ADN metiltransferasa
Las metiltransferasas de ADN (DNMT) son enzimas que catalizan la adición de grupos metilo a los residuos de citosina en el ADN, lo que lleva al silenciamiento génico. La metilación aberrante del ADN está asociada con diversas enfermedades, incluido el cáncer. Los inhibidores de DNMT bloquean la actividad de estas enzimas, lo que lleva a la reactivación de genes silenciados y la inducción de apoptosis en células cancerosas. Los inhibidores de DNMT se utilizan ampliamente en la investigación epigenética y la terapia contra el cáncer. En CymitQuimica, ofrecemos una gama de inhibidores de DNMT de alta calidad para apoyar su investigación en epigenética, metilación del ADN y biología del cáncer.
Se han encontrado 421 productos de "ADN metiltransferasa"
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GSK-A
CAS:<p>GSK-A is a Histone Lysine Methyltransferase EZH2 inhibitor.</p>Fórmula:C21H25N5O2Forma y color:SolidPeso molecular:379.46CARM1-IN-3
CAS:<p>CARM1-IN-3 (compound 17b) is a potent, selective inhibitor of co-activator associated arginine methyltransferase (CARM1), exhibiting IC50 values of 0.07 µM for</p>Fórmula:C24H32N4O2Pureza:98%Forma y color:SolidPeso molecular:408.54EPZ-030456
CAS:<p>EPZ-030456 is an effective and selective inhibitor of the SMYD3.</p>Fórmula:C28H34ClN5O4SForma y color:SolidPeso molecular:572.12MS023 trihydrochloride
CAS:<p>MS023 trihydrochloride (MS023 3HCl) is a PRMT inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer research.</p>Fórmula:C17H28Cl3N3OPureza:99.81%Forma y color:SolidPeso molecular:396.78PRT543
CAS:<p>PRT543 is a potent selective inhibitor of the protein arginine methyltransferase 5 (PRMT5), showing a wide range of antitumor activities in vitro and in vivo. The compound also showed an inhibitory effect on methyltransferase activity of the PRMT5/MEP50 complex with an IC50 value of 10.8 nM.</p>Fórmula:C17H17ClN4O4Forma y color:SolidPeso molecular:376.79RK-701
CAS:<p>RK-701: G9a inhibitor, IC50 23-27 nM, increases HbF/γ-Globin/BGLT3, decreases H3K9me2, inhibits BCL11A/ZBTB7A.</p>Fórmula:C26H30N4O3Forma y color:SolidPeso molecular:446.54EPZ031686
CAS:<p>EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.</p>Fórmula:C26H34ClF3N4O4SPureza:99.67%Forma y color:SolidPeso molecular:591.09(1-Nitroethene-1,2-diyl)dibenzene
CAS:<p>(1-Nitroethene-1,2-diyl)dibenzene (alpha-Nitrostilbene; α-Nitrostilbene) serves as an inhibitor of protein arginine methyltransferase 1 (PRMT1; histone H4 methylation assay with an IC50 of 11 μM). At concentrations of 10 and 100 μM, it also inhibits histone H4 methylation caused by PRMT8 but does not affect methylation of histone H3.1 induced by CARM1 or Set7/9.</p>Fórmula:C14H11NO2Forma y color:SolidPeso molecular:225.24PRMT5-IN-48
CAS:<p>PRMT5-IN-48 (compound D3) is an orally active PRMT5 inhibitor with an IC50 of 20.7 nM, displaying antitumor activity. It effectively suppresses the growth of various cancer cells, induces apoptosis, and causes cell cycle arrest at the G0/G1 phase. PRMT5-IN-48 is applicable for research in non-Hodgkin's lymphoma (NHL).</p>Fórmula:C30H37N5O3Forma y color:SolidPeso molecular:515.646PRMT5-IN-49
CAS:<p>PRMT5-IN-49 (Compound 4b16) is an inhibitor of PRMT5.</p>Fórmula:C19H22N2O2Forma y color:SolidPeso molecular:310.39W4275
CAS:<p>W4275 (Compound 42) is a selective NSD2 inhibitor with oral activity and an IC50 of 17 nM. It exhibits antiproliferative activity, with an IC50 of 230 nM against RS411 cells, and significantly inhibits tumor growth in an RS411 tumor xenograft model. Pharmacokinetic analysis in mice shows that W4275 has a favorable oral bioavailability (F is 27.34%). W4275 holds potential for use in cancer research.</p>Fórmula:C25H36N6O3Forma y color:SolidPeso molecular:468.59O6BTG-C8-αGlu
CAS:<p>O6BTG-C8-αGlu is an O6-methylguanine-DNA methyltransferase (MGMT) inhibitor with an IC50 of 0.45 μM. At a concentration of 0.1 μM, it fully inhibits MGMT in HeLaS3 cells and demonstrates no cytotoxicity even at prolonged high doses (up to 20 μM). This compound is suitable for research on MGMT-related cancers.</p>Fórmula:C24H34BrN5O7SForma y color:SolidPeso molecular:616.525PRMT5-IN-37
CAS:<p>PRMT5-IN-37 (compound 29), an orally active inhibitor of PRMT5, is utilized for cancer research.</p>Fórmula:C21H15F4N5O2Forma y color:SolidPeso molecular:445.37NSD2-PWWP1-IN-1
CAS:<p>NSD2-PWWP1-IN-1 (compound 31) is a potent inhibitor of NSD2-PWWP1 with an IC50 value of 0.64 µM, demonstrating potential applications in cancer research.</p>Fórmula:C28H30N4Forma y color:SolidPeso molecular:422.565MM-589
CAS:<p>MM-589 is a potent WD repeat domain 5 (WDR5) inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.</p>Fórmula:C28H44N8O5Pureza:98%Forma y color:SolidPeso molecular:572.70AMI-408
CAS:<p>AMI-408 is a PRMT1 inhibitor that effectively reduces the levels of H4R3me2as in MLL-GAS7 leukemia cells.</p>Fórmula:C20H13Cl2N6NaO5SForma y color:SolidPeso molecular:543.32RL5a
CAS:<p>RL5a (compound C23) is a novel inhibitor of SETD8.</p>Fórmula:C17H19N3OForma y color:SolidPeso molecular:281.35EED ligand 1
<p>EED ligand 1: potent PRC2 inhibitor targeting EED subunit.</p>Fórmula:C19H19FN8OForma y color:SolidPeso molecular:394.41RK-0080552
CAS:<p>RK-0080552 (RK-552) is an inhibitor of the NSD2 histone methyltransferase. It demonstrates significant cytotoxicity against multiple myeloma (MM) cells harboring the t(4;14) translocation. This compound suppresses the IRF4 gene and decreases the dimethylation of histone H3 at lysine 36. RK-0080552 holds promise for research in hematologic malignancies.</p>Fórmula:C12H6N6O2Forma y color:SolidPeso molecular:266.215EZH2-IN-12
<p>EZH2-IN-12 (Compound 5) is a potent inhibitor of EZH2, which has potential for studies of CNS malignancies.</p>Fórmula:C23H23Cl2N3O3Forma y color:SolidPeso molecular:460.35
