ADN metiltransferasa
Las metiltransferasas de ADN (DNMT) son enzimas que catalizan la adición de grupos metilo a los residuos de citosina en el ADN, lo que lleva al silenciamiento génico. La metilación aberrante del ADN está asociada con diversas enfermedades, incluido el cáncer. Los inhibidores de DNMT bloquean la actividad de estas enzimas, lo que lleva a la reactivación de genes silenciados y la inducción de apoptosis en células cancerosas. Los inhibidores de DNMT se utilizan ampliamente en la investigación epigenética y la terapia contra el cáncer. En CymitQuimica, ofrecemos una gama de inhibidores de DNMT de alta calidad para apoyar su investigación en epigenética, metilación del ADN y biología del cáncer.
Se han encontrado 421 productos de "ADN metiltransferasa"
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GNA002
CAS:<p>GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).</p>Fórmula:C42H55NO8Pureza:98%Forma y color:SolidPeso molecular:701.89EZH2-IN-11
CAS:<p>EZH2-IN-11, a potent E2HZ inhibitor with potential for cancer treatment, is highlighted in patent WO2019204490A1.</p>Fórmula:C28H36ClN3O5SForma y color:SolidPeso molecular:562.12EZH2-IN-9
CAS:<p>EZH2-IN-9 inhibits EZH2, targeting SET mutations linked to cancer by reducing H3K27me3 levels.</p>Fórmula:C28H32ClF2N3O5SForma y color:SolidPeso molecular:596.09AA-CW236
CAS:<p>AA-CW236 is a covalent inhibitor of human O(6)-alkylguanine DNA methyltransferase (MGMT).</p>Fórmula:C17H16ClF3N4O2Forma y color:SolidPeso molecular:400.78NSD3-IN-1
CAS:<p>NSD3-IN-1, a histone methyltransferase NSD3 inhibitor, demonstrates an IC50 of 28.58 μM.</p>Fórmula:C13H13N5OSForma y color:SolidPeso molecular:287.34ZLD1039
CAS:<p>ZLD1039, an oral EZH2 inhibitor, shows strong PRC2 inhibition at low nanomolar IC50s, and halts breast cancer growth and spread.</p>Fórmula:C36H48N6O3Pureza:99.5%Forma y color:SolidPeso molecular:612.8BI-9321
CAS:<p>BI-9321: Selective NSD3-PWWP1 antagonist, Kd 166 nM. Inactive against NSD2-PWWP1/NSD3-PWWP2.</p>Fórmula:C22H21FN4Pureza:98%Forma y color:SolidPeso molecular:360.43CPI-905
CAS:<p>CPI-905 is a potent and selective EZH2 inhibitor with IC50 value of 39.5 nM.</p>Fórmula:C18H20N2O5Forma y color:SolidPeso molecular:344.36UNC0379 TFA
CAS:<p>UNC0379 TFA inhibits SETD8 (IC50: 7.3 μM), selective for 15+ methyltransferases.</p>Fórmula:C25H36F3N5O4Forma y color:SolidPeso molecular:527.589DDO-2093 dihydrochloride
<p>DDO-2093 dihydrochloride: potent MLL1-WDR5 inhibitor, IC50=8.6 nM, Kd=11.6 nM, antitumor.</p>Fórmula:C29H39Cl3FN9O3Forma y color:SolidPeso molecular:687.04BAY-598 R-isomer
CAS:<p>BAY-598 R-isomer, a SMYD2-selective inhibitor, is the R-enantiomer of BAY589, not targeting PAR1.</p>Fórmula:C22H20Cl2F2N6O3Forma y color:SolidPeso molecular:525.34PRMT5-IN-10
CAS:<p>PRMT5-IN-10 exhibits promising structure-dependent inhibitory effect on the protein methyltransferase PRMT5:MEP50 complex.</p>Fórmula:C13H17N5O4Forma y color:SolidPeso molecular:307.31DCE_254
CAS:<p>DCE_254 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines.</p>Fórmula:C21H17N9OSPureza:98%Forma y color:SolidPeso molecular:443.48Dihydro-5-azacytidine acetate
CAS:<p>Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1</p>Fórmula:C10H18N4O7Pureza:98%Forma y color:SolidPeso molecular:306.27CSV0C018875
CAS:<p>CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor with lower cytotoxicity than BIX-01294 [1].</p>Fórmula:C18H17ClN2OForma y color:SolidPeso molecular:312.79NSD3-IN-2
CAS:<p>NSD3-IN-2: Potent NSD3 inhibitor, IC50 17.97μM, halts NSCLC growth (H460, H1299, H1650) with anticancer effects.</p>Fórmula:C17H15N5OSForma y color:SolidPeso molecular:337.4EZH2-IN-7
CAS:<p>EZH2-IN-7 inhibits EZH2, reducing H3K27me3 and tumor growth (e.g., breast, prostate cancer, leukemia). Potential in cancer research.</p>Fórmula:C31H37D2N5O3SForma y color:SolidPeso molecular:563.755-Aza-4'-thio-2'-deoxycytidine
CAS:<p>5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd), a sulfur-containing deoxy-cytidine analog, serves as an orally active inhibitor of DNA methyltransferase I (DNMT1). It exhibits potential antitumor effects and DNA hypomethylating properties [1].</p>Fórmula:C8H12N4O3SForma y color:SolidPeso molecular:244.27NSD3-IN-3
CAS:<p>"NSD3-IN-3, a potent anticancer agent, inhibits NSD3 (IC50: 1.86 μM) and hampers H460 lung cancer cell growth."</p>Fórmula:C15H17N5O2SForma y color:SolidPeso molecular:331.39G9a-IN-2
CAS:<p>G9a-IN-2 (Compound 7i) is an inhibitor of the histone methyltransferase G9a, with an IC50 of 0.024 μM. It can reduce the levels of H3K9me2 and induce the expression of γ-globin mRNA. G9a-IN-2 shows potential for improving Sickle Cell Disease (SCD).</p>Fórmula:C30H42N4O4Forma y color:SolidPeso molecular:522.68
