ADN metiltransferasa
Las metiltransferasas de ADN (DNMT) son enzimas que catalizan la adición de grupos metilo a los residuos de citosina en el ADN, lo que lleva al silenciamiento génico. La metilación aberrante del ADN está asociada con diversas enfermedades, incluido el cáncer. Los inhibidores de DNMT bloquean la actividad de estas enzimas, lo que lleva a la reactivación de genes silenciados y la inducción de apoptosis en células cancerosas. Los inhibidores de DNMT se utilizan ampliamente en la investigación epigenética y la terapia contra el cáncer. En CymitQuimica, ofrecemos una gama de inhibidores de DNMT de alta calidad para apoyar su investigación en epigenética, metilación del ADN y biología del cáncer.
Se han encontrado 422 productos de "ADN metiltransferasa"
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(Rac)-RG108
CAS:<p>(Rac)-RG108 (NSC401077) is an inhibitor of DNMT1, effectively blocking DNA methyltransferases.</p>Fórmula:C19H14N2O4Forma y color:SolidPeso molecular:334.326CARM1-IN-3 dihydrochloride
<p>CARM1-IN-3 dihydrochloride (17b) is a potent CARM1 inhibitor (IC50: 0.07 μM) with selectivity over CARM3 (IC50 >25 μM).</p>Fórmula:C24H34Cl2N4O2Forma y color:SolidPeso molecular:481.46W4275
CAS:<p>W4275 (Compound 42) is a selective NSD2 inhibitor with oral activity and an IC50 of 17 nM. It exhibits antiproliferative activity, with an IC50 of 230 nM against RS411 cells, and significantly inhibits tumor growth in an RS411 tumor xenograft model. Pharmacokinetic analysis in mice shows that W4275 has a favorable oral bioavailability (F is 27.34%). W4275 holds potential for use in cancer research.</p>Fórmula:C25H36N6O3Forma y color:SolidPeso molecular:468.59AMI-408
CAS:<p>AMI-408 is a PRMT1 inhibitor that effectively reduces the levels of H4R3me2as in MLL-GAS7 leukemia cells.</p>Fórmula:C20H13Cl2N6NaO5SForma y color:SolidPeso molecular:543.32PRMT5-IN-1
CAS:<p>PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).</p>Fórmula:C19H19ClN4O5Pureza:98%Forma y color:SolidPeso molecular:418.83Dot1L-IN-1
CAS:<p>The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.</p>Fórmula:C32H36ClN9O2SPureza:98%Forma y color:SolidPeso molecular:646.21GSK3368715
CAS:<p>GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s</p>Fórmula:C20H38N4O2Pureza:98%Forma y color:SolidPeso molecular:366.54MM-589 TFA
CAS:<p>MM-589 TFA is a potent WD repeat domain 5 (WDR5)inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.</p>Fórmula:C30H45F3N8O7Pureza:98%Forma y color:SolidPeso molecular:686.72PRMT5-IN-18
CAS:<p>PRMT5-IN-18 (Compound 002) is a potent inhibitor of PRMT5 and can be used in the study of PRMT5-mediated diseases, such as tumours.</p>Fórmula:C32H42N4O4Forma y color:SolidPeso molecular:546.70PRMT5-IN-48
CAS:<p>PRMT5-IN-48 (compound D3) is an orally active PRMT5 inhibitor with an IC50 of 20.7 nM, displaying antitumor activity. It effectively suppresses the growth of various cancer cells, induces apoptosis, and causes cell cycle arrest at the G0/G1 phase. PRMT5-IN-48 is applicable for research in non-Hodgkin's lymphoma (NHL).</p>Fórmula:C30H37N5O3Forma y color:SolidPeso molecular:515.646AMG-193
CAS:<p>AMG-193 is an inhibitor of the MTA-PRMT5 complex and is used in the study of cancer, respiratory diseases and digestive disorders.</p>Fórmula:C22H19F3N4O3Pureza:99.52%Forma y color:SolidPeso molecular:444.41ORIC-944
CAS:<p>ORIC-944 is an orally available, selective variant of PRC2 with anticancer activity for the study of prostate cancer.</p>Fórmula:C26H25FN6OPureza:98.08%Forma y color:SolidPeso molecular:456.52EZM0414
CAS:<p>EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 with IC50 of 18 nM in SETD2 biochemical assay and IC50 of 34 nM in a cellular assay.</p>Fórmula:C22H29FN4O2Pureza:99.58%Forma y color:SolidPeso molecular:400.49LLY-283
CAS:<p>LLY-283, PRMT5 inhibitor, IC50 22 nM, Kd 6 nM, oral, selective, with antitumor effects.</p>Fórmula:C17H18N4O4Pureza:99.49%Forma y color:SolidPeso molecular:342.35GSK3368715 dihydrochloride
CAS:<p>GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is a PRMTs inhibitor , with anticancer activity, for the study of advanced solid tumors.</p>Fórmula:C20H40Cl2N4O2Pureza:99.66% - 99.66%Forma y color:SolidPeso molecular:439.46BRD0639
CAS:<p>BRD0639 is a first-in-class PRMT5-substrate interaction inhibitor for PBM-dependent PRMT5 activity studies.</p>Fórmula:C21H22ClN5O4SPureza:99.85%Forma y color:SolidPeso molecular:475.95Sinefungin
CAS:<p>Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral</p>Fórmula:C15H23N7O5Pureza:98.12%Forma y color:SolidPeso molecular:381.39EHMT2-IN-2
CAS:<p>EHMT2-IN-2 Used in the research of blood disease or cancer. EHMT2-IN-2 is a potent EHMT inhibitor, with IC50s of all <100 nM for EHMT1 peptide, EHMT2 peptide and cellular EHMT2.</p>Fórmula:C21H22N6OForma y color:SolidPeso molecular:374.44CARM1-IN-1 hydrochloride
CAS:<p>CARM1-IN-1 hydrochloride is a potent and selective inhibitor of CARM1 (IC50: 8.6 μM) with minimal inhibition of PRMT1 and SET7.</p>Fórmula:C26H22Br2ClNO3Forma y color:SolidPeso molecular:591.72BLL5 Maleate
CAS:<p>BLL5 Maleate is a first-in-class selective PRMT5 inhibitor, it blocks EBV-driven B lymphocyte transformation and survival while leaving normal B cells unaffected.</p>Fórmula:C21H21N3Pureza:98%Forma y color:SolidPeso molecular:315.41Igermetostat
CAS:<p>Igermetostat, an EZH2 inhibitor, is utilized both in vivo and in vitro for cancer research [1].</p>Fórmula:C32H46N4O4Pureza:98%Forma y color:SolidPeso molecular:550.73BBDDL2059
CAS:<p>BBDDL2059 is a selective covalent inhibitor targeting EZH2, exhibiting an IC50 of 1.5 nM against the EZH2-Y641F mutant.</p>Fórmula:C27H36N4O4SPureza:98%Forma y color:SolidPeso molecular:512.66Ref: TM-T79200
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