ADN metiltransferasa
Las metiltransferasas de ADN (DNMT) son enzimas que catalizan la adición de grupos metilo a los residuos de citosina en el ADN, lo que lleva al silenciamiento génico. La metilación aberrante del ADN está asociada con diversas enfermedades, incluido el cáncer. Los inhibidores de DNMT bloquean la actividad de estas enzimas, lo que lleva a la reactivación de genes silenciados y la inducción de apoptosis en células cancerosas. Los inhibidores de DNMT se utilizan ampliamente en la investigación epigenética y la terapia contra el cáncer. En CymitQuimica, ofrecemos una gama de inhibidores de DNMT de alta calidad para apoyar su investigación en epigenética, metilación del ADN y biología del cáncer.
Se han encontrado 455 productos de "ADN metiltransferasa"
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JNJ-64619178
CAS:JNJ-64619178: selective, oral, pseudo-irreversible PRMT5 inhibitor (IC50: 0.14 nM), effective in lung cancer.Fórmula:C22H23BrN6O2Pureza:98.86% - 99.98%Forma y color:SolidPeso molecular:483.36Ref: TM-T15624
1mg88,00€5mg170,00€10mg274,00€25mg567,00€50mg944,00€100mg1.659,00€1mL*10mM (DMSO)182,00€GSK3326595
CAS:GSK3326595 (EPZ015938) is an inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50:6.2 nM.).Fórmula:C24H32N6O3Pureza:98.88% - 99.63%Forma y color:SolidPeso molecular:452.55SGI-1027
CAS:SGI-1027 (DNA Methyltransferase Inhibitor II) is an effective and selective inhibitor of DNA methyltransferase (DNMT).Fórmula:C27H23N7OPureza:99.45% - 99.78%Forma y color:SolidPeso molecular:461.52Ref: TM-T1904
5mg58,00€10mg94,00€25mg163,00€50mg296,00€100mg467,00€500mg1.035,00€1mL*10mM (DMSO)74,00€RG108
CAS:RG108 (N-Phthalyl-L-tryptophan) is an DNA methyltransferase inhibitor(IC50=115 nM).Fórmula:C19H14N2O4Pureza:98% - 99.43%Forma y color:SolidPeso molecular:334.33Ref: TM-T2038
5mg47,00€10mg69,00€25mg117,00€50mg205,00€100mg286,00€200mg401,00€500mg652,00€1mL*10mM (DMSO)56,00€Metoprine
CAS:Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.Fórmula:C11H10Cl2N4Pureza:98.42%Forma y color:SolidPeso molecular:269.13BIX-01294 trihydrochloride
CAS:BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.Fórmula:C28H38N6O2·3HClPureza:99.41% - 99.95%Forma y color:SolidPeso molecular:600.02Ref: TM-T1959
2mg52,00€5mg71,00€10mg107,00€25mg192,00€50mg274,00€100mg472,00€200mg642,00€1mL*10mM (DMSO)111,00€MS37452
CAS:MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).Fórmula:C22H26N2O5Pureza:99.39%Forma y color:SolidPeso molecular:398.45Ref: TM-T21767
5mg51,00€10mg88,00€25mg170,00€50mg305,00€100mg527,00€500mg1.121,00€1mL*10mM (DMSO)57,00€EPZ004777 hydrochloride
CAS:EPZ004777 hydrochloride (EPZ004777 HCl) is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.Fórmula:C28H42ClN7O4Forma y color:SolidPeso molecular:576.13UNC6934
CAS:UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.Fórmula:C24H21N5O4Pureza:98.67%Forma y color:SolidPeso molecular:443.45Ref: TM-T9584
1mg49,00€5mg97,00€10mg160,00€25mg344,00€50mg512,00€100mg707,00€200mg938,00€1mL*10mM (DMSO)106,00€UNC0638
CAS:UNC0638 inhibits G9a and GLP lysine methyltransferases with IC50 <15 nM and 19 nM, respectively, showing high selectivity.Fórmula:C30H47N5O2Pureza:98.88% - 99.53%Forma y color:SolidPeso molecular:509.73MIV-6R
CAS:MIV-6R inhibits Menin-MLL interaction (IC50: 56 nM) and can be used to study leukemia.Fórmula:C27H35N3OPureza:99.81% - 99.88%Forma y color:SolidPeso molecular:417.59MRK-740
CAS:MRK-740 is a PRDM9 histone methyltransferase inhibitor that inhibits H3K4 methylation.Fórmula:C25H32N6O3Pureza:99.66%Forma y color:SolidPeso molecular:464.56(S)-HH2853
CAS:(S)-HH2853 is a potent EZH1/2 inhibitor, aromatic, <100 nM IC50 for EZH2_Y641F, promising for anti-tumor/autoimmune research.Fórmula:C31H36F3N7O3Pureza:97.18% - 99.74%Forma y color:SolidPeso molecular:611.66CBHcy
CAS:CBHcy, a dual substrate analog, is a specific BHMT inhibitor that may induce cysteinemia.Fórmula:C9H17NO4SPureza:>99.99% - >99.99%Forma y color:SolidPeso molecular:235.3BI-9321 trihydrochloride
CAS:BI-9321 trihydrochloride (BI9321 trihydrochloride) is an NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression.Fórmula:C22H24Cl3FN4Pureza:99.12% - 99.34%Forma y color:SolidPeso molecular:469.81MS023 dihydrochloride
CAS:MS023 dihydrochloride (MS023 2HCl) is a human type I protein arginine methyltransferase inhibitor with antitumour activity for the study of breast cancer.Fórmula:C17H27Cl2N3OPureza:99.52%Forma y color:SolidPeso molecular:360.32TNG-462
CAS:TNG-462 is a oral, potent and selective PRMT5 inhibitor for the treatment of MTAP-deficient and/or MTA-accumulating cancers (e.g., pancreatic & bladder).Fórmula:C28H36N6O2SPureza:98.7%Forma y color:SolidPeso molecular:520.69Ref: TM-T79873
1mg156,00€5mg269,00€10mg404,00€25mg607,00€50mg912,00€100mg1.378,00€200mg1.853,00€1mL*10mM (DMSO)309,00€PFI-2
CAS:PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over otherFórmula:C23H25F4N3O3SPureza:99.38%Forma y color:SolidPeso molecular:499.52Ref: TM-T1987
1mgA consultar2mg58,00€5mg90,00€10mg129,00€25mg240,00€50mg416,00€100mg658,00€200mgA consultarGSK2807 Trifluoroacetate
CAS:GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).Fórmula:C21H33F3N8O7Pureza:99.95%Forma y color:SolidPeso molecular:566.53TETi76
CAS:TETi76 is an orally active inhibitor from the TET family, demonstrating IC50 values of 1.5, 9.4, and 8.8 μM against TET1, TET2, and TET3, respectively. The compound competitively binds to the active sites of TET enzymes, reducing cytosine hydroxymethylation and restricting clonal growth in mutated TET2 in vitro and in vivo, without affecting the growth of normal hematopoietic progenitor cells. TETi76 is utilized in leukemia research.Fórmula:C10H16O5Forma y color:SolidPeso molecular:216.23
