ADN metiltransferasa
Las metiltransferasas de ADN (DNMT) son enzimas que catalizan la adición de grupos metilo a los residuos de citosina en el ADN, lo que lleva al silenciamiento génico. La metilación aberrante del ADN está asociada con diversas enfermedades, incluido el cáncer. Los inhibidores de DNMT bloquean la actividad de estas enzimas, lo que lleva a la reactivación de genes silenciados y la inducción de apoptosis en células cancerosas. Los inhibidores de DNMT se utilizan ampliamente en la investigación epigenética y la terapia contra el cáncer. En CymitQuimica, ofrecemos una gama de inhibidores de DNMT de alta calidad para apoyar su investigación en epigenética, metilación del ADN y biología del cáncer.
Se han encontrado 422 productos de "ADN metiltransferasa"
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5'-Azido-5'-deoxyadenosine
CAS:<p>5'-Azido-5'-deoxyadenosine is a purine nucleoside analogue, inhibit Trichomonas vaginalis and PRMT5 , click chemistry alkyne, DBCO, or BCN groups.</p>Fórmula:C10H12N8O3Pureza:99.84%Forma y color:SolidPeso molecular:292.25PROTAC EZH2 Degrader-1
CAS:<p>PROTAC EZH2 Degrader-1 suppresses EZH2 methyltransferase activity with IC50 2.7 nM, serving as a potent tool in cancer research and EZH2 inhibition studies.</p>Fórmula:C54H67N7O8Forma y color:SolidPeso molecular:942.15MS8511 hydrochloride
CAS:<p>MS8511 hydrochloride is a selective G9a/GLP inhibitor with IC50 values of 100 nM and 140 nM respectively, exhibiting covalent and irreversible characteristics.</p>Fórmula:C28H42ClN5O3Forma y color:SolidPeso molecular:532.12(R)-HH2853
CAS:<p>(R)-HH2853, a mutant EZH2 inhibitor, IC50 <100 nM for EZH2-Y641F, targets cancer/autoimmune diseases.</p>Fórmula:C31H36F3N7O3Pureza:97.53% - 98.85%Forma y color:SolidPeso molecular:611.662'-Deoxy-2'-fluoro-β-D-arabinocytidine hydrochloride
CAS:<p>2'-Deoxy-2'-fluoro-beta-D-arabinocytidine HCl inhibits DNA methyltransferase with potential anti-tumor properties.</p>Fórmula:C9H13ClFN3O4Pureza:99.69%Forma y color:SolidPeso molecular:281.67O6BTG-octylglucoside
CAS:O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor (IC50s: 10 nM and 32 nM in HeLa S3 cells and in vitro (cell extracts)).Fórmula:C24H34BrN5O7SPureza:98%Forma y color:SolidPeso molecular:616.53EZM0414 TFA
CAS:<p>EZM0414 TFA (SETD2-IN-1 TFA) is a SETD2 inhibitor with anticancer and antiproliferative effects for the study of leukemia and immune dysfunction.</p>Fórmula:C24H30F4N4O4Pureza:98.88%Forma y color:SolidPeso molecular:514.51DA-3003-1
CAS:<p>DA-3003-1 (NSC 663284) is a Cdc25 dual specificity phosphatase inhibitor with antitumor activity and inhibits Cdc25B2, Cdc25A, Cdc25B2, and Cdc25C.</p>Fórmula:C15H16ClN3O3Pureza:99.27% - 99.79%Forma y color:SolidPeso molecular:321.76EHMT2-IN-1
CAS:<p>EHMT2-IN-1: potent EHMT inhibitor, for blood disorders/cancer research; IC50s <100 nM for EHMT1/2 peptides and cellular EHMT2.</p>Fórmula:C18H23N7OForma y color:SolidPeso molecular:353.42(R)-GSK-3685032
CAS:<p>(R)-GSK-3685032 is a selective, reversible DNMT1 inhibitor, non-covalent, IC50: 0.036 μM; reduces DNA methylation, inhibits cancer growth.</p>Fórmula:C22H24N6OSForma y color:SolidPeso molecular:420.54EPZ020411
CAS:<p>EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).</p>Fórmula:C25H38N4O3Forma y color:SolidPeso molecular:442.6PR5-LL-CM01
CAS:<p>PR5-LL-CM01 is a novel protein arginine methyltransferase 5 (PRMT5) inhibitor in colorectal and pancreatic cancers.</p>Fórmula:C23H27N7Forma y color:SolidPeso molecular:401.51AZ505 ditrifluoroacetate
CAS:<p>AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).</p>Fórmula:C33H40Cl2F6N4O8Forma y color:SolidPeso molecular:805.595-Aza-2'-deoxycytidine
CAS:Fórmula:C8H12N4O4Pureza:>98.0%(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:228.21AS-85
CAS:<p>AS-85 is an ASH1L inhibitor with anti-leukemic activity that inhibits leukemic cell growth and increases cLogP.</p>Fórmula:C26H28F3N5O3S2Pureza:98.96%Forma y color:SolidPeso molecular:579.66UNC0379
CAS:<p>UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.</p>Fórmula:C23H35N5O2Pureza:94.41% - 99.97%Forma y color:SolidPeso molecular:413.56EPZ005687
CAS:<p>EPZ005687 is a potent and selective inhibitor of EZH2.</p>Fórmula:C32H37N5O3Pureza:97.06% - 99.64%Forma y color:SolidPeso molecular:539.67Piribedil
CAS:Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease.Fórmula:C16H18N4O2Pureza:99.79% - 99.82%Forma y color:SolidPeso molecular:298.34MRTX-1719
CAS:<p>MRTX-1719 is a potent and selective inhibitor of the PRMT5/MTA complex with an IC50 value of <10 nM against PRMT5/MTAMTAPDELSDMA cell lines.Cost-effective and quality-assured.</p>Fórmula:C23H18ClFN6O2Pureza:98.27% - 99.18%Forma y color:SolidPeso molecular:464.88C-7280948
CAS:<p>C-7280948 is a PRMT1 inhibitor.</p>Fórmula:C14H16N2O2SPureza:99.55% - ≥95%Forma y color:SolidPeso molecular:276.35
