ADN metiltransferasa
Las metiltransferasas de ADN (DNMT) son enzimas que catalizan la adición de grupos metilo a los residuos de citosina en el ADN, lo que lleva al silenciamiento génico. La metilación aberrante del ADN está asociada con diversas enfermedades, incluido el cáncer. Los inhibidores de DNMT bloquean la actividad de estas enzimas, lo que lleva a la reactivación de genes silenciados y la inducción de apoptosis en células cancerosas. Los inhibidores de DNMT se utilizan ampliamente en la investigación epigenética y la terapia contra el cáncer. En CymitQuimica, ofrecemos una gama de inhibidores de DNMT de alta calidad para apoyar su investigación en epigenética, metilación del ADN y biología del cáncer.
Se han encontrado 421 productos de "ADN metiltransferasa"
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LEM-14
CAS:<p>LEM-14 is a potent NSD2-specific inhibitor (IC50:132 μM).LEM-14 may be used in the study of multiple myeloma.</p>Fórmula:C25H26N4O4SPureza:98.3%Forma y color:SolidPeso molecular:478.56UNC0321
CAS:<p>UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays.</p>Fórmula:C27H45N7O3Pureza:99.80%Forma y color:SolidPeso molecular:515.69MS0124
CAS:<p>MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.</p>Fórmula:C20H29N5O3Pureza:98.97%Forma y color:SolidPeso molecular:387.48RK-0133114
<p>RK-0133114, R-enantiomer of RK-701, is a G9a inhibitor (IC50 = 3.7 μM) for SCD research.</p>Fórmula:C26H30N4O3Forma y color:SolidPeso molecular:446.54MAK683-CH2CH2COOH
CAS:<p>MAK683-CH2CH2COOH, an EED-targeting chemical, serves as a foundation for EED degrader-1 and PROTAC EED degrader-2 design.</p>Fórmula:C23H21FN6O3Pureza:98%Forma y color:SolidPeso molecular:448.45PRMT5-IN-16
CAS:<p>PRMT5-IN-16 (Compound 20) is an antitumor PRMT5 inhibitor linked to epigenetic changes.</p>Fórmula:C25H34N8O2Forma y color:SolidPeso molecular:478.59EPZ011989 HCl(1598383-40-4 Free base)
CAS:<p>EPZ011989 is a highly potent and selective oral EZH2 inhibitor with Ki value <3 nM.</p>Fórmula:C35H51N5O4·HClForma y color:SolidPeso molecular:642.27DY-46-2
CAS:<p>DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is used in cancer and tumor research.</p>Fórmula:C19H22N6O5SPureza:99.12% - 99.12%Forma y color:SolidPeso molecular:446.48CM-579 trihydrochloride (1846570-40-8 free base)
<p>CM-579 trihydrochloride is a first-in-class reversible and dual inhibitor of G9a and DNMT (IC50s: 16 nM, 32 nM) with potent in vitro cellular activity in a wide</p>Fórmula:C29H43Cl3N4O3Pureza:98%Forma y color:SolidPeso molecular:602.04EZH2-IN-14
CAS:<p>EZH2-IN-14 selectively inhibits EZH2 at 12 nM IC50, has >200-fold specificity over EZH1, reducing H3K27me3 levels.</p>Fórmula:C31H39N7O2Forma y color:SolidPeso molecular:541.69PRMT5-IN-25
CAS:<p>PRMT5-IN-25 (compound 503) is a potent inhibitor of PRMT5, exhibiting an inhibition constant (K i) of 0.06 nM and demonstrating antiproliferative properties [1</p>Fórmula:C24H21F3N6OPureza:98%Forma y color:SolidPeso molecular:466.46GSK-3484862
CAS:<p>Gsk-3484862 is a non covalent inhibitor of DNA methyltransferase DNMT1 with anticancer activity.</p>Fórmula:C19H19N5OSPureza:99.87% - 99.963%Forma y color:SolidPeso molecular:365.45UNC8153 TFA
CAS:<p>UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating a</p>Fórmula:C35H38F3N5O7Pureza:96.44%Forma y color:SolidPeso molecular:697.7SMYD3-IN-1
CAS:<p>SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).</p>Fórmula:C28H31ClN4O3Pureza:98%Forma y color:SolidPeso molecular:507.02Bisegliptin
CAS:<p>Bisegliptin(KRP-104) is a small molecule compound with anti-diabetic activity.</p>Fórmula:C18H26FN3O3Pureza:98%Forma y color:SolidPeso molecular:351.42PRMT5-IN-28
CAS:<p>PRMT5-IN-28 (compound 36) serves as an inhibitor of the protein arginine methyltransferase 5 (PRMT5) enzyme, which is implicated in various cellular processes</p>Fórmula:C18H19ClN4O5Pureza:98%Forma y color:SolidPeso molecular:406.82WM-586
CAS:<p>WM-586 is a covalent inhibitor of WDR5 that impedes the WDR5-MYC binding.</p>Fórmula:C20H20F3N5O3SPureza:98%Forma y color:SolidPeso molecular:467.47MS67
CAS:<p>MS67 selectively degrades WDR5 with a 63 nM Kd, has anticancer effects, and is inactive against other protein classes.</p>Fórmula:C52H59F4N9O7SForma y color:SolidPeso molecular:1030.14PRMT5-IN-29
CAS:<p>PRMT5-IN-29 is a potent, orally active inhibitor of PRMT5, exhibiting an IC50 value of 1.5 μM, showing promise for use in advanced cancer research [1].</p>Fórmula:C18H20Cl3N5O5Pureza:98%Forma y color:SolidPeso molecular:492.74DNMT-IN-3
CAS:<p>DNMT-IN-3 is a DNA Methyltransferase (DNMT) inhibitor with an IC50 of 60 nM against Plasmodium falciparum (Plasmodium), demonstrating antimalarial activity and suitability for malaria-related research [1].</p>Fórmula:C37H39N7OForma y color:SolidPeso molecular:597.75
