Daño al ADN / Reparación del ADN
Los inhibidores de daño/ reparación del ADN son compuestos que interfieren con los procesos involucrados en la detección y reparación de daños en el ADN. Estos inhibidores son fundamentales para estudiar los mecanismos de estabilidad genómica, mutagénesis y respuesta al daño del ADN. También son importantes en la investigación del cáncer, ya que muchos tumores dependen de vías específicas de reparación del ADN para sobrevivir. Al inhibir estas vías, los inhibidores de daño/reparación del ADN pueden aumentar la eficacia de la quimioterapia y la radioterapia. En CymitQuimica, ofrecemos una amplia gama de inhibidores de daño/reparación del ADN de alta calidad para apoyar su investigación en biología molecular, oncología y farmacología.
Subcategorías de "Daño al ADN / Reparación del ADN"
- ATM / ATR(71 productos)
- Alquilación de ADN(11 productos)
- ADN metiltransferasa(422 productos)
- ADN girasa(11 productos)
- ADN-PK(50 productos)
- MTH1(1 productos)
- Antimetabolito / análogo nucleósido(1.388 productos)
- Transcriptasa inversa(43 productos)
- Sirtuin(88 productos)
- Telomerasa(33 productos)
- Topoisomerasa(136 productos)
Mostrar 3 subcategorías más
Se han encontrado 963 productos de "Daño al ADN / Reparación del ADN"
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2′-Deoxy-5-nitrocytidine
CAS:<p>2′-Deoxy-5-nitrocytidine is a DNA Methyltransferase inhibitor that can be used for cancer research[1].</p>Fórmula:C9H12N4O6Forma y color:SolidPeso molecular:272.21ATR-IN-10
CAS:<p>ATR-IN-10 is a potent and highly selective inhibitor of ATR kinase (IC50: 2.978 μM).</p>Fórmula:C27H24N4OForma y color:SolidPeso molecular:420.51A 9387
CAS:<p>A 9387 is an inhibitor of resolvase protein.</p>Fórmula:C12H6Br2Cl2O2SForma y color:SolidPeso molecular:444.95BRD0539
CAS:<p>BRD0539 is a cell-permeable spCas9 inhibitor that blocks the binding of spCas9 to DNA and inhibits Streptococcus pyogenes Cas9 (SpCas9).</p>Fórmula:C25H25FN2O3SPureza:98.03%Forma y color:SolidPeso molecular:452.54Leurubicin
CAS:<p>Leurubicin is used as a prodrug of doxorubicin.</p>Fórmula:C33H40N2O12Pureza:98.66% - >99.99%Forma y color:SolidPeso molecular:656.68S26948
CAS:<p>S26948 is a PPARγ agonist.</p>Fórmula:C28H25NO7SPureza:98%Forma y color:SolidPeso molecular:519.57MHY908
CAS:MHY908, a novel inhibitor of melanogenesis, potently inhibits mushroom tyrosinase activity in a dose-dependent manner.Fórmula:C17H14ClNO3SPureza:98%Forma y color:SolidPeso molecular:347.82MD001
CAS:<p>MD001 is a PPARα/γ agonist, binds at Kds 9.55/0.14 μM, boosts transcription, and regulates glucose, lipid levels in diabetic mice.</p>Fórmula:C25H18O5Forma y color:SolidPeso molecular:398.41PPARγ agonist 5
CAS:<p>PPARγ agonist 5 is a selective and potent PPARγ agonist that has shown research potential for cancer disease.</p>Fórmula:C33H31N5OForma y color:SolidPeso molecular:513.63Naveglitazar racemate
CAS:<p>Naveglitazar racemate is the racemate of Naveglitazar.</p>Fórmula:C25H26O6Pureza:98%Forma y color:SolidPeso molecular:422.47Guadecitabine sodium
CAS:<p>Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .</p>Fórmula:C18H24N9NaO10PPureza:98%Forma y color:SolidPeso molecular:580.407GW409544
CAS:<p>GW409544 is an agonist of PPAR-alpha and PPAR-gamma.</p>Fórmula:C31H30N2O5Pureza:98%Forma y color:SolidPeso molecular:510.58SIRT2-IN-9
CAS:<p>SIRT2-IN-9: selective SIRT2 inhibitor; IC50=1.3μM; halts MCF-7 cell growth; for cancer study.</p>Fórmula:C21H22N6OS2Pureza:99.5%Forma y color:SolidPeso molecular:438.57Romazarit
CAS:<p>Romazarit, a propionic acid derivative, is used as a PPARα agonist and acts as an antirheumatic drug.</p>Fórmula:C15H16ClNO4Pureza:98%Forma y color:SolidPeso molecular:309.74Hepsulfam
CAS:Hepsulfam is an anticancer agent. It also displays excellent antileukemic activity (a median IC50: 0.91 μg/mL in a panel of different tumors).Fórmula:C7H18N2O6S2Forma y color:SolidPeso molecular:290.36HDAC-IN-5
CAS:<p>HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor.</p>Fórmula:C26H24F3N5O2SPureza:98%Forma y color:SolidPeso molecular:527.56CP-67804
CAS:<p>CP 67804 enhances topoisomerase II-mediated DNA cleaving.</p>Fórmula:C18H13F2NO4Forma y color:SolidPeso molecular:345.3PluriSIn #2
CAS:<p>PluriSIn #2 is a selective topoisomerase II α (topo2α) transcription inhibitor exhibiting cytotoxicity towards undifferentiated, leukaemogenic hPSCs.</p>Fórmula:C11H8FN3O3Pureza:98% - 99.79%Forma y color:SolidPeso molecular:249.2CCT128930
CAS:<p>'CCT128930, potent Akt2 inhibitor (IC50=6 nM), 28x more selective over PKA.'</p>Fórmula:C18H20ClN5Pureza:99.07% - 99.18%Forma y color:SolidPeso molecular:341.84HWL-088
CAS:<p>HWL-088 is a potent free fatty acid receptor 1 (FFA1/GPR40) agonist. HWL-088 significantly improves glucose tolerance in normal and diabetic models.</p>Fórmula:C22H19FO4Forma y color:SolidPeso molecular:366.38PPARα/δ agonist 1
CAS:PPARα/δ agonist 1 is a potent PPARα/PPARδ dual agonist with EC50 values of 7.0 nM for PPARα and 8.4 nM for PPARδ.Fórmula:C22H22F3N3O5Forma y color:SolidPeso molecular:465.42BMS-711939
CAS:<p>BMS-711939: Potent PPARα agonist, EC50=4 nM, shown effective and safe in preclinical trials.</p>Fórmula:C22H20ClFN2O6Forma y color:SolidPeso molecular:462.86CAY10767
CAS:<p>CAY10767 is a PPARα agonist with an EC50 of 37 nM; over 2700x selective against PPARγ/δ.</p>Fórmula:C22H20FNO3Forma y color:SolidPeso molecular:365.4Lexitropsin
CAS:<p>Lexitropsin is a novel anticancer drug.</p>Fórmula:C20H29N5O4Forma y color:SolidPeso molecular:403.48Naveglitazar
CAS:<p>Naveglitazar (LY 519818, LY 9818), a PPAR modulator in phase II trials for type 2 diabetes.</p>Fórmula:C25H26O6Forma y color:SolidPeso molecular:422.47PPARγ agonist 4
CAS:<p>PPARγ agonist 4 (Compound 18b), a potent and selective PPARγ agonist, demonstrates antitumor efficacy only when used in conjunction with Imatinib.</p>Fórmula:C24H22FN3OForma y color:SolidPeso molecular:387.45ICRF-196
CAS:<p>ICRF-196 is a Topoisomerase II Inhibitor and antineoplastic agent.</p>Fórmula:C12H18N4O4Forma y color:SolidPeso molecular:282.3NU-7163
CAS:<p>NU-7163 is a potent and selective inhibitor of ATP-competitive DNA-PK.</p>Fórmula:C18H17NO3Pureza:98%Forma y color:SolidPeso molecular:295.33Chlornaphazine
CAS:<p>Chlornaphazine is an antineoplastic and has been identified as a human carcinogen.</p>Fórmula:C14H15Cl2NPureza:98%Forma y color:Less Plates Or Brown Solid (Ntp 1992) Physical Description Colorless Plates Or Brown Solid (Ntp 1992)Peso molecular:268.18PPARγ agonist 6
CAS:<p>PPARγ agonist 6 (Compound 12) is a potent agonist of selective PPARγ. PPARγ agonist 6 has potential for cancer disease research.</p>Fórmula:C27H26N2O4Forma y color:SolidPeso molecular:442.51Arazine
CAS:<p>Arazine, a cell-permeable G protein modulator, is an isoprenylcysteine methyltransferase substrate.</p>Fórmula:C20H33NO3SPureza:90%Forma y color:SolidPeso molecular:367.55Ertiprotafib
CAS:<p>Ertiprotafib (PTP 112), a PTP1B and IKK-β inhibitor, is a novel insulin sensitizer for the study of type 2 diabetes and breast cancer.</p>Fórmula:C31H27BrO3SPureza:98.70%Forma y color:SolidPeso molecular:559.51DRF 2519
CAS:<p>DRF 2519 is an activator of PPAR-alpha and PPAR-gamma.</p>Fórmula:C20H18N2O5SForma y color:SolidPeso molecular:398.43Sirt2-IN-1
CAS:<p>Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).</p>Fórmula:C28H27N7O2S2Pureza:99.57% - 99.84%Forma y color:SolidPeso molecular:557.69DNA-PK-IN-7
CAS:<p>DNA-PK-IN-7 is a potent DNA-PK inhibitor (IC50= 1 nM) (WO2021104277A1, compound 5).</p>Fórmula:C19H21N9O2Forma y color:SolidPeso molecular:407.43Topoisomerase I inhibitor 7
CAS:<p>Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I.</p>Fórmula:C22H19N3O5Forma y color:SolidPeso molecular:405.4Chiglitazar
CAS:Chiglitazar is a PPAR α/γ/δ agonist and insulin sensitizer used in the treatment of type 2 diabetes mellitus , anti-inflammatory and anti-fibrotic.Fórmula:C36H29FN2O4Forma y color:SolidPeso molecular:572.63LG100754
CAS:LG100754 (UVI 2112) is an insulin sensitizer and RXR modulator, antagonizing RXR homodimers while agonizing RXR:PPARα/γ heterodimers.Fórmula:C26H36O3Forma y color:SolidPeso molecular:396.569-Hydroxyellipticine hydrochloride
CAS:<p>9-Hydroxyellipticine hydrochloride is an inhibitor of Topo II and RyR, exhibits antitumor and antileukemic activity, and inhibits carrageenan gum-induced edema.</p>Fórmula:C17H15ClN2OPureza:98%Forma y color:SolidPeso molecular:298.77NU/ICRF 500
CAS:<p>NU/ICRF 500 is a novel anthracenyl-amino acid catalytic inhibitor of topoisomerase II.</p>Fórmula:C17H15N3O5Pureza:98%Forma y color:SolidPeso molecular:341.32NSC-311068
CAS:<p>NSC-311068: A selective TET1 inhibitor, reducing 5hmC and AML cell viability with high TET1.</p>Fórmula:C10H6N4O4SForma y color:SolidPeso molecular:278.24BNS-22
CAS:<p>BNS-22 is a DNA topoisomerase II (Topo II) inhibitor, induces mitotic abnormalities and exhibits antiproliferative activity against human cancer cells.</p>Fórmula:C24H25NO5Pureza:99.62%Forma y color:SolidPeso molecular:407.46S-Aristeromycinylhomocysteine
CAS:<p>S-Aristeromycinylhomocysteine is an inhibitor of adenosylmethionine decarboxylase.</p>Fórmula:C15H22N6O4SForma y color:SolidPeso molecular:382.44GW 9578
CAS:<p>GW 9578 is a PPARα agonist with potent lipid-lowering activity for the study of psoriasis, arthritis, alopecia, asthma and type I diabetes.</p>Fórmula:C26H34F2N2O3SPureza:98%Forma y color:SolidPeso molecular:492.62AM-3102
CAS:<p>AM-3102: An OEA analog; boosts PPARα, delays eating, resists hydrolysis, mimics OEA potency, and weakly binds CB1/CB2.</p>Fórmula:C21H41NO2Forma y color:SolidPeso molecular:339.56DNA-PK-IN-4
CAS:<p>DNA-PK-IN-4, an imidazolinone, targets DNA-PKcs to hinder tumor DNA repair and induce apoptosis, showing cancer research potential.</p>Fórmula:C20H24N6O3Forma y color:SolidPeso molecular:396.44Topoisomerase IV inhibitor 2
CAS:<p>Compound 5d, a potent TOPO IV inhibitor (IC50: 0.35 μM), also inhibits DNA gyrase (IC50: 0.55 μM) and has antibacterial activity.</p>Fórmula:C33H30FN7O6SPureza:98%Forma y color:SolidPeso molecular:671.7GW0072
CAS:<p>GW0072 is a partial agonist of PPARγ.</p>Fórmula:C36H44N2O4SForma y color:SolidPeso molecular:600.81ATR-IN-23
CAS:<p>ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces</p>Fórmula:C20H22N6O3S2Pureza:98%Forma y color:SolidPeso molecular:458.56HDAC ligand-1
CAS:<p>HDAC ligand-1 is a synthetic precursor utilized in the production of PROTAC-based HDAC degraders [1].</p>Fórmula:C7H8N2OPureza:98%Forma y color:SolidPeso molecular:136.15
