ADN metiltransferasa
Las metiltransferasas de ADN (DNMT) son enzimas que catalizan la adición de grupos metilo a los residuos de citosina en el ADN, lo que lleva al silenciamiento génico. La metilación aberrante del ADN está asociada con diversas enfermedades, incluido el cáncer. Los inhibidores de DNMT bloquean la actividad de estas enzimas, lo que lleva a la reactivación de genes silenciados y la inducción de apoptosis en células cancerosas. Los inhibidores de DNMT se utilizan ampliamente en la investigación epigenética y la terapia contra el cáncer. En CymitQuimica, ofrecemos una gama de inhibidores de DNMT de alta calidad para apoyar su investigación en epigenética, metilación del ADN y biología del cáncer.
Se han encontrado 422 productos de "ADN metiltransferasa"
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GSK591
CAS:<p>GSK591 (GSK3203591), Alternative Names are EPZ015866, GSK3203591, is a potent selective inhibitor of the arginine methyltransferase PRMT5 (IC50=11 nM).</p>Fórmula:C22H28N4O2Pureza:99.35% - 99.45%Forma y color:SolidPeso molecular:380.48Succinic acid sodium
CAS:<p>Succinic acid sodium is an orally active anxiolytic.</p>Fórmula:C4H6O4·xNaForma y color:SolidPiribedil
CAS:<p>Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease.</p>Fórmula:C16H18N4O2Pureza:99.79% - 99.82%Forma y color:SolidPeso molecular:298.34CM-272
CAS:<p>CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.</p>Fórmula:C28H38N4O3Pureza:97.83%Forma y color:SolidPeso molecular:478.633-deazaneplanocin A HCl
CAS:<p>3-deazaneplanocin A HCl is both an S-adenosyl-l-homocysteine hydrolase inhibitor and an enhancer of zeste homolog 2(EZH2) inhibitor.</p>Fórmula:C12H15ClN4O3Pureza:93.24% - 98.9%Forma y color:SolidPeso molecular:298.73UNC3866 TFA(1872382-47-2 free base)
CAS:<p>UNC3866 TFA is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.</p>Fórmula:C45H67F3N6O10Pureza:98.43%Forma y color:SolidPeso molecular:909.04EPZ005687
CAS:<p>EPZ005687 is a potent and selective inhibitor of EZH2.</p>Fórmula:C32H37N5O3Pureza:97.06% - 99.64%Forma y color:SolidPeso molecular:539.67Amodiaquine
CAS:<p>Amodiaquine is a synthetic aminoquinoline, used to treat malaria.</p>Fórmula:C20H22ClN3OPureza:99.78% - 99.99%Forma y color:Crystals From Absolute Ethanol SolidPeso molecular:355.86GSK3685032
CAS:<p>GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM).</p>Fórmula:C22H24N6OSPureza:98.56% - 99.49%Forma y color:SolidPeso molecular:420.53SETDB1-TTD-IN-1 TFA
<p>SETDB1-TTD-IN-1 TFA: potent, selective SETDB1-TTD inhibitor (Kd: 88 nM), useful for related biological research.</p>Fórmula:C30H32F3N5O4Forma y color:SolidPeso molecular:583.6GSK126
CAS:<p>GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).</p>Fórmula:C31H38N6O2Pureza:98% - 99.67%Forma y color:SolidPeso molecular:526.67EED226
CAS:<p>EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.</p>Fórmula:C17H15N5O3SPureza:98.14% - 99.33%Forma y color:SolidPeso molecular:369.4GSK3326595
CAS:<p>GSK3326595 (EPZ015938) is an inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50:6.2 nM.).</p>Fórmula:C24H32N6O3Pureza:97.7% - 99.63%Forma y color:SolidPeso molecular:452.55A-196
CAS:<p>A-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over</p>Fórmula:C18H16Cl2N4Pureza:99.92%Forma y color:SolidPeso molecular:359.25JNJ-64619178
CAS:<p>JNJ-64619178: selective, oral, pseudo-irreversible PRMT5 inhibitor (IC50: 0.14 nM), effective in lung cancer.</p>Fórmula:C22H23BrN6O2Pureza:98.44% - 99.63%Forma y color:SolidPeso molecular:483.36MM-102 TFA
CAS:<p>MM-102 TFA is a potent WDR5/MLL inhibitor with IC50 of 2.4 nM; it disrupts MLL1-WDR5 interaction, impeding H3K4 HMT activity.</p>Fórmula:C37H50F5N7O6Pureza:99.4% - 99.78%Forma y color:SolidPeso molecular:783.83JQEZ5
CAS:<p>JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM).</p>Fórmula:C30H38N8O2Pureza:98.14% - ≥98%Forma y color:SolidPeso molecular:542.68WDR5-0103
CAS:<p>WDR5-0103 (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd: 450 nM).</p>Fórmula:C21H25N3O4Pureza:98% - 99.61%Forma y color:SolidPeso molecular:383.44C-7280948
CAS:<p>C-7280948 is a PRMT1 inhibitor.</p>Fórmula:C14H16N2O2SPureza:99.55% - ≥95%Forma y color:SolidPeso molecular:276.35MIV-6R
CAS:<p>MIV-6R inhibits Menin-MLL interaction (IC50: 56 nM) and can be used to study leukemia.</p>Fórmula:C27H35N3OPureza:99.81% - 99.88%Forma y color:SolidPeso molecular:417.59
