ADN-PK
La DNA-PK (quinasa dependiente de ADN) es una enzima clave involucrada en la reparación de rupturas de doble hebra de ADN a través de la vía de unión de extremos no homólogos (NHEJ). Los inhibidores de DNA-PK bloquean la actividad de esta quinasa, impidiendo la reparación de rupturas de ADN y provocando un aumento en la muerte celular, particularmente en células cancerosas. Los inhibidores de DNA-PK son herramientas valiosas en la investigación y terapia contra el cáncer, especialmente en combinación con otros tratamientos que dañan el ADN. En CymitQuimica, ofrecemos una gama completa de inhibidores de DNA-PK de alta calidad para apoyar su investigación en reparación de ADN, biología del cáncer y desarrollo terapéutico.
Se han encontrado 49 productos de "ADN-PK"
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KU-57788
CAS:NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).Fórmula:C25H19NO3SPureza:98% - >99.99%Forma y color:SolidPeso molecular:413.49Torin 2
CAS:Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.Fórmula:C24H15F3N4OPureza:98.31% - 99.32%Forma y color:SolidPeso molecular:432.4PIK-90
CAS:PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .
Fórmula:C18H17N5O3Pureza:98.25% - ≥95%Forma y color:SolidPeso molecular:351.36Leniolisib
CAS:Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).
Fórmula:C21H25F3N6O2Pureza:99.88%Forma y color:SolidPeso molecular:450.46Voxtalisib
CAS:Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Fórmula:C13H14N6OPureza:98.21% - 99.69%Forma y color:SolidPeso molecular:270.29Ref: TM-T7014
1mg38,00€2mg49,00€5mg79,00€10mg124,00€25mg240,00€50mg384,00€100mg560,00€1mL*10mM (DMSO)79,00€Samotolisib
CAS:Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.
Fórmula:C23H26N4O3Pureza:98.41% - 99.69%Forma y color:SolidPeso molecular:406.48PI3K-IN-1
CAS:PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.Fórmula:C31H29N5O6SPureza:97.03% - 98%Forma y color:SolidPeso molecular:599.66PIK-75 hydrochloride
CAS:PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.Fórmula:C16H14BrN5O4S·HClPureza:97.82%Forma y color:SolidPeso molecular:488.74PI-3065
CAS:PI-3065 is a novel potent and selective PI3K p110δ inhibitor.Fórmula:C27H31FN6OSPureza:99.84% - ≥95%Forma y color:SolidPeso molecular:506.64PIK-75
CAS:PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).
Fórmula:C16H14BrN5O4SPureza:98.52% - >99.99%Forma y color:SolidPeso molecular:452.28NU-7163
CAS:NU-7163 is a potent and selective inhibitor of ATP-competitive DNA-PK.Fórmula:C18H17NO3Pureza:98%Forma y color:SolidPeso molecular:295.33DNA-PK-IN-3
CAS:DNA-PK-IN-3 is a potent DNA-PK inhibitor, enhancing radio/chemotherapy and reducing tumors with limited side effects.Fórmula:C19H19N9OForma y color:SolidPeso molecular:389.41DNA-PK-IN-1
CAS:DNA-PK-IN-1 is a potent inhibitor of DNA-PK. DNA-PK-IN-1 has potential for cancer disease research.Fórmula:C23H26N8O2Forma y color:SolidPeso molecular:446.5DNA-PK-IN-5
CAS:DNA-PK-IN-5: potent DNA-PK inhibitor, reduces tumor repair, induces apoptosis, enhances radiotherapy, overcomes resistance.Fórmula:C21H22N8O2Forma y color:SolidPeso molecular:418.45DNA-PK-IN-7
CAS:DNA-PK-IN-7 is a potent DNA-PK inhibitor (IC50= 1 nM) (WO2021104277A1, compound 5).Fórmula:C19H21N9O2Forma y color:SolidPeso molecular:407.43DNA-PK-IN-4
CAS:DNA-PK-IN-4, an imidazolinone, targets DNA-PKcs to hinder tumor DNA repair and induce apoptosis, showing cancer research potential.Fórmula:C20H24N6O3Forma y color:SolidPeso molecular:396.44(R)-(-)-Rolipram
CAS:(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.Fórmula:C16H21NO3Pureza:99.54%Forma y color:SolidPeso molecular:275.34DNA-PK-IN-10
CAS:DNA-PK-IN-10 is a DNA-PK inhibitor utilized in the research of breast cancer and non-small cell lung cancer [1].Fórmula:C25H28N6O2Pureza:98%Forma y color:SolidPeso molecular:444.53SU-11752
CAS:SU-11752 selectively inhibits DNA-PK by competing with ATP, enhances ionizing radiation sensitivity without affecting cell cycle or ATM activity.Fórmula:C26H27N3O5SForma y color:SolidPeso molecular:493.57ZL-2201
CAS:ZL-2201 is a potent inhibitor of DNA-PK, demonstrating an IC50 value of 1 nM.Fórmula:C20H25N9O5SPureza:98%Forma y color:SolidPeso molecular:503.54
