Sirtuin

Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum …

Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism …

Niacinamide is an important compound functioning as a component of the coenzyme NAD. Its primary …

SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).

Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).

5-O-Feruloylquinic acid is a potent Sirt1 agonist, it is a potential lead compound that can …

Benzamide, N-(3-imidazo[2,1-b]thiazol-6-ylphenyl)-2-methoxy exhibits antidiabetic, anti-inflammatory and antitumor activities.

PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a …

SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM. SIRT1-IN-1 is …

WAY-270360 is a sirtuin modulator and an epidermal growth factor receptor (EGFR) inhibitor.

RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor …

Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.

Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl) is a sirtuin modulator and useful for increasing the lifespan of a cell, …

(+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2.

4H-1,2,4-Triazole, 3-(phenoxymethyl)-4-phenyl-5-[(phenylmethyl)thio]- is an inhibitor of SIRT2 with antitumor activity.

MC3482 is a specific inhibitor of sirtuin5 (SIRT5).

Sirtuin modulator 1 is a modulator of SIRT1 with EC1.5 of < 1 μM.

JGB1741 is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. …

Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.

E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma …

Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).

N-Caffeoyltryptophan, a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 …

Tenovin-6 is a p53 transcriptional activity agonist.

Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes …

UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)

SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold …

AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 μM).that prevents hippocampal neurodegeneration in Alzheimer's disease …

SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).

Splitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a …

Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: …

Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin …

Suramin Sodium is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic …

Tenovin-3 acts as a p53 activator.

Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and …

Selisistat R-enantiomer is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat …

Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 …

SRT2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.

OSS_128167 is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).

AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 …

SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).

AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models …

Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally …

4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)

SRT1460 is a SIRT1 activator.

YK-3-237 reduces acetylation of mtp53 and exhibits anti-proliferative effects toward triple-negative breast cancer (TNBC) cells …

Scopolin formation is increased by the enhanced activity of PAL. Scopolin can reduce the clinical …

CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that …

Selisistat S-enantiomer is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows …

1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.

Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: …

B2 promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease

3-TYP is a selective SIRT3 inhibitor.

Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which …

SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 …

Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin …

lithospermic acid B is a water-soluble antioxidant from Salvia extract. It plays significant role of …

Kuchinashi yellow has anti atherosclerosis and hypolipidemic effects.

EX 527 is an effective and specific SIRT1 inhibitor (IC50: 38 nM) and shows >200-fold …

SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent …

SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent …

MC2184 is the inhibitor of human recombinant SIRT1.

Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.