ADN metiltransferasa
Las metiltransferasas de ADN (DNMT) son enzimas que catalizan la adición de grupos metilo a los residuos de citosina en el ADN, lo que lleva al silenciamiento génico. La metilación aberrante del ADN está asociada con diversas enfermedades, incluido el cáncer. Los inhibidores de DNMT bloquean la actividad de estas enzimas, lo que lleva a la reactivación de genes silenciados y la inducción de apoptosis en células cancerosas. Los inhibidores de DNMT se utilizan ampliamente en la investigación epigenética y la terapia contra el cáncer. En CymitQuimica, ofrecemos una gama de inhibidores de DNMT de alta calidad para apoyar su investigación en epigenética, metilación del ADN y biología del cáncer.
Se han encontrado 422 productos de "ADN metiltransferasa"
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Tazemetostat
CAS:<p>Tazemetostat (EPZ6438): Oral EZH2 inhibitor, blocks histone H3K27 methylation, potential cancer therapy.</p>Fórmula:C34H44N4O4Pureza:98.24% - ≥95%Forma y color:SolidPeso molecular:572.74MS049
CAS:<p>MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.</p>Fórmula:C15H24N2OPureza:98.91%Forma y color:SolidPeso molecular:248.36EPZ004777
CAS:<p>EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.</p>Fórmula:C28H41N7O4Pureza:98.99% - 99.32%Forma y color:SolidPeso molecular:539.67SGC707
CAS:<p>SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.</p>Fórmula:C16H18N4O2Pureza:98.45% - 99.79%Forma y color:SolidPeso molecular:298.34TP-064
CAS:<p>TP-064: Potent, selective PRMT4 inhibitor, IC50 < 10nM for H3 methylation, 100x selectivity, blocks MED12 methylation at 43nM.</p>Fórmula:C28H34N4O2Pureza:97.85%Forma y color:SolidPeso molecular:458.6UNC1215
CAS:<p>UNC1215, a potent MBT antagonist, targets L3MBTL3 with high selectivity (IC50: 40 nM, Kd: 120 nM, 50x versus MBT family).</p>Fórmula:C32H43N5O2Pureza:98% - 99.04%Forma y color:SolidPeso molecular:529.72MRTX9768
CAS:<p>MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.</p>Fórmula:C24H17FN6OPureza:97.02%Forma y color:SolidPeso molecular:424.43EED226
CAS:<p>EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.</p>Fórmula:C17H15N5O3SPureza:98.14% - 99.33%Forma y color:SolidPeso molecular:369.4AMI-1
CAS:<p>AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1).</p>Fórmula:C21H14N2Na2O9S2Pureza:97.53% - 99.9%Forma y color:DrypowderPeso molecular:548.45γ-Oryzanol
CAS:<p>γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in the</p>Fórmula:C40H58O4Pureza:mixture - mixtureForma y color:White Or White Crystalline Powder OdourlessPeso molecular:602.9BIX-01294
CAS:<p>BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).</p>Fórmula:C28H38N6O2Pureza:98.58% - 99.64%Forma y color:SolidPeso molecular:490.643-deazaneplanocin A HCl
CAS:<p>3-deazaneplanocin A HCl is both an S-adenosyl-l-homocysteine hydrolase inhibitor and an enhancer of zeste homolog 2(EZH2) inhibitor.</p>Fórmula:C12H15ClN4O3Pureza:93.24% - 98.9%Forma y color:SolidPeso molecular:298.73OTS186935 hydrochloride
<p>OTS186935 HCl inhibits SUV39H2 (IC50 6.49 nM), curbs tumor growth in mice, and modulates γ-H2AX in cancer cells.</p>Fórmula:C25H27Cl2N5O2Forma y color:SolidPeso molecular:522.31AZ505
CAS:<p>AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).</p>Fórmula:C29H38Cl2N4O4Pureza:98.18%Forma y color:SolidPeso molecular:577.54Tazemetostat hydrobromide
CAS:<p>Tazemetostat hydrobromide: potent, selective EZH2 inhibitor; blocks PRC2/wild-type EZH2 (Ki: 2.5 nM) & EZH1 (IC50: 392 nM).</p>Fórmula:C34H45BrN4O4Pureza:99.8%Forma y color:SolidPeso molecular:653.65WDR5-0103
CAS:<p>WDR5-0103 (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd: 450 nM).</p>Fórmula:C21H25N3O4Pureza:98% - 99.61%Forma y color:SolidPeso molecular:383.44Succinic acid sodium
CAS:<p>Succinic acid sodium is an orally active anxiolytic.</p>Fórmula:C4H6O4·xNaForma y color:SolidA-196
CAS:<p>A-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective over</p>Fórmula:C18H16Cl2N4Pureza:99.92%Forma y color:SolidPeso molecular:359.25Piribedil
CAS:Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease.Fórmula:C16H18N4O2Pureza:99.79% - 99.82%Forma y color:SolidPeso molecular:298.34C-7280948
CAS:<p>C-7280948 is a PRMT1 inhibitor.</p>Fórmula:C14H16N2O2SPureza:99.55% - ≥95%Forma y color:SolidPeso molecular:276.35
