ADN metiltransferasa
Las metiltransferasas de ADN (DNMT) son enzimas que catalizan la adición de grupos metilo a los residuos de citosina en el ADN, lo que lleva al silenciamiento génico. La metilación aberrante del ADN está asociada con diversas enfermedades, incluido el cáncer. Los inhibidores de DNMT bloquean la actividad de estas enzimas, lo que lleva a la reactivación de genes silenciados y la inducción de apoptosis en células cancerosas. Los inhibidores de DNMT se utilizan ampliamente en la investigación epigenética y la terapia contra el cáncer. En CymitQuimica, ofrecemos una gama de inhibidores de DNMT de alta calidad para apoyar su investigación en epigenética, metilación del ADN y biología del cáncer.
Se han encontrado 421 productos de "ADN metiltransferasa"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Procaine Hydrochloride
CAS:Fórmula:C13H20N2O2·HClPureza:>98.0%(T)(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:272.771-Hydrazinophthalazine Hydrochloride
CAS:Fórmula:C8H8N4·HClPureza:>99.0%(T)(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:196.64N-Phthalyl-L-tryptophan
CAS:Fórmula:C19H14N2O4Pureza:>98.0%(T)(HPLC)Forma y color:Light yellow to Amber to Dark green powder to crystalinePeso molecular:334.33(-)-Epigallocatechin Gallate Hydrate
CAS:Fórmula:C22H18O11·xH2OPureza:>98.0%(HPLC)Forma y color:White to Light yellow to Light orange powder to crystalPeso molecular:458.38 (as Anhydrous)Caffeic Acid
CAS:Fórmula:C9H8O4Pureza:>98.0%(T)(HPLC)Forma y color:White to Orange to Green powder to crystalPeso molecular:180.165-Azacytidine
CAS:Fórmula:C8H12N4O5Pureza:>98.0%(T)Forma y color:White to Almost white powder to crystalPeso molecular:244.21Genistein
CAS:Fórmula:C15H10O5Pureza:>98.0%(HPLC)Forma y color:White to Light yellow to Light orange powder to crystalPeso molecular:270.24Zebularine
CAS:Fórmula:C9H12N2O5Pureza:>98.0%(T)(HPLC)Forma y color:White to Light yellow powder to crystalPeso molecular:228.20Chlorogenic Acid
CAS:Fórmula:C16H18O9Pureza:>98.0%(T)(HPLC)Forma y color:White to Light yellow powder to crystalPeso molecular:354.31DC-05
CAS:<p>DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).</p>Fórmula:C25H25N3OPureza:98.95%Forma y color:SolidPeso molecular:383.49Levetiracetam
CAS:<p>Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset</p>Fórmula:C8H14N2O2Pureza:99.67% - 99.86%Forma y color:White Crystalline PowderPeso molecular:170.21Phthalazine, 1-hydrazinyl-, hydrochloride (1:1)
CAS:Fórmula:C8H9ClN4Pureza:98%Forma y color:SolidPeso molecular:196.63692(1H)-Pyrimidinone, 1-β-D-ribofuranosyl-
CAS:Fórmula:C9H12N2O5Pureza:98%Forma y color:SolidPeso molecular:228.2020(1S,3R,4R,5R)-3-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,4,5-trihydroxycyclohexane-1-carboxylic acid
CAS:Fórmula:C16H18O9Pureza:98%Forma y color:SolidPeso molecular:354.3087Ref: IN-DA00I681
1g30,00€5g52,00€10g75,00€1kgA consultar25g153,00€100g489,00€250gA consultar500gA consultar50kg41.345,00€250mg26,00€4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-
CAS:Fórmula:C15H10O5Pureza:97%Forma y color:SolidPeso molecular:270.2369Ref: IN-DA00I8G3
1g26,00€5g24,00€10g31,00€1kg686,00€25g52,00€50g77,00€5kgA consultar100g114,00€10kgA consultar250g181,00€500g320,00€100mg26,00€(E)-3,4-dihydroxycinnamic acid
CAS:Fórmula:C9H8O4Pureza:98%Forma y color:SolidPeso molecular:180.1574EBI-2511
CAS:<p>EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).</p>Fórmula:C34H48N4O4Pureza:99.74%Forma y color:SolidPeso molecular:576.77Diperodon hydrochloride
CAS:<p>Diperodon hydrochloride (Diperocaine) is a local anesthetic that can be broken down by serolytic enzymes to produce local anesthetic effects.</p>Fórmula:C22H28ClN3O4Pureza:99.91%Forma y color:SolidPeso molecular:433.934-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
CAS:Fórmula:C8H12N4O4Pureza:98%Forma y color:SolidPeso molecular:228.2053Ref: IN-DA002NLT
1g99,00€5g255,00€10g563,00€25gA consultar50gA consultar5mg30,00€100gA consultar100mg31,00€250mg53,00€4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
CAS:Fórmula:C8H12N4O5Pureza:98%Forma y color:SolidPeso molecular:244.2047BVT948
CAS:<p>BVT948 is a protein tyrosine phosphatase (PTP) inhibitor.It can also inhibit lysine methyltransferase SETD8 (KMT5A) and several cytochrome P450 (P450) isoforms.</p>Fórmula:C14H11NO3Pureza:98.87%Forma y color:SolidPeso molecular:241.24Dihydro-5-azacytidine FA
<p>Dihydro-5-azacytidine FA (DHAC) is a pyrimidine analog that has antitumor activity, inhibits cell growth, inhibits DNA methylation, and may be used in the study of malignant mesothelioma.</p>Fórmula:C9H16N4O7Pureza:>99.99%Forma y color:SolidPeso molecular:292.25Tulmimetostat
CAS:<p>Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advanced</p>Fórmula:C28H36ClN3O5SPureza:98.04% - 99.872%Forma y color:SolidPeso molecular:562.12Amodiaquine dihydrochloride dihydrate
CAS:<p>Amodiaquine dihydrochloride dihydrate (Amodiaquin hydrochloride) is an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory effects</p>Fórmula:C20H28Cl3N3O3Pureza:99.97%Forma y color:SolidPeso molecular:464.825-Azacytidine
CAS:<p>5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity.</p>Fórmula:C8H12N4O5Pureza:99.31% - 99.79%Forma y color:Crystals From Methanol Physical Description White Crystalline Powder (Ntp 1992)Peso molecular:244.2A-395
CAS:<p>A-395 blocks PRC2 (EZH2-EED-SUZ12) interactions, strongly inhibiting the complex with an IC50 of 18 nM.</p>Fórmula:C26H35FN4O2SPureza:98.43%Forma y color:SolidPeso molecular:486.65iso-Azalansta
CAS:<p>(2R,4S)-Azalanstat (Iso-Azalansta) is a selective heme oxygenase (HO) inhibitor that is used in the study of cardiovascular disease.</p>Fórmula:C22H24ClN3O2SPureza:99.53% - 99.89%Forma y color:SoildPeso molecular:429.96(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl 3,4,5-trihydroxybenzoate
CAS:Fórmula:C22H18O11Pureza:98%Forma y color:SolidPeso molecular:458.3717Ref: IN-DA00IK6L
1g22,00€5g24,00€10g31,00€1kg527,00€25g55,00€50g80,00€5kgA consultar100g114,00€250g177,00€500g302,00€Valemetostat
CAS:<p>Valemetostat (DS-3201) is a first-in-class EZH1/2 dual inhibitor, which can be used to study T-cell lymphoma.Cost-effective and quality-assured.</p>Fórmula:C26H34ClN3O4Pureza:98.38% - 99.08%Forma y color:SolidPeso molecular:488.02Decitabine
CAS:<p>Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity.</p>Fórmula:C8H12N4O4Pureza:98.06% - 99.87%Forma y color:Physical Description Fine White Crystalline Powder Used As A DrugPeso molecular:228.21MAK683
CAS:<p>MAK683 is an inhibitor of embryonic ectoderm development (EED) (IC50s: 59, 89, 26 nM in EED Alphascreen binding, LC-MS and ELISA assay).</p>Fórmula:C20H17FN6OPureza:98.25% - 99.92%Forma y color:SolidPeso molecular:376.39Dot1L-IN-8
<p>Dot1L-IN-8 (Compound 15) is an effective Dot1L inhibitor. It suppresses the viability of HL-60, K562, MV4-11, HH, and KG-1 cells, with IC50 values of 0.45, 1.03, 0.68, 1.66, and 1.12 μM, respectively.</p>Fórmula:C41H53N7O3SForma y color:SolidPeso molecular:723.97BAY-6035
CAS:<p>BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more than 100-fold selectivity over other histone methyltransferases.</p>Fórmula:C22H28N4O3Pureza:99.97%Forma y color:SolidPeso molecular:396.48Methylation Compound Library
<p>xnum methylation-related compounds that can be used for high-throughput and high-content screening.</p>Forma y color:Odour SolidEZH2-IN-5
CAS:<p>EZH2-IN-5, potent EZH2 inhibitor; IC50: 1.52 nM (wild-type), 4.07 nM (Tyr641 mutant).</p>Fórmula:C26H37BrN4O2Forma y color:SolidPeso molecular:517.512Aclantate
CAS:<p>Aclantate is a nonsteroidal anti-inflammatory drug.</p>Fórmula:C15H14ClNO4SPureza:98%Forma y color:SolidPeso molecular:339.79Nanaomycin A
CAS:<p>Nanaomycin A, a quinone antibiotic, reactivates cancer suppressor genes and inhibits DNMT3B (IC50=500nM).</p>Fórmula:C16H14O6Pureza:98%Forma y color:SolidPeso molecular:302.28HDACs/EZH2-IN-1
<p>HDACs/EZH2-IN-1 (Compound 22a) is a dual inhibitor of HDACs and EZH2, exhibiting potent inhibitory activity, with EZH2 Y641N being suppressed by 98% at 50 nM. It selectively targets HDAC1 and HDAC6, with IC50 values of 0.23 μM and 0.07 μM, respectively. HDACs/EZH2-IN-1 effectively inhibits the proliferation of diffuse large B-cell lymphoma cells harboring EZH2 mutations and various acute myeloid leukemia cells. Additionally, this compound has the capability to induce cellular differentiation and apoptosis (Apoptosis).</p>Fórmula:C29H36BrN7O4Forma y color:SolidPeso molecular:626.54Chaetocin
CAS:<p>Chaetocin: a natural histone methyltransferase inhibitor; IC50 of 0.8, 2.5, and 3 μM for dSU(VAR)3-9, G9a, DIM5.</p>Fórmula:C30H28N6O6S4Pureza:98.36% - 98.82%Forma y color:SolidPeso molecular:696.84UNC6852
CAS:<p>UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.</p>Fórmula:C43H48N10O6SPureza:96.64%Forma y color:SolidPeso molecular:832.97UNC7096
<p>UNC7096 is a potent, selective degrader of NSD2-PWWP1, exhibiting a dissociation constant (Kd) of 46 nM, and shows promise for treating NSD2-related diseases [1</p>Fórmula:C61H87N7O18SPureza:98%Forma y color:SolidPeso molecular:1238.44GpC Methyltransferase
<p>GpC Methyltransferase (GpC) is an enzyme that methylates DNA, specifically targeting cytosine residues within GpC dinucleotides of non-nucleosomal DNA in vitro.</p>EZH2-IN-15
CAS:<p>A compound inhibits EZH2, overexpressed in cancers, affecting Treg activity and innate immunity.</p>Fórmula:C32H44N4O4Pureza:99.88%Forma y color:SolidPeso molecular:548.72LSD1-IN-32
<p>LSD1-IN-32 (compound 11e) is a potent inhibitor of LSD1, with an IC50 value of 0.99 µM. It effectively impedes RANKL-induced osteoclastogenesis, bone resorption, and F-actin ring formation, indicating its potential use in osteoporosis research.</p>Fórmula:C36H56N2O3Si2Peso molecular:620.38295Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH
CAS:<p>Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b), an EZH2 degrader, is employed in lymphoma research [1].</p>Fórmula:C34H43N3O7Forma y color:SolidPeso molecular:605.72SW2_152F
<p>SW2_152F: Potent CBX2 ChD inhibitor, Kd 80 nM, 24-1000x selective over other CBXs in vitro.</p>Fórmula:C45H62Cl3N7O8Forma y color:SolidPeso molecular:935.37BBDDL2204
<p>BBDDL2204 (compound 13) is a potent and selective covalent inhibitor of EZH2, demonstrating an IC50 of 2.5 nM against EZH2Y641F.</p>Fórmula:C37H47N5O5SForma y color:SolidPeso molecular:673.32979TB22
<p>TB22 is a non-nucleoside inhibitor of DOT1LR231Q with anticancer activity. It inhibits the malignant phenotype of lung cancer cells harboring the R231Q mutation via the MAPK/ERK signaling pathway, making it useful for lung cancer research.</p>Forma y color:Odour SolidPARP/EZH2-IN-2
<p>PARP/EZH2-IN-2 (compound 12e) functions as a dual inhibitor targeting both PARP1 and EZH2, with IC50 values of 6.89 and 27.34 nM, respectively. This compound exhibits anticancer activity without toxicity to normal cells, achieving synthetic lethality indirectly by increasing PARP1 sensitivity through EZH2 inhibition, and inducing cell death by modulating excessive autophagy.</p>Fórmula:C33H31N7O3Peso molecular:573.24884MRTX9768 hydrochloride
<p>MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor.</p>Forma y color:SolidUNC 0631
CAS:<p>UNC 0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).</p>Fórmula:C37H61N7O2Pureza:98.76%Forma y color:SolidPeso molecular:635.93E67-2
CAS:<p>E67-2: Low-toxic, KIAA1718 inhibitor with IC50 of 3.4μM, targets H3K9/H3K4 demethylases.</p>Fórmula:C21H36N6O2Forma y color:SolidPeso molecular:404.559MAK683-CH2CH2COOH hydrochloride
<p>MAK683-CH2CH2COOH, an EED binder, was key in crafting PROTAC EED degrader-1 and -2 targeting VHL-E3 ligase.</p>Fórmula:C23H22ClFN6O3Forma y color:SolidPeso molecular:484.91CS-VIP 8 TFA
<p>CS-VIP 8 TFA is a selective allosteric inhibitor of the WDR5 protein (Ki= 0.008 μM). It induces a conformational change in the MLL1 complex, leading to the dissociation of MLL1 from the complex, thereby inhibiting the MLL1 histone methyltransferase activity and modulating HOX gene expression. CS-VIP 8 TFA shows potential for research in hematological disorders such as leukemia.</p>Fórmula:C45H53F7N12O9Forma y color:SolidPeso molecular:1038.39467UNC10013
<p>UNC10013 is an allosteric modulator of SETDB1, exhibiting negative allosteric regulation through covalent bond formation with Cys385 on the 3TD domain. It has a kinact/KI value of 1.0 × 10^6 M^-1*s^-1. UNC10013 effectively disrupts SETDB1-mediated Akt methylation, holding potential for application in cancer and neurodegenerative disease research.</p>Forma y color:Odour SolidFTX-6058 hydrochloride
CAS:<p>FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.</p>Fórmula:C22H19ClFN5O2Forma y color:SolidPeso molecular:439.87XF067-68
CAS:<p>XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 ( WDR5 )[1] .</p>Fórmula:C52H59F4N9O7SForma y color:SolidPeso molecular:1030.14XF056-132
CAS:<p>XF056-132 is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader [1] .</p>Fórmula:C51H57F4N9O7SForma y color:SolidPeso molecular:1016.11MRK-990
<p>MRK-990 is an inhibitor of PRMT that targets both PRMT5 and PRMT9, with IC50 values of 30 nM and 10 nM, respectively.</p>Forma y color:Odour SolidSAH-EZH2
CAS:<p>EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.</p>Fórmula:C155H256N48O40Pureza:98%Forma y color:SolidPeso molecular:3432.05C 21
CAS:<p>PRMT1 inhibitor, IC50=1.8μM; 5x more selective than PRMT6; >250x over PRMT3, CARM1.</p>Fórmula:C90H161ClN36O24Pureza:98%Forma y color:SolidPeso molecular:2166.94Anticancer agent 126
<p>Anticancer agent 126 (compound 12), a WDR5 inhibitor, exhibits anticancer properties by disrupting the WDR5-MYC interaction in cells, subsequently reducing MYC</p>Fórmula:C25H11BBr2F2N2O3S4Pureza:98%Forma y color:SolidPeso molecular:724.23MS8511 HCl
<p>MS8511 HCl is a G9a/GLP inhibitor with anticancer activity that can be used in the study of a variety of cancers including brain cancer.</p>Fórmula:C28H42ClN5O3Pureza:98.9% - 98.96%Forma y color:SolidPeso molecular:532.12PRMT5 ligand 1
CAS:<p>PRMT5ligand 1 is a ligand of PRMT5, used as a target protein ligand in the synthesis of the PROTAC degrader MS4322.</p>Fórmula:C20H26N6O2Forma y color:SolidPeso molecular:382.459DC-S239
CAS:<p>Ethyl 2-amino-4-methyl-5-thiophene carboxylate is a SETD7 inhibitor (IC50=4.59μM) with anticancer properties.</p>Fórmula:C15H15N3O5SPureza:99.37%Forma y color:SolidPeso molecular:349.36WDR5-MYC-IN-1
<p>WDR5-MYC-IN-1 (compound 4o) is an effective inhibitor of the WDR5-MYC interaction, demonstrating a Ki value of 1.0 µM and exhibiting antiproliferative activity.</p>Forma y color:Odour SolidEZH2-IN-4
CAS:<p>EZH2-IN-4, an oral EZH2 inhibitor, targets WT and mutant forms with IC50s of 0.923 nM and 2.65 nM, showing strong anti-cancer effects.</p>Fórmula:C29H41N3O3SForma y color:SolidPeso molecular:511.73DNMT1/HDAC-IN-1
<p>DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.</p>Forma y color:Odour SolidPRMT5-IN-15
CAS:<p>PRMT5-IN-15 is a PRMT5 inhibitor with an IC 50 value of 0.84 nM.</p>Fórmula:C24H23F3N6O2Forma y color:SolidPeso molecular:484.483SW2_110A acetate
<p>SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD).</p>Fórmula:C44H64N6O9Pureza:98%Forma y color:SoildPeso molecular:821.01CS-VIP 8
<p>CS-VIP 8 is a selective allosteric inhibitor of the WDR5 protein (Ki= 0.008 μM). It induces conformational changes in the MLL1 complex, causing the dissociation of MLL1 from the complex and inhibiting MLL1 histone methyltransferase activity, thereby regulating HOX gene expression. CS-VIP 8 shows potential for research in hematological diseases such as leukemia.</p>Fórmula:C43H52F4N12O7Forma y color:SolidPeso molecular:924.4018EEDi-5273
CAS:<p>EEDi-5273: Potent oral EED inhibitor, IC50 ~0.2 nM; induces complete, lasting tumor regression.</p>Fórmula:C26H22F4N6O2Forma y color:SolidPeso molecular:526.496MS2133
<p>MS2133 is a DOT1L PROTAC degrader. It facilitates the ubiquitination and degradation of DOT1L in THP-1 and MV4-11 cells, with DC50 values of 56 nM and 25 nM, respectively, and reduces H3K79 methylation. MS2133 also inhibits the growth of MLL-r leukemia cells, demonstrating anticancer activity.</p>Fórmula:C58H66ClF3N14O11S2Forma y color:SolidPeso molecular:1290.41175MS049 2HCl (1502816-23-0(free base))
<p>MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.</p>Fórmula:C15H26Cl2N2OPureza:99.9%Forma y color:SolidPeso molecular:321.28SW2_110A
CAS:<p>SW2_110A: Cell-permeable, CBX8 ChD inhibitor, Kd 800 nM; 5x selective over other CBXs in vitro.</p>Fórmula:C42H60N6O7Pureza:98%Forma y color:SolidPeso molecular:760.96AS-254s
<p>AS-254s is an inhibitor of absent, small, or homeotic-like 1 protein (ASH1L), with an IC50 of 94 nM (FP assay). It exhibits antiproliferative activity against leukemia cells with MLL1 rearrangement, with a GI50 of less than 1 μM. Additionally, AS-254s can induce differentiation in MLL1-r leukemia cells.</p>Fórmula:C36H41ClN6O3S2Forma y color:SolidPeso molecular:705.332PRMT3-IN-4
<p>PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.</p>Forma y color:Odour SolidG9a-IN-3
<p>G9a-IN-3 (compound 16g) is a potent G9a inhibitor with an IC50 of 0.002 μM. It is applicable for research in sickle cell disease.</p>Fórmula:C26H29N5O3Forma y color:SolidPeso molecular:459.22704PARP/EZH2-IN-1
CAS:<p>PARP/EZH2-IN-1: Dual PARP (IC50 6.87 nM) & EZH2 (IC50 36.51 nM) inhibitor, potential for BRCA-wild-type triple-negative breast cancer.</p>Fórmula:C43H41FN8O5Forma y color:SolidPeso molecular:768.85EPZ020411 2HCl (1700663-41-7(free base))
<p>EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).</p>Fórmula:C25H40Cl2N4O3Pureza:98%Forma y color:SolidPeso molecular:515.51PRMT5-IN-4
CAS:<p>PRMT5-IN-4 (compound AAA-1) is a PRMT5 inhibitor.</p>Fórmula:C11H13N3O4SForma y color:SolidPeso molecular:283.3PRMT5-IN-11
CAS:<p>PRMT5-IN-11 demonstrates potent structure-dependent inhibition against the protein methyltransferase PRMT5:MEP50 complex at submicromolar concentrations.</p>Fórmula:C13H17N5O4Forma y color:SolidPeso molecular:307.31PRMT5-IN-13
CAS:<p>PRMT5-IN-13 is a selective inhibitor of protein arginine methyltransferase 5 (prmt5) .</p>Fórmula:C18H17ClN4O4Forma y color:SolidPeso molecular:388.81MS1943
CAS:<p>MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).</p>Fórmula:C42H54N8O3Pureza:95.41% - 95.82%Forma y color:SolidPeso molecular:718.93CARM1/IKZF3 ligand 1
<p>CARM1/IKZF3 ligand 1 functions as an inhibitor of CARM1 and serves as a target protein ligand for the synthesis of PROTAC CARM1/IKZF3 degrader-1.</p>Fórmula:C27H35ClN6O3Forma y color:SolidPeso molecular:527.06PRMT5-IN-14
CAS:<p>PRMT5-IN-14 is a PRMT5 inhibitor to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.</p>Fórmula:C18H18Cl2N4O4Forma y color:SolidPeso molecular:425.27Dihydro-5-azacytidine
CAS:<p>Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties.</p>Fórmula:C8H14N4O5Pureza:>99.99%Forma y color:SolidPeso molecular:246.22CPI-1328
CAS:<p>CPI-1328 is an EZH2 inhibitor with a K i value of 63 fM.</p>Fórmula:C28H36ClN3O4SForma y color:SolidPeso molecular:546.12GSK 591 dihydrochloride
CAS:<p>Strong PRMT5 inhibitor with 4 nM IC50, surpassing other PRMTs; halts MCL growth in lab tests.</p>Fórmula:C22H30Cl2N4O2Forma y color:SolidPeso molecular:453.41EML734
CAS:<p>EML734 is a potent, selective inhibitor of PRMT7 and PRMT9, demonstrating inhibitory concentration 50 (IC50) values of 315 nM for PRMT7 and 0.89 μM for PRMT9.</p>Fórmula:C27H32N10O7Pureza:98%Forma y color:SolidPeso molecular:608.61IHMT-EZH2-426
<p>IHMT-EZH2-426 (compound 38) is a potent, covalent degrader of EZH2, demonstrating IC50 values of 1.3 nM for EZH2 wild-type, 1.2 nM for EZH2-A687V, and 1.7-3.5</p>Fórmula:C31H35FN4O4SPureza:98%Forma y color:SolidPeso molecular:578.7PRMT5-IN-34
<p>PRMT5-IN-34 (Compound C) is an inhibitor of MTA-cooperative protein arginine methyltransferase 5 (PRMT5/MAT).</p>Fórmula:C23H19F2N5O2Peso molecular:435.15068ML234
<p>ML234 is a dual inhibitor targeting EZH2/LSD1, with IC50 values of 0.09 and 0.12 μM, respectively. It demonstrates strong antiproliferative effects on prostate cancer cell lines LNCAP, PC3, and 22RV1. Additionally, ML234 inhibits tumor growth in a 22RV1 xenograft mouse model, showing potential as a research agent in prostate cancer therapeutics.</p>Forma y color:Odour SolidCARM1 degrader-1
<p>PROTAC CARM1 degrader-1 (compound 3b) serves as a highly potent degrader (DC50=8.1 nM) of the co-activator associated arginine methyltransferase (CARM1).</p>Fórmula:C71H98N12O8SPureza:98%Forma y color:SolidPeso molecular:1279.68CARM1 degrader-2
<p>PROTAC CARM1 degrader-2 (compound 3e), with a DC50 value of 8.8 nM, is a VHL- and proteasome-dependent degrader of co-activator associated</p>Fórmula:C72H100N12O7SPureza:98%Forma y color:SolidPeso molecular:1277.71Dot1L-IN-9
<p>Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor with an IC50 of 125 nM. It effectively reduces H3K79 dimethylation and is utilized in leukemia research.</p>Forma y color:Odour SolidFTX-6058
CAS:<p>FTX-6058 is an oral inhibitor of EED that induces HbF and may treat hemoglobinopathies like sickle cell and β-thalassemia.</p>Fórmula:C22H18FN5O2Forma y color:SolidPeso molecular:403.417PROTAC EED degrader-1
<p>PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.</p>Fórmula:C55H60FN11O8SPureza:98%Forma y color:SolidPeso molecular:1054.2Dot1L-IN-1 TFA
<p>Dot1L-IN-1 TFA: potent inhibitor, K i =2 pM, IC 50 <0.1 nM; reduces H3K79 dimethylation (IC 50 =3 nM) & HoxA9 promoter activity (IC 50 =17 nM).</p>Fórmula:C34H37ClF3N9O4SForma y color:SolidPeso molecular:760.23A-893
CAS:<p>A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .</p>Fórmula:C29H38Cl2N4O4Forma y color:SolidPeso molecular:577.54UNC4976
<p>UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.</p>Fórmula:C47H70N6O8Pureza:98%Forma y color:SolidPeso molecular:847.09PROTAC EED degrader-2
<p>PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.</p>Fórmula:C50H58FN11O6SPureza:98%Forma y color:SolidPeso molecular:960.13GSK3735967
CAS:<p>GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.</p>Fórmula:C25H31N7OSForma y color:SolidPeso molecular:477.62MAK-683 hydrochloride
CAS:<p>MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, 26nM measured in EED Alphascreen, ELISA.Cost-effective and quality-assured.</p>Fórmula:C20H18ClFN6OPureza:97.02% - >99.99%Forma y color:SolidPeso molecular:412.85Histone H3K9me3 (1-15) TFA
<p>Histone H3K9me3 (1-15) (H3(1-15)K9me3) TFA is used as a substrate. This post-translational modification (PTM) of histone H3K9me3 is indicative of heterochromatin surrounding the centromere.</p>Fórmula:C66H124N25O21·xC2HF3O2PRMT5-IN-12
CAS:<p>PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .</p>Fórmula:C32H40N4O4Forma y color:SolidPeso molecular:544.696DDO-2093
CAS:<p>DDO-2093 inhibits MLL1-WDR5 interaction (IC50: 8.6 nM, Kd: 11.6 nM), with strong antitumor properties and selectivity.</p>Fórmula:C29H37ClFN9O3Forma y color:SolidPeso molecular:614.12Larsucosterol Ammonium salt
CAS:<p>Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.</p>Fórmula:C27H49NO5SPureza:>99.99% - >99.99%Forma y color:SoildPeso molecular:499.75EPZ-719
CAS:<p>EPZ-719: Potent SETD2 inhibitor, IC50=0.005μM, high selectivity, potential for targeted epigenetic therapy.</p>Fórmula:C22H31FN4O3SForma y color:SolidPeso molecular:450.57MS9715
<p>MS9715 is a potent and selective NSD3-targeting PROTAC, designed by leveraging BI-9321, which targets the PWWP1 domain of NSD3, in conjunction with an E3 ligase</p>Fórmula:C58H74FN9O5SPureza:98%Forma y color:SolidPeso molecular:1028.33MC3343
CAS:<p>MC3343, a DNMT1/3A inhibitor, affects tumor proliferation by blocking osteosarcoma cells in the G1 or G2/M phase and induces osteogenic differentiation.</p>Fórmula:C27H23N7OPureza:99.73%Forma y color:SolidPeso molecular:461.52PRMT5-IN-9
CAS:<p>PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.</p>Fórmula:C25H23F3N6OForma y color:SolidPeso molecular:480.495UNC2399
CAS:<p>UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its IC</p>Fórmula:C67H104N10O17SForma y color:SolidPeso molecular:1353.68MS9024
<p>MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.</p>Forma y color:Odour SolidNSD2-IN-4
<p>NSD2-IN-4 is a potent, selective inhibitor of the NSD2-SET domain, showing promise for the treatment of diseases related to NSD2 [1].</p>Fórmula:C18H14ClN3O3Pureza:98%Forma y color:SolidPeso molecular:355.78ORIC-944 TFA
<p>ORIC-944 TFA is an orally bioavailable selective polycomb repressive complex 2 (PRC2) inhibitor with antitumor activity.</p>Fórmula:C28H26F4N6O3Forma y color:SoildPeso molecular:570.54EZH2-IN-22
CAS:<p>EZH2-IN-22 (example 92) is a potent EZH2 inhibitor, exhibiting IC50 values of <0.00051 µM for EZH2(Y641N) and EZH2(Y641F), and 0.00052 µM for EZH2 (wt). Additionally, EZH2-IN-22 demonstrates antiproliferative activity.</p>Fórmula:C36H50N4O8Forma y color:SolidPeso molecular:666.8MS33
CAS:<p>MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.</p>Fórmula:C64H84F3N11O7SForma y color:SolidPeso molecular:1208.5PRMT4-IN-3
<p>PRMT4-IN-3 (compound 56) serves as a potent class I protein arginine methyltransferase (PRMT) inhibitor, specifically targeting PRMT4 with an IC50 value of 37</p>Fórmula:C23H29N7OPureza:98%Forma y color:SolidPeso molecular:419.52WDR5-47
CAS:<p>WDR5-47 is a potent small molecule to disturb the interaction of MLL1-WDR5 with IC50 value of 0.3μM.</p>Fórmula:C19H20ClFN4O3Pureza:98.15%Forma y color:SoildPeso molecular:406.84NSC 370284
CAS:<p>NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.</p>Fórmula:C21H25NO6Pureza:99.74%Forma y color:SolidPeso molecular:387.43PRMT1-IN-1
CAS:<p>PRMT1-IN-1 is a PRMT1 inhibitor.</p>Fórmula:C20H7Br6NO5Forma y color:SolidPeso molecular:820.702CM112
<p>CM112 is a selective degrader of protein arginine methyltransferase 1 (PRMT1), which connects a hydrophobic adamantane tag to MS023 via a 5-PEG linker. It induces the degradation of PRMT1 in various solid tumor cell lines. CM112 also targets the non-enzymatic functions of PRMT1 by reducing the stability of the orphan receptor TR3. This compound shows potential for cancer research.</p>Fórmula:C39H61N5O7Forma y color:SolidPeso molecular:711.4571SETD7-IN-1
<p>SETD7-IN-1 (compound 7), a PFI-2 analogue, acts as both a substrate and inhibitor of histone lysine methyltransferase SETD7, exhibiting an inhibitory</p>Pureza:98%Forma y color:Odour SolidSGC3027
<p>SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.</p>Fórmula:C41H47ClN6O6SPureza:98%Forma y color:SolidPeso molecular:787.37PRMT5-MTA-IN-2
<p>PRMT5-MTA-IN-2 (compound 1) is a synergistic inhibitor of PRMT5 with an IC50 of less than 1.5 nM.</p>Fórmula:C30H25F2N7O2Forma y color:SolidPeso molecular:553.56OTS186935 FA
<p>OTS186935 FA is a protein methyltransferase SUV39H2 inhibitor.OTS186935 FA inhibits tumor growth in MDA-MB-231 breast cancer cells.</p>Fórmula:C26H28ClN5O4Pureza:99.52%Forma y color:SoildPeso molecular:509.98LLY-284
CAS:<p>LLY-284, a less active PRMT5 inhibitor diastereomer of LLY-283, serves as its negative control.</p>Fórmula:C17H18N4O4Pureza:98%Forma y color:SolidPeso molecular:342.35ND-L11B free base
<p>ND-L11B is an effective degrader of the nuclear receptor binding SET domain protein 2 (NSD2) and RE-IIBP, with DC50 values of 1.48 μM and 0.8 μM, respectively, and a Dmax close to 80%.</p>Fórmula:C37H51F3N10O2Forma y color:SolidPeso molecular:724.862EEDi-5285
CAS:<p>EEDi-5285: potent EED inhibitor, orally active, IC50=0.2nM, targets EED protein, anti-cancer properties.</p>Fórmula:C24H22FN5O3SPureza:100%Forma y color:SolidPeso molecular:479.53EPZ-025654
CAS:<p>EPZ-025654 is an effective and selective inhibitor of arginine methyltransferase CARM1.</p>Fórmula:C29H33ClN8O3Forma y color:SolidPeso molecular:577.08Gintemetostat
CAS:<p>Gintemetostat (KTX-1001) is a potent NSD2 inhibitor (IC50=0.001-0.01μM) for treating NSD2-dysregulated cancers.</p>Fórmula:C25H26F4N8O2Forma y color:SolidPeso molecular:546.52AMI-1 free acid
CAS:<p>AMI-1: Potent reversible PRMT inhibitor; IC50: 8.8 μM (hPRMT1), 3.0 μM (yeast-Hmt1p); blocks substrate binding.</p>Fórmula:C21H16N2O9S2Pureza:97.8%Forma y color:SolidPeso molecular:504.49PROTAC EZH2 Degrader-1
CAS:<p>PROTAC EZH2 Degrader-1 suppresses EZH2 methyltransferase activity with IC50 2.7 nM, serving as a potent tool in cancer research and EZH2 inhibition studies.</p>Fórmula:C54H67N7O8Forma y color:SolidPeso molecular:942.15MS8511 hydrochloride
CAS:<p>MS8511 hydrochloride is a selective G9a/GLP inhibitor with IC50 values of 100 nM and 140 nM respectively, exhibiting covalent and irreversible characteristics.</p>Fórmula:C28H42ClN5O3Forma y color:SolidPeso molecular:532.122'-Deoxy-2'-fluoro-β-D-arabinocytidine hydrochloride
CAS:<p>2'-Deoxy-2'-fluoro-beta-D-arabinocytidine HCl inhibits DNA methyltransferase with potential anti-tumor properties.</p>Fórmula:C9H13ClFN3O4Pureza:99.69%Forma y color:SolidPeso molecular:281.67O6BTG-octylglucoside
CAS:<p>O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor (IC50s: 10 nM and 32 nM in HeLa S3 cells and in vitro (cell extracts)).</p>Fórmula:C24H34BrN5O7SPureza:98%Forma y color:SolidPeso molecular:616.53(R)-GSK-3685032
CAS:<p>(R)-GSK-3685032 is a selective, reversible DNMT1 inhibitor, non-covalent, IC50: 0.036 μM; reduces DNA methylation, inhibits cancer growth.</p>Fórmula:C22H24N6OSForma y color:SolidPeso molecular:420.545-Aza-2'-deoxycytidine
CAS:Fórmula:C8H12N4O4Pureza:>98.0%(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:228.21DA-3003-1
CAS:<p>DA-3003-1 (NSC 663284) is a Cdc25 dual specificity phosphatase inhibitor with antitumor activity and inhibits Cdc25B2, Cdc25A, Cdc25B2, and Cdc25C.</p>Fórmula:C15H16ClN3O3Pureza:99.27% - 99.79%Forma y color:SolidPeso molecular:321.76EHMT2-IN-1
CAS:<p>EHMT2-IN-1: potent EHMT inhibitor, for blood disorders/cancer research; IC50s <100 nM for EHMT1/2 peptides and cellular EHMT2.</p>Fórmula:C18H23N7OForma y color:SolidPeso molecular:353.42EZM0414 TFA
CAS:<p>EZM0414 TFA (SETD2-IN-1 TFA) is a SETD2 inhibitor with anticancer and antiproliferative effects for the study of leukemia and immune dysfunction.</p>Fórmula:C24H30F4N4O4Pureza:98.88%Forma y color:SolidPeso molecular:514.51(R)-HH2853
CAS:<p>(R)-HH2853, a mutant EZH2 inhibitor, IC50 <100 nM for EZH2-Y641F, targets cancer/autoimmune diseases.</p>Fórmula:C31H36F3N7O3Pureza:97.53% - 98.85%Forma y color:SolidPeso molecular:611.66PR5-LL-CM01
CAS:<p>PR5-LL-CM01 is a novel protein arginine methyltransferase 5 (PRMT5) inhibitor in colorectal and pancreatic cancers.</p>Fórmula:C23H27N7Forma y color:SolidPeso molecular:401.515'-Azido-5'-deoxyadenosine
CAS:<p>5'-Azido-5'-deoxyadenosine is a purine nucleoside analogue, inhibit Trichomonas vaginalis and PRMT5 , click chemistry alkyne, DBCO, or BCN groups.</p>Fórmula:C10H12N8O3Pureza:99.84%Forma y color:SolidPeso molecular:292.25AS-85
CAS:<p>AS-85 is an ASH1L inhibitor with anti-leukemic activity that inhibits leukemic cell growth and increases cLogP.</p>Fórmula:C26H28F3N5O3S2Pureza:98.96%Forma y color:SolidPeso molecular:579.66AZ505 ditrifluoroacetate
CAS:<p>AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).</p>Fórmula:C33H40Cl2F6N4O8Forma y color:SolidPeso molecular:805.59EPZ020411
CAS:<p>EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).</p>Fórmula:C25H38N4O3Forma y color:SolidPeso molecular:442.6O6-Benzylguanine
CAS:Fórmula:C12H11N5OPureza:>98.0%(T)(HPLC)Forma y color:White to Light yellow powder to crystalPeso molecular:241.255-Methyl-2'-deoxycytidine
CAS:<p>5-Methyl-2'-deoxycytidine (5MedCyd) is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo.</p>Fórmula:C10H15N3O4Pureza:99.18% - 99.69%Forma y color:SolidPeso molecular:241.245-Fluoro-2'-deoxycytidine
CAS:<p>5-Fluoro-2'-deoxycytidine (2'-DEOXY-5-FLUOROCYTIDINE) is an inhibitor of DNA methyltransferase (DNMT) .</p>Fórmula:C9H12FN3O4Pureza:97.91%Forma y color:Fine White PowderPeso molecular:245.21GSK503
CAS:<p>GSK-503, a potent EZH2 inhibitor, has potential antitumor activity.</p>Fórmula:C31H38N6O2Pureza:98% - 99.89%Forma y color:SolidPeso molecular:526.676-Thioguanine
CAS:<p>6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.</p>Fórmula:C5H5N5SPureza:98.34% - >99.99%Forma y color:Odorless Or Almost Odorless Pale Yellow Crystalline PowderPeso molecular:167.19UNC3866 TFA(1872382-47-2 free base)
CAS:<p>UNC3866 TFA is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.</p>Fórmula:C45H67F3N6O10Pureza:98.43%Forma y color:SolidPeso molecular:909.04SGC2085
CAS:<p>SGC2085 is an effective and selective coactivator-associated arginine methyltransferase 1 (CARM1) inhibitor (IC50: 50 nM).</p>Fórmula:C19H24N2O2Pureza:99.61% - 99.71%Forma y color:SolidPeso molecular:312.41BRD4770
CAS:<p>BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence.</p>Fórmula:C25H23N3O3Pureza:99.82%Forma y color:SolidPeso molecular:413.47Zebularine
CAS:<p>Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor.</p>Fórmula:C9H12N2O5Pureza:99.04% - >99.99%Forma y color:SolidPeso molecular:228.2MR837
CAS:<p>MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist.</p>Fórmula:C16H14N2OSPureza:99.77% - 99.85%Forma y color:SolidPeso molecular:282.36GSK343
CAS:<p>GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against</p>Fórmula:C31H39N7O2Pureza:98% - 99.9%Forma y color:SolidPeso molecular:541.69GSK126
CAS:<p>GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).</p>Fórmula:C31H38N6O2Pureza:98% - 99.67%Forma y color:SolidPeso molecular:526.67EED226
CAS:<p>EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.</p>Fórmula:C17H15N5O3SPureza:98.14% - 99.33%Forma y color:SolidPeso molecular:369.4Succinic acid sodium
CAS:<p>Succinic acid sodium is an orally active anxiolytic.</p>Fórmula:C4H6O4·xNaForma y color:Solidγ-Oryzanol
CAS:<p>γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in the</p>Fórmula:C40H58O4Pureza:mixture - mixtureForma y color:White Or White Crystalline Powder OdourlessPeso molecular:602.9MS023
CAS:<p>MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8,</p>Fórmula:C17H25N3OPureza:98.31% - 99.87%Forma y color:SolidPeso molecular:287.4Amodiaquine
CAS:<p>Amodiaquine is a synthetic aminoquinoline, used to treat malaria.</p>Fórmula:C20H22ClN3OPureza:99.78% - 99.99%Forma y color:Crystals From Absolute Ethanol SolidPeso molecular:355.86GSK3326595
CAS:<p>GSK3326595 (EPZ015938) is an inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50:6.2 nM.).</p>Fórmula:C24H32N6O3Pureza:97.7% - 99.63%Forma y color:SolidPeso molecular:452.55OTS186935 hydrochloride
<p>OTS186935 HCl inhibits SUV39H2 (IC50 6.49 nM), curbs tumor growth in mice, and modulates γ-H2AX in cancer cells.</p>Fórmula:C25H27Cl2N5O2Forma y color:SolidPeso molecular:522.31MRTX9768
CAS:<p>MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.</p>Fórmula:C24H17FN6OPureza:97.02%Forma y color:SolidPeso molecular:424.43Pinometostat
CAS:<p>Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor. Pinometostat has antitumor activity. Cost effective and quality assured.</p>Fórmula:C30H42N8O3Pureza:99.19% - 99.86%Forma y color:SolidPeso molecular:562.71TP-064
CAS:<p>TP-064: Potent, selective PRMT4 inhibitor, IC50 < 10nM for H3 methylation, 100x selectivity, blocks MED12 methylation at 43nM.</p>Fórmula:C28H34N4O2Pureza:97.85%Forma y color:SolidPeso molecular:458.6AMI-1
CAS:<p>AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1).</p>Fórmula:C21H14N2Na2O9S2Pureza:97.53% - 99.9%Forma y color:DrypowderPeso molecular:548.45HLCL-61 hydrochloride
CAS:<p>HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.</p>Fórmula:C23H24N2O·ClHPureza:99.88% - 99.95%Forma y color:SolidPeso molecular:380.91CM-579 trihydrochloride
<p>CM-579 trihydrochloride: reversible G9a/DNMT inhibitor with IC50s 16 nM (G9a) & 32 nM (DNMT); potent against various cancer cells.</p>Fórmula:C29H43Cl3N4O3Forma y color:SolidPeso molecular:602.04BRD9539
CAS:<p>BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μM</p>Fórmula:C24H21N3O3Pureza:98% - 99.57%Forma y color:SolidPeso molecular:399.44SETDB1-TTD-IN-1
CAS:<p>SETDB1-TTD-IN-1 is a potent and selective inhibitor of SET domain bifurcated protein 1 tandem tudor domain (SETDB1-TTD, Kd = 88 nM).Cost-effective and quality-assured.</p>Fórmula:C28H31N5O2Pureza:98.26% - 99.96%Forma y color:SolidPeso molecular:469.58LLY-507
CAS:<p>LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.</p>Fórmula:C36H42N6OPureza:99.58% - 99.93%Forma y color:SolidPeso molecular:574.76MS049
CAS:<p>MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.</p>Fórmula:C15H24N2OPureza:98.91%Forma y color:SolidPeso molecular:248.36PF-06726304
CAS:<p>PF-06726304: potent EZH2 inhibitor, effective against tumors, Kis at 0.7 nM (wild-type) and 3.0 nM (Y641N mutant).</p>Fórmula:C22H21Cl2N3O3Pureza:98.19% - 99.51%Forma y color:SolidPeso molecular:446.33SGC707
CAS:<p>SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.</p>Fórmula:C16H18N4O2Pureza:98.45% - 99.79%Forma y color:SolidPeso molecular:298.34OICR-9429
CAS:<p>OICR-9429 blocks WDR5 binding to MLL/Histone 3, hindering acute myeloid leukemia cell growth in vitro.</p>Fórmula:C29H32F3N5O3Pureza:97.07% - 99.93%Forma y color:SolidPeso molecular:555.59Tazemetostat
CAS:<p>Tazemetostat (EPZ6438): Oral EZH2 inhibitor, blocks histone H3K27 methylation, potential cancer therapy.</p>Fórmula:C34H44N4O4Pureza:98.24% - ≥95%Forma y color:SolidPeso molecular:572.74GSK591
CAS:<p>GSK591 (GSK3203591), Alternative Names are EPZ015866, GSK3203591, is a potent selective inhibitor of the arginine methyltransferase PRMT5 (IC50=11 nM).</p>Fórmula:C22H28N4O2Pureza:99.35% - 99.45%Forma y color:SolidPeso molecular:380.482',3',5'-triacetyl-5-Azacytidine
CAS:<p>2',3',5'-triacetyl-5-Azacytidine (Nsc291930) is a prodrug form of 5-azacytidine that may be rapidly absorbed orally.</p>Fórmula:C14H18N4O8Pureza:98.34%Forma y color:SolidPeso molecular:370.31UNC1999
CAS:<p>UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).</p>Fórmula:C33H43N7O2Pureza:99.19% - >99.99%Forma y color:SolidPeso molecular:569.74BIX-01294
CAS:<p>BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).</p>Fórmula:C28H38N6O2Pureza:98.58% - 99.64%Forma y color:SolidPeso molecular:490.64TC-E 5003
CAS:<p>TC-E 5003 (NSC-30176) is a selective inhibitor of PRMT1 with IC50 of 1.5 μM.</p>Fórmula:C16H14Cl2N2O4SPureza:97.01%Forma y color:SolidPeso molecular:401.26UNC1215
CAS:<p>UNC1215, a potent MBT antagonist, targets L3MBTL3 with high selectivity (IC50: 40 nM, Kd: 120 nM, 50x versus MBT family).</p>Fórmula:C32H43N5O2Pureza:98% - 99.04%Forma y color:SolidPeso molecular:529.72MT-DADMe-ImmA
CAS:<p>MT-DADMe-ImmA (MTDIA) is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP, Ki: 90 pM).</p>Fórmula:C13H19N5OSPureza:99.56%Forma y color:SolidPeso molecular:293.39Tazemetostat hydrobromide
CAS:<p>Tazemetostat hydrobromide: potent, selective EZH2 inhibitor; blocks PRC2/wild-type EZH2 (Ki: 2.5 nM) & EZH1 (IC50: 392 nM).</p>Fórmula:C34H45BrN4O4Pureza:99.8%Forma y color:SolidPeso molecular:653.65SGC0946
CAS:<p>SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.</p>Fórmula:C28H40BrN7O4Pureza:98% - 99.82%Forma y color:SolidPeso molecular:618.57AZ505
CAS:<p>AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).</p>Fórmula:C29H38Cl2N4O4Pureza:98.18%Forma y color:SolidPeso molecular:577.54Gambogenic acid
CAS:<p>Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.</p>Fórmula:C38H46O8Pureza:97.47% - 99.6%Forma y color:SolidPeso molecular:630.77EPZ004777
CAS:<p>EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.</p>Fórmula:C28H41N7O4Pureza:98.99% - 99.32%Forma y color:SolidPeso molecular:539.67EPZ005687
CAS:<p>EPZ005687 is a potent and selective inhibitor of EZH2.</p>Fórmula:C32H37N5O3Pureza:97.06% - 99.64%Forma y color:SolidPeso molecular:539.67OAC1
CAS:<p>OAC1 (BAS 00287861) activates Oct4, boosts iPSC efficiency, and speeds up reprogramming.</p>Fórmula:C14H11N3OPureza:99.49% - 99.65%Forma y color:SolidPeso molecular:237.26
![(1S,3R,4R,5R)-3-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,4,5-trihydroxycyclohexane-1-carb…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb-webp%2FDA00I681.webp&w=3840&q=75)
![4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb-webp%2FDA002NLT.webp&w=3840&q=75)
![4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-o…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb-webp%2FDA003824.webp&w=3840&q=75)
