Topoisomerasa
Las topoisomerasas son enzimas que regulan la topología del ADN durante procesos como la replicación, transcripción y segregación de cromosomas, introduciendo rupturas transitorias en las hebras de ADN para aliviar el estrés torsional. Los inhibidores de topoisomerasa interfieren con este proceso, lo que lleva a la acumulación de rupturas en el ADN y la inducción de la muerte celular, particularmente en células que se dividen rápidamente. Estos inhibidores se utilizan ampliamente como agentes quimioterapéuticos en el tratamiento del cáncer. En CymitQuimica, ofrecemos una amplia gama de inhibidores de topoisomerasa de alta calidad para apoyar su investigación en replicación del ADN, terapia contra el cáncer y regulación del ciclo celular.
Se han encontrado 133 productos de "Topoisomerasa"
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NH2-methylpropanamide-Exatecan TFA
CAS:Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.Fórmula:C30H30F4N4O7Pureza:98%Forma y color:SolidPeso molecular:634.58SDOX
CAS:SDOX, a prodrug, releases Doxorubicin selectively in high-GSH tumor cells, minimizing harm to healthy tissue.Fórmula:C69H97NO20S2Pureza:98%Forma y color:SolidPeso molecular:1324.63Gimatecan
CAS:Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Fórmula:C25H25N3O5Pureza:98.47%Forma y color:SolidPeso molecular:447.48Topotecan acetate
CAS:Topotecan acetate is an inhibitor of topoisomerase.Fórmula:C25H27N3O7Forma y color:SolidPeso molecular:481.498Topoisomerase I/II inhibitor 7
CAS:Compound 5h (Topoisomerase I/II inhibitor 7) is a Topoisomerase I/II inhibitor.Fórmula:C18H13ClN2O3Forma y color:SolidPeso molecular:340.76Topoisomerase II inhibitor 18
CAS:Topoisomerase II inhibitor 18 (Compound IV), a Quinoxaline derivative, exhibits an IC 50 of 7.5 μM in inhibiting topoisomerase II. It impedes PC-3 cell proliferation, arrests the cell cycle at the S phase, and induces apoptosis. Moreover, this compound demonstrates substantial antitumor activity against cancer [1].Fórmula:C20H21N3OSForma y color:SolidPeso molecular:351.47LMP517
CAS:LMP517 (NSC 781517), an indenoisoquinoline, is a potent dual TOP1 and TOP2 inhibitor that shows better antitumor activity than its parent compound LMP744 against H82 (Small Cell Lung Cancer) xenografts, inducing TOP1 cleavage complexes (TOP1ccs) and TOP2ccs [1].Fórmula:C22H19FN2O5Forma y color:SolidPeso molecular:410.4Karenitecin
CAS:Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
Fórmula:C25H28N2O4SiPureza:98%Forma y color:SolidPeso molecular:448.59Anticancer agent 215
CAS:Anticanceragent 215 (1) is a camptothecin derivative with IC50 values of 5.2 nM and 8.2 nM against MCF-7 and MDA-MB-231 cells, respectively.Fórmula:C23H22FN3O4Forma y color:SolidPeso molecular:423.44Intoplicine
CAS:Intoplicine is an inhibitor of DNA topoisomerase I and II.Fórmula:C21H24N4OPureza:98%Forma y color:SolidPeso molecular:348.44Saintopin
CAS:Saintopin is an antitumor antibiotic and an inhibitor of DNA topoisomerases I and II, which induces DNA cleavage [1] [2].Fórmula:C18H10O7Forma y color:SolidPeso molecular:338.27Edotecarin
CAS:Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).Fórmula:C29H28N4O11Pureza:98%Forma y color:SolidPeso molecular:608.55TH1338
CAS:TH1338 is an orally active camptothecin derivative with significant blood-brain barrier permeability and cytotoxicity, used in cancer research.
Fórmula:C22H21N3O4Pureza:98.77%Forma y color:SolidPeso molecular:391.42
