Daño al ADN / Reparación del ADN
Los inhibidores de daño/ reparación del ADN son compuestos que interfieren con los procesos involucrados en la detección y reparación de daños en el ADN. Estos inhibidores son fundamentales para estudiar los mecanismos de estabilidad genómica, mutagénesis y respuesta al daño del ADN. También son importantes en la investigación del cáncer, ya que muchos tumores dependen de vías específicas de reparación del ADN para sobrevivir. Al inhibir estas vías, los inhibidores de daño/reparación del ADN pueden aumentar la eficacia de la quimioterapia y la radioterapia. En CymitQuimica, ofrecemos una amplia gama de inhibidores de daño/reparación del ADN de alta calidad para apoyar su investigación en biología molecular, oncología y farmacología.
Subcategorías de "Daño al ADN / Reparación del ADN"
- ATM / ATR(71 productos)
- Alquilación de ADN(11 productos)
- ADN metiltransferasa(422 productos)
- ADN girasa(11 productos)
- ADN-PK(51 productos)
- MTH1(1 productos)
- Antimetabolito / análogo nucleósido(1.388 productos)
- Transcriptasa inversa(43 productos)
- Sirtuin(88 productos)
- Telomerasa(33 productos)
- Topoisomerasa(136 productos)
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Se han encontrado 959 productos de "Daño al ADN / Reparación del ADN"
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17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid
CAS:<p>Aspirin-enhanced COX-2 metabolite of DHA, activates Nrf2 and PPARγ, inhibits inflammation, with EC50 ~200 nM, effective at 5-25 μM.</p>Fórmula:C22H30O3Forma y color:SolidPeso molecular:342.479Silatecan
CAS:<p>Silatecan is a useful organic compound for research related to life sciences. The catalog number is T67968 and the CAS number is 220913-32-6.</p>Fórmula:C26H30N2O5SiForma y color:SoildPeso molecular:478.61GJ071 oxalate
CAS:<p>GJ071 oxalate is a Nonsense suppressor that induces readthrough by inserting amino acids at premature termination codons.</p>Fórmula:C20H29N3O7SPureza:99.97%Forma y color:SolidPeso molecular:455.53Saroglitazar Magnesium
CAS:<p>Saroglitazar Magnesium: a PPAR agonist, strong on PPARα (EC50 0.65pM), moderate on PPARγ (EC50 3nM).</p>Fórmula:C50H56MgN2O8S2Pureza:98.1%Forma y color:SolidPeso molecular:901.43Wistin
CAS:<p>Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist [1] [2] .</p>Fórmula:C23H24O10Forma y color:SolidPeso molecular:460.43TRF1-TIN2 interaction-IN-1
<p>TRF1-TIN2 interaction-IN-1 (Compound 40) is an inhibitor of the TRF1-TIN2 interaction. It binds to the TRFH domain of TRF1 (KD= 29 μM) and competitively inhibits the binding of the TIN2 peptide (IC50= 67 μM). By occupying a hotspot at the TRF1-TIN2 interface, TRF1-TIN2 interaction-IN-1 disrupts the interaction between TRF1 and TIN2. This compound can remove TRF1 from the shelterin complex, making it useful for research on shelterin-related cancers.</p>Fórmula:C19H18O6SForma y color:SolidPeso molecular:374.41(±)4(5)-DiHDPA lactone
CAS:<p>(±)5(6)-DiHET lactone is a 1,5 cyclic ester derived from (±)5(6)-DiHET , which, in turn, is a potential derivative of epoxidation of arachidonic acid at the α-5</p>Fórmula:C22H32O3Forma y color:SolidPeso molecular:344.495Z26395438
CAS:<p>Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.</p>Fórmula:C17H15FN2OPureza:99.63%Forma y color:SolidPeso molecular:282.31PPAR agonist 6
<p>PPAR agonist6 (compound 5a) acts as an agonist for PPAR, exhibiting EC50 values of 3.6 μM and 2.6 μM for PPARα and PPARβ/δ respectively. Additionally, PPAR agonist6 inhibits the transactivation of a TNFα-dependent NF-κB-driven reporter gene in L929 cells [1].</p>Forma y color:Odour SolidDichlorogelignate
CAS:<p>Dichlorogelignate (compound 4) acts as a selective inhibitor of topoisomerase II (Topo II), achieving 100% inhibition at 50 μM [1].</p>Fórmula:C32H34O18Forma y color:SolidPeso molecular:706.6GpC Methyltransferase
<p>GpC Methyltransferase (GpC) is an enzyme that methylates DNA, specifically targeting cytosine residues within GpC dinucleotides of non-nucleosomal DNA in vitro.</p>CAY10599
CAS:<p>CAY10599 has a wide range of applications in life science related research.</p>Fórmula:C38H41NO5Forma y color:SolidPeso molecular:591.748Topoisomerase IIα-IN-9
CAS:Compound EN300-20599, with CAS No. 16346-97-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound EN300-20599 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Fórmula:C14H14O4SForma y color:SolidPeso molecular:278.32Et-29
CAS:<p>Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.</p>Fórmula:C34H46N6O6SPureza:99.52%Forma y color:SolidPeso molecular:666.83NHC-triphosphate tetrasodium
<p>NHC-triphosphate tetrasodium, a metabolite of β-d-N4-Hydroxycytidine, acts as a viral polymerase substrate affecting HCV RNA replication.</p>Fórmula:C9H12N3Na4O15P3Forma y color:SolidPeso molecular:587.08HDAC-IN-52
CAS:<p>HDAC-IN-52: Pyridine-based inhibitor for HDAC1/2/3/10 with IC50s 0.189-0.446 μM, used in cancer studies.</p>Fórmula:C24H20N4O2Pureza:99.47%Forma y color:SolidPeso molecular:396.44Anti-obesity agent 1
<p>Compound 4 (Anti-obesity agent 1) demonstrates potential for enhanced lipolysis, highlighting its anti-obesity characteristics.</p>Fórmula:C21H22N2O6Forma y color:SolidPeso molecular:398.409Tibesaikosaponin V
CAS:<p>TKV, a triterpene diglycoside from Bupleurum chinense, curbs lipid build-up and fat content in adipocytes without harm and hinders fat cell differentiation.</p>Fórmula:C42H68O15Forma y color:SolidPeso molecular:812.98(R)-VX-984
CAS:<p>(R)-VX-984 ((R)-M9831) is the (R)-enantiomer of VX-984. VX-984 is a potent inhibitor of DNA-PK.</p>Fórmula:C23H21D2N7OPureza:98%Forma y color:SolidPeso molecular:415.49ABP/PPAR modulator 1
<p>ABP/PPAR modulator 1 is an orally active multi-regulator of FABP and PPAR, exhibiting IC50 values of 0.65 μM for FABP1 and 1.08 μM for FABP4, and EC50 values of 9.19 μM, 2.20 μM, and 1.58 μM for PPARα, PPARγ, and PPARδ, respectively. It demonstrates potent activity against metabolic dysfunction-associated steatohepatitis (MASH). Additionally, ABP/PPAR modulator 1 dose-dependently improves various pathological features of fatty liver in a WD + Carbon tetrachloride-induced MASH mouse model.</p>Fórmula:C33H39NO7Forma y color:SolidPeso molecular:561.67
