ADN metiltransferasa
Las metiltransferasas de ADN (DNMT) son enzimas que catalizan la adición de grupos metilo a los residuos de citosina en el ADN, lo que lleva al silenciamiento génico. La metilación aberrante del ADN está asociada con diversas enfermedades, incluido el cáncer. Los inhibidores de DNMT bloquean la actividad de estas enzimas, lo que lleva a la reactivación de genes silenciados y la inducción de apoptosis en células cancerosas. Los inhibidores de DNMT se utilizan ampliamente en la investigación epigenética y la terapia contra el cáncer. En CymitQuimica, ofrecemos una gama de inhibidores de DNMT de alta calidad para apoyar su investigación en epigenética, metilación del ADN y biología del cáncer.
Se han encontrado 459 productos de "ADN metiltransferasa"
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BIX-01294 trihydrochloride
CAS:BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.Fórmula:C28H38N6O2·3HClPureza:99.41% - 99.95%Forma y color:SolidPeso molecular:600.02Ref: TM-T1959
2mg50,00€5mg67,00€10mg102,00€25mg182,00€50mg259,00€100mg447,00€200mg607,00€1mL*10mM (DMSO)105,00€UNC1999
CAS:UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).Fórmula:C33H43N7O2Pureza:99.19% - >99.99%Forma y color:SolidPeso molecular:569.74Ref: TM-T3057
1mg34,00€2mg46,00€5mg66,00€10mg92,00€25mg167,00€50mg259,00€100mg401,00€200mg580,00€1mL*10mM (DMSO)94,00€AMI-1
CAS:AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1).
Fórmula:C21H14N2Na2O9S2Pureza:97.53% - 99.9%Forma y color:DrypowderPeso molecular:548.45MS37452
CAS:MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).Fórmula:C22H26N2O5Pureza:99.39%Forma y color:SolidPeso molecular:398.45Ref: TM-T21767
5mg49,00€10mg84,00€25mg166,00€50mg289,00€100mg500,00€500mg1.063,00€1mL*10mM (DMSO)54,00€Zebularine
CAS:Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor.Fórmula:C9H12N2O5Pureza:99.04% - >99.99%Forma y color:SolidPeso molecular:228.2GSK126
CAS:GSK126 (GSK2816126A) is a excellently specific EZH2 methyltransferase inhibitor ( IC50=9.9 nM).Fórmula:C31H38N6O2Pureza:98% - 99.67%Forma y color:SolidPeso molecular:526.67Ref: TM-T2079
2mg42,00€5mg62,00€10mg94,00€25mg143,00€50mg215,00€100mg331,00€200mg432,00€1mL*10mM (DMSO)71,00€UNC3866 TFA(1872382-47-2 free base)
CAS:UNC3866 TFA is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.Fórmula:C45H67F3N6O10Pureza:98.43%Forma y color:SolidPeso molecular:909.045-Methyl-2'-deoxycytidine
CAS:5-Methyl-2'-deoxycytidine (5MedCyd) is a pyrimidine nucleoside that when incorporated into single-stranded DNA can act in cis to signal de novo.Fórmula:C10H15N3O4Pureza:99.18% - 99.69%Forma y color:SolidPeso molecular:241.24CM-579 trihydrochloride
CM-579 trihydrochloride: reversible G9a/DNMT inhibitor with IC50s 16 nM (G9a) & 32 nM (DNMT); potent against various cancer cells.Fórmula:C29H43Cl3N4O3Forma y color:SolidPeso molecular:602.04GSK343
CAS:GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity againstFórmula:C31H39N7O2Pureza:98% - 99.9%Forma y color:SolidPeso molecular:541.69Amodiaquine hydrochloride
CAS:Amodiaquine dihydrochloride: 4-aminoquinoline antimalarial, histamine N-methyltransferase inhibitor (Ki 18.6 nM), Nurr1 agonist, anti-inflammatory.Fórmula:C20H24Cl3N3OForma y color:SolidPeso molecular:428.78TP-064
CAS:TP-064: Potent, selective PRMT4 inhibitor, IC50 < 10nM for H3 methylation, 100x selectivity, blocks MED12 methylation at 43nM.Fórmula:C28H34N4O2Pureza:97.85%Forma y color:SolidPeso molecular:458.6Ref: TM-T28996
1mg38,00€2mg49,00€5mg79,00€10mg119,00€25mg245,00€50mg487,00€100mg710,00€1mL*10mM (DMSO)80,00€TNG-462
CAS:TNG-462 is a oral, potent and selective PRMT5 inhibitor for the treatment of MTAP-deficient and/or MTA-accumulating cancers (e.g., pancreatic & bladder).Fórmula:C28H36N6O2SPureza:98.7%Forma y color:SolidPeso molecular:520.69Ref: TM-T79873
1mg156,00€5mg269,00€10mg404,00€25mg607,00€50mg912,00€100mg1.378,00€200mg1.853,00€1mL*10mM (DMSO)309,00€MRK-740
CAS:MRK-740 is a PRDM9 histone methyltransferase inhibitor that inhibits H3K4 methylation.Fórmula:C25H32N6O3Pureza:99.66%Forma y color:SolidPeso molecular:464.56CBHcy
CAS:CBHcy, a dual substrate analog, is a specific BHMT inhibitor that may induce cysteinemia.Fórmula:C9H17NO4SPureza:>99.99% - >99.99%Forma y color:SolidPeso molecular:235.3MS023 dihydrochloride
CAS:MS023 dihydrochloride (MS023 2HCl) is a human type I protein arginine methyltransferase inhibitor with antitumour activity for the study of breast cancer.Fórmula:C17H27Cl2N3OPureza:99.52%Forma y color:SolidPeso molecular:360.32(S)-HH2853
CAS:(S)-HH2853 is a potent EZH1/2 inhibitor, aromatic, <100 nM IC50 for EZH2_Y641F, promising for anti-tumor/autoimmune research.Fórmula:C31H36F3N7O3Pureza:97.18% - 99.74%Forma y color:SolidPeso molecular:611.66MIV-6R
CAS:MIV-6R inhibits Menin-MLL interaction (IC50: 56 nM) and can be used to study leukemia.Fórmula:C27H35N3OPureza:99.81% - 99.88%Forma y color:SolidPeso molecular:417.59BI-9321 trihydrochloride
CAS:BI-9321 trihydrochloride (BI9321 trihydrochloride) is an NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression.Fórmula:C22H24Cl3FN4Pureza:99.12% - 99.34%Forma y color:SolidPeso molecular:469.81PFI-2
CAS:PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over otherFórmula:C23H25F4N3O3SPureza:99.38%Forma y color:SolidPeso molecular:499.52Ref: TM-T1987
1mgA consultar2mg58,00€5mg90,00€10mg129,00€25mg240,00€50mg416,00€100mg658,00€200mgA consultar
