ADN metiltransferasa
Las metiltransferasas de ADN (DNMT) son enzimas que catalizan la adición de grupos metilo a los residuos de citosina en el ADN, lo que lleva al silenciamiento génico. La metilación aberrante del ADN está asociada con diversas enfermedades, incluido el cáncer. Los inhibidores de DNMT bloquean la actividad de estas enzimas, lo que lleva a la reactivación de genes silenciados y la inducción de apoptosis en células cancerosas. Los inhibidores de DNMT se utilizan ampliamente en la investigación epigenética y la terapia contra el cáncer. En CymitQuimica, ofrecemos una gama de inhibidores de DNMT de alta calidad para apoyar su investigación en epigenética, metilación del ADN y biología del cáncer.
Se han encontrado 421 productos de "ADN metiltransferasa"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
FTX-6058
CAS:<p>FTX-6058 is an oral inhibitor of EED that induces HbF and may treat hemoglobinopathies like sickle cell and β-thalassemia.</p>Fórmula:C22H18FN5O2Forma y color:SolidPeso molecular:403.417PROTAC EED degrader-1
<p>PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.</p>Fórmula:C55H60FN11O8SPureza:98%Forma y color:SolidPeso molecular:1054.2GSK3735967
CAS:<p>GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.</p>Fórmula:C25H31N7OSForma y color:SolidPeso molecular:477.62A-893
CAS:<p>A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .</p>Fórmula:C29H38Cl2N4O4Forma y color:SolidPeso molecular:577.54UNC4976
<p>UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.</p>Fórmula:C47H70N6O8Pureza:98%Forma y color:SolidPeso molecular:847.09PROTAC EED degrader-2
<p>PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27),is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.11.</p>Fórmula:C50H58FN11O6SPureza:98%Forma y color:SolidPeso molecular:960.13CS-VIP 8
<p>CS-VIP 8 is a selective allosteric inhibitor of the WDR5 protein (Ki= 0.008 μM). It induces conformational changes in the MLL1 complex, causing the dissociation of MLL1 from the complex and inhibiting MLL1 histone methyltransferase activity, thereby regulating HOX gene expression. CS-VIP 8 shows potential for research in hematological diseases such as leukemia.</p>Fórmula:C43H52F4N12O7Forma y color:SolidPeso molecular:924.4018UNC 0631
CAS:<p>UNC 0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).</p>Fórmula:C37H61N7O2Pureza:98.76%Forma y color:SolidPeso molecular:635.93PARP/EZH2-IN-1
CAS:<p>PARP/EZH2-IN-1: Dual PARP (IC50 6.87 nM) & EZH2 (IC50 36.51 nM) inhibitor, potential for BRCA-wild-type triple-negative breast cancer.</p>Fórmula:C43H41FN8O5Forma y color:SolidPeso molecular:768.85PRMT5-IN-12
CAS:<p>PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5 .</p>Fórmula:C32H40N4O4Forma y color:SolidPeso molecular:544.696WDR5-MYC-IN-1
<p>WDR5-MYC-IN-1 (compound 4o) is an effective inhibitor of the WDR5-MYC interaction, demonstrating a Ki value of 1.0 µM and exhibiting antiproliferative activity.</p>Forma y color:Odour SolidBAY-6035
CAS:<p>BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more than 100-fold selectivity over other histone methyltransferases.</p>Fórmula:C22H28N4O3Pureza:99.97%Forma y color:SolidPeso molecular:396.48MS1943
CAS:<p>MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).</p>Fórmula:C42H54N8O3Pureza:95.41% - 95.82%Forma y color:SolidPeso molecular:718.93EPZ-025654
CAS:<p>EPZ-025654 is an effective and selective inhibitor of arginine methyltransferase CARM1.</p>Fórmula:C29H33ClN8O3Forma y color:SolidPeso molecular:577.08EEDi-5285
CAS:<p>EEDi-5285: potent EED inhibitor, orally active, IC50=0.2nM, targets EED protein, anti-cancer properties.</p>Fórmula:C24H22FN5O3SPureza:100%Forma y color:SolidPeso molecular:479.53SW2_110A acetate
<p>SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD).</p>Fórmula:C44H64N6O9Pureza:98%Forma y color:SoildPeso molecular:821.01UNC2399
CAS:<p>UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its IC</p>Fórmula:C67H104N10O17SForma y color:SolidPeso molecular:1353.68MS9024
<p>MS9024 is a degrader of DNA methyltransferase 1 (DNMT1), facilitating its degradation in HCT116 cells via the ubiquitin-proteasome pathway, with a DC50 of 35 nM (DC50 values are 254 nM in MDA-MB-468 and 101 nM in H1299). Additionally, MS9024 inhibits DNMT1 with an IC50 of 0.43 μM.</p>Forma y color:Odour SolidG9a-IN-3
<p>G9a-IN-3 (compound 16g) is a potent G9a inhibitor with an IC50 of 0.002 μM. It is applicable for research in sickle cell disease.</p>Fórmula:C26H29N5O3Forma y color:SolidPeso molecular:459.22704PRMT1-IN-1
CAS:<p>PRMT1-IN-1 is a PRMT1 inhibitor.</p>Fórmula:C20H7Br6NO5Forma y color:SolidPeso molecular:820.702FTX-6058 hydrochloride
CAS:<p>FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.</p>Fórmula:C22H19ClFN5O2Forma y color:SolidPeso molecular:439.87MS33
CAS:<p>MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.</p>Fórmula:C64H84F3N11O7SForma y color:SolidPeso molecular:1208.5ND-L11B free base
<p>ND-L11B is an effective degrader of the nuclear receptor binding SET domain protein 2 (NSD2) and RE-IIBP, with DC50 values of 1.48 μM and 0.8 μM, respectively, and a Dmax close to 80%.</p>Fórmula:C37H51F3N10O2Forma y color:SolidPeso molecular:724.862CPI-1328
CAS:<p>CPI-1328 is an EZH2 inhibitor with a K i value of 63 fM.</p>Fórmula:C28H36ClN3O4SForma y color:SolidPeso molecular:546.12XF056-132
CAS:<p>XF056-132 is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader [1] .</p>Fórmula:C51H57F4N9O7SForma y color:SolidPeso molecular:1016.11MS049 2HCl (1502816-23-0(free base))
<p>MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.</p>Fórmula:C15H26Cl2N2OPureza:99.9%Forma y color:SolidPeso molecular:321.28SGC3027
<p>SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.</p>Fórmula:C41H47ClN6O6SPureza:98%Forma y color:SolidPeso molecular:787.37PRMT5-IN-15
CAS:<p>PRMT5-IN-15 is a PRMT5 inhibitor with an IC 50 value of 0.84 nM.</p>Fórmula:C24H23F3N6O2Forma y color:SolidPeso molecular:484.483EEDi-5273
CAS:<p>EEDi-5273: Potent oral EED inhibitor, IC50 ~0.2 nM; induces complete, lasting tumor regression.</p>Fórmula:C26H22F4N6O2Forma y color:SolidPeso molecular:526.496CM112
<p>CM112 is a selective degrader of protein arginine methyltransferase 1 (PRMT1), which connects a hydrophobic adamantane tag to MS023 via a 5-PEG linker. It induces the degradation of PRMT1 in various solid tumor cell lines. CM112 also targets the non-enzymatic functions of PRMT1 by reducing the stability of the orphan receptor TR3. This compound shows potential for cancer research.</p>Fórmula:C39H61N5O7Forma y color:SolidPeso molecular:711.4571EPZ020411 2HCl (1700663-41-7(free base))
<p>EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).</p>Fórmula:C25H40Cl2N4O3Pureza:98%Forma y color:SolidPeso molecular:515.51PRMT4-IN-3
<p>PRMT4-IN-3 (compound 56) serves as a potent class I protein arginine methyltransferase (PRMT) inhibitor, specifically targeting PRMT4 with an IC50 value of 37</p>Fórmula:C23H29N7OPureza:98%Forma y color:SolidPeso molecular:419.52NSC 370284
CAS:<p>NSC 370284 inhibits STAT3/5, reducing AML cell viability with TET1 overexpression in vitro/in vivo.</p>Fórmula:C21H25NO6Pureza:99.74%Forma y color:SolidPeso molecular:387.43UNC10013
<p>UNC10013 is an allosteric modulator of SETDB1, exhibiting negative allosteric regulation through covalent bond formation with Cys385 on the 3TD domain. It has a kinact/KI value of 1.0 × 10^6 M^-1*s^-1. UNC10013 effectively disrupts SETDB1-mediated Akt methylation, holding potential for application in cancer and neurodegenerative disease research.</p>Forma y color:Odour SolidDDO-2093
CAS:<p>DDO-2093 inhibits MLL1-WDR5 interaction (IC50: 8.6 nM, Kd: 11.6 nM), with strong antitumor properties and selectivity.</p>Fórmula:C29H37ClFN9O3Forma y color:SolidPeso molecular:614.12EZH2-IN-15
CAS:<p>A compound inhibits EZH2, overexpressed in cancers, affecting Treg activity and innate immunity.</p>Fórmula:C32H44N4O4Pureza:99.88%Forma y color:SolidPeso molecular:548.72Gintemetostat
CAS:<p>Gintemetostat (KTX-1001) is a potent NSD2 inhibitor (IC50=0.001-0.01μM) for treating NSD2-dysregulated cancers.</p>Fórmula:C25H26F4N8O2Forma y color:SolidPeso molecular:546.52AMI-1 free acid
CAS:<p>AMI-1: Potent reversible PRMT inhibitor; IC50: 8.8 μM (hPRMT1), 3.0 μM (yeast-Hmt1p); blocks substrate binding.</p>Fórmula:C21H16N2O9S2Pureza:97.8%Forma y color:SolidPeso molecular:504.49EZM0414 TFA
CAS:<p>EZM0414 TFA (SETD2-IN-1 TFA) is a SETD2 inhibitor with anticancer and antiproliferative effects for the study of leukemia and immune dysfunction.</p>Fórmula:C24H30F4N4O4Pureza:98.88%Forma y color:SolidPeso molecular:514.51PROTAC EZH2 Degrader-1
CAS:<p>PROTAC EZH2 Degrader-1 suppresses EZH2 methyltransferase activity with IC50 2.7 nM, serving as a potent tool in cancer research and EZH2 inhibition studies.</p>Fórmula:C54H67N7O8Forma y color:SolidPeso molecular:942.15(R)-HH2853
CAS:<p>(R)-HH2853, a mutant EZH2 inhibitor, IC50 <100 nM for EZH2-Y641F, targets cancer/autoimmune diseases.</p>Fórmula:C31H36F3N7O3Pureza:97.53% - 98.85%Forma y color:SolidPeso molecular:611.66MS8511 hydrochloride
CAS:<p>MS8511 hydrochloride is a selective G9a/GLP inhibitor with IC50 values of 100 nM and 140 nM respectively, exhibiting covalent and irreversible characteristics.</p>Fórmula:C28H42ClN5O3Forma y color:SolidPeso molecular:532.125'-Azido-5'-deoxyadenosine
CAS:<p>5'-Azido-5'-deoxyadenosine is a purine nucleoside analogue, inhibit Trichomonas vaginalis and PRMT5 , click chemistry alkyne, DBCO, or BCN groups.</p>Fórmula:C10H12N8O3Pureza:99.84%Forma y color:SolidPeso molecular:292.252'-Deoxy-2'-fluoro-β-D-arabinocytidine hydrochloride
CAS:<p>2'-Deoxy-2'-fluoro-beta-D-arabinocytidine HCl inhibits DNA methyltransferase with potential anti-tumor properties.</p>Fórmula:C9H13ClFN3O4Pureza:99.69%Forma y color:SolidPeso molecular:281.67O6BTG-octylglucoside
CAS:<p>O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor (IC50s: 10 nM and 32 nM in HeLa S3 cells and in vitro (cell extracts)).</p>Fórmula:C24H34BrN5O7SPureza:98%Forma y color:SolidPeso molecular:616.53DA-3003-1
CAS:<p>DA-3003-1 (NSC 663284) is a Cdc25 dual specificity phosphatase inhibitor with antitumor activity and inhibits Cdc25B2, Cdc25A, Cdc25B2, and Cdc25C.</p>Fórmula:C15H16ClN3O3Pureza:99.27% - 99.79%Forma y color:SolidPeso molecular:321.76EHMT2-IN-1
CAS:<p>EHMT2-IN-1: potent EHMT inhibitor, for blood disorders/cancer research; IC50s <100 nM for EHMT1/2 peptides and cellular EHMT2.</p>Fórmula:C18H23N7OForma y color:SolidPeso molecular:353.425-Aza-2'-deoxycytidine
CAS:Fórmula:C8H12N4O4Pureza:>98.0%(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:228.21EPZ020411
CAS:<p>EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).</p>Fórmula:C25H38N4O3Forma y color:SolidPeso molecular:442.6AS-85
CAS:<p>AS-85 is an ASH1L inhibitor with anti-leukemic activity that inhibits leukemic cell growth and increases cLogP.</p>Fórmula:C26H28F3N5O3S2Pureza:98.96%Forma y color:SolidPeso molecular:579.66
