ADN metiltransferasa
Las metiltransferasas de ADN (DNMT) son enzimas que catalizan la adición de grupos metilo a los residuos de citosina en el ADN, lo que lleva al silenciamiento génico. La metilación aberrante del ADN está asociada con diversas enfermedades, incluido el cáncer. Los inhibidores de DNMT bloquean la actividad de estas enzimas, lo que lleva a la reactivación de genes silenciados y la inducción de apoptosis en células cancerosas. Los inhibidores de DNMT se utilizan ampliamente en la investigación epigenética y la terapia contra el cáncer. En CymitQuimica, ofrecemos una gama de inhibidores de DNMT de alta calidad para apoyar su investigación en epigenética, metilación del ADN y biología del cáncer.
Se han encontrado 421 productos de "ADN metiltransferasa"
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DC_517
CAS:<p>DC_517 is an inhibitor of DNA methyltransferase 1 (DNMT1) ( IC50: 1.7 μM; Kd: 0.91 μM).</p>Fórmula:C33H35N3O2Forma y color:SolidPeso molecular:505.65EML741
CAS:<p>EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b.</p>Fórmula:C31H49N5O2Pureza:98%Forma y color:SolidPeso molecular:523.75DCE_42
CAS:<p>DCE_42 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines.</p>Fórmula:C22H19N9O2SPureza:98%Forma y color:SolidPeso molecular:473.51Furamidine
CAS:<p>Furamidine is a PRMT1-selective, cell-permeable inhibitor (IC50: 9.4μM), also targeting TDP-1, and is an antiparasitic bisbenzamidine derivative.</p>Fórmula:C18H16N4OPureza:98%Forma y color:SolidPeso molecular:304.35CMP-5 hydrochloride
CAS:<p>CMP-5 hydrochloride: potent, selective PRMT5 inhibitor; inactive against PRMT1/4/7; blocks S2Me-H4R3 on histones.</p>Fórmula:C21H22ClN3Pureza:98%Forma y color:SolidPeso molecular:351.87EZM 2302
CAS:<p>EZM 2302 (GSK3359088) is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM).Cost-effective and quality-assured.</p>Fórmula:C29H37ClN6O5Pureza:97.47% - ≥98%Forma y color:SolidPeso molecular:585.09BIX-01338 hydrate
CAS:<p>BIX-01338 hydrate is an inhibitor of histone lysine methyltransferase.</p>Fórmula:C32H26F3N3O7Pureza:98%Forma y color:SolidPeso molecular:621.56Dot1L-IN-2
CAS:<p>Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively</p>Fórmula:C27H24N8OPureza:98%Forma y color:SolidPeso molecular:476.53PRMT5-IN-C17
CAS:<p>PRMT5-IN-C17 is a novel potent, selective, and cell active protein arginine methyltransferase 5 (PRMT5) inhibitor.</p>Fórmula:C18H17N3O4SForma y color:SolidPeso molecular:371.415WKS
CAS:<p>5WKS, or ZINC97756584, is a G9a inhibitor targeting H3K9me2 for gene silencing research in autoimmune diseases and tumors.</p>Fórmula:C24H36ClN5O2Pureza:98%Forma y color:SolidPeso molecular:462.03WDR5-IN-4
CAS:<p>WIN site inhibitor 1 is a WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5) inhibitor (Kd: 0.1 nM), with anti-cancer activity.</p>Fórmula:C25H22Cl2FN5OPureza:98%Forma y color:SolidPeso molecular:498.38RSC-133
CAS:<p>promotes the reprogramming of human somatic cells to pluripotent stem cells</p>Fórmula:C18H15N3O2Pureza:98%Forma y color:SolidPeso molecular:305.33OTS186935
CAS:OTS186935 is a inhibitor of protein methyltransferase SUV39H2(IC50 of 6.49 nM).Fórmula:C25H26ClN5O2Pureza:98%Forma y color:SolidPeso molecular:463.96Guadecitabine sodium
CAS:<p>Guadecitabine sodium is a inhibitor of second-generation DNA methyltransferases (DNMT) .</p>Fórmula:C18H24N9NaO10PPureza:98%Forma y color:SolidPeso molecular:580.407TFMB-(S)-2-HG
CAS:<p>TFMB-(S)-2-HG (TFMB S 2 HG) is a highly effective inhibitor of TET2, the 5'-methylcytosine hydroxylase.</p>Fórmula:C13H11F3O4Pureza:98.07%Forma y color:SolidPeso molecular:288.22UNC2327
CAS:<p>UNC2327 is a potent and selective inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50:230 nM).</p>Fórmula:C14H17N5O2SPureza:98%Forma y color:SolidPeso molecular:319.38SGC6870
CAS:<p>SGC6870 is a novel potent, selective, and cell-active inhibitor of PRMT6 with IC50 of 77 ± 6 nM, being selective over all other PRMTs and 23 methyltransferases.</p>Fórmula:C23H21BrN2O2SForma y color:SolidPeso molecular:469.39CM-579
CAS:<p>CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.</p>Fórmula:C29H40N4O3Pureza:99.23%Forma y color:SolidPeso molecular:492.65NSC-311068
CAS:<p>NSC-311068: A selective TET1 inhibitor, reducing 5hmC and AML cell viability with high TET1.</p>Fórmula:C10H6N4O4SForma y color:SolidPeso molecular:278.24DNMT3A-IN-1
CAS:<p>DNMT3A-IN-1 is a potent, selective DNMT3A inhibitor with KI 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC).</p>Fórmula:C30H38N6O4Forma y color:SolidPeso molecular:546.66
