Daño al ADN / Reparación del ADN
Los inhibidores de daño/ reparación del ADN son compuestos que interfieren con los procesos involucrados en la detección y reparación de daños en el ADN. Estos inhibidores son fundamentales para estudiar los mecanismos de estabilidad genómica, mutagénesis y respuesta al daño del ADN. También son importantes en la investigación del cáncer, ya que muchos tumores dependen de vías específicas de reparación del ADN para sobrevivir. Al inhibir estas vías, los inhibidores de daño/reparación del ADN pueden aumentar la eficacia de la quimioterapia y la radioterapia. En CymitQuimica, ofrecemos una amplia gama de inhibidores de daño/reparación del ADN de alta calidad para apoyar su investigación en biología molecular, oncología y farmacología.
Subcategorías de "Daño al ADN / Reparación del ADN"
- ATM / ATR(71 productos)
- Alquilación de ADN(11 productos)
- ADN metiltransferasa(422 productos)
- ADN girasa(11 productos)
- ADN-PK(50 productos)
- MTH1(1 productos)
- Antimetabolito / análogo nucleósido(1.388 productos)
- Transcriptasa inversa(43 productos)
- Sirtuin(88 productos)
- Telomerasa(33 productos)
- Topoisomerasa(136 productos)
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Se han encontrado 962 productos de "Daño al ADN / Reparación del ADN"
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Hepsulfam
CAS:Hepsulfam is an anticancer agent. It also displays excellent antileukemic activity (a median IC50: 0.91 μg/mL in a panel of different tumors).Fórmula:C7H18N2O6S2Forma y color:SolidPeso molecular:290.36NC190 sodium
CAS:NC190 inhibits topoisomerase II, halts FM3A cell growth (IC50: 0.019 μg/ml in 48h), and suppresses DNA synthesis by 90% at 0.1 μg/ml.Fórmula:C23H22N4NaO5Pureza:98%Forma y color:SolidPeso molecular:457.442DB-959 (free base)
CAS:<p>DB-959 is a potential agonist of PPAR.</p>Fórmula:C25H27NO5Forma y color:SolidPeso molecular:421.49Resminostat
CAS:<p>Resminostat (4SC-201) is an orally bioavailable inhibitor of histone deacetylases (HDACs) with potential antineoplastic activity.</p>Fórmula:C16H19N3O4SPureza:99.46%Forma y color:SolidPeso molecular:349.4Mitobronitol
CAS:<p>Mitobronitol, a brominated mannitol analog, is an alkylating anticancer drug that aids in reducing allogeneic bone marrow transplant risks.</p>Fórmula:C6H12Br2O4Forma y color:SolidPeso molecular:307.97DSO-5a
CAS:<p>DSO-5a, a potent and selective orally active BB3 agonist, is a DMAKO-00 derivative that enhances ppar-γ activity via BB3 and stimulates ERK1/2 phosphorylation.</p>Fórmula:C23H24N2O7Pureza:98%Forma y color:SolidPeso molecular:440.453,6-Diamino-9(10H)-acridone
CAS:<p>3,6-Diamino-9(10H)-acridone is an inhibitor of topoisomerase [1].</p>Fórmula:C13H11N3OForma y color:SolidPeso molecular:225.25NHC-triphosphate
CAS:<p>NHC-triphosphate is a weak alternative substrate for the viral polymerase and changes the mobility of the product in polyacrylamide electrophoresis gels.</p>Fórmula:C9H16N3O15P3Pureza:98%Forma y color:SolidPeso molecular:499.16NK314
CAS:<p>NK314, a benzo[c]phenanthridine, inhibits topoisomerase II causing DNA breaks within 1h, even without proteinase K digestion.</p>Fórmula:C22H20ClNO4Forma y color:SolidPeso molecular:397.85Naveglitazar
CAS:<p>Naveglitazar (LY 519818, LY 9818), a PPAR modulator in phase II trials for type 2 diabetes.</p>Fórmula:C25H26O6Forma y color:SolidPeso molecular:422.47DNA-PK-IN-5
CAS:DNA-PK-IN-5: potent DNA-PK inhibitor, reduces tumor repair, induces apoptosis, enhances radiotherapy, overcomes resistance.Fórmula:C21H22N8O2Forma y color:SolidPeso molecular:418.45Mipicoledine
CAS:DM-CHOC-PEN is a DNA alkylation agent that may be used to treat brain cancer.Fórmula:C35H48Cl5NO4Forma y color:SolidPeso molecular:724.02BMS-711939
CAS:<p>BMS-711939: Potent PPARα agonist, EC50=4 nM, shown effective and safe in preclinical trials.</p>Fórmula:C22H20ClFN2O6Forma y color:SolidPeso molecular:462.86HWL-088
CAS:<p>HWL-088 is a potent free fatty acid receptor 1 (FFA1/GPR40) agonist. HWL-088 significantly improves glucose tolerance in normal and diabetic models.</p>Fórmula:C22H19FO4Forma y color:SolidPeso molecular:366.38Topoisomerase II inhibitor 4
CAS:<p>Compound E17, a topoisomerase II inhibitor, halts cell cycle at G2/M, possesses anticancer properties and cytotoxic effects.</p>Fórmula:C25H25N5O4Forma y color:SolidPeso molecular:459.5CCT128930
CAS:<p>'CCT128930, potent Akt2 inhibitor (IC50=6 nM), 28x more selective over PKA.'</p>Fórmula:C18H20ClN5Pureza:99.07% - 99.18%Forma y color:SolidPeso molecular:341.84PluriSIn #2
CAS:<p>PluriSIn #2 is a selective topoisomerase II α (topo2α) transcription inhibitor exhibiting cytotoxicity towards undifferentiated, leukaemogenic hPSCs.</p>Fórmula:C11H8FN3O3Pureza:98% - 99.79%Forma y color:SolidPeso molecular:249.2HDAC-IN-5
CAS:<p>HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor.</p>Fórmula:C26H24F3N5O2SPureza:98%Forma y color:SolidPeso molecular:527.56Ertiprotafib
CAS:<p>Ertiprotafib (PTP 112), a PTP1B and IKK-β inhibitor, is a novel insulin sensitizer for the study of type 2 diabetes and breast cancer.</p>Fórmula:C31H27BrO3SPureza:98.70%Forma y color:SolidPeso molecular:559.51Sirt2-IN-1
CAS:<p>Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).</p>Fórmula:C28H27N7O2S2Pureza:99.57% - 99.84%Forma y color:SolidPeso molecular:557.69C-333H
CAS:C-333H is a new PPARalpha/gamma dual agonist.Fórmula:C28H26N2O6Pureza:98%Forma y color:SolidPeso molecular:486.52Guadecitabine sodium
CAS:<p>Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .</p>Fórmula:C18H24N9NaO10PPureza:98%Forma y color:SolidPeso molecular:580.407Topoisomerase I inhibitor 7
CAS:<p>Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I.</p>Fórmula:C22H19N3O5Forma y color:SolidPeso molecular:405.4Chiglitazar
CAS:Chiglitazar is a PPAR α/γ/δ agonist and insulin sensitizer used in the treatment of type 2 diabetes mellitus , anti-inflammatory and anti-fibrotic.Fórmula:C36H29FN2O4Forma y color:SolidPeso molecular:572.63LG100754
CAS:LG100754 (UVI 2112) is an insulin sensitizer and RXR modulator, antagonizing RXR homodimers while agonizing RXR:PPARα/γ heterodimers.Fórmula:C26H36O3Forma y color:SolidPeso molecular:396.569-Hydroxyellipticine hydrochloride
CAS:<p>9-Hydroxyellipticine hydrochloride is an inhibitor of Topo II and RyR, exhibits antitumor and antileukemic activity, and inhibits carrageenan gum-induced edema.</p>Fórmula:C17H15ClN2OPureza:98%Forma y color:SolidPeso molecular:298.77Topoisomerase II inhibitor 16
CAS:<p>Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of trypanosomal topoisomerase II, possessing the</p>Fórmula:C19H12F4N6OPureza:98%Forma y color:SolidPeso molecular:416.33Topoisomerase IV inhibitor 1
CAS:<p>Compound 7d: Inhibits TOPO IV (IC50: 0.23 μM), DNA gyrase (IC50: 0.43 μM), antibacterial against S. aureus (MIC: 0.972 μM), E. coli (MIC: 0.608 μM).</p>Fórmula:C34H32FN7O6SPureza:98%Forma y color:SolidPeso molecular:685.72PB131
CAS:<p>PB131, a selective and brain-permeable HDAC6 inhibitor, exhibits high binding affinity (IC50: 1.8 nM) and potent anti-inflammatory activity, making it suitable</p>Fórmula:C16H16FN3O2Pureza:98%Forma y color:SolidPeso molecular:301.32PARP10-IN-2
CAS:<p>PARP10-IN-2 is a potent inhibitor of PARP10, a mono-ADP-ribosyltransferase, with an IC50 value of 3.64 μM for human PARP10.PARP10-IN-2 also inhibited PARP2 and</p>Fórmula:C14H10N2O2Pureza:99.27%Forma y color:SolidPeso molecular:238.24NSC16168
CAS:NSC16168 is a selective ERCC1-XPF inhibitor that inhibits DNA repair and potentiates the antitumor activity of cisplatin.Fórmula:C17H15NO9S3Pureza:99.88%Forma y color:SolidPeso molecular:473.5Dehydroepiandrosterone sulfate
CAS:<p>Dehydroepiandrosterone sulfate (PB-005) influences the migration of neurons, arborization of dendrites, and formation of new synapses.</p>Fórmula:C19H28O5SPureza:97.18%Forma y color:SolidPeso molecular:368.49ISX-1
CAS:<p>ISX-1 inhibits adipogenesis and promotes osteoblastogenesis. ISX-1 can be used in studies about osteoporosis and osteopenia.</p>Fórmula:C14H14N4O2SPureza:98.7%Forma y color:SolidPeso molecular:302.35BRD4097
CAS:<p>BRD4097, a negative control in the HDAC1/2/3/8 assay, is a selective histone deacetylase (HDAC3) inhibitor that can be used to protect b-cells and improve</p>Fórmula:C16H17N3O2Pureza:99.75%Forma y color:SolidPeso molecular:283.33Linotroban
CAS:<p>Linotroban（CL-871502） is a potent selective thromboxane (TXA2) receptor antagonist with antithrombotic activity.</p>Fórmula:C14H15NO5S2Pureza:97.95% - >99.99%Forma y color:SolidPeso molecular:341.4BRD2492
CAS:<p>BRD2492 is an HDAC1 and HDAC2 inhibitor with antiproliferative activity, inhibits HDAC1/2 and induces apoptosis.</p>Fórmula:C20H18N4O2Pureza:99.56%Forma y color:SolidPeso molecular:346.38Dazmegrel
CAS:<p>Dazmegrel (UK 38,485) is a thromboxane A2 (TXA2) synthase inhibitor for the prevention of increased whole platelet aggregation in normal pregnancy.</p>Fórmula:C16H17N3O2Pureza:98.81%Forma y color:SolidPeso molecular:283.33Vutiglabridin
CAS:<p>Vutiglabridin (HSG4112), a PON2 modulator, is more stable and aids weight loss than Glabridin. In phase 2 trials for obesity, shows promise for PD therapy.</p>Fórmula:C22H26O4Pureza:98.47% - 99.07%Forma y color:SolidPeso molecular:354.44Cevoglitazar
CAS:Cevoglitazar (LBM-642) is a PPARɑ agonist and PPARγ agonist. Cevoglitazar potently reduces food intake and body weight in obese mice and cynomolgus monkeys.Fórmula:C27H21F3N2O6SPureza:97%Forma y color:SolidPeso molecular:558.53Chloroquinoxaline sulfonamide
CAS:Chloroquinoxaline sulfonamide (Chloroquinoxaline) is an organic micropollutant with antimicrobial activity.Fórmula:C14H11ClN4O2SPureza:99.79% - 99.89%Forma y color:SolidPeso molecular:334.78DN-1289
<p>DN-1289: oral, BBB-penetrating, selectively inhibits DLK (IC50=17nM) & LZK (IC50=40nM), blocks p-c-Jun in mouse optic nerve crush.</p>Fórmula:C18H19F4N7O2Pureza:98.56%Forma y color:SolidPeso molecular:441.38SIRT5 inhibitor 1
CAS:<p>SIRT5 inhibitor 1 targets human Sirtuin 5 deacylase, with an IC50 of 0.11 μM, linked to aging diseases.</p>Fórmula:C31H39FN6O6S2Pureza:97.8%Forma y color:SolidPeso molecular:674.81Cedazuridine
CAS:<p>Cedazuridine ((4R)-2'-Deoxy-2',2'-difluoro-3,4,5,6-tetrahydrouridine) is an oral inhibitor of cytidine deaminase with antineoplastic properties.</p>Fórmula:C9H14F2N2O5Pureza:99.66%Forma y color:SolidPeso molecular:268.21AGI-24512
CAS:<p>AGI-24512 is a inhibitor of methionine adenosyltransferase 2A (MATA2 ).It is useful for treatment of cancer and blocks growth of MTAP-deleted cancer cells in</p>Fórmula:C24H24N4O2Pureza:98.55%Forma y color:SolidPeso molecular:400.47Procainamide
CAS:<p>Procainamide: DNMT1 inhibitor, Class 1A antiarrhythmic, promising for cancer and arrhythmia research.</p>Fórmula:C13H21N3OPureza:99.92% - 99.92%Forma y color:SolidPeso molecular:235.33L82
CAS:<p>L82: A selective, non-competitive DNA Lig1 inhibitor with anti-proliferative effects on breast cancer cells. IC50=12 μM.</p>Fórmula:C11H8ClN5O4Pureza:97.45% - 98.91%Forma y color:SolidPeso molecular:309.67BTB09089
CAS:<p>BTB09089 (GPR65 agonist ) is a T cell death-associated gene 8 (TDAG8/GPR65)-specific agonist.BTB09089 induces TDAG8 expression and regulates cytokine production</p>Fórmula:C14H12Cl2N4OS2Pureza:99.78%Forma y color:SoildPeso molecular:387.31BRD 9757
CAS:<p>BRD 9757 (N-Hydroxy-1-cyclopentene-1-carboxamide) is a selective inhibitor of HDAC6 (IC50 = 30 nM).</p>Fórmula:C6H9NO2Pureza:98.39% - 99.87%Forma y color:SolidPeso molecular:127.14SIRT6-IN-5
CAS:<p>SIRT6-IN-5: potent, selective SIRT6 inhibitor; IC50=34 μM; immunosuppressive, enhances chemo, boosts H3K9 acetylation, glucose uptake, curbs T-cell growth.</p>Fórmula:C19H14N2O6Pureza:98.77%Forma y color:SolidPeso molecular:366.32HDAC8-IN-20a
CAS:<p>HDAC8-IN-20a (HDAC8 inhibitor-20a) is a potent and selective HDAC8 inhibitor with an IC50 of 27 nM.</p>Fórmula:C15H15NO4Pureza:98.24% - 99.22%Forma y color:SolidPeso molecular:273.28
