ADN metiltransferasa
Las metiltransferasas de ADN (DNMT) son enzimas que catalizan la adición de grupos metilo a los residuos de citosina en el ADN, lo que lleva al silenciamiento génico. La metilación aberrante del ADN está asociada con diversas enfermedades, incluido el cáncer. Los inhibidores de DNMT bloquean la actividad de estas enzimas, lo que lleva a la reactivación de genes silenciados y la inducción de apoptosis en células cancerosas. Los inhibidores de DNMT se utilizan ampliamente en la investigación epigenética y la terapia contra el cáncer. En CymitQuimica, ofrecemos una gama de inhibidores de DNMT de alta calidad para apoyar su investigación en epigenética, metilación del ADN y biología del cáncer.
Se han encontrado 421 productos de "ADN metiltransferasa"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
(R)-OR-S1
CAS:<p>(R)-OR-S1 is a SAM-competitive, highly selective, orally bioavailable dual inhibitor of EZH1/2.</p>Fórmula:C26H34BrN3O4Pureza:98%Forma y color:SolidPeso molecular:532.47MS453
CAS:<p>MS453 is a potent and selective SETD8 inhibitor with an IC50 value of 804 nM.</p>Fórmula:C20H27N5O3Forma y color:SolidPeso molecular:385.46S-Aristeromycinylhomocysteine
CAS:<p>S-Aristeromycinylhomocysteine is an inhibitor of adenosylmethionine decarboxylase.</p>Fórmula:C15H22N6O4SForma y color:SolidPeso molecular:382.44DS-437
CAS:<p>DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3.</p>Fórmula:C15H23N7O4SPureza:98%Forma y color:SolidPeso molecular:397.45ZLD10A
CAS:<p>ZLD10A is a highly potent and selective small molecule inhibitor of EZH2.</p>Fórmula:C37H48N4O4Pureza:98%Forma y color:SolidPeso molecular:612.8LEM-14-1189
CAS:<p>LEM-14-1189 inhibits NSD1/2/3 (IC50: 418/111/60 μM), targets nuclear receptors, and may treat cancer and blood diseases.</p>Fórmula:C35H34N6O5S2Pureza:98.06%Forma y color:SolidPeso molecular:682.81OTS186935 trihydrochloride
CAS:<p>OTS186935 trihydrochloride is a protein methyltransferase inhibitor of SUV39H2(IC50 of 6.49 nM).</p>Fórmula:C25H29Cl4N5O2Pureza:98%Forma y color:SolidPeso molecular:573.34Dot1L-IN-5
CAS:<p>Dot1L-IN-5 is a potent inhibitor of the disruptor of telomeric silencing 1-like protein ( DOT1L ) with an IC 50 SPA DOT1L of 0.17 nM [1].</p>Fórmula:C23H19ClF2N8O5SForma y color:SolidPeso molecular:592.96Valemetostat tosylate
CAS:<p>Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.</p>Fórmula:C33H42ClN3O7SPureza:98%Forma y color:SolidPeso molecular:660.22Furamidine dihydrochloride
CAS:<p>Furamidine dihydrochloride is a cell-permeable, selective PRMT1 inhibitor that also binds AT-rich DNA. It blocks proliferation in leukemia cell lines.</p>Fórmula:C18H18Cl2N4OPureza:98.16%Forma y color:SolidPeso molecular:377.27MM-102
CAS:<p>MM-102 (HMTase Inhibitor IX) is a potent inhibitor of WDR5/MLL interaction with IC50 of 2.4 nM and Ki of less than 1 nM in a WDR5 binding assay.Cost-effective and quality-assured.</p>Fórmula:C35H49F2N7O4Pureza:98.77% - 99.99%Forma y color:SolidPeso molecular:669.8SW155246
CAS:<p>SW155246 is a potent and selective inhibitor of DNMT1 (DNA methyltransferase 1; IC50 of 1.2 μM).</p>Fórmula:C16H11ClN2O5SPureza:98.99%Forma y color:SolidPeso molecular:378.79EPZ032597
CAS:<p>EPZ032597 is a novel selective inhibitor of SMYD2 with an IC50 of 16 nM. EPZ032597 has anticancer activity and prevent and treat pancreatic cancer</p>Fórmula:C20H23N7OPureza:99.70%Forma y color:SolidPeso molecular:377.44PRMT4-IN-1
CAS:<p>PRMT4-IN-1 is a selective inhibitor of PRMT4, demonstrating an IC50 value of 3.2 nM, and has been shown to reduce the relative viability of MCF7 cells [1].</p>Fórmula:C23H28FN3OPureza:98%Forma y color:SolidPeso molecular:381.49EZH2-IN-3
CAS:<p>EZH2-IN-3 is an inhibitor of EZH2 and EZH1 with selective impact on diffuse large B cell lymphoma cell growth.</p>Fórmula:C27H28ClN5O2Pureza:98%Forma y color:SolidPeso molecular:490Dot1L-IN-7
CAS:<p>Dot1L-IN-7 (compound 25), a potent DOT1L inhibitor with an IC50 of 1.0 μM, selectively kills MLL-AF9, sparing E2A-HLF cells.</p>Fórmula:C23H27N9O2Forma y color:SolidPeso molecular:461.52SMYD2-IN-1
CAS:<p>SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).</p>Fórmula:C25H25Cl2F2N7O2Pureza:98%Forma y color:SolidPeso molecular:564.416-Methyl-5-azacytidine
CAS:<p>6-Methyl-5-azacytidine is a potent DNMT inhibitor.</p>Fórmula:C9H14N4O5Pureza:98%Forma y color:SolidPeso molecular:258.23F5446
CAS:<p>F5446 is a selective small molecule SUV39H1 methyltransferase inhibitor, promotes apoptosis in colorectal cancer cells by inhibiting the deposition of H3K9me3.</p>Fórmula:C26H17ClN2O8SPureza:98.56%Forma y color:SolidPeso molecular:552.94Tetrahydrouridine
CAS:<p>Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.</p>Fórmula:C9H16N2O6Pureza:98%Forma y color:SolidPeso molecular:248.23
