-24 (Compound 1) is an ATR inhibitor with demonstrated anticancer activity [1].</p>Fórmula:C23H26N6O2Pureza:98%Forma y color:SolidPeso molecular:418.49Ref: TM-T79058
Producto descatalogadoLerzeparib
CAS:<p>Lerzeparib is a PARP (ADP-ribose polymerase) inhibitor that exhibits antineoplastic activity [1].</p>Fórmula:C21H20FN3O2Pureza:98%Forma y color:SolidPeso molecular:365.4MDL-811
CAS:<p>MDL-811, an allosteric activator of SIRT6, markedly enhances the deacetylation of histone H3 at lysine residues 9, 18, and 56 (H3K9Ac, H3K18Ac, and H3K56Ac),</p>Fórmula:C25H25BrCl2FN3O5S2Pureza:98%Forma y color:SolidPeso molecular:681.42Antitumor agent-104
CAS:<p>Antitumor Agent-104 (Compound 9) serves as an antineoplastic by impeding DNA repair mechanisms in tumor cells, primarily through the inhibition of PARP1 enzyme</p>Fórmula:C31H33FN6O3Pureza:98%Forma y color:SolidPeso molecular:556.63PARP7-IN-16 free base
CAS:<p>PARP7-IN-16 free base is the freebase form of PARP7-IN-16. As a selective oral inhibitor of PARP-1/2/7, it demonstrates IC50 values of 0.94, 0.87, and 0.21 nM, respectively. This compound is utilized in the research of breast and prostate cancer.</p>Fórmula:C25H27FN4O4Forma y color:SolidPeso molecular:466.50Ref: TM-T200703
Producto descatalogado
