Daño al ADN / Reparación del ADN
Los inhibidores de daño/ reparación del ADN son compuestos que interfieren con los procesos involucrados en la detección y reparación de daños en el ADN. Estos inhibidores son fundamentales para estudiar los mecanismos de estabilidad genómica, mutagénesis y respuesta al daño del ADN. También son importantes en la investigación del cáncer, ya que muchos tumores dependen de vías específicas de reparación del ADN para sobrevivir. Al inhibir estas vías, los inhibidores de daño/reparación del ADN pueden aumentar la eficacia de la quimioterapia y la radioterapia. En CymitQuimica, ofrecemos una amplia gama de inhibidores de daño/reparación del ADN de alta calidad para apoyar su investigación en biología molecular, oncología y farmacología.
Subcategorías de "Daño al ADN / Reparación del ADN"
- ATM / ATR(71 productos)
- Alquilación de ADN(11 productos)
- ADN metiltransferasa(422 productos)
- ADN girasa(11 productos)
- ADN-PK(50 productos)
- MTH1(1 productos)
- Antimetabolito / análogo nucleósido(1.388 productos)
- Transcriptasa inversa(43 productos)
- Sirtuin(88 productos)
- Telomerasa(33 productos)
- Topoisomerasa(136 productos)
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Se han encontrado 963 productos de "Daño al ADN / Reparación del ADN"
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Topoisomerase II inhibitor 4
CAS:<p>Compound E17, a topoisomerase II inhibitor, halts cell cycle at G2/M, possesses anticancer properties and cytotoxic effects.</p>Fórmula:C25H25N5O4Forma y color:SolidPeso molecular:459.5HDAC-IN-58
CAS:<p>HDAC-IN-58, a selective HDAC6 inhibitor, exhibits potent inhibitory activity with an IC50 of 2.06 nM, rendering it suitable for research into chronic</p>Fórmula:C16H13ClF2N4O3SPureza:98%Forma y color:SolidPeso molecular:414.81Guadecitabine
CAS:<p>Guadecitabine is a second-generation DNA methyltransferases inhibitor. It is used for research on acute myeloid leukemia and myelodysplastic syndromes.</p>Fórmula:C18H24N9O10PPureza:98%Forma y color:SolidPeso molecular:557.41G3335
CAS:<p>H-Trp-Glu-OH: Selective, reversible PPARγ modulator; cell-permeable; Kd ~8μM; potential diabetes lead.</p>Fórmula:C16H19N3O5Forma y color:SolidPeso molecular:333.34PB131
CAS:<p>PB131, a selective and brain-permeable HDAC6 inhibitor, exhibits high binding affinity (IC50: 1.8 nM) and potent anti-inflammatory activity, making it suitable</p>Fórmula:C16H16FN3O2Pureza:98%Forma y color:SolidPeso molecular:301.32Topoisomerase IV inhibitor 1
CAS:<p>Compound 7d: Inhibits TOPO IV (IC50: 0.23 μM), DNA gyrase (IC50: 0.43 μM), antibacterial against S. aureus (MIC: 0.972 μM), E. coli (MIC: 0.608 μM).</p>Fórmula:C34H32FN7O6SPureza:98%Forma y color:SolidPeso molecular:685.72Topoisomerase II inhibitor 16
CAS:<p>Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of trypanosomal topoisomerase II, possessing the</p>Fórmula:C19H12F4N6OPureza:98%Forma y color:SolidPeso molecular:416.33Topoisomerase IIα-IN-1
CAS:<p>Topoisomerase IIα-IN-1 (compound 2) is a DNA-binding ligands and a potent inhibitor of TopoIIα, a topoisomerase.</p>Fórmula:C22H20N4O5Forma y color:SolidPeso molecular:420.42Aldoxorubicin
CAS:Aldoxorubicin, an albumin-binding prodrug of Doxorubicin, exhibits potent antitumor effects in cancer lines and mouse models.Fórmula:C37H42N4O13Pureza:98%Forma y color:SolidPeso molecular:750.75Huanglongmycin N
CAS:<p>Huanglongmycin N acts as a DNA topoisomerase I inhibitor, demonstrating an EC50 value of 14 μM.</p>Fórmula:C19H16O5Forma y color:SolidPeso molecular:324.33F-14512
CAS:<p>F-14512, a DNA topoisomerase II inhibitor, is used potentially for the treatment of acute myeloid leukemia.</p>Fórmula:C33H47N5O8Forma y color:SolidPeso molecular:641.76Eicosatetraynoic acid
CAS:<p>ETYA activates PPARα/γ at 10μM, inhibits cyclooxygenase (ID50=8μM) and lipoxygenase (ID50=4μM).</p>Fórmula:C20H24O2Pureza:98%Forma y color:SolidPeso molecular:296.4RSC-133
CAS:promotes the reprogramming of human somatic cells to pluripotent stem cellsFórmula:C18H15N3O2Pureza:98%Forma y color:SolidPeso molecular:305.33ST247
CAS:<p>ST247: Potent PPARβ/δ inverse agonist, blocks CCL2 expression and agonist-driven PPARβ/δ transcription, promotes co-repressor interaction.</p>Fórmula:C19H26N2O5S2Forma y color:SolidPeso molecular:426.55Inolitazone dihydrochloride
CAS:Inolitazone dihydrochloride is an effective, high-affinity PPARγ agonist; its biological activity is dependent on PPARγ (IC50:0.8 nM) to inhibit cell growth.Fórmula:C27H28Cl2N4O4SForma y color:SolidPeso molecular:575.51TFMB-(S)-2-HG
CAS:<p>TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase.</p>Fórmula:C13H11F3O4Pureza:98.07%Forma y color:SolidPeso molecular:288.22Reglitazar
CAS:Reglitazar, a dual PPARα/γ agonist, enhances insulin signaling, reduces insulin resistance, and lowers hypertriglyceridemia in obese rats.Fórmula:C22H20N2O5Pureza:97.07% - 98.72%Forma y color:SolidPeso molecular:392.4Elaidyl-sulfamide
CAS:<p>Elaidyl-sulfamide is a sulfamoyl analogue of oleoylethanolamide (OEA). ES is a lipid mediator of satiety that acts through the PPARα.</p>Fórmula:C18H38N2O2SPureza:98%Forma y color:SolidPeso molecular:346.57XR 5944
CAS:XR 5944 is an effective DNA binder that stabilizes topoisomerase-dependent cleavage and has shown superior efficacy in a variety of mouse and human tumor modelsFórmula:C34H34N8O2Pureza:98.29% - 98.66%Forma y color:SolidPeso molecular:586.69GW2433
CAS:<p>GW2433 is an agonist of PPAR receptor.</p>Fórmula:C28H28Cl3FN2O4Forma y color:SolidPeso molecular:581.89CP 775146
CAS:<p>PPARα agonist</p>Fórmula:C26H33NO4Pureza:98%Forma y color:SolidPeso molecular:423.54Cas9-IN-3
CAS:<p>Cas9-IN-3 is a potent inhibitor of Cas9 with IC50 of 28 μM. CRISPR/Cas systems have revolutionized gene editing in several species [1].</p>Fórmula:C19H21NOForma y color:SolidPeso molecular:279.38CAY10744
CAS:<p>CAY10744, a topoisomerase II-α inhibitor (78.9% at 20 μM), blocks cancer cell proliferation with varying IC50s and induces apoptosis in T47D cells.</p>Fórmula:C24H16ClNO2Forma y color:SolidPeso molecular:385.84Procarbazine free base
CAS:<p>Procarbazine: chemo drug for Hodgkin's, brain cancer; liver-activated; MAO inhibitor.</p>Fórmula:C12H19N3OPureza:98%Forma y color:SolidPeso molecular:221.3ZINC17167211
CAS:<p>ZINC17167211 is a selective peroxisome proliferator-activated receptors-α agonist.</p>Fórmula:C24H17FN2O6SPureza:98%Forma y color:SolidPeso molecular:480.46A 20832
CAS:<p>A-20832 blocks strand cleavage in resolvase-driven recombination; doesn't prevent resolvase-res binding or synapse formation, only binds at res site I.</p>Fórmula:C10H14Cl2O3Pureza:98%Forma y color:SolidPeso molecular:253.12ZINC08438472
CAS:<p>ZINC08438472 is a selective peroxisome proliferator-activated receptors-α agonist.</p>Fórmula:C25H25NO8SPureza:98%Forma y color:SolidPeso molecular:499.53Exifone
CAS:<p>Exifone (NSC-680919) is a mixed, nonessential activator of HDAC1 that is capable of binding to both free and substrate-bound enzyme, resulting in an increased</p>Fórmula:C13H10O7Pureza:99.77% - 99.95%Forma y color:Yellow SolidPeso molecular:278.21Givinostat hydrochloride monohydrate
CAS:<p>Givinostat hydrochloride monohydrate (ITF2357) is an HDAC inhibitor.</p>Fórmula:C24H27N3O4·HCl·H2OPureza:97.97% - 99.51%Forma y color:SolidPeso molecular:475.97XR-11576
CAS:XR-11576 is a DNA topoisomerase I and II inhibitor for the treatment of solid tumors.Fórmula:C23H24N4O2Pureza:98%Forma y color:SolidPeso molecular:388.46(S)-Gyramide A
CAS:<p>(S)-Gyramide A is a bacterial DNA gyrase inhibitor that acts by exhibiting antimicrobial activity and inhibiting bacterial cell division.</p>Fórmula:C21H27FN2O3SPureza:98%Forma y color:SolidPeso molecular:406.51CLX 0921
CAS:<p>CLX 0921, a PPAR gamma agonist, is used potentially for the treatment of type 2 diabetes.</p>Fórmula:C28H25NO7SPureza:98%Forma y color:SolidPeso molecular:519.57A-1062
CAS:<p>A-1062, a resolvase-binding inhibitor, inhibits resolvase binding to the res site.</p>Fórmula:C18H10O6SPureza:98%Forma y color:SolidPeso molecular:354.33C-333H
CAS:C-333H is a new PPARalpha/gamma dual agonist.Fórmula:C28H26N2O6Pureza:98%Forma y color:SolidPeso molecular:486.52ICRF-193
CAS:<p>ICRF-193 is a DNA topoisomerase II inhibitor.</p>Fórmula:C12H18N4O4Forma y color:SolidPeso molecular:282.3Seladelpar Lysine dihydrate
CAS:<p>Seladelpar lysine, a selective PPAR-δ agonist, is used for the therapy of Homozygous Familial Hypercholesterolemia (HoFH).</p>Fórmula:C27H41F3N2O9SPureza:98%Forma y color:SolidPeso molecular:626.68KRP-297
CAS:KRP297 is a PPAR agonist potentially for the treatment of type 2 diabetes and dyslipidemia.Fórmula:C20H17F3N2O4SForma y color:SolidPeso molecular:438.42DNA-PK-IN-1
CAS:<p>DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-PK-IN-1 has potential for cancer disease research.</p>Fórmula:C23H26N8O2Forma y color:SolidPeso molecular:446.5ARTD10/PARP10-IN-1
CAS:<p>ARTD10/PARP10-IN-1 is a PARP inhibitor that inhibits ARTD8/PARP14 and has anticancer and antitumour activity for the study of prostate cancer.</p>Fórmula:C12H12N2O4Pureza:99.14%Forma y color:SolidPeso molecular:248.23Gartisertib
CAS:Gartisertib (VX-803) is an ATR inhibitor with anti-tumor activity, inhibiting the anti-proliferative effects induced in ccRCC cells.Fórmula:C25H29F2N9O3Pureza:99.52%Forma y color:SolidPeso molecular:541.55DC_501
CAS:<p>DC_501 is a selective non-nucleoside DNA methyltransferase 1 inhibitor.</p>Fórmula:C25H23Cl2N3OPureza:98%Forma y color:SolidPeso molecular:452.38Daniquidone
CAS:<p>Daniquidone (Batracylin) is a potent dual inhibitor of DNA topoisomerase I and DNA topoisomerase II with cytotoxic and antiproliferative activity for neoplasms</p>Fórmula:C15H11N3OPureza:98.39% - 99.52%Forma y color:SolidPeso molecular:249.2713-Oxo-9E,11E-octadecadienoic acid
CAS:<p>13-Oxo-9E,11E-octadecadienoic acid from tomato juice, an isomer of 9-oxo-ODA, activates PPARα and lowers triglycerides in diabetic mice.</p>Fórmula:C18H30O3Pureza:98%Forma y color:SolidPeso molecular:294.43Tetrahydrouridine
CAS:Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.Fórmula:C9H16N2O6Pureza:98%Forma y color:SolidPeso molecular:248.23CM-579
CAS:<p>CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.</p>Fórmula:C29H40N4O3Pureza:99.23%Forma y color:SolidPeso molecular:492.65DC_517
CAS:<p>DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).</p>Fórmula:C33H35N3O2Forma y color:SolidPeso molecular:505.65ATR-IN-15
CAS:<p>ATR-IN-15, an ATR kinase inhibitor, has an IC50 of 8 nM and also targets LoVo cells, DNA-PK, and PI3K with higher IC50 values.</p>Fórmula:C19H22N8OForma y color:SolidPeso molecular:378.43SW155246
CAS:SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM).Fórmula:C16H11ClN2O5SPureza:98.99%Forma y color:SolidPeso molecular:378.79L-764406
CAS:<p>L-764406 is a partial agonist of human PPAR gamma.</p>Fórmula:C15H11ClN2O2SPureza:98%Forma y color:SolidPeso molecular:318.78DNA-PK-IN-3
CAS:<p>DNA-PK-IN-3 is a potent DNA-PK inhibitor, enhancing radio/chemotherapy and reducing tumors with limited side effects.</p>Fórmula:C19H19N9OForma y color:SolidPeso molecular:389.41
