ADN metiltransferasa
Las metiltransferasas de ADN (DNMT) son enzimas que catalizan la adición de grupos metilo a los residuos de citosina en el ADN, lo que lleva al silenciamiento génico. La metilación aberrante del ADN está asociada con diversas enfermedades, incluido el cáncer. Los inhibidores de DNMT bloquean la actividad de estas enzimas, lo que lleva a la reactivación de genes silenciados y la inducción de apoptosis en células cancerosas. Los inhibidores de DNMT se utilizan ampliamente en la investigación epigenética y la terapia contra el cáncer. En CymitQuimica, ofrecemos una gama de inhibidores de DNMT de alta calidad para apoyar su investigación en epigenética, metilación del ADN y biología del cáncer.
Se han encontrado 451 productos de "ADN metiltransferasa"
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A-395
CAS:<p>A-395 blocks PRC2 (EZH2-EED-SUZ12) interactions, strongly inhibiting the complex with an IC50 of 18 nM.</p>Fórmula:C26H35FN4O2SPureza:98.43%Forma y color:SolidPeso molecular:486.65Phthalazine, 1-hydrazinyl-, hydrochloride (1:1)
CAS:Fórmula:C8H9ClN4Pureza:98%Forma y color:SolidPeso molecular:196.6369(E)-3,4-dihydroxycinnamic acid
CAS:Fórmula:C9H8O4Pureza:98%Forma y color:SolidPeso molecular:180.1574Dihydro-5-azacytidine FA
Dihydro-5-azacytidine FA (DHAC) is a pyrimidine analog that has antitumor activity, inhibits cell growth, inhibits DNA methylation, and may be used in the study of malignant mesothelioma.Fórmula:C9H16N4O7Pureza:>99.99%Forma y color:SolidPeso molecular:292.25Decitabine
CAS:Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity.Fórmula:C8H12N4O4Pureza:98.06% - 99.87%Forma y color:Physical Description Fine White Crystalline Powder Used As A DrugPeso molecular:228.21Diperodon hydrochloride
CAS:Diperodon hydrochloride (Diperocaine) is a local anesthetic that can be broken down by serolytic enzymes to produce local anesthetic effects.Fórmula:C22H28ClN3O4Pureza:99.91%Forma y color:SolidPeso molecular:433.93EBI-2511
CAS:EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).Fórmula:C34H48N4O4Pureza:99.74%Forma y color:SolidPeso molecular:576.77DC-05
CAS:<p>DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).</p>Fórmula:C25H25N3OPureza:98.95%Forma y color:SolidPeso molecular:383.49iso-Azalansta
CAS:(2R,4S)-Azalanstat (Iso-Azalansta) is a selective heme oxygenase (HO) inhibitor that is used in the study of cardiovascular disease.Fórmula:C22H24ClN3O2SPureza:99.53% - 99.89%Forma y color:SoildPeso molecular:429.96BVT948
CAS:BVT948 is a protein tyrosine phosphatase (PTP) inhibitor.It can also inhibit lysine methyltransferase SETD8 (KMT5A) and several cytochrome P450 (P450) isoforms.Fórmula:C14H11NO3Pureza:98.87%Forma y color:SolidPeso molecular:241.24(1S,3R,4R,5R)-3-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,4,5-trihydroxycyclohexane-1-carboxylic acid
CAS:Fórmula:C16H18O9Pureza:98%Forma y color:SolidPeso molecular:354.3087Ref: IN-DA00I681
1g30,00€5g52,00€10g75,00€1kgA consultar25g153,00€100g489,00€250gA consultar500gA consultar50kg41.345,00€250mg26,00€DNMT1/HDAC-IN-1
DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.Forma y color:Odour SolidE67-2
CAS:E67-2: Low-toxic, KIAA1718 inhibitor with IC50 of 3.4μM, targets H3K9/H3K4 demethylases.Fórmula:C21H36N6O2Forma y color:SolidPeso molecular:404.559EZH2-IN-5
CAS:EZH2-IN-5, potent EZH2 inhibitor; IC50: 1.52 nM (wild-type), 4.07 nM (Tyr641 mutant).Fórmula:C26H37BrN4O2Forma y color:SolidPeso molecular:517.512MS2133
<p>MS2133 is a DOT1L PROTAC degrader. It facilitates the ubiquitination and degradation of DOT1L in THP-1 and MV4-11 cells, with DC50 values of 56 nM and 25 nM, respectively, and reduces H3K79 methylation. MS2133 also inhibits the growth of MLL-r leukemia cells, demonstrating anticancer activity.</p>Fórmula:C58H66ClF3N14O11S2Forma y color:SolidPeso molecular:1290.41175Larsucosterol Ammonium salt
CAS:Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.Fórmula:C27H49NO5SPureza:>99.99% - >99.99%Forma y color:SoildPeso molecular:499.75
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